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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3336
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pklr
Name: pyruvate kinase L/R
Acc ID: CHEBI:28757
Term: fructose
Definition: A ketohexose that is an isomer of glucose.
Chemical ID: MESH:D005632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pklraffects degradationEXP 6480464CTDFructose affects the degradation of PKLR mRNAPMID:2414297
Pklraffects expressionEXP 6480464CTDFructose affects the expression of PKLR mRNAPMID:6759123
Pklrincreases expressionEXP 6480464CTDFructose results in increased expression of PKLR mRNAPMID:18346472 PMID:19053045 PMID:21122807 PMID:2193023 PMID:2824512 PMID:6526814
Pklrmultiple interactionsEXP 6480464CTDAtorvastatin inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA]PMID:19053045 PMID:21122807 PMID:2414297
Pklrincreases expressionISOPklr (Mus musculus)6480464CTDFructose results in increased expression of PKLR mRNAPMID:17786952 PMID:28123933
Pklrmultiple interactionsISOPklr (Mus musculus)6480464CTDFGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]; lactisole inhibits the reaction [Fructose results in increased expression of PKLR mRNA]PMID:17786952 PMID:28123933
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