1. |
Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A. |
Abrass CK and Hansen KM, J Biol Chem. 2010 Apr 23;285(17):12925-34. doi: 10.1074/jbc.M109.061754. Epub 2010 Feb 18.
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2. |
Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. |
Akool el-S, etal., J Immunol. 2008 Aug 15;181(4):2831-45.
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3. |
SMAD4 mutation segregating in a family with juvenile polyposis, aortopathy, and mitral valve dysfunction. |
Andrabi S, etal., Am J Med Genet A. 2011 May;155A(5):1165-9. doi: 10.1002/ajmg.a.33968. Epub 2011 Apr 4.
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4. |
Genotype-defined cancer risk in juvenile polyposis syndrome. |
Aytac E, etal., Br J Surg. 2015 Jan;102(1):114-8. doi: 10.1002/bjs.9693. Epub 2014 Nov 12.
|
5. |
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. |
Bornstein S, etal., J Clin Invest. 2009 Nov;119(11):3408-19. doi: 10.1172/JCI38854. Epub 2009 Oct 19.
|
6. |
A novel SMAD4 gene mutation in seminoma germ cell tumors. |
Bouras M, etal., Cancer Res. 2000 Feb 15;60(4):922-8.
|
7. |
Transforming growth factor-beta pathway in human renal cell carcinoma and surrounding normal-appearing renal parenchyma. |
Cardillo MR, etal., Anal Quant Cytol Histol. 2001 Apr;23(2):109-17.
|
8. |
[Effect of Budesonide on Smad4, PDGF-A and PAI-1 in a rat model of pulmonary fibrosis]. |
Chen JP, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 May;28(5):478-80.
|
9. |
Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF. |
Dai C and Liu Y, J Am Soc Nephrol. 2004 Jun;15(6):1402-12.
|
10. |
Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. |
Dong MX, etal., World J Gastroenterol. 2009 Oct 14;15(38):4753-62.
|
11. |
[Effect of schisandrin B on lung mRNA expression of transforming growth factor-beta1 signal transduction molecule in rat lungs exposed to silica]. |
Fan LH, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011 Apr;29(4):255-9.
|
12. |
Zhonghua zhong liu za zhi [Chinese journal of oncology] |
Fan Z, etal., Zhonghua Zhong Liu Za Zhi. 2001 Mar;23(2):135-7.
|
13. |
Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP-HHT syndrome. |
Gallione C, etal., Am J Med Genet A. 2010 Feb;152A(2):333-9. doi: 10.1002/ajmg.a.33206.
|
14. |
SMAD4 mutations found in unselected HHT patients. |
Gallione CJ, etal., J Med Genet. 2006 Oct;43(10):793-7. Epub 2006 Apr 13.
|
15. |
A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4). |
Gallione CJ, etal., Lancet. 2004 Mar 13;363(9412):852-9.
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16. |
Disruption of Smad4 in odontoblasts causes multiple keratocystic odontogenic tumors and tooth malformation in mice. |
Gao Y, etal., Mol Cell Biol. 2009 Nov;29(21):5941-51. doi: 10.1128/MCB.00706-09. Epub 2009 Aug 24.
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17. |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
|
18. |
Rat ISS GO annotations from GOA human gene data--August 2006 |
GOA data from the GO Consortium
|
19. |
Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. |
Hao J, etal., Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H3020-30.
|
20. |
Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. |
Hara S, etal., Exp Toxicol Pathol. 2014 Aug;66(5-6):225-34. doi: 10.1016/j.etp.2014.02.002. Epub 2014 Mar 26.
|
21. |
Prevalence of thoracic aortopathy in patients with juvenile Polyposis Syndrome-Hereditary Hemorrhagic Telangiectasia due to SMAD4. |
Heald B, etal., Am J Med Genet A. 2015 Aug;167A(8):1758-62. doi: 10.1002/ajmg.a.37093. Epub 2015 Apr 30.
|
22. |
Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. |
Horvath LG, etal., Prostate. 2004 May 15;59(3):234-42.
|
23. |
Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot. |
Howe JR, etal., Am J Hum Genet. 2002 May;70(5):1357-62. Epub 2002 Mar 27.
|
24. |
Mutations in the SMAD4/DPC4 gene in juvenile polyposis. |
Howe JR, etal., Science. 1998 May 15;280(5366):1086-8.
|
25. |
[Changes in TGF-beta1/Smads signaling pathway in rats with chemical hepatocarcinogenesis]. |
Hua YP, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Oct;28(10):1848-52.
|
26. |
Effect of wound type on Smad 2 and 4 translocation. |
Hutcheon AE, etal., Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2362-8.
|
27. |
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. |
Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
|
28. |
SMAD4 germinal mosaicism in a family with juvenile polyposis and hypertrophic osteoarthropathy. |
Lamireau T, etal., J Pediatr Gastroenterol Nutr. 2005 Jul;41(1):117-20.
|
29. |
Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome. |
Le Goff C, etal., Nat Genet. 2011 Dec 11;44(1):85-8. doi: 10.1038/ng.1016.
|
30. |
Expression of DPC4/Smad4 gene in stone-containing intrahepatic bile duct. |
Lee KT, etal., J Surg Oncol. 2006 Sep 15;94(4):338-43. doi: 10.1002/jso.20517.
|
31. |
Expression of Smad2 and Smad4, transforming growth factor-beta signal transducers in rat endometrium during the estrous cycle, pre-, and peri-implantation. |
Lin HY, etal., Anim Reprod Sci 2004 Feb;80(3-4):303-16.
|
32. |
Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells. |
Liu L, etal., Am J Physiol Gastrointest Liver Physiol 2003 Nov;285(5):G1056-67. Epub 2003 Jul 10.
|
33. |
cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. |
Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7.
|
34. |
Inactivation of Smad4 leads to impaired ocular development and cataract formation. |
Liu Y, etal., Biochem Biophys Res Commun. 2010 Oct 1;400(4):476-82. doi: 10.1016/j.bbrc.2010.08.065. Epub 2010 Aug 22.
|
35. |
Expression and location of Smad2, 4 mRNAs during and after liver fibrogenesis of rats. |
Liu Y, etal., World J Gastroenterol. 2006 Mar 14;12(10):1577-82.
|
36. |
Loss of Smad4 expression predicts liver metastasis in human colorectal cancer. |
Losi L, etal., Oncol Rep. 2007 May;17(5):1095-9.
|
37. |
Effects of platycodins on liver complications of type 2 diabetes. |
Luan H, etal., Mol Med Rep. 2014 Sep;10(3):1597-603. doi: 10.3892/mmr.2014.2363. Epub 2014 Jul 4.
|
38. |
Downregulation of secretory leukocyte proteinase inhibitor in chronic obstructive lung disease: the role of TGF-beta/Smads signaling pathways. |
Luo BL, etal., Arch Med Res. 2008 May;39(4):388-96. doi: 10.1016/j.arcmed.2008.02.002.
|
39. |
Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer. |
Maliekal TT, etal., Oncogene. 2003 Jul 31;22(31):4889-97.
|
40. |
TGFbeta in Cancer. |
Massagué J, Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001.
|
41. |
Rat ISS GO annotations from MGI mouse gene data--August 2006 |
MGD data from the GO Consortium
|
42. |
Expression of Smad4 during rat ovarian development. |
Miao ZL, etal., Di Yi Jun Yi Da Xue Xue Bao. 2005 Feb;25(2):127-31.
|
43. |
KAI1, CAR, and Smad4 expression in the progression of colorectal tumor. |
Mikami T, etal., J Gastroenterol. 2001 Jul;36(7):465-9. doi: 10.1007/s005350170069.
|
44. |
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. |
Miyaki M, etal., Oncogene. 1999 May 20;18(20):3098-103. doi: 10.1038/sj.onc.1202642.
|
45. |
SMAD4 gene mutation predicts poor prognosis in patients undergoing resection for colorectal liver metastases. |
Mizuno T, etal., Eur J Surg Oncol. 2018 May;44(5):684-692. doi: 10.1016/j.ejso.2018.02.247. Epub 2018 Mar 7.
|
46. |
Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. |
Morty RE, etal., Arterioscler Thromb Vasc Biol. 2007 May;27(5):1072-8. Epub 2007 Mar 8.
|
47. |
Significance of pSmad2/3 and Smad4 in hepatitis C virus-related liver fibrosis and hepatocellular carcinoma. |
Moussa MM, etal., APMIS. 2018 Jun;126(6):477-485. doi: 10.1111/apm.12844.
|
48. |
Electronic Transfer of LocusLink and RefSeq Data |
NCBI rat LocusLink and RefSeq merged data July 26, 2002
|
49. |
Altered expression of Smad family members in injured motor neurons of rat. |
Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
|
50. |
OMIM Disease Annotation Pipeline |
OMIM Disease Annotation Pipeline
|
51. |
Expression and localization of the transforming growth factor-beta type I receptor and Smads in preneoplastic lesions during chemical hepatocarcinogenesis in rats. |
Park do Y, etal., J Korean Med Sci 2003 Aug;18(4):510-9.
|
52. |
TGF-beta signaling is disrupted in endometrioid-type endometrial carcinomas. |
Piestrzeniewicz-Ulanska D, etal., Gynecol Oncol. 2004 Oct;95(1):173-80.
|
53. |
KEGG Annotation Import Pipeline |
Pipeline to import KEGG annotations from KEGG into RGD
|
54. |
PID Annotation Import Pipeline |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD
|
55. |
Deletion of Smad4 reduces hepatic inflammation and fibrogenesis during nonalcoholic steatohepatitis progression. |
Qin G, etal., J Dig Dis. 2018 May;19(5):301-313. doi: 10.1111/1751-2980.12599. Epub 2018 Jun 6.
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56. |
Smad signaling in the rat model of monocrotaline pulmonary hypertension. |
Ramos MF, etal., Toxicol Pathol. 2008 Feb;36(2):311-20. doi: 10.1177/0192623307311402. Epub 2008 Mar 26.
|
57. |
GOA pipeline |
RGD automated data pipeline
|
58. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
|
59. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
|
60. |
Age-dependent expression of Pten and Smad4 genes in the urogenital system of Wistar rats. |
Rocha BR, etal., Acta Cir Bras. 2014;29 Suppl 1:34-8.
|
61. |
Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal. |
Roth S, etal., J Med Genet. 2000 Apr;37(4):298-300.
|
62. |
SMAD proteins are involved in apoptosis induction in ventricular cardiomyocytes. |
Schneiders D, etal., Cardiovasc Res. 2005 Jul 1;67(1):87-96. Epub 2005 Mar 23.
|
63. |
BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. |
Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
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64. |
Mechanisms of TGF-beta signaling from cell membrane to the nucleus. |
Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
|
65. |
Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model. |
Shojaei-Zarghani S, etal., Biomed Pharmacother. 2021 Feb;134:111140. doi: 10.1016/j.biopha.2020.111140. Epub 2020 Dec 24.
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66. |
Association between Altered Expression and Genetic Variations of Transforming Growth Factor ß-Smad Pathway with Chronic Myeloid Leukemia. |
Shokeen Y, etal., Int J Hematol Oncol Stem Cell Res. 2018 Jan 1;12(1):14-22.
|
67. |
Smad4 mediates activation of mitogen-activated protein kinases by TGF-beta in pancreatic acinar cells. |
Simeone DM, etal., Am J Physiol Cell Physiol. 2001 Jul;281(1):C311-9.
|
68. |
Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer. |
Sunde JS, etal., Cancer Res. 2006 Sep 1;66(17):8404-12.
|
69. |
SMAD4 haploinsufficiency associates with augmented colonic inflammation in select humans and mice. |
Szigeti R, etal., Ann Clin Lab Sci. 2012 Fall;42(4):401-8.
|
70. |
Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. |
Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
|
71. |
Biologically different subgroups of invasive ductal carcinoma of the pancreas: Dpc4 status according to the ratio of intraductal carcinoma components. |
Takahashi H, etal., Clin Cancer Res. 2004 Jun 1;10(11):3772-9. doi: 10.1158/1078-0432.CCR-03-0120.
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72. |
Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers. |
Takakura S, etal., Genes Chromosomes Cancer. 1999 Mar;24(3):264-71.
|
73. |
Inhibiting scar formation in vitro and in vivo by adenovirus-mediated mutant Smad4: a preliminary report. |
Tan WQ, etal., Exp Dermatol. 2011 Feb;20(2):119-24. doi: 10.1111/j.1600-0625.2010.01186.x.
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74. |
[Smad4 and TGF-beta1 expression and clinical significance in bladder transitional cell carcinoma] |
Tang ZY, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Jun;31(3):363-6.
|
75. |
Tentative Sequence Identification Numbers |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
|
76. |
Activin signal transduction in the fetal rat adrenal gland and in human H295R cells. |
Wang EY, etal., J Endocrinol 2003 Jul;178(1):137-48.
|
77. |
MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival. |
Wang Y, etal., PLoS One. 2013 Jul 29;8(7):e68744. doi: 10.1371/journal.pone.0068744. Print 2013.
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78. |
[Expressions of transforming growth factor-beta(1) and Smad4 in rat models of chronic nonbacterial prostatitis and their clinical significance]. |
Wang YM, etal., Zhonghua Nan Ke Xue. 2010 Jun;16(6):490-4.
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79. |
Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. |
Wei XH, etal., Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002.
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80. |
Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. |
Wong CK, etal., Mol Cancer Res. 2020 Mar;18(3):414-423. doi: 10.1158/1541-7786.MCR-19-0525. Epub 2020 Jan 13.
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81. |
Pancreatic cancer: molecular pathogenesis and new therapeutic targets. |
Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
|
82. |
Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers. |
Woodford-Richens KL, etal., Am J Pathol. 2001 Oct;159(4):1293-300.
|
83. |
Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study. |
Xie W, etal., Cancer Res. 2002 Jan 15;62(2):497-505.
|
84. |
TGF-beta signaling alterations and susceptibility to colorectal cancer. |
Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
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85. |
Non-virus-mediated transfer of siRNAs against Runx2 and Smad4 inhibit heterotopic ossification in rats. |
Xue T, etal., Gene Ther. 2010 Mar;17(3):370-9. doi: 10.1038/gt.2009.154. Epub 2009 Nov 26.
|
86. |
Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer. |
Yan P, etal., Clin Cancer Res. 2016 Jun 15;22(12):3037-47. doi: 10.1158/1078-0432.CCR-15-0939. Epub 2016 Feb 9.
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87. |
Inactivation of Smad4 is a prognostic factor in intrahepatic cholangiocarcinoma. |
Yan XQ, etal., Chin Med J (Engl). 2013 Aug;126(16):3039-43.
|
88. |
Smad4 expression in hepatocellular carcinoma differs by hepatitis status. |
Yao L, etal., Asian Pac J Cancer Prev. 2012;13(4):1297-303. doi: 10.7314/apjcp.2012.13.4.1297.
|
89. |
Apoptosis incidence and protein expression of p53, TGF-beta receptor II, p27Kip1, and Smad4 in benign, premalignant, and malignant human prostate. |
Zeng L, etal., Hum Pathol. 2004 Mar;35(3):290-7.
|
90. |
Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. |
Zhang M, etal., J Biol Chem. 2010 Mar 19;285(12):8703-10. doi: 10.1074/jbc.M109.093526. Epub 2010 Jan 22.
|
91. |
[High glucose induces sumoylation of Smad4 via SUMO2/3 in glomerular mesangial cells]. |
Zhou XQ, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 May;45(3):380-5.
|
92. |
Involvement of mutations in the DPC4 promoter in endometrial carcinoma development. |
Zhou Y, etal., Mol Carcinog. 1999 May;25(1):64-72.
|