Gene:	Smad4 ( Rattus norvegicus ) SMAD family member 4
Description:	transduces signal from TGF-beta; deletion of human homolog gene is associated with pancreatic carcinomas
Synonyms:	Madh4; MAD (mothers against decapentaplegic, Drosophila) homolog 4; MAD homolog 4 (Drosophila);
ArrayIDs:	5966653; 1386984_at; 5853614; 6103063; 6705185; 6228221; rc_AI008639_at; 1367910_at; 6631513; 5736557; 6484554; A_43_P12002; 5748288; 6661202; 6258964; 6046646; 6394808; 6013895; 6055928; 5901942; 6611577; 6353446;  (details...)
Gene Type:	protein-coding
Additional Data
primer pair:	69173
Homologs
Homo sapiens: SMAD4     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Smad4     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Smad4 genome assembly 3.1 18 70504785 - 70534814     Rat Celera Assembly 18 65246064 - 65276480     RGSC genome assembly v3.4 18 70431585 - 70461613     Cytogenetic 18 q12.3 Mus musculus Smad4 Mouse genome assembly build 36.1 18 73798667 - 73863395     Cytogenetic 18 18 E2 Homo sapiens SMAD4 human genome assembly 18 46810610 - 46860144     Human genome assembly build 36.2 18 46810611 - 46860145     Cytogenetic 18 q21.1   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology transcription factor activity,  collagen binding,  transforming growth factor beta receptor, common-partner cytoplasmic mediator activity ...  (details...)
Biological Process	Gene Ontology SMAD protein complex assembly,  BMP signaling pathway,  positive regulation of transcription from RNA polymerase II promoter ...  (details...)
Cellular Component	Gene Ontology protein complex,  nucleus,  nucleoplasm ...  (details...)
Disease	Note Reference deletions in human gene are associated with pancreatic carcinomas 734492 Ontology Prostatic Intraepithelial Neoplasia,  Ovarian Neoplasms,  Colorectal Neoplasms ...  (details...)
Pathway	Ontology transforming growth factor-beta Smad dependent signaling pathway,  altered transforming growth factor-beta Smad dependent signaling pathway,  SMAD dependent signaling pathways ...  (details...)
External Links
Databases	DATABASE ID SOURCE SMART: DWB IPI SMART: DWA IPI PROSITE: MH2 IPI PROSITE: MH1 IPI UNIPARC: UPI0001B79DD6 IPI UNIPARC: UPI0000135A7C IPI KEGG Report: rno:50554 ENTREZGENE HomoloGene Group ID: 31310 ENTREZGENE Germonline: 3033 Pfam: MH1 IPI Pfam: MH2 IPI KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 04350 ENTREZGENE KEGG Pathway: 04110 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04520 ENTREZGENE InterPro: MAD_homology1_Dwarfin-type. IPI InterPro: SMAD_dom-like. IPI InterPro: MAD_homology_MH1. IPI InterPro: Dwarfin. IPI InterPro: SMAD_FHA_domain. IPI InterPro: SMAD_dom_Dwarfin-type. IPI Ensembl Protein: ENSRNOP00000063487 IPI Ensembl Protein: ENSRNOP00000021113 IPI IPI: IPI00198545 IPI IPI: IPI00948865 IPI Gene3D-CATH: MH2_Dwarfin-type IPI Gene3D-CATH: MAD_MH1 IPI Entrez Gene: Smad4 ENTREZGENE TIGR: TC217262 UniProt: SMAD4_RAT IPI Ensembl Genes: ENSRNOG00000015634 IPI RatMap: 45129 ENTREZGENE Superfamily-SCOP: SMAD_FHA IPI Superfamily-SCOP: MAD_MH1 IPI PANTHER: Dwarfin IPI
Sequences	Nucleotide: AB010954 Get FASTA Search GEO Profiles Nucleotide: AF056002 Get FASTA Search GEO Profiles Nucleotide: CH473971 Get FASTA Search GEO Profiles Nucleotide: NM_019275 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: NP_062148 Get FASTA Protein: EDM14795 Get FASTA Protein: EDM14796 Get FASTA Protein: EDM14797 Get FASTA Protein: BAA83092 Get FASTA Protein: AAC12781 Get FASTA Protein: O70437 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 9774
References
Curated References	31 references in RGD related to Smad4
Other References	11 other references at PubMed related to Smad4
Database Information
RGD ID	3033
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 23-OCT-08: Smad4 SMAD family member 4 Smad4 MAD homolog 4 (Drosophila) APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 19-MAR-08: Smad4 MAD homolog 4 (Drosophila) Smad4 SMAD family member 4 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 14-FEB-08: Smad4 SMAD family member 4 Smad4 SMAD family member 4 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 17-NOV-05: Smad4 MAD homolog 4 (Drosophila) Madh4 APPROVED Symbol updated 1299863 10-JUN-02: Madh4 MAD homolog 4 (Drosophila) APPROVED Name updated 70584