Related Pages:
 Gene Ontology

Related Sites:
 Ratmap
 MGI
 NCBI
 UniGene
 HomoloGene
 Entrez Gene
 Gene Index Project


Gene:
Akt2 ( Rattus norvegicus )
v-akt murine thymoma viral oncogene homolog 2
Description:an enzyme exhibiting protein serine/threonine kinase activity, ATP binding, protein binding (APPL1); involved in protein kinase B signaling cascade, positive regulation of sodium ion transport, negative regulation of apoptosis and other processes; found in the mitochondrion, plasma membrane, insulin-responsive compartment and other components; associated with Carcinoma,Hepatocellular; Obesity, Colonic Neoplasms and other diseases; associated with increased circulating insulin level, increased circulating glucose level, postnatal growth retardation (all mouse ortholog); part of phosphatidylinositol 3-kinase-Akt signaling pathway, insulin responsive facilitative sugar transporter mediated glucose transport pathway, type 2 diabetes mellitus pathway (human ortholog)
Synonyms:RAC protein kinase beta, RAC-PK beta; thymoma viral proto-oncogene 2; murine thymoma viral (v-akt) oncogene homolog 2;  
ArrayIDs:A_43_P15267; 6394270; 1388765_at; rc_AA946508_at; 6494750; 6466480; 5897610; 6029573; 6226724; 1387353_at; 1368832_at; 5741888; D30041_at; 6569433; 6404216; 5833767; 5902930; 6233573; GE20335; 6521766; 5723971; rc_AI105076_s_at; 6666673; 6204768; 6006341; 6086551; 6184240; 6125573; 6408064; 6241346;  (details...)
Gene Type:protein-coding
 
Additional Data
 
Homologs
Homo sapiens: AKT2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Akt2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusAkt2genome assembly 3.1182764343 - 82804655
  Rat Celera Assembly177307278 - 77345638
  RGSC genome assembly v3.4182686233 - 82726544
  Cytogenetic1q22
Mus musculusAkt2Mouse genome assembly build 36.1728390877 - 28424473
  Cytogenetic77 B1
Homo sapiensAKT2human genome assembly1945431555 - 45483034
  Human genome assembly build 36.21945431556 - 45483036
  Cytogenetic19q13.1-q13.2
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
 
 Annotation
Molecular Function
NoteReference
may act as a protein-serine/threonine kinase632176
Gene Ontology
protein binding,  nucleotide binding,  ATP binding ...  (details...)
Biological Process
NoteReference
may play a role in the phosphatidylinositol 3-kinase (PI3-K) signaling pathway632179
Gene Ontology
positive regulation of nitric oxide biosynthetic process,  response to osmotic stress,  negative regulation of caspase activity ...  (details...)
Cellular Component
Gene Ontology
mitochondrion,  lamellipodium,  vesicle ...  (details...)
Disease
Ontology
Ischemia,  Glioma,  Carcinoma, Hepatocellular ...  (details...)
Phenotype
Ontology
postnatal growth retardation,  increased circulating insulin level,  increased circulating glucose level (details...)
Expression
NoteReference
expressed in testis and other tissues632176
Pathway
Ontology
altered phosphatodylinositol 3-kinase-Akt signaling pathway,  type 2 diabetes mellitus pathway,  insulin responsive facilitative sugar transporter mediated glucose transport pathway ...  (details...)
Protein
NoteReference
protein sequence contains 481 amino acids632176
Domain
NoteReference
contains a pleckstrin homology domain632176
contains a protein-serine/threonine kinase catalytic domain632176
Physical interaction
NoteReference
may bind protein kinase C632176
 
 External Links
Databases
DATABASEIDSOURCE
SMART:PHIPI
SMART:S_TKcIPI
SMART:S_TK_XIPI
PROSITE:AGC_KINASE_CTERIPI
PROSITE:PROTEIN_KINASE_ATPIPI
PROSITE:PROTEIN_KINASE_DOMIPI
PROSITE:PROTEIN_KINASE_STIPI
PROSITE:PH_DOMAINIPI
UNIPARC:UPI000012577EIPI
KEGG Report:rno:25233ENTREZGENE
HomoloGene Group ID:48773ENTREZGENE
Germonline:2082
Pfam:Pkinase_CIPI
Pfam:PkinaseIPI
Pfam:PHIPI
KEGG Pathway:04370ENTREZGENE
KEGG Pathway:05221ENTREZGENE
KEGG Pathway:04920ENTREZGENE
KEGG Pathway:04210ENTREZGENE
KEGG Pathway:04662ENTREZGENE
KEGG Pathway:04150ENTREZGENE
KEGG Pathway:04620ENTREZGENE
KEGG Pathway:04530ENTREZGENE
KEGG Pathway:04660ENTREZGENE
KEGG Pathway:05222ENTREZGENE
KEGG Pathway:05211ENTREZGENE
KEGG Pathway:05215ENTREZGENE
KEGG Pathway:05200ENTREZGENE
KEGG Pathway:05212ENTREZGENE
KEGG Pathway:05223ENTREZGENE
KEGG Pathway:04722ENTREZGENE
KEGG Pathway:05218ENTREZGENE
KEGG Pathway:04010ENTREZGENE
KEGG Pathway:04630ENTREZGENE
KEGG Pathway:04910ENTREZGENE
KEGG Pathway:05214ENTREZGENE
KEGG Pathway:04510ENTREZGENE
KEGG Pathway:04666ENTREZGENE
KEGG Pathway:04664ENTREZGENE
KEGG Pathway:04012ENTREZGENE
KEGG Pathway:05213ENTREZGENE
KEGG Pathway:05210ENTREZGENE
KEGG Pathway:05220ENTREZGENE
KEGG Pathway:04062ENTREZGENE
InterPro:Serine/threonine_Kinase_Rac.IPI
InterPro:Ser/Thr_prot_kinase_dom.IPI
InterPro:AGC-kinase_C.IPI
InterPro:Kinase-like_dom.IPI
InterPro:PH_type.IPI
InterPro:Ser/Thr_prot_kinase_AS.IPI
InterPro:Se/Thr_prot_kinase-like_dom.IPI
InterPro:Protein_kinase_ATP_BS.IPI
InterPro:Prot_kinase_cat_dom.IPI
InterPro:Pleckstrin_homology.IPI
InterPro:Pkinase_C.IPI
IPI:IPI00212846IPI
Ensembl Protein:ENSRNOP00000025303IPI
Gene3D-CATH:PH_typeIPI
Entrez Gene:Akt2ENTREZGENE
UniProt:Q3HSE5_RATIPI
UniProt:AKT2_RATIPI
Ensembl Genes:ENSRNOG00000018677IPI
RatMap:41117ENTREZGENE
Superfamily-SCOP:Kinase_likeIPI
PANTHER:AktIPI
Sequences
Nucleotide:D30041Get FASTASearch GEO Profiles
Nucleotide:CH473979Get FASTASearch GEO Profiles
Nucleotide:DQ198085Get FASTASearch GEO Profiles
Nucleotide:NM_017093Get FASTASearch GEO Profiles
(View all 4 Nucleotide Accessions)
Protein:EDM07942Get FASTA
Protein:EDM07943Get FASTA
Protein:EDM07944Get FASTA
Protein:EDM07940Get FASTA
Protein:BAA06280Get FASTA
Protein:EDM07941Get FASTA
Protein:ABA42095Get FASTA
Protein:P47197Get FASTA
Protein:Q3HSE5Get FASTA
Protein:NP_058789Get FASTA
(View all 10 Protein Accessions)
Clusters
UniGene:87066
 
 References
Curated References
45 references in RGD related to Akt2
Other References
36 other references at PubMed related to Akt2
 
 Database Information
RGD ID2082
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
26-SEP-08: Akt2 v-akt murine thymoma viral oncogene homolog 2 Akt2 thymoma viral proto-oncogene 2 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863
17-NOV-05: Akt2 thymoma viral proto-oncogene 2 murine thymoma viral (v-akt) oncogene homolog 2 APPROVED Name updated 1299863
10-JUN-02: Akt2 Murine thymoma viral (v-akt) oncogene homolog 2 APPROVED Symbol and Name status set to approved 70586

       

Contact Us |  About Us |  Jobs at RGD