Chek2 (checkpoint kinase 2) - Rat Genome Database

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Gene: Chek2 (checkpoint kinase 2) Rattus norvegicus
Analyze
Symbol: Chek2
Name: checkpoint kinase 2
RGD ID: 621543
Description: Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to bisphenol A; positive regulation of anoikis; and regulation of cell cycle phase transition. Predicted to be located in Golgi apparatus and PML body. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with chromosome, telomeric region. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2); PARTICIPATES IN p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Chk2; CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); protein kinase Chk2; Rad53; serine/threonine-protein kinase Chk2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,448,838 - 51,481,159 (-)NCBIGRCr8
mRatBN7.21245,788,823 - 45,821,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,788,827 - 45,821,286 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1246,965,158 - 46,996,598 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,570,878 - 47,602,332 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,631,400 - 46,662,854 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,845,574 - 51,878,098 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,845,796 - 51,877,624 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01253,583,932 - 53,616,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,933,900 - 45,965,427 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11245,797,764 - 45,829,292 (-)NCBI
Celera1247,348,969 - 47,380,486 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenocortical carcinoma  (ISO)
bone osteosarcoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
colitis  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Heart Defects, Multiple Types, 3  (ISO)
congestive heart failure  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Dysmyelinating Leukodystrophy with Oligodontia  (ISO)
embryonal carcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrioid Carcinomas  (ISO)
Familial Prostate Cancer  (ISO)
female breast cancer  (ISO)
gastrointestinal carcinoma  (ISO)
Gastrointestinal Hemorrhage  (ISO)
genetic disease  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
hypomyelinating leukodystrophy 7  (ISO)
Kidney Neoplasms  (IEP)
leiomyosarcoma  (ISO)
Li-Fraumeni syndrome  (ISO)
Li-Fraumeni syndrome 1  (ISO)
Li-Fraumeni syndrome 2  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
Lynch syndrome 1  (ISO)
male breast cancer  (ISO)
Male Breast Neoplasms  (ISO)
melanoma  (ISO)
Metabolic Syndrome  (IEP)
methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency  (ISO)
microcephaly, short stature, and limb abnormalities  (ISO)
NATURAL KILLER CELL ENTEROPATHY  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
non-Hodgkin lymphoma  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic carcinoma  (ISO)
primary ovarian insufficiency  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Somatic  (ISO)
Prostatic Neoplasms  (ISO)
sarcoma  (ISO)
seminoma  (ISO)
squamous cell neoplasm  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
thrombocytopenia  (ISO)
Triple Negative Breast Neoplasms  (ISO)
urinary bladder cancer  (IEP,ISO)
Uterine Cervical Neoplasms  (ISO)
uterine corpus cancer  (ISO)
vestibular schwannomatosis  (ISO)
Vulvar Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1S)-bornane-2,3-dione  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-amino-1,8-naphthalimide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methoxy-TEMPO  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-fluorouracil  (ISO)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
anthocyanin  (ISO)
antirheumatic drug  (ISO)
aphidicolin  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
atrazine  (ISO)
auraptene  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
Brevetoxin B  (ISO)
busulfan  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofarabine  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
CX-5461  (ISO)
decabromodiphenyl ether  (ISO)
Decamethylcyclopentasiloxane  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorvos  (EXP)
dieldrin  (EXP)
diethyl sulfate  (ISO)
digitoxin  (ISO)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioscin  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
fenvalerate  (EXP)
fisetin  (ISO)
flavanones  (ISO)
floxuridine  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (EXP)
furan  (EXP,ISO)
furosemide  (EXP)
genistein  (ISO)
gingerol  (ISO)
glyphosate  (EXP)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
hellebrigenin  (ISO)
hexamethylcyclotrisiloxane  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
irinotecan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoflavones  (ISO)
isoflurane  (EXP)
isosilybin A  (ISO)
kaempferol  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leptomycin B  (ISO)
levonorgestrel  (ISO)
Licochalcone B  (ISO)
lovastatin  (EXP)
melphalan  (ISO)
metformin  (ISO)
methimazole  (EXP)
methoxsalen  (ISO)
methoxychlor  (ISO)
methyl isocyanate  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morin  (ISO)
myristicin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP)
nicotine  (ISO)
Nonidet P-40  (ISO)
NORCANTHARIDIN  (ISO)
O-methyleugenol  (EXP)
octamethylcyclotetrasiloxane  (ISO)
oroxylin A  (ISO)
oxaliplatin  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
pentobarbital  (EXP)
phenytoin  (ISO)
PhIP  (ISO)
pifithrin-?  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
promethazine  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
ruxolitinib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
selinexor  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
triadimefon  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tungsten  (EXP)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
wortmannin  (ISO)
yttrium chloride  (EXP)
zearalenone  (ISO)
zidovudine  (ISO)
zinc pyrithione  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours. Bartkova J, etal., Oncogene. 2001 Sep 13;20(41):5897-902.
2. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Chaturvedi P, etal., Oncogene 1999 Jul 15;18(28):4047-54.
3. A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer. Cybulski C, etal., J Med Genet. 2006 Nov;43(11):863-6.
4. Mutations in CHEK2 associated with prostate cancer risk. Dong X, etal., Am J Hum Genet 2003 Feb;72(2):270-80. Epub 2003 Jan 17.
5. Effect of ATM, CHEK2 and ERBB2 TAGSNPs and haplotypes on endometrial cancer risk. Einarsdottir K, etal., Hum Mol Genet. 2007 Jan 15;16(2):154-64. Epub 2006 Dec 12.
6. BRCA1/BRCA2 rearrangements and CHEK2 common mutations are infrequent in Italian male breast cancer cases. Falchetti M, etal., Breast Cancer Res Treat. 2007 Jul 28;.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing. Girard E, etal., Int J Cancer. 2019 Apr 15;144(8):1962-1974. doi: 10.1002/ijc.31921. Epub 2018 Nov 13.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway. Hu B, etal., J Biol Chem. 2001 May 25;276(21):17693-8. Epub 2001 Mar 7.
11. The effects of G2-phase enrichment and checkpoint abrogation on low-dose hyper-radiosensitivity. Krueger SA, etal., Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1509-17. doi: 10.1016/j.ijrobp.2010.01.028.
12. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
13. Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer. Laitman Y, etal., Isr Med Assoc J. 2007 Nov;9(11):791-6.
14. The complexity of p53 stabilization and activation. Lavin MF and Gueven N, Cell Death Differ. 2006 Jun;13(6):941-50.
15. Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation. Liu L, etal., Mol Biol Cell. 2009 Dec;20(23):4885-98. doi: 10.1091/mbc.E09-07-0550. Epub 2009 Oct 7.
16. Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Meijers-Heijboer H, etal., Nat Genet. 2002 May;31(1):55-9. Epub 2002 Apr 22.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Telomere attrition and Chk2 activation in human heart failure. Oh H, etal., Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5378-83. Epub 2003 Apr 17.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo. Ou TT, etal., J Ethnopharmacol. 2011 Apr 26;135(1):162-72. doi: 10.1016/j.jep.2011.03.011. Epub 2011 Mar 17.
22. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. Pabla N, etal., J Biol Chem. 2008 Mar 7;283(10):6572-83. Epub 2007 Dec 27.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. Analysis of CHK2 in vulval neoplasia. Reddy A, etal., Br J Cancer. 2002 Mar 4;86(5):756-60.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Comprehensive gene review and curation RGD comprehensive gene curation
30. Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2. Spallarossa P, etal., Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2169-81. Epub 2009 Oct 2.
31. CHEK2 variants predispose to benign, borderline and low-grade invasive ovarian tumors. Szymanska-Pasternak J, etal., Gynecol Oncol. 2006 Sep;102(3):429-31. Epub 2006 Jul 10.
32. Premature cardiac senescence in DahlS.Z-Lepr(fa)/Lepr(fa) rats as a new animal model of metabolic syndrome. Takahashi K, etal., Nagoya J Med Sci. 2014 Feb;76(1-2):35-49.
33. Cellular distribution of cell cycle-related molecules in the renal tubules of rats treated with renal carcinogens for 28 days: relationship between cell cycle aberration and carcinogenesis. Taniai E, etal., Arch Toxicol. 2012 Sep;86(9):1453-64. doi: 10.1007/s00204-012-0829-z. Epub 2012 Mar 13.
34. Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers. Williams LH, etal., Clin Cancer Res. 2006 Dec 1;12(23):6967-72.
35. Bisphenol A induces oxidative stress-associated DNA damage in INS-1 cells. Xin F, etal., Mutat Res Genet Toxicol Environ Mutagen. 2014 Jul 15;769:29-33. doi: 10.1016/j.mrgentox.2014.04.019. Epub 2014 May 21.
36. Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells. Yoo BH, etal., Int J Cancer. 2012 Jul 15;131(2):357-66. doi: 10.1002/ijc.26368. Epub 2011 Nov 2.
37. Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function. Yu TX, etal., Nucleic Acids Res. 2011 Oct;39(19):8472-87. doi: 10.1093/nar/gkr567. Epub 2011 Jul 10.
38. Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128. Zempolich K, etal., Gynecol Oncol. 2008 May;109(2):275-9. Epub 2008 Mar 4.
39. Germline mutations in the CHEK2 kinase gene are associated with an increased risk of bladder cancer. Zlowocka E, etal., Int J Cancer. 2008 Feb 1;122(3):583-6.
Additional References at PubMed
PMID:10710310   PMID:11298456   PMID:12402044   PMID:12717439   PMID:14744935   PMID:15149599   PMID:16481012   PMID:16794575   PMID:17101782   PMID:18239682   PMID:18317453   PMID:18614044  
PMID:18644861   PMID:20364141   PMID:22266820   PMID:22851694   PMID:24550317  


Genomics

Comparative Map Data
Chek2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,448,838 - 51,481,159 (-)NCBIGRCr8
mRatBN7.21245,788,823 - 45,821,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,788,827 - 45,821,286 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1246,965,158 - 46,996,598 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,570,878 - 47,602,332 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,631,400 - 46,662,854 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,845,574 - 51,878,098 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,845,796 - 51,877,624 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01253,583,932 - 53,616,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,933,900 - 45,965,427 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11245,797,764 - 45,829,292 (-)NCBI
Celera1247,348,969 - 47,380,486 (-)NCBICelera
Cytogenetic Map12q16NCBI
CHEK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382228,687,743 - 28,741,834 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2228,687,743 - 28,742,422 (-)EnsemblGRCh38hg38GRCh38
GRCh372229,083,731 - 29,137,822 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,413,731 - 27,467,822 (-)NCBINCBI36Build 36hg18NCBI36
Build 342227,408,284 - 27,462,376NCBI
Celera2212,883,692 - 12,937,801 (-)NCBICelera
Cytogenetic Map22q12.1ENTREZGENE
HuRef2212,048,435 - 12,103,008 (-)NCBIHuRef
CHM1_12229,042,794 - 29,096,883 (-)NCBICHM1_1
T2T-CHM13v2.02229,149,178 - 29,203,469 (-)NCBIT2T-CHM13v2.0
Chek2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,987,668 - 111,022,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5110,987,845 - 111,022,011 (+)EnsemblGRCm39 Ensembl
GRCm385110,839,800 - 110,874,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,839,979 - 110,874,145 (+)EnsemblGRCm38mm10GRCm38
MGSCv375111,269,036 - 111,303,152 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365111,080,319 - 111,114,435 (+)NCBIMGSCv36mm8
Celera5107,972,108 - 108,006,794 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.73NCBI
Chek2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554552,969,270 - 3,003,173 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554552,969,113 - 3,008,004 (-)NCBIChiLan1.0ChiLan1.0
CHEK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22338,686,176 - 38,740,325 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12241,385,261 - 41,439,422 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0229,757,038 - 9,811,171 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12227,455,226 - 27,512,555 (-)NCBIpanpan1.1PanPan1.1panPan2
CHEK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,052,256 - 22,145,675 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2621,427,961 - 22,240,624 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2621,923,947 - 22,017,275 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02622,425,372 - 22,519,047 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2622,426,963 - 22,476,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,135,806 - 22,229,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02622,399,429 - 22,492,792 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02622,461,722 - 22,555,609 (-)NCBIUU_Cfam_GSD_1.0
Chek2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118113,022,347 - 113,064,864 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366572,805,959 - 2,848,180 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366572,805,947 - 2,848,180 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHEK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1445,929,715 - 45,967,290 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11445,699,833 - 45,967,350 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CHEK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11911,567,529 - 11,621,180 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1911,567,528 - 11,604,792 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045114,532,627 - 114,585,653 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chek2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,035,200 - 5,070,332 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247475,035,045 - 5,072,555 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chek2
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:20
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000056800
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
RH130548  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,812,979 - 45,813,268 (+)MAPPERmRatBN7.2
Rnor_6.01251,869,727 - 51,870,015NCBIRnor6.0
Rnor_5.01253,608,086 - 53,608,374UniSTSRnor5.0
RGSC_v3.41245,957,530 - 45,957,818UniSTSRGSC3.4
Celera1247,372,589 - 47,372,877UniSTS
RH 3.4 Map12779.63UniSTS
Cytogenetic Map12q16UniSTS
RH141098  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,790,817 - 45,791,035 (+)MAPPERmRatBN7.2
Rnor_6.01251,847,569 - 51,847,786NCBIRnor6.0
Rnor_5.01253,585,927 - 53,586,144UniSTSRnor5.0
RGSC_v3.41245,935,372 - 45,935,589UniSTSRGSC3.4
Celera1247,350,441 - 47,350,658UniSTS
RH 3.4 Map12782.91UniSTS
Cytogenetic Map12q16UniSTS
AU049427  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,798,756 - 45,799,048 (+)MAPPERmRatBN7.2
Rnor_6.01251,855,507 - 51,855,798NCBIRnor6.0
Rnor_5.01253,593,865 - 53,594,156UniSTSRnor5.0
RGSC_v3.41245,943,310 - 45,943,601UniSTSRGSC3.4
Celera1247,358,377 - 47,358,668UniSTS
Cytogenetic Map12q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 18 25 18 18 18 21 18 32 2
Low 25 32 23 1 23 8 10 53 17 9 9 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056800   ⟹   ENSRNOP00000053643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,795,474 - 45,820,879 (-)Ensembl
Rnor_6.0 Ensembl1251,846,097 - 51,877,624 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085591   ⟹   ENSRNOP00000074651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,788,827 - 45,821,286 (-)Ensembl
Rnor_6.0 Ensembl1251,845,796 - 51,876,876 (-)Ensembl
RefSeq Acc Id: NM_053677   ⟹   NP_446129
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,449,140 - 51,480,667 (-)NCBI
mRatBN7.21245,789,346 - 45,820,879 (-)NCBI
Rnor_6.01251,846,097 - 51,877,624 (-)NCBI
Rnor_5.01253,583,932 - 53,616,450 (-)NCBI
RGSC_v3.41245,933,900 - 45,965,427 (-)RGD
Celera1247,348,969 - 47,380,486 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249518   ⟹   XP_006249580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,448,838 - 51,481,145 (-)NCBI
mRatBN7.21245,788,823 - 45,821,353 (-)NCBI
Rnor_6.01251,845,574 - 51,878,094 (-)NCBI
Rnor_5.01253,583,932 - 53,616,450 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249519   ⟹   XP_006249581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,448,838 - 51,481,159 (-)NCBI
mRatBN7.21245,788,823 - 45,821,382 (-)NCBI
Rnor_6.01251,845,574 - 51,878,090 (-)NCBI
Rnor_5.01253,583,932 - 53,616,450 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249520   ⟹   XP_006249582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,448,838 - 51,481,136 (-)NCBI
mRatBN7.21245,788,823 - 45,821,349 (-)NCBI
Rnor_6.01251,845,574 - 51,878,091 (-)NCBI
Rnor_5.01253,583,932 - 53,616,450 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249521   ⟹   XP_006249583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,448,838 - 51,481,146 (-)NCBI
mRatBN7.21245,788,823 - 45,821,358 (-)NCBI
Rnor_6.01251,845,574 - 51,878,098 (-)NCBI
Rnor_5.01253,583,932 - 53,616,450 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063270986   ⟹   XP_063127056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,448,838 - 51,481,007 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446129   ⟸   NM_053677
- UniProtKB: Q9R019 (UniProtKB/TrEMBL),   A6J285 (UniProtKB/TrEMBL),   F7F4E2 (UniProtKB/TrEMBL),   A0A0G2K8L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249582   ⟸   XM_006249520
- Peptide Label: isoform X1
- UniProtKB: Q9R019 (UniProtKB/TrEMBL),   A6J285 (UniProtKB/TrEMBL),   F7F4E2 (UniProtKB/TrEMBL),   A0A0G2K8L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249583   ⟸   XM_006249521
- Peptide Label: isoform X1
- UniProtKB: Q9R019 (UniProtKB/TrEMBL),   A6J285 (UniProtKB/TrEMBL),   F7F4E2 (UniProtKB/TrEMBL),   A0A0G2K8L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249581   ⟸   XM_006249519
- Peptide Label: isoform X1
- UniProtKB: Q9R019 (UniProtKB/TrEMBL),   A6J285 (UniProtKB/TrEMBL),   F7F4E2 (UniProtKB/TrEMBL),   A0A0G2K8L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249580   ⟸   XM_006249518
- Peptide Label: isoform X1
- UniProtKB: Q9R019 (UniProtKB/TrEMBL),   A6J285 (UniProtKB/TrEMBL),   F7F4E2 (UniProtKB/TrEMBL),   A0A0G2K8L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074651   ⟸   ENSRNOT00000085591
RefSeq Acc Id: ENSRNOP00000053643   ⟸   ENSRNOT00000056800
RefSeq Acc Id: XP_063127056   ⟸   XM_063270986
- Peptide Label: isoform X2
Protein Domains
FHA   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R019-F1-model_v2 AlphaFold Q9R019 1-545 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621543 AgrOrtholog
BioCyc Gene G2FUF-18828 BioCyc
Ensembl Genes ENSRNOG00000037509 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056800.2 UniProtKB/TrEMBL
  ENSRNOT00000085591.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro FHA_dom UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
KEGG Report rno:114212 UniProtKB/TrEMBL
NCBI Gene 114212 ENTREZGENE
PANTHER OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE CHK2 UniProtKB/TrEMBL
Pfam FHA UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Chek2 PhenoGen
PROSITE FHA_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037509 RatGTEx
SMART FHA UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SMAD_FHA UniProtKB/TrEMBL
UniProt A0A0G2K8L3 ENTREZGENE, UniProtKB/TrEMBL
  A6J284_RAT UniProtKB/TrEMBL
  A6J285 ENTREZGENE, UniProtKB/TrEMBL
  A6J287_RAT UniProtKB/TrEMBL
  F7F4E2 ENTREZGENE, UniProtKB/TrEMBL
  Q9R019 ENTREZGENE
UniProt Secondary Q9R019 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-12-06 Chek2  checkpoint kinase 2  Chek2  CHK2 checkpoint homolog (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Chek2  CHK2 checkpoint homolog (S. pombe)    protein kinase Chk2  Name updated 1299863 APPROVED
2004-09-10 Chek2  protein kinase Chk2  Rad53    Symbol and Name updated 1299863 APPROVED
2002-08-07 Rad53  protein kinase Chk2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation phosphorylated and activated in response to DNA damage in an ATM dependent manner 633752