Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek2
Name: checkpoint kinase 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek2decreases expressionEXP 6480464CTDEstradiol results in decreased expression of CHEK2 mRNAPMID:32145629
Chek2increases phosphorylationEXP 6480464CTDEstradiol results in increased phosphorylation of CHEK2 proteinPMID:23788033
Chek2multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of CHEK2 protein]PMID:23788033
Chek2decreases expressionISOCHEK2 (Homo sapiens)6480464CTDEstradiol results in decreased expression of CHEK2 mRNAPMID:23373633
Chek2increases expressionISOChek2 (Mus musculus)6480464CTDEstradiol results in increased expression of CHEK2 mRNAPMID:25210133
Chek2multiple interactionsISOChek2 (Mus musculus)6480464CTDESR1 protein promotes the reaction [Estradiol results in increased expression of CHEK2 mRNA]PMID:25210133
Go Back to source page   Continue to Ontology report