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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek2
Name: checkpoint kinase 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek2increases expressionEXP 6480464CTDCisplatin results in increased expression of CHEK2 protein modified formPMID:26739623
Chek2multiple interactionsEXP 6480464CTDLovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK2 protein modified form]PMID:26739623
Chek2increases activityISOCHEK2 (Homo sapiens)6480464CTDCisplatin results in increased activity of CHEK2 proteinPMID:21324906 PMID:21592546
Chek2increases expressionISOCHEK2 (Homo sapiens)6480464CTDCisplatin results in increased expression of CHEK2 mRNAPMID:25450742
Chek2increases phosphorylationISOCHEK2 (Homo sapiens)6480464CTDCisplatin results in increased phosphorylation of CHEK2 proteinPMID:21285353 PMID:21445297 PMID:21750216 PMID:37802411
Chek2increases phosphorylationISOChek2 (Mus musculus)6480464CTDCisplatin results in increased phosphorylation of CHEK2 proteinPMID:21285353
Chek2multiple interactionsISOCHEK2 (Homo sapiens)6480464CTD3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK2 protein]; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of CHEK2 mRNA; BMI1 inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK2 protein]; Cisplatin results in increased phosphorylation of and results in increased activity of CHEK2 protein; ERCC6 protein inhibits the reaction [Cisplatin results in increased activity of CHEK2 protein]; MSH2 protein promotes the reaction [Cisplatin results in increased phosphorylation of CHEK2 protein]PMID:21107699 PMID:21285353 PMID:21324906 PMID:21445297 PMID:30871063 PMID:37802411
Chek2multiple interactionsISOChek2 (Mus musculus)6480464CTD[7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Cisplatin results in increased expression of CHEK2 mRNA]; MSH2 protein promotes the reaction [Cisplatin results in increased phosphorylation of CHEK2 protein]PMID:21285353 PMID:22003191
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