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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek2
Name: checkpoint kinase 2
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek2multiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CHEK2 mRNA]PMID:18544905
Chek2multiple interactionsISOCHEK2 (Homo sapiens)6480464CTDAscorbic Acid inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of CHEK2 protein]; Ascorbic Acid inhibits the reaction [potassium chromate(VI) results in increased expression of CHEK2 protein modified form]; Ascorbic Acid inhibits the reaction [potassium chromate(VI) results in increased phosphorylation of CHEK2 protein]PMID:25977998 PMID:31388677
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