RGD Reference Report - The complexity of p53 stabilization and activation. - Rat Genome Database

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The complexity of p53 stabilization and activation.

Authors: Lavin, MF  Gueven, N 
Citation: Lavin MF and Gueven N, Cell Death Differ. 2006 Jun;13(6):941-50.
RGD ID: 2316156
Pubmed: PMID:16601750   (View Abstract at PubMed)
DOI: DOI:10.1038/sj.cdd.4401925   (Journal Full-text)

A number of proteins are activated by stress stimuli but none so spectacularly or with the degree of complexity as the tumour suppressor p53 (human p53 gene or protein). Once stabilized, p53 is responsible for the transcriptional activation of a series of proteins involved in cell cycle control, apoptosis and senescence. This protein is present at low levels in resting cells but after exposure to DNA-damaging agents and other stress stimuli it is stabilized and activated by a series of post-translational modifications that free it from MDM2 (mouse double minute 2 but used interchangeably to denote human also), a ubiquination ligase that ubiquitinates it prior to proteasome degradation. The stability of p53 is also influenced by a series of other interacting proteins. In this review, we discuss the post-translational modifications to p53 in response to different stresses and the consequences of these changes.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Atm  (ATM serine/threonine kinase)
Chek1  (checkpoint kinase 1)
Chek2  (checkpoint kinase 2)
Mdm2  (MDM2 proto-oncogene)
Mdm4  (MDM4 regulator of p53)
Tp53  (tumor protein p53)

Genes (Mus musculus)
Atm  (ataxia telangiectasia mutated)
Chek1  (checkpoint kinase 1)
Chek2  (checkpoint kinase 2)
Mdm2  (transformed mouse 3T3 cell double minute 2)
Mdm4  (transformed mouse 3T3 cell double minute 4)
Trp53  (transformation related protein 53)

Genes (Homo sapiens)
ATM  (ATM serine/threonine kinase)
CHEK1  (checkpoint kinase 1)
CHEK2  (checkpoint kinase 2)
MDM2  (MDM2 proto-oncogene)
MDM4  (MDM4 regulator of p53)
TP53  (tumor protein p53)


Additional Information