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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek2
Name: checkpoint kinase 2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek2decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of CHEK2 mRNAPMID:19801496 PMID:27181935
Chek2multiple interactionsEXP 6480464CTDFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of CHEK2 mRNA]PMID:27181935
Chek2decreases expressionISOCHEK2 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of CHEK2 mRNAPMID:36634904
Chek2decreases expressionISOChek2 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of CHEK2 mRNAPMID:29653124
Chek2increases phosphorylationISOCHEK2 (Homo sapiens)6480464CTDDoxorubicin results in increased phosphorylation of CHEK2 proteinPMID:17085670 PMID:21646468 PMID:36634904
Chek2increases phosphorylationISOChek2 (Mus musculus)6480464CTDDoxorubicin results in increased phosphorylation of CHEK2 proteinPMID:22242153
Chek2multiple interactionsISOCHEK2 (Homo sapiens)6480464CTD[3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide affects the susceptibility to Doxorubicin] which results in decreased expression of CHEK2 mRNA; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]; Doxorubicin results in increased phosphorylation of and results in increased activity of CHEK2 protein; Go 6976 inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of CHEK2 protein]PMID:15489221 PMID:17320279 PMID:18347191 PMID:34519926
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