Chek2 (checkpoint kinase 2) - Rat Genome Database

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Gene: Chek2 (checkpoint kinase 2) Heterocephalus glaber
Analyze
Symbol: Chek2
Name: checkpoint kinase 2
RGD ID: 18904985
Description: ENCODES a protein that exhibits kinase activity (ortholog); protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to bisphenol A (ortholog); cellular response to gamma radiation (ortholog); cellular response to xenobiotic stimulus (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); bone osteosarcoma (ortholog); breast cancer (ortholog); FOUND IN chromosome, telomeric region (inferred); cytoplasm (inferred); Golgi apparatus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase Chk2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,035,200 - 5,070,332 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247475,035,045 - 5,072,555 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenocortical carcinoma  (ISO)
bone osteosarcoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
colitis  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Heart Defects, Multiple Types, 3  (ISO)
congestive heart failure  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Dysmyelinating Leukodystrophy with Oligodontia  (ISO)
embryonal carcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrioid Carcinomas  (ISO)
Familial Prostate Cancer  (ISO)
female breast cancer  (ISO)
gastrointestinal carcinoma  (ISO)
Gastrointestinal Hemorrhage  (ISO)
genetic disease  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
hypomyelinating leukodystrophy 7  (ISO)
Kidney Neoplasms  (ISO)
leiomyosarcoma  (ISO)
Li-Fraumeni syndrome  (ISO)
Li-Fraumeni syndrome 1  (ISO)
Li-Fraumeni syndrome 2  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
Lynch syndrome 1  (ISO)
male breast cancer  (ISO)
Male Breast Neoplasms  (ISO)
melanoma  (ISO)
Metabolic Syndrome  (ISO)
methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency  (ISO)
microcephaly, short stature, and limb abnormalities  (ISO)
NATURAL KILLER CELL ENTEROPATHY  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
non-Hodgkin lymphoma  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic carcinoma  (ISO)
primary ovarian insufficiency  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Somatic  (ISO)
Prostatic Neoplasms  (ISO)
sarcoma  (ISO)
seminoma  (ISO)
squamous cell neoplasm  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
thrombocytopenia  (ISO)
Triple Negative Breast Neoplasms  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
uterine corpus cancer  (ISO)
vestibular schwannomatosis  (ISO)
Vulvar Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Chek2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,035,200 - 5,070,332 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247475,035,045 - 5,072,555 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CHEK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382228,687,743 - 28,741,834 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2228,687,743 - 28,742,422 (-)EnsemblGRCh38hg38GRCh38
GRCh372229,083,731 - 29,137,822 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,413,731 - 27,467,822 (-)NCBINCBI36Build 36hg18NCBI36
Build 342227,408,284 - 27,462,376NCBI
Celera2212,883,692 - 12,937,801 (-)NCBICelera
Cytogenetic Map22q12.1ENTREZGENE
HuRef2212,048,435 - 12,103,008 (-)NCBIHuRef
CHM1_12229,042,794 - 29,096,883 (-)NCBICHM1_1
T2T-CHM13v2.02229,149,178 - 29,203,469 (-)NCBIT2T-CHM13v2.0
Chek2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,987,668 - 111,022,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5110,987,845 - 111,022,011 (+)EnsemblGRCm39 Ensembl
GRCm385110,839,800 - 110,874,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,839,979 - 110,874,145 (+)EnsemblGRCm38mm10GRCm38
MGSCv375111,269,036 - 111,303,152 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365111,080,319 - 111,114,435 (+)NCBIMGSCv36mm8
Celera5107,972,108 - 108,006,794 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.73NCBI
Chek2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,448,838 - 51,481,159 (-)NCBIGRCr8
mRatBN7.21245,788,823 - 45,821,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,788,827 - 45,821,286 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1246,965,158 - 46,996,598 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,570,878 - 47,602,332 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,631,400 - 46,662,854 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,845,574 - 51,878,098 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,845,796 - 51,877,624 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01253,583,932 - 53,616,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,933,900 - 45,965,427 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11245,797,764 - 45,829,292 (-)NCBI
Celera1247,348,969 - 47,380,486 (-)NCBICelera
Cytogenetic Map12q16NCBI
Chek2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554552,969,270 - 3,003,173 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554552,969,113 - 3,008,004 (-)NCBIChiLan1.0ChiLan1.0
CHEK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22338,686,176 - 38,740,325 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12241,385,261 - 41,439,422 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0229,757,038 - 9,811,171 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12227,455,226 - 27,512,555 (-)NCBIpanpan1.1PanPan1.1panPan2
CHEK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,052,256 - 22,145,675 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2621,427,961 - 22,240,624 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2621,923,947 - 22,017,275 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02622,425,372 - 22,519,047 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2622,426,963 - 22,476,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,135,806 - 22,229,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02622,399,429 - 22,492,792 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02622,461,722 - 22,555,609 (-)NCBIUU_Cfam_GSD_1.0
Chek2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118113,022,347 - 113,064,864 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366572,805,959 - 2,848,180 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366572,805,947 - 2,848,180 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHEK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1445,929,715 - 45,967,290 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11445,699,833 - 45,967,350 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CHEK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11911,567,529 - 11,621,180 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1911,567,528 - 11,604,792 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045114,532,627 - 114,585,653 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000015622   ⟹   ENSHGLP00000015462
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247475,035,200 - 5,070,332 (-)Ensembl
RefSeq Acc Id: XM_013071930   ⟹   XP_012927384
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247475,035,045 - 5,072,476 (-)NCBI
RefSeq Acc Id: XM_013071931   ⟹   XP_012927385
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247475,035,045 - 5,072,477 (-)NCBI
RefSeq Acc Id: XM_021257150   ⟹   XP_021112809
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247475,035,045 - 5,072,457 (-)NCBI
RefSeq Acc Id: XM_021257151   ⟹   XP_021112810
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247475,035,045 - 5,072,555 (-)NCBI
RefSeq Acc Id: XM_021257152   ⟹   XP_021112811
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247475,035,045 - 5,072,552 (-)NCBI
RefSeq Acc Id: XM_021257153   ⟹   XP_021112812
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247475,035,045 - 5,072,418 (-)NCBI
RefSeq Acc Id: XM_021257154   ⟹   XP_021112813
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247475,035,045 - 5,070,158 (-)NCBI
RefSeq Acc Id: XR_002394436
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247475,035,191 - 5,072,480 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021112810   ⟸   XM_021257151
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J943 (UniProtKB/TrEMBL),   G5APY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112811   ⟸   XM_021257152
- Peptide Label: isoform X3
RefSeq Acc Id: XP_012927385   ⟸   XM_013071931
- Peptide Label: isoform X2
- UniProtKB: G5APY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927384   ⟸   XM_013071930
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J943 (UniProtKB/TrEMBL),   G5APY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112809   ⟸   XM_021257150
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J943 (UniProtKB/TrEMBL),   G5APY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112812   ⟸   XM_021257153
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021112813   ⟸   XM_021257154
- Peptide Label: isoform X3
RefSeq Acc Id: ENSHGLP00000015462   ⟸   ENSHGLT00000015622


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011056 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100017476 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000015622 ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLT00100024034 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro FHA_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101721212 UniProtKB/TrEMBL
NCBI Gene Chek2 ENTREZGENE
PANTHER OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE CHK2 UniProtKB/TrEMBL
Pfam FHA UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE FHA_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART FHA UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0P6J943 ENTREZGENE, UniProtKB/TrEMBL
  G5APY6 ENTREZGENE, UniProtKB/TrEMBL