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GENE - TERM ANNOTATION REPORT

RGD ID: 18904985
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Chek2
Name: checkpoint kinase 2
Acc ID: PW:0000718
Term: p53 signaling pathway
Definition: p53 transcription factor is a tumor suppressor frequently mutated in cancer. p53 is at the hub of many signaling and regulatory pathways. In response to various stresses, it promotes apoptosis, cell cycle arrest and other defense pathways via transcription dependent as well as independent routes. A key regulator of p53 is Mdm2. Mdm2 is a transcriptional target of p53 thus providing a negative feedback loop.
Definition Source(s): PMID:18783169, PMID:18927276, PMID:19007744, PMID:19407794, PMID:19776744
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek2 ISOCHEK2 (Homo sapiens)9068941RGD PMID:16601750 PMID:19450511 REF_RGD_ID:2316155 REF_RGD_ID:2316156
Chek2 ISOCHEK2 (Homo sapiens)9068941PID PID:200206
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