Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:excitatory extracellular ligand-gated monoatomic ion channel activity
go back to main search page
Accession:GO:0005231 term browser browse the term
Definition:Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential.
Synonyms:xref: reactome:R-HSA-399711 "Activation of Ca impermeable AMPA receptors";   reactome:R-HSA-399712 "Activation of Ca permeable AMPA receptors";   reactome:R-HSA-420980 "Activation of Ca permeable AMPA receptors";   reactome:R-HSA-432164 "Ca2+ influx into the post-synaptic cell";   reactome:R-HSA-438037 "Membrane depolarization upon activation of Ca impermeable AMPA receptors"


show annotations for term's descendants           Sort by:
excitatory extracellular ligand-gated monoatomic ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr3a 5-hydroxytryptamine receptor 3A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:49,279,291...49,308,444
Ensembl chr 8:49,279,173...49,308,444 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 enables IDA PMID:17582331 UniProt PMID:17582331 RGD:8553505 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
acetylcholine-gated monoatomic cation-selective channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit enables
contributes_to		 IDA
ISO
IBA		 (PMID:9221765)
GO_REF:0000033
MGI:87890|MGI:87893|MGI:87894|MGI:87895 (PMID:2383398)		 RGD
GO_Central		 PMID:2383398 PMID:9221765 PMID:1702709 PMID:22461452 GO_REF:0000033, RGD:68734, RGD:8549758 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840 		JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit enables IBA
ISO		 GO_REF:0000033
MGI:3774038 (PMID:18077337)		 GO_Central
RGD		 PMID:18077337 GO_REF:0000033 NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476 		JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit enables IDA
ISO
IBA		 (PMID:8906617)
GO_REF:0000033		 RGD
GO_Central		 PMID:8906617 PMID:2832952 GO_REF:0000033, RGD:728252 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit enables IMP
IEA
ISO
IGI
IBA		 GO_REF:0000107
(PMID:8906617)
PMID:21540349
GO_REF:0000002
GO_REF:0000033
MGI:2155602 (PMID:11923417)		 Ensembl
RGD
InterPro
GO_Central		 PMID:8906617 PMID:11923417 PMID:11297818 PMID:21540349 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:1643016, RGD:12790638 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit enables IDA
IC
IMP
IEA
ISO
IBA		 GO_REF:0000002
(PMID:8906617)
GO_REF:0000107
GO_REF:0000033
MGI:1926251|MGI:3511287|MGI:87891 (PMID:11222635), (PMID:12130686), (PMID:15528443), (PMID:15569257), (PMID:15741168)		 InterPro
RGD
Ensembl
GO_Central		 PMID:8906617 PMID:11222635 PMID:12130686 PMID:15528443 PMID:15569257 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:727641, RGD:2303190, RGD:8549520 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit enables IMP
IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central
RGD		 PMID:12814364 PMID:11297818 GO_REF:0000002 GO_REF:0000033, RGD:1298760, RGD:1643016 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit enables IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
MGI:2179133 (PMID:11850448)		 Ensembl
GO_Central
RGD		 PMID:11850448 GO_REF:0000033 GO_REF:0000107 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit enables IDA
IMP
IEA
ISO
IBA		 GO_REF:0000002
GO_REF:0000107
PMID:21540349
(PMID:12508119), (PMID:18387948), (PMID:21718690), (PMID:8145738), (PMID:8906617)
PMID:11222635
PMID:15760934
GO_REF:0000033
MGI:1888407 (PMID:11834293), (PMID:9037516), (PMID:9364063), (PMID:9495872)		 InterPro
Ensembl
RGD
GO_Central		 PMID:8145738 PMID:8906617 PMID:9037516 PMID:9364063 PMID:9495872 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:727702, RGD:1600971, RGD:1643016, RGD:8549520, RGD:12790638, RGD:8554133, RGD:8554382 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit enables IDA
ISO
IEA
IBA		 (PMID:25282151)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
MGI:2158742 (PMID:18077337)		 RGD
InterPro
Ensembl
GO_Central		 PMID:18077337 PMID:25282151 PMID:7954834 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:728400 NCBI chr14:42,235,218...42,241,939
Ensembl chr14:42,235,226...42,242,192 		JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit enables
contributes_to		 IDA
IEA
IBA
ISO		 GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
MGI:87885|MGI:87893|MGI:87894|MGI:87895 (PMID:2383398)
MGI:87893|MGI:87895 (PMID:8798466)		 InterPro
Ensembl
GO_Central
RGD		 PMID:2383398 PMID:8798466 PMID:1702709 PMID:22461452 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:68734, RGD:8549758 NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit enables IDA
IC
IMP
IGI
ISO
IBA		 PMID:21540349
(PMID:18387948), (PMID:8906617)
GO_REF:0000033
MGI:1926253|MGI:87888 (PMID:11222635), (PMID:15569257), (PMID:15741168), (PMID:17470777), (PMID:9614223)		 RGD
GO_Central		 PMID:8906617 PMID:9614223 PMID:11222635 PMID:15569257 PMID:15741168 More... GO_REF:0000033, RGD:727635, RGD:2303190, RGD:8549520, RGD:12790638 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit enables IC
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:9030613 GO_REF:0000033, RGD:2303190 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit enables IC
ISO
IEA
IBA		 (PMID:18387948)
GO_REF:0000002
GO_REF:0000033		 RGD
InterPro
GO_Central		 PMID:18387948 PMID:9030613 GO_REF:0000002 GO_REF:0000033, RGD:2303190 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit enables
contributes_to		 IDA
IBA
ISO		 GO_REF:0000033
MGI:87890|MGI:87895 (PMID:8798466)
MGI:87885|MGI:87890|MGI:87894|MGI:87895 (PMID:2383398)		 GO_Central
RGD		 PMID:2383398 PMID:8798466 PMID:1702709 PMID:22461452 GO_REF:0000033, RGD:68734, RGD:8549758 NCBI chr 9:87,862,417...87,870,833
Ensembl chr 9:87,862,407...87,870,833 		JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit enables
contributes_to		 IDA
IEA
IBA
ISO		 GO_REF:0000002
GO_REF:0000033
MGI:87885|MGI:87890|MGI:87893 (PMID:2383398)		 InterPro
GO_Central
RGD		 PMID:2383398 PMID:22461452 GO_REF:0000002 GO_REF:0000033, RGD:8549758 NCBI chr10:55,331,211...55,339,923
Ensembl chr10:55,331,212...55,335,530 		JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit enables IDA
IEA
IBA
ISO		 GO_REF:0000002
GO_REF:0000033
MGI:87885|MGI:87890|MGI:87893 (PMID:2383398), (PMID:8798466)		 InterPro
GO_Central
RGD		 PMID:2383398 PMID:8798466 PMID:1702709 PMID:22461452 GO_REF:0000002 GO_REF:0000033, RGD:68734, RGD:8549758 NCBI chr 9:87,878,085...87,884,193
Ensembl chr 9:87,878,085...87,914,482 		JBrowse link
extracellularly ATP-gated monoatomic cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx1 purinergic receptor P2X 1 enables IDA
ISO
IBA
IEA		 (PMID:8961184)
GO_REF:0000033
GO_REF:0000117		 RGD
GO_Central
UniProt		 PMID:8961184 PMID:16934235 GO_REF:0000033 GO_REF:0000117, RGD:1642659 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623 		JBrowse link
G P2rx2 purinergic receptor P2X 2 enables IDA
ISO
IBA
IEA
IMP		 MGI:1097160|MGI:2687349 (PMID:12917379), (PMID:15081800)
GO_REF:0000033
GO_REF:0000117
(PMID:23345450)		 RGD
GO_Central
UniProt		 PMID:12917379 PMID:15081800 PMID:23345450 PMID:17517890 PMID:15317863 More... GO_REF:0000033 GO_REF:0000117, RGD:1642653, RGD:1642666, RGD:1642665, RGD:1642661, RGD:1642659 NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891 		JBrowse link
G P2rx3 purinergic receptor P2X 3 enables IDA
ISO
IBA
IEA		 MGI:2665170 (PMID:15081800)
GO_REF:0000033
GO_REF:0000117
(PMID:27626375)
PMID:7566119		 RGD
GO_Central
UniProt		 PMID:15081800 PMID:27626375 PMID:16934235 PMID:7566119 PMID:12581826 GO_REF:0000033 GO_REF:0000117, RGD:1642659, RGD:729168, RGD:1642675 NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178 		JBrowse link
G P2rx4 purinergic receptor P2X 4 enables IDA
ISO
IBA
IEA		 (PMID:15081800)
GO_REF:0000033
GO_REF:0000117
PMID:12819199
PMID:8551329
(PMID:10515189), (PMID:9016352)		 RGD
GO_Central
UniProt		 PMID:9016352 PMID:10515189 PMID:15081800 PMID:16934235 PMID:16282518 More... GO_REF:0000033 GO_REF:0000117, RGD:1642659, RGD:1642691, RGD:1642695, RGD:61682, RGD:1642695 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G P2rx5 purinergic receptor P2X 5 enables IDA
ISO
IBA		 (PMID:11404011)
GO_REF:0000033		 RGD
GO_Central		 PMID:11404011 PMID:12135987 GO_REF:0000033, RGD:729229 NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423 		JBrowse link
G P2rx6 purinergic receptor P2X 6 enables IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000117		 GO_Central
UniProt
RGD		 PMID:8786426 GO_REF:0000033 GO_REF:0000117, RGD:729425 NCBI chr11:83,439,922...83,450,449
Ensembl chr11:83,439,924...83,450,481 		JBrowse link
G P2rx7 purinergic receptor P2X 7 enables IDA
ISO
IBA
IEA		 MGI:2386080 (PMID:12677010), (PMID:15713258)
GO_REF:0000033
GO_REF:0000117
PMID:8614837
(PMID:9038151)		 RGD
GO_Central
UniProt		 PMID:9038151 PMID:12677010 PMID:15713258 PMID:17394459 PMID:8614837 GO_REF:0000033 GO_REF:0000117, RGD:1642698, RGD:69918 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
extracellularly glutamate-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc17a7 solute carrier family 17 member 7 enables ISO (PMID:19169251) RGD PMID:19169251 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588 		JBrowse link
G Slc1a7 solute carrier family 1 member 7 enables ISO (MGI:7294459|PMID:32233906), (MGI:7310191|PMID:16973698) RGD PMID:16973698 PMID:32233906 MGI:7294459 MGI:7310191 NCBI chr 5:122,731,003...122,775,139
Ensembl chr 5:122,731,003...122,775,134 		JBrowse link
extracellularly glutamate-gated ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 enables ISO (PMID:14687553) RGD PMID:14687553 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 IDA RGD PMID:1977421 RGD:61622 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 enables ISS
ISO		 GO_REF:0000024
(PMID:28180184)		 UniProt
RGD		 PMID:28180184 GO_REF:0000024 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A contributes_to IMP PMID:9425000 UniProt PMID:9425000 RGD:8554578 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B IDA RGD PMID:1350383 RGD:727540 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
extracellularly glycine-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glra1 glycine receptor, alpha 1 enables IDA
ISO
IEA
ISS		 MGI:1856177|MGI:1856362 (MGI:5707576|PMID:24801766), (PMID:16672662), (PMID:8062927)
GO_REF:0000107
GO_REF:0000002
(PMID:16144831), (PMID:2155780), (PMID:7920629), (PMID:8137830)		 RGD
Ensembl
InterPro		 PMID:2155780 PMID:7920629 PMID:8062927 PMID:8137830 PMID:16144831 More... GO_REF:0000002 GO_REF:0000107 MGI:5707576, RGD:625689, RGD:8553668 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162 		JBrowse link
G Glra2 glycine receptor, alpha 2 enables TAS
IEA
ISO		 GO_REF:0000002
GO_REF:0000107
(PMID:2155780)		 InterPro
Ensembl
RGD		 PMID:2155780 PMID:1645300 GO_REF:0000002 GO_REF:0000107, RGD:728718 NCBI chr  X:29,020,377...29,241,666
Ensembl chr  X:29,020,557...29,241,666 		JBrowse link
G Glra3 glycine receptor, alpha 3 enables IDA
IEA
ISO		 GO_REF:0000002
PMID:23895467
(PMID:26416729)		 InterPro
RGD		 PMID:26416729 PMID:2176214 PMID:23895467 GO_REF:0000002, RGD:728440, RGD:11035333 NCBI chr16:34,199,937...34,848,773
Ensembl chr16:34,204,811...34,848,753 		JBrowse link
G Glra4 glycine receptor alpha 4 enables ISO (MGI:5751681|PMID:10762330) RGD PMID:10762330 MGI:5751681 NCBI chr  X:100,110,517...100,131,042
Ensembl chr  X:100,110,517...100,131,042 		JBrowse link
G Glrb glycine receptor, beta contributes_to
enables		 ISO
IEA
ISS		 (PMID:8717357)
MGI:1856363 (PMID:12809985), (PMID:16672662)
GO_REF:0000002		 RGD
InterPro		 PMID:8717357 PMID:12809985 PMID:16672662 PMID:8717357 GO_REF:0000002, RGD:8554374 NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489 		JBrowse link
extracellularly glycine-gated ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glra1 glycine receptor, alpha 1 IDA RGD PMID:15574743 RGD:1598572 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162 		JBrowse link
G Glrb glycine receptor, beta enables TAS
ISO
ISS
IDA		 (PMID:11929858)
PMID:8717357		 RGD PMID:11929858 PMID:14976213 PMID:8717357 PMID:15574743 RGD:1300220, RGD:8554374, RGD:1598572 NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20488
    transporter activity 1237
      transmembrane transporter activity 1143
        monoatomic ion transmembrane transporter activity 759
          monoatomic ion channel activity 448
            ligand-gated monoatomic ion channel activity 183
              extracellular ligand-gated monoatomic ion channel activity 70
                excitatory extracellular ligand-gated monoatomic ion channel activity 38
                  acetylcholine-gated monoatomic cation-selective channel activity 16
                  extracellularly ATP-gated monoatomic cation channel activity 7
                  extracellularly glutamate-gated ion channel activity + 7
                  extracellularly glycine-gated ion channel activity + 5
Path 2
Term Annotations click to browse term
  molecular_function 20488
    transporter activity 1237
      transmembrane transporter activity 1143
        passive transmembrane transporter activity 507
          channel activity 507
            gated channel activity 331
              ligand-gated channel activity 187
                ligand-gated monoatomic ion channel activity 183
                  extracellular ligand-gated monoatomic ion channel activity 70
                    excitatory extracellular ligand-gated monoatomic ion channel activity 38
                      acetylcholine-gated monoatomic cation-selective channel activity 16
                      extracellularly ATP-gated monoatomic cation channel activity 7
                      extracellularly glutamate-gated ion channel activity + 7
                      extracellularly glycine-gated ion channel activity + 5
paths to the root