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ONTOLOGY REPORT - ANNOTATIONS

Term:extracellularly ATP-gated monoatomic cation channel activity
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Accession:GO:0004931 term browser browse the term
Definition:Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Comment:Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'.
Synonyms:broad_synonym: extracellularly ATP-gated cation channel activity;   purinoceptor;   purinoreceptor
 related_synonym: P2X receptor
 xref: reactome:R-HSA-877187 "P2X7 mediates loss of intracellular K+"


show annotations for term's descendants           Sort by:
extracellularly ATP-gated monoatomic cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx1 purinergic receptor P2X 1 enables IDA
IEA
IBA
ISO		 GO_REF:0000117
GO_REF:0000033
(PMID:8961184)		 UniProt
GO_Central
RGD		 PMID:8961184 PMID:16934235 GO_REF:0000033 GO_REF:0000117, RGD:1642659 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623 		JBrowse link
G P2rx2 purinergic receptor P2X 2 enables IDA
IMP
ISO
IEA
IBA		 (PMID:23345450)
GO_REF:0000117
GO_REF:0000033
MGI:1097160|MGI:2687349 (PMID:12917379), (PMID:15081800)		 RGD
UniProt
GO_Central		 PMID:12917379 PMID:15081800 PMID:23345450 PMID:17517890 PMID:16934235 More... GO_REF:0000033 GO_REF:0000117, RGD:1642653, RGD:1642659, RGD:1642661, RGD:1642665, RGD:1642666 NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891 		JBrowse link
G P2rx3 purinergic receptor P2X 3 enables IDA
ISO
IEA
IBA		 PMID:7566119
(PMID:27626375)
GO_REF:0000117
GO_REF:0000033
MGI:2665170 (PMID:15081800)		 RGD
UniProt
GO_Central		 PMID:15081800 PMID:27626375 PMID:16934235 PMID:12581826 PMID:7566119 GO_REF:0000033 GO_REF:0000117, RGD:1642659, RGD:1642675, RGD:729168 NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178 		JBrowse link
G P2rx4 purinergic receptor P2X 4 enables IDA
ISO
IEA
IBA		 PMID:12819199
(PMID:10515189), (PMID:9016352)
PMID:8551329
GO_REF:0000117
GO_REF:0000033
(PMID:15081800)		 RGD
UniProt
GO_Central		 PMID:9016352 PMID:10515189 PMID:15081800 PMID:16934235 PMID:12819199 More... GO_REF:0000033 GO_REF:0000117, RGD:1642659, RGD:1642695, RGD:61682, RGD:1642695, RGD:1642691 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G P2rx5 purinergic receptor P2X 5 enables IDA
IEA
IBA
ISO		 GO_REF:0000117
GO_REF:0000033
(PMID:11404011)		 UniProt
GO_Central
RGD		 PMID:11404011 PMID:12135987 GO_REF:0000033 GO_REF:0000117, RGD:729229 NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423 		JBrowse link
G P2rx6 purinergic receptor P2X 6 enables IDA
IEA
IBA		 GO_REF:0000117
GO_REF:0000033		 UniProt
GO_Central
RGD		 PMID:8786426 GO_REF:0000033 GO_REF:0000117, RGD:729425 NCBI chr11:83,439,922...83,450,449
Ensembl chr11:83,439,924...83,450,481 		JBrowse link
G P2rx7 purinergic receptor P2X 7 enables IDA
ISO
IEA
IBA		 (PMID:9038151)
PMID:8614837
GO_REF:0000117
GO_REF:0000033
GO_REF:0000118
MGI:2386080 (PMID:12677010), (PMID:15713258)		 RGD
UniProt
GO_Central
TreeGrafter		 PMID:9038151 PMID:12677010 PMID:15713258 PMID:17394459 PMID:8614837 GO_REF:0000033 GO_REF:0000117 GO_REF:0000118, RGD:1642698, RGD:69918 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        monoatomic ion transmembrane transporter activity 752
          monoatomic ion channel activity 457
            monoatomic cation channel activity 347
              ligand-gated monoatomic cation channel activity 129
                extracellularly ATP-gated monoatomic cation channel activity 7
Path 2
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        passive transmembrane transporter activity 519
          channel activity 519
            gated channel activity 332
              ligand-gated channel activity 187
                ligand-gated monoatomic ion channel activity 183
                  extracellular ligand-gated monoatomic ion channel activity 70
                    excitatory extracellular ligand-gated monoatomic ion channel activity 38
                      extracellularly ATP-gated monoatomic cation channel activity 7
paths to the root