ONTOLOGY REPORT - ANNOTATIONS
Term: negative regulation of CD4-positive, alpha-beta T cell differentiation
Accession: GO:0043371
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Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms: exact_synonym: down regulation of CD4-positive, alpha beta T cell differentiation; downregulation of CD4-positive, alpha beta T cell differentiation; negative regulation of CD4-positive T lymphocyte differentiation; negative regulation of CD4-positive T-cell differentiation; negative regulation of CD4-positive, alpha beta T lymphocyte differentiation
narrow_synonym: inhibition of CD4-positive, alpha beta T cell differentiation
related_synonym: negative regulation of CD4-positive, alpha beta T cell development
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Cbfb
core-binding factor subunit beta
involved_in
ISO
(MGI:3772948|PMID:18258917)
RGD
PMID:18258917
MGI:3772948
NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751
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Hmgb1
high mobility group box 1
involved_in
ISO
(PMID:22473704)
RGD
PMID:22473704
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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Runx1
RUNX family transcription factor 1
involved_in
ISS ISO
GO_REF:0000024 (MGI:3772948|PMID:18258917)
UniProt RGD
PMID:18258917
GO_REF:0000024 MGI:3772948
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
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Runx3
RUNX family transcription factor 3
involved_in
ISO
(MGI:3772948|PMID:18258917)
RGD
PMID:18258917
MGI:3772948
NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156
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Ascl2
achaete-scute family bHLH transcription factor 2
involved_in
ISO
(MGI:5565031|PMID:24463518)
RGD
PMID:24463518
MGI:5565031
NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406
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Il4r
interleukin 4 receptor
acts_upstream_of_or_within
ISO
MGI:96109 (PMID:16424184)
RGD
PMID:16424184
NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
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Jak3
Janus kinase 3
involved_in
ISS ISO
GO_REF:0000024 (MGI:3719947|PMID:16020505)
BHF-UCL RGD
PMID:16020505
GO_REF:0000024 MGI:3719947
NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
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Tnfsf4
TNF superfamily member 4
involved_in
ISO
(MGI:4942267|PMID:9670042)
RGD
PMID:9670042
MGI:4942267
NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
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Ascl2
achaete-scute family bHLH transcription factor 2
involved_in
ISO
(MGI:5565031|PMID:24463518)
RGD
PMID:24463518
MGI:5565031
NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406
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Foxp3
forkhead box P3
involved_in
ISO
(PMID:23169781)
RGD
PMID:23169781
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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Il2
interleukin 2
involved_in
ISO
RNAcentral:URS000039ED8D_10090 (MGI:5634593|PMID:25642768)
RGD
PMID:25642768
MGI:5634593
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il4
interleukin 4
acts_upstream_of_or_within
ISO
(PMID:18792410)
RGD
PMID:18792410
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Pf4
platelet factor 4
IDA
RGD
PMID:24986443
RGD:329901907
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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Rc3h1
ring finger and CCCH-type domains 1
involved_in
ISO
(MGI:6142401|PMID:25282160)
RGD
PMID:25282160
MGI:6142401
NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
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Rc3h2
ring finger and CCCH-type domains 2
involved_in
ISO
(MGI:6142401|PMID:25282160)
RGD
PMID:25282160
MGI:6142401
NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933
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Smad7
SMAD family member 7
involved_in
IEA ISO
GO_REF:0000107 (MGI:5634593|PMID:25642768)
Ensembl RGD
PMID:25642768
GO_REF:0000107 MGI:5634593
NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
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Tbx21
T-box transcription factor 21
involved_in
ISO
(MGI:4868293|PMID:21151104)
RGD
PMID:21151104
MGI:4868293
NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
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Zbtb7b
zinc finger and BTB domain containing 7B
acts_upstream_of_or_within
ISO
MGI:3530739 (PMID:23034280)
RGD
PMID:23034280
NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
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Zc3h12a
zinc finger CCCH type containing 12A
involved_in
ISS ISO
GO_REF:0000024 (MGI:6142401|PMID:25282160)
UniProt RGD
PMID:25282160
GO_REF:0000024 MGI:6142401
NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
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Loxl3
lysyl oxidase-like 3
involved_in
ISO
(MGI:5825383|PMID:28065600) (PMID:28065600)
RGD
PMID:28065600
MGI:5825383
NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466
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Tbx21
T-box transcription factor 21
involved_in
ISO
(MGI:4868293|PMID:21151104)
RGD
PMID:21151104
MGI:4868293
NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
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Tnfsf18
TNF superfamily member 18
involved_in
ISO
(MGI:5551556|PMID:24107315)
RGD
PMID:24107315
MGI:5551556
NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169
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Anxa1
annexin A1
involved_in
ISS ISO IEA
GO_REF:0000024 (PMID:17008549) GO_REF:0000107
UniProt RGD Ensembl
PMID:17008549
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Ascl2
achaete-scute family bHLH transcription factor 2
involved_in
ISO
(MGI:5565031|PMID:24463518)
RGD
PMID:24463518
MGI:5565031
NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406
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Bcl6
BCL6, transcription repressor
acts_upstream_of_or_within
ISO
MGI:96559 (PMID:12594267)
RGD
PMID:12594267
NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
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Hlx
H2.0-like homeobox
acts_upstream_of_or_within
ISO
MGI:105367|MGI:2182089 (PMID:16424184)
RGD
PMID:16424184
NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750
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Socs5
suppressor of cytokine signaling 5
involved_in
ISO
(MGI:3687909|PMID:12242343)
RGD
PMID:12242343
MGI:3687909
NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834
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Zfp35
zinc finger protein 35
involved_in
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr18:15,268,852...15,284,334
Ensembl chr18:15,268,814...15,285,088
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Rc3h1
ring finger and CCCH-type domains 1
acts_upstream_of_or_within
ISO
MGI:3581675 (PMID:15917799)
RGD
PMID:15917799
NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
biological_process
19692
immune system process
2822
leukocyte activation
1032
lymphocyte activation
837
T cell activation
591
alpha-beta T cell activation
200
CD4-positive, alpha-beta T cell activation
133
CD4-positive, alpha-beta T cell differentiation
103
negative regulation of CD4-positive, alpha-beta T cell differentiation
25
negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +
0
negative regulation of T-helper cell differentiation +
21
Path 2
biological_process
19692
cellular process
18168
cellular developmental process
4695
cell differentiation
4694
cell development
3269
hemopoiesis
1061
leukocyte differentiation
674
mononuclear cell differentiation
544
lymphocyte differentiation
447
T cell differentiation
324
alpha-beta T cell differentiation
141
CD4-positive, alpha-beta T cell differentiation
103
regulation of CD4-positive, alpha-beta T cell differentiation
60
negative regulation of CD4-positive, alpha-beta T cell differentiation
25
negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +
0
negative regulation of T-helper cell differentiation +
21