ONTOLOGY REPORT - ANNOTATIONS
Term: alpha-beta T cell differentiation
Accession: GO:0046632
browse the term
Definition: The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex.
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms: exact_synonym: alpha-beta T lymphocyte differentiation
related_synonym: alpha-beta T cell development
alpha-beta T cell differentiation
G
Anxa1
annexin A1
ISO
1
223,478,436
223,494,455
RGD:1624291
RGD
G
Anxa1
annexin A1
IEA
1
223,478,436
223,494,455
RGD:1600115
ENSEMBL
G
Bcl11b
B-cell CLL/lymphoma 11B (zinc finger protein)
ISO
6
132,292,671
132,384,572
RGD:1624291
RGD
G
Bcl11b
B-cell CLL/lymphoma 11B (zinc finger protein)
IEA
6
132,292,671
132,384,572
RGD:1600115
ENSEMBL
G
Blm
Bloom syndrome, RecQ helicase-like
ISO
1
136,271,573
136,358,077
RGD:1624291
RGD
G
Blm
Bloom syndrome, RecQ helicase-like
IEA
1
136,271,573
136,358,077
RGD:1600115
ENSEMBL
G
Lef1
lymphoid enhancer binding factor 1
ISO
2
228,550,263
228,673,131
RGD:1624291
RGD
G
Lef1
lymphoid enhancer binding factor 1
IBA
2
228,550,263
228,673,131
RGD:1600115
RefGenome
G
Rpl22
ribosomal protein L22
ISO
5
169,557,840
169,564,566
RGD:1624291
RGD
G
Tcf7
transcription factor 7 (T-cell specific, HMG-box)
ISO
10
37,686,862
37,716,831
RGD:1624291
RGD
G
Tcf7
transcription factor 7 (T-cell specific, HMG-box)
IEA
10
37,686,862
37,716,831
RGD:1600115
ENSEMBL
beta selection
G
Syk
spleen tyrosine kinase
ISO
17
18,440,672
18,498,001
RGD:1624291
RGD
G
Syk
spleen tyrosine kinase
IEA
17
18,440,672
18,498,001
RGD:1600115
ENSEMBL
G
Zap70
zeta-chain (TCR) associated protein kinase 70
ISO
9
35,693,089
35,715,071
RGD:1624291
RGD
G
Zap70
zeta-chain (TCR) associated protein kinase 70
IEA
9
35,693,089
35,715,071
RGD:1600115
ENSEMBL
CD4-positive, alpha-beta T cell differentiation
G
Nkx2-3
NK2 homeobox 3
ISO
1
247,221,087
247,224,040
RGD:1624291
RGD
G
Nkx2-3
NK2 homeobox 3
IEA
1
247,221,087
247,224,040
RGD:1600115
ENSEMBL
G
Pax1
paired box 1
ISO
3
136,006,504
136,018,849
RGD:1624291
RGD
G
Pax1
paired box 1
IEA
3
136,006,504
136,018,849
RGD:1600115
ENSEMBL
G
Rsad2
radical S-adenosyl methionine domain containing 2
ISS
6
44,100,775
44,113,910
RGD:1600115
UniProtKB
G
Rsad2
radical S-adenosyl methionine domain containing 2
ISO
6
44,100,775
44,113,910
RGD:1624291
RGD
G
Satb1
SATB homeobox 1
ISO
9
3,307,651
3,391,348
RGD:1624291
RGD
G
Satb1
SATB homeobox 1
IEA
9
3,307,651
3,391,348
RGD:1600115
ENSEMBL
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
G
Foxp3
forkhead box P3
ISO
X
26,950,006
26,965,329
RGD:1624291
RGD
G
Foxp3
forkhead box P3
ISO
X
26,950,006
26,965,329
RGD:1624291
RGD
G
Foxp3
forkhead box P3
IEA
X
26,950,006
26,965,329
RGD:1600115
ENSEMBL
G
Fut7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
ISO
3
3,590,174
3,593,046
RGD:1624291
RGD
G
Fut7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
IEA
3
3,590,174
3,593,046
RGD:1600115
ENSEMBL
G
Ncor1
nuclear receptor co-repressor 1
ISO
10
48,481,110
48,628,538
RGD:1624291
RGD
CD8-positive, alpha-beta T cell differentiation
G
Irf1
interferon regulatory factor 1
ISO
10
39,220,600
39,227,602
RGD:1624291
RGD
G
Irf1
interferon regulatory factor 1
IEA
10
39,220,600
39,227,602
RGD:1600115
ENSEMBL
G
Pax1
paired box 1
ISO
3
136,006,504
136,018,849
RGD:1624291
RGD
G
Pax1
paired box 1
IEA
3
136,006,504
136,018,849
RGD:1600115
ENSEMBL
G
Satb1
SATB homeobox 1
ISO
9
3,307,651
3,391,348
RGD:1624291
RGD
G
Satb1
SATB homeobox 1
ISO
9
3,307,651
3,391,348
RGD:1624291
RGD
G
Satb1
SATB homeobox 1
IEA
9
3,307,651
3,391,348
RGD:1600115
ENSEMBL
G
Tnfsf8
tumor necrosis factor (ligand) superfamily, member 8
ISO
RGD:1624291
RGD
CD8-positive, alpha-beta T cell differentiation involved in immune response
G
Eomes
eomesodermin
ISO
8
123,376,689
123,383,451
RGD:1624291
RGD
G
Eomes
eomesodermin
ISO
8
123,376,689
123,383,451
RGD:1624291
RGD
G
Ifng
interferon gamma
ISO
7
57,621,756
57,625,792
RGD:1624291
RGD
G
Ifng
interferon gamma
IEA
7
57,621,756
57,625,792
RGD:1600115
ENSEMBL
CD8-positive, alpha-beta T cell lineage commitment
G
Bcl2
B-cell CLL/lymphoma 2
ISO
13
12,730,736
12,905,108
RGD:1624291
RGD
G
Bcl2
B-cell CLL/lymphoma 2
IEA
13
12,730,736
12,905,108
RGD:1600115
ENSEMBL
negative regulation of alpha-beta T cell differentiation
G
Gli3
GLI family zinc finger 3
IMP
17
57,594,102
57,867,710
RGD:2290270
BHF-UCL
G
Gli3
GLI family zinc finger 3
ISO
17
57,594,102
57,867,710
RGD:1624291
RGD
G
Gli3
GLI family zinc finger 3
ISO
17
57,594,102
57,867,710
RGD:2290270
RGD
G
Ihh
Indian hedgehog
ISO
9
74,287,115
74,293,332
RGD:1624291
RGD
G
Ihh
Indian hedgehog
IEA
9
74,287,115
74,293,332
RGD:1600115
ENSEMBL
G
Shh
sonic hedgehog
ISO
4
2,200,504
2,209,657
RGD:1624291
RGD
G
Shh
sonic hedgehog
IEA
4
2,200,504
2,209,657
RGD:1600115
ENSEMBL
negative regulation of T-helper 1 cell differentiation
G
Il4r
interleukin 4 receptor
ISO
1
184,612,903
184,637,863
RGD:1624291
RGD
G
Il4r
interleukin 4 receptor
IEA
1
184,612,903
184,637,863
RGD:1600115
ENSEMBL
G
Jak3
Janus kinase 3
ISO
16
18,878,139
18,889,441
RGD:1624291
RGD
G
Jak3
Janus kinase 3
ISS
16
18,878,139
18,889,441
RGD:1600115
BHF-UCL
G
Tnfsf4
tumor necrosis factor (ligand) superfamily, member 4
ISO
13
77,026,337
77,050,223
RGD:1624291
RGD
G
Tnfsf4
tumor necrosis factor (ligand) superfamily, member 4
IEA
13
77,026,337
77,050,223
RGD:1600115
ENSEMBL
negative regulation of T-helper 17 cell differentiation
G
Il4
interleukin 4
ISO
10
39,074,582
39,080,134
RGD:1624291
RGD
G
Il4
interleukin 4
IEA
10
39,074,582
39,080,134
RGD:1600115
ENSEMBL
negative regulation of T-helper 2 cell differentiation
G
Bcl6
B-cell CLL/lymphoma 6
ISO
11
79,006,123
79,030,555
RGD:1624291
RGD
G
Bcl6
B-cell CLL/lymphoma 6
IEA
11
79,006,123
79,030,555
RGD:1600115
ENSEMBL
G
Hlx
H2.0-like homeobox
ISO
13
100,685,757
100,691,658
RGD:1624291
RGD
G
Hlx
H2.0-like homeobox
IEA
13
100,685,757
100,691,658
RGD:1600115
ENSEMBL
G
Socs5
suppressor of cytokine signaling 5
ISO
6
10,552,177
10,582,783
RGD:1624291
RGD
G
Socs5
suppressor of cytokine signaling 5
IEA
6
10,552,177
10,582,783
RGD:1600115
ENSEMBL
G
Zfp35
zinc finger protein 35
ISO
18
15,749,584
15,765,238
RGD:1624291
RGD
negative regulation of T-helper cell differentiation
G
Rc3h1
ring finger and CCCH-type domains 1
ISO
13
76,493,343
76,530,107
RGD:1624291
RGD
NK T cell differentiation
G
Itk
IL2-inducible T-cell kinase
ISO
10
31,455,982
31,518,075
RGD:1624291
RGD
G
Itk
IL2-inducible T-cell kinase
IEA
10
31,455,982
31,518,075
RGD:1600115
ENSEMBL
G
Txk
TXK tyrosine kinase
ISO
14
37,867,565
37,923,075
RGD:1624291
RGD
G
Txk
TXK tyrosine kinase
IEA
14
37,867,565
37,923,075
RGD:1600115
ENSEMBL
positive regulation of alpha-beta T cell differentiation
G
Ada
adenosine deaminase
ISO
3
154,636,530
154,660,637
RGD:1624291
RGD
G
Ada
adenosine deaminase
ISO
3
154,636,530
154,660,637
RGD:1624291
RGD
G
Ada
adenosine deaminase
ISO
3
154,636,530
154,660,637
RGD:1624291
RGD
G
Ada
adenosine deaminase
IEA
3
154,636,530
154,660,637
RGD:1600115
ENSEMBL
G
Gli3
GLI family zinc finger 3
IMP
17
57,594,102
57,867,710
RGD:2290270
BHF-UCL
G
Gli3
GLI family zinc finger 3
ISO
17
57,594,102
57,867,710
RGD:1624291
RGD
G
Gli3
GLI family zinc finger 3
ISO
17
57,594,102
57,867,710
RGD:2290270
RGD
G
Ihh
Indian hedgehog
ISO
9
74,287,115
74,293,332
RGD:1624291
RGD
G
Ihh
Indian hedgehog
IEA
9
74,287,115
74,293,332
RGD:1600115
ENSEMBL
G
Itpkb
inositol-trisphosphate 3-kinase B
ISO
13
96,044,260
96,138,456
RGD:1624291
RGD
G
Itpkb
inositol-trisphosphate 3-kinase B
IEA
13
96,044,260
96,138,456
RGD:1600115
ENSEMBL
G
Nkap
NFKB activating protein
ISO
X
7,762,215
7,781,862
RGD:1624291
RGD
G
Nkap
NFKB activating protein
ISS
X
7,762,215
7,781,862
RGD:1600115
UniProtKB
G
Pnp
purine nucleoside phosphorylase
ISO
15
26,929,784
26,937,434
RGD:1624291
RGD
G
Pnp
purine nucleoside phosphorylase
ISO
15
26,929,784
26,937,434
RGD:1624291
RGD
G
Pnp
purine nucleoside phosphorylase
ISO
15
26,929,784
26,937,434
RGD:1624291
RGD
G
Pnp
purine nucleoside phosphorylase
ISO
15
26,929,784
26,937,434
RGD:1624291
RGD
G
Shh
sonic hedgehog
ISO
4
2,200,504
2,209,657
RGD:1624291
RGD
G
Shh
sonic hedgehog
IEA
4
2,200,504
2,209,657
RGD:1600115
ENSEMBL
G
Shh
sonic hedgehog
ISS
4
2,200,504
2,209,657
RGD:1600115
UniProtKB
G
Syk
spleen tyrosine kinase
ISO
17
18,440,672
18,498,001
RGD:1624291
RGD
G
Syk
spleen tyrosine kinase
IEA
17
18,440,672
18,498,001
RGD:1600115
ENSEMBL
G
Zap70
zeta-chain (TCR) associated protein kinase 70
ISO
9
35,693,089
35,715,071
RGD:1624291
RGD
G
Zap70
zeta-chain (TCR) associated protein kinase 70
ISO
9
35,693,089
35,715,071
RGD:1624291
RGD
G
Zap70
zeta-chain (TCR) associated protein kinase 70
ISO
9
35,693,089
35,715,071
RGD:1624291
RGD
G
Zap70
zeta-chain (TCR) associated protein kinase 70
IEA
9
35,693,089
35,715,071
RGD:1600115
ENSEMBL
positive regulation of CD4-positive, alpha-beta T cell differentiation
G
Cd83
CD83 molecule
ISO
17
26,705,646
26,725,470
RGD:1624291
RGD
G
Cd83
CD83 molecule
IEA
17
26,705,646
26,725,470
RGD:1600115
ENSEMBL
G
Nckap1l
NCK associated protein 1 like
ISO
7
142,351,954
142,397,045
RGD:1624291
RGD
G
Nckap1l
NCK associated protein 1 like
IEA
7
142,351,954
142,397,045
RGD:1600115
ENSEMBL
G
Sash3
SAM and SH3 domain containing 3
ISO
X
134,511,776
134,526,489
RGD:1624291
RGD
G
Sash3
SAM and SH3 domain containing 3
IEA
X
134,511,776
134,526,489
RGD:1600115
ENSEMBL
G
Tnfsf4
tumor necrosis factor (ligand) superfamily, member 4
ISO
13
77,026,337
77,050,223
RGD:1624291
RGD
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
G
Foxp3
forkhead box P3
ISO
X
26,950,006
26,965,329
RGD:1624291
RGD
G
Foxp3
forkhead box P3
ISO
X
26,950,006
26,965,329
RGD:1624291
RGD
G
Foxp3
forkhead box P3
IBA
X
26,950,006
26,965,329
RGD:1600115
RefGenome
G
Gimap5
GTPase, IMAP family member 5
IMP
4
76,836,521
76,843,214
RGD:2303772
RGD
G
Il2rg
interleukin 2 receptor, gamma
ISO
X
89,342,055
89,345,715
RGD:1624291
RGD
positive regulation of CD8-positive, alpha-beta T cell differentiation
G
Nckap1l
NCK associated protein 1 like
ISO
7
142,351,954
142,397,045
RGD:1624291
RGD
G
Nckap1l
NCK associated protein 1 like
IEA
7
142,351,954
142,397,045
RGD:1600115
ENSEMBL
positive regulation of NK T cell differentiation
G
Ap3b1
adaptor-related protein complex 3, beta 1 subunit
ISO
2
24,670,078
24,872,770
RGD:1624291
RGD
G
Ap3b1
adaptor-related protein complex 3, beta 1 subunit
IEA
2
24,670,078
24,872,770
RGD:1600115
ENSEMBL
G
Ap3d1
adaptor-related protein complex 3, delta 1 subunit
ISO
7
10,480,810
10,516,163
RGD:1624291
RGD
G
Ap3d1
adaptor-related protein complex 3, delta 1 subunit
IEA
7
10,480,810
10,516,163
RGD:1600115
ENSEMBL
G
Cd1d1
CD1d1 molecule
ISO
2
179,011,165
179,014,672
RGD:1624291
RGD
G
Cd1d1
CD1d1 molecule
ISO
2
179,011,165
179,014,672
RGD:1624291
RGD
G
Ikzf1
IKAROS family zinc finger 1
ISO
14
92,560,200
92,657,336
RGD:1624291
RGD
G
Ikzf1
IKAROS family zinc finger 1
IEA
14
92,560,200
92,657,336
RGD:1600115
ENSEMBL
G
Tgfbr2
transforming growth factor, beta receptor II
ISO
8
120,593,595
120,680,453
RGD:1624291
RGD
G
Tgfbr2
transforming growth factor, beta receptor II
IEA
8
120,593,595
120,680,453
RGD:1600115
ENSEMBL
positive regulation of T-helper 1 cell differentiation
G
Hlx
H2.0-like homeobox
ISO
13
100,685,757
100,691,658
RGD:1624291
RGD
G
Hlx
H2.0-like homeobox
IEA
13
100,685,757
100,691,658
RGD:1600115
ENSEMBL
G
Ripk2
receptor-interacting serine-threonine kinase 2
ISO
5
30,714,817
30,745,941
RGD:1624291
RGD
G
Ripk2
receptor-interacting serine-threonine kinase 2
IEA
5
30,714,817
30,745,941
RGD:1600115
ENSEMBL
G
Socs5
suppressor of cytokine signaling 5
ISO
6
10,552,177
10,582,783
RGD:1624291
RGD
G
Socs5
suppressor of cytokine signaling 5
IEA
6
10,552,177
10,582,783
RGD:1600115
ENSEMBL
positive regulation of T-helper 17 cell lineage commitment
G
Il23a
Interleukin 23, alpha subunit p19
ISO
7
1,584,112
1,586,226
RGD:1624291
RGD
G
Il23a
Interleukin 23, alpha subunit p19
IEA
7
1,584,112
1,586,226
RGD:1600115
ENSEMBL
positive regulation of T-helper 2 cell differentiation
G
Il4r
interleukin 4 receptor
ISO
1
184,612,903
184,637,863
RGD:1624291
RGD
G
Il4r
interleukin 4 receptor
IEA
1
184,612,903
184,637,863
RGD:1600115
ENSEMBL
G
Il6
interleukin 6
ISO
4
456,799
461,376
RGD:1624291
RGD
G
Il6
interleukin 6
IEA
4
456,799
461,376
RGD:1600115
ENSEMBL
G
Prkcz
protein kinase C, zeta
ISO
5
172,061,825
172,172,793
RGD:1624291
RGD
G
Prkcz
protein kinase C, zeta
ISS
5
172,061,825
172,172,793
RGD:1600115
UniProtKB
G
Rara
retinoic acid receptor, alpha
ISO
10
87,740,479
87,753,265
RGD:1624291
RGD
G
Rara
retinoic acid receptor, alpha
IEA
10
87,740,479
87,753,265
RGD:1600115
ENSEMBL
G
Tnfsf4
tumor necrosis factor (ligand) superfamily, member 4
ISO
13
77,026,337
77,050,223
RGD:1624291
RGD
G
Tnfsf4
tumor necrosis factor (ligand) superfamily, member 4
IEA
13
77,026,337
77,050,223
RGD:1600115
ENSEMBL
regulation of CD4-positive, alpha-beta T cell differentiation
G
Gata3
GATA binding protein 3
ISO
17
79,991,587
80,011,574
RGD:1624291
RGD
G
Gata3
GATA binding protein 3
IEA
17
79,991,587
80,011,574
RGD:1600115
ENSEMBL
G
Zbtb7b
zinc finger and BTB domain containing 7B
ISO
2
181,576,165
181,578,156
RGD:1624291
RGD
regulation of CD8-positive, alpha-beta T cell differentiation
G
Zbtb7b
zinc finger and BTB domain containing 7B
ISO
2
181,576,165
181,578,156
RGD:1624291
RGD
regulation of T-helper 1 cell differentiation
G
Il27
interleukin 27
IEA
1
185,730,394
185,735,604
RGD:1600115
ENSEMBL
G
Il27
interleukin 27
ISO
1
185,730,394
185,735,604
RGD:1624291
RGD
regulation of T-helper cell differentiation
G
Il12rb2
interleukin 12 receptor, beta 2
NAS
4
96,929,755
96,995,733
RGD:1331512
RGD
T-helper 1 cell differentiation
G
Il18r1
interleukin 18 receptor 1
ISO
9
39,627,915
39,659,828
RGD:1624291
RGD
G
Lef1
lymphoid enhancer binding factor 1
ISO
2
228,550,263
228,673,131
RGD:1624291
RGD
G
Lef1
lymphoid enhancer binding factor 1
IEA
2
228,550,263
228,673,131
RGD:1600115
ENSEMBL
G
Relb
v-rel reticuloendotheliosis viral oncogene homolog B
ISO
RGD:1624291
RGD
G
Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
ISO
2
180,552,405
180,570,359
RGD:1624291
RGD
G
Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
IEA
2
180,552,405
180,570,359
RGD:1600115
ENSEMBL
T-helper 1 cell lineage commitment
G
Il4
interleukin 4
ISO
10
39,074,582
39,080,134
RGD:1624291
RGD
G
Il4
interleukin 4
IEA
10
39,074,582
39,080,134
RGD:1600115
ENSEMBL
G
Stat6
signal transducer and activator of transcription 6, interleukin-4 induced
ISO
7
67,623,534
67,642,283
RGD:1624291
RGD
G
Stat6
signal transducer and activator of transcription 6, interleukin-4 induced
IEA
7
67,623,534
67,642,283
RGD:1600115
ENSEMBL
T-helper 17 cell differentiation
G
Batf
basic leucine zipper transcription factor, ATF-like
ISS
6
109,793,076
109,817,614
RGD:1600115
UniProtKB
G
Batf
basic leucine zipper transcription factor, ATF-like
ISO
6
109,793,076
109,817,614
RGD:1624291
RGD
G
Batf
basic leucine zipper transcription factor, ATF-like
ISO
6
109,793,076
109,817,614
RGD:1624291
RGD
T-helper 17 cell lineage commitment
G
Batf
basic leucine zipper transcription factor, ATF-like
ISS
6
109,793,076
109,817,614
RGD:1600115
UniProtKB
G
Batf
basic leucine zipper transcription factor, ATF-like
ISO
6
109,793,076
109,817,614
RGD:1624291
RGD
G
Batf
basic leucine zipper transcription factor, ATF-like
ISO
6
109,793,076
109,817,614
RGD:1624291
RGD
G
Irf4
interferon regulatory factor 4
ISO
17
40,170,409
40,189,976
RGD:1624291
RGD
T-helper 2 cell differentiation
G
Batf
basic leucine zipper transcription factor, ATF-like
ISS
6
109,793,076
109,817,614
RGD:1600115
UniProtKB
G
Batf
basic leucine zipper transcription factor, ATF-like
ISO
6
109,793,076
109,817,614
RGD:1624291
RGD
G
Batf
basic leucine zipper transcription factor, ATF-like
ISO
6
109,793,076
109,817,614
RGD:1624291
RGD
G
Bcl3
B-cell CLL/lymphoma 3
ISO
1
79,122,801
79,137,035
RGD:1624291
RGD
G
Bcl3
B-cell CLL/lymphoma 3
IEA
1
79,122,801
79,137,035
RGD:1600115
ENSEMBL
G
Gata3
GATA binding protein 3
ISO
17
79,991,587
80,011,574
RGD:1624291
RGD
G
Gata3
GATA binding protein 3
IEA
17
79,991,587
80,011,574
RGD:1600115
ENSEMBL
G
Il4
interleukin 4
ISO
10
39,074,582
39,080,134
RGD:1624291
RGD
G
Il4
interleukin 4
IEA
10
39,074,582
39,080,134
RGD:1600115
ENSEMBL
T-helper cell differentiation
G
Atp7a
ATPase, Cu++ transporting, alpha polypeptide
ISO
X
94,192,540
94,249,776
RGD:1624291
RGD
G
Atp7a
ATPase, Cu++ transporting, alpha polypeptide
IEA
X
94,192,540
94,249,776
RGD:1600115
ENSEMBL
G
Il12b
interleukin 12B
ISO
10
29,558,955
29,568,331
RGD:1624291
RGD
G
Ptger4
prostaglandin E receptor 4 (subtype EP4)
ISO
2
54,423,280
54,433,907
RGD:1624291
RGD
G
Ptger4
prostaglandin E receptor 4 (subtype EP4)
ISS
2
54,423,280
54,433,907
RGD:1600115
UniProtKB
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