Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:innate immune response activating cell surface receptor signaling pathway
go back to main search page
Accession:GO:0002220 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a cell surface receptor that leads to the activation of an innate immune response.
Synonyms:exact_synonym: activation of innate immune response by cell surface receptor signaling pathway;   innate immune response activating cell surface receptor signalling pathway


show annotations for term's descendants           Sort by:
cell surface pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581 		JBrowse link
G CLEC7A C-type lectin domain containing 7A acts_upstream_of_or_within ISO (PMID:12719478) MGI PMID:12719478 NCBI chr 5:61,832,910...61,846,441
Ensembl chr 5:61,832,954...61,846,434 		JBrowse link
G FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) involved_in ISO (PMID:21037097) UniProt PMID:21037097 NCBI chr 1:274,106,276...274,111,970
Ensembl chr 1:274,103,877...274,111,970 		JBrowse link
G FFAR2 free fatty acid receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:44,899,879...44,904,461
Ensembl chr 6:44,901,159...44,904,459 		JBrowse link
G LBP lipopolysaccharide binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,398,935...41,429,467
Ensembl chr17:41,393,818...41,429,551 		JBrowse link
G MBL2 mannose binding lectin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
G TLR2 toll like receptor 2 acts_upstream_of_or_within ISO (PMID:12719478) MGI PMID:12719478 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LRRFIP2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) MGI PMID:19265123 NCBI chr13:21,666,896...21,790,352
Ensembl chr13:21,670,424...21,793,043 		JBrowse link
negative regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOD1 aconitate decarboxylase 1 involved_in ISO (MGI:5490396|PMID:23609450) UniProt PMID:23609450 MGI:5490396 NCBI chr11:49,077,152...49,088,218
Ensembl chr11:49,077,492...49,087,104 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,793,492...75,903,496 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:56,200,455...56,296,151
Ensembl chr15:56,200,455...56,295,064 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15220916) Ensembl
MGI		 PMID:15220916 GO_REF:0000107 NCBI chr 6:34,132,127...34,167,446
Ensembl chr 6:34,130,938...34,177,534 		JBrowse link
G TLR6 toll like receptor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:30,159,744...30,180,650
Ensembl chr 8:30,159,754...30,180,650 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6695864|PMID:31134514) ARUK-UCL PMID:31134514 MGI:6695864 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
negative regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOD1 aconitate decarboxylase 1 involved_in ISO (MGI:5490396|PMID:23609450) UniProt PMID:23609450 MGI:5490396 NCBI chr11:49,077,152...49,088,218
Ensembl chr11:49,077,492...49,087,104 		JBrowse link
G BPIFB1 BPI fold containing family B member 1 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:36,782,307...36,809,756
Ensembl chr17:36,782,307...36,809,754 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:261,732,280...261,859,833
Ensembl chr 1:261,659,660...261,859,022 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,793,492...75,903,496 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:56,200,455...56,296,151
Ensembl chr15:56,200,455...56,295,064 		JBrowse link
G MIR140 microRNA mir-140 involved_in ISO (PMID:30233718)
(PMID:30321456)		 ARUK-UCL PMID:30233718 PMID:30321456 NCBI chr 6:17,077,530...17,077,599
Ensembl chr 6:17,077,507...17,077,620 		JBrowse link
G MIR20A microRNA mir-20a involved_in ISO (PMID:29653364) ARUK-UCL PMID:29653364 NCBI chr11:60,735,109...60,735,179
Ensembl chr11:60,735,099...60,735,196 		JBrowse link
G MIR708 microRNA mir-708 involved_in ISO (PMID:31599428) ARUK-UCL PMID:31599428 NCBI chr 9:13,780,171...13,780,250
Ensembl chr 9:13,780,171...13,780,250 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:22,263,549...22,274,131
Ensembl chr12:22,263,657...22,271,643 		JBrowse link
G RAB7B RAB7B, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:66,635,636...66,666,034
Ensembl chr 9:66,635,638...66,666,036 		JBrowse link
G SQSTM1 sequestosome 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938 		JBrowse link
G TAX1BP1 Tax1 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:44,827,908...44,910,265
Ensembl chr18:44,827,095...44,910,235 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:19412184) UniProt PMID:19412184 NCBI chr 2:119,758,622...119,778,650 JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6695864|PMID:31134514)
(MGI:6152919|PMID:29407460)		 ARUK-UCL PMID:29407460 PMID:31134514 MGI:6152919 MGI:6695864 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
G TRIM32 tripartite motif containing 32 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:257,051,421...257,066,911
Ensembl chr 1:257,054,228...257,066,909 		JBrowse link
negative regulation of toll-like receptor 5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:26,474,158...26,489,771
Ensembl chr 1:26,473,938...26,489,822 		JBrowse link
positive regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYBA cytochrome b-245 alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,162...1,021,420 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (MGI:5788395|PMID:16267105) UniProt PMID:16267105 MGI:5788395 NCBI chr11:7,195,556...7,321,071 JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:56,200,455...56,296,151
Ensembl chr15:56,200,455...56,295,064 		JBrowse link
G PJA2 praja ring finger ubiquitin ligase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:114,319,972...114,675,761
Ensembl chr 2:114,319,991...114,558,272 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:53,374,559...53,394,172
Ensembl chr 9:53,375,644...53,394,165 		JBrowse link
G TLR1 toll like receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:30,147,600...30,155,454
Ensembl chr 8:30,147,624...30,155,466 		JBrowse link
positive regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (MGI:5788395|PMID:16267105) UniProt PMID:16267105 MGI:5788395 NCBI chr11:7,195,556...7,321,071 JBrowse link
G IFI35 interferon induced protein 35 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:19,879,386...19,890,330
Ensembl chr12:19,879,387...19,890,314 		JBrowse link
G LBP lipopolysaccharide binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,398,935...41,429,467
Ensembl chr17:41,393,818...41,429,551 		JBrowse link
G LTF lactotransferrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:29,413,886...29,445,751
Ensembl chr13:29,413,886...29,445,739 		JBrowse link
G NINJ1 ninjurin 1 involved_in ISO (MGI:6694429|PMID:25860173) UniProt PMID:25860173 MGI:6694429 NCBI chr 3:42,654,536...42,672,830
Ensembl chr 3:42,654,228...42,672,778 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:15,315,283...15,336,785
Ensembl chr 2:15,315,282...15,334,820 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19734906) Ensembl
MGI		 PMID:19734906 GO_REF:0000107 NCBI chr 3:77,740,460...77,796,911
Ensembl chr 3:77,713,489...77,796,914 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:106,692,102...106,758,101
Ensembl chr 4:106,686,604...106,758,099 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:22685567)
(PMID:19412184)		 UniProt PMID:19412184 PMID:22685567 NCBI chr 2:119,758,622...119,778,650 JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:53,374,559...53,394,172
Ensembl chr 9:53,375,644...53,394,165 		JBrowse link
G WDFY1 WD repeat and FYVE domain containing 1 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr15:125,674,142...125,720,187
Ensembl chr15:125,669,842...125,720,158 		JBrowse link
G ZNRF1 zinc and ring finger 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:12,555,655...12,668,807 JBrowse link
G ZNRF1 zinc and ring finger 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 6:12,555,664...12,668,804 JBrowse link
regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:39,089,157...39,124,969
Ensembl chr13:39,089,077...39,129,781 		JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:6270783|PMID:27219021) UniProt PMID:27219021 MGI:6270783 NCBI chr 5:79,356,046...79,412,235
Ensembl chr 5:79,356,067...79,412,235 		JBrowse link
G FLOT1 flotillin 1 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chr 7:23,253,157...23,265,165
Ensembl chr 7:23,253,162...23,265,106 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609 		JBrowse link
regulation of toll-like receptor 6 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6695864|PMID:31134514) ARUK-UCL PMID:31134514 MGI:6695864 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
stimulatory C-type lectin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLEC12B C-type lectin domain family 12 member B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:61,908,463...61,915,328
Ensembl chr 5:61,908,731...61,915,328 		JBrowse link
G CLEC7A C-type lectin domain containing 7A involved_in ISO (MGI:3844414|PMID:19136564) ARUK-UCL PMID:19136564 MGI:3844414 NCBI chr 5:61,832,910...61,846,441
Ensembl chr 5:61,832,954...61,846,434 		JBrowse link
G KLRD1 killer cell lectin like receptor D1 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:61,662,083...61,673,109
Ensembl chr 5:61,666,654...61,673,129 		JBrowse link
G KLRK1 killer cell lectin like receptor K1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12645935) Ensembl
MGI		 PMID:12645935 GO_REF:0000107 NCBI chr 5:61,646,691...61,655,386
Ensembl chr 5:61,647,043...61,656,192 		JBrowse link
G LOC100519314 natural killer cells antigen CD94 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:61,724,744...61,736,667 JBrowse link
G LOC100523789 NKG2-A/NKG2-B type II integral membrane protein involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:61,621,869...61,633,693 JBrowse link
G LOC102165642 natural killer cells antigen CD94-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:61,583,868...61,596,985 JBrowse link
G LOC106507517 C-type lectin domain family 7 member A-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:61,503,931...61,526,167 JBrowse link
G LOC106507518 natural killer cells antigen CD94-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:61,533,765...61,544,200 JBrowse link
G PLCG2 phospholipase C gamma 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:6,433,146...6,603,092
Ensembl chr 6:6,433,153...6,603,060 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,670...2,161,171 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:45,309,199...45,312,562
Ensembl chr 6:45,309,201...45,312,539 		JBrowse link
stimulatory killer cell immunoglobulin-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:45,309,199...45,312,562
Ensembl chr 6:45,309,201...45,312,539 		JBrowse link
TIRAP-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TIRAP TIR domain containing adaptor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:53,374,559...53,394,172
Ensembl chr 9:53,375,644...53,394,165 		JBrowse link
toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMGB1 high mobility group box 1 involved_in IDA (PMID:14660645) UniProt PMID:14660645 NCBI chr11:7,195,556...7,321,071 JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:10549626) Ensembl
MGI
GO_Central		 PMID:10549626 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:124,717,604...124,724,855
Ensembl chr  X:124,717,612...124,724,860 		JBrowse link
G LGALS9 galectin 9 NOT|involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr12:44,155,079...44,173,634 JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:15220916) Ensembl
MGI		 PMID:15220916 GO_REF:0000107 NCBI chr 6:34,132,127...34,167,446
Ensembl chr 6:34,130,938...34,177,534 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:108,038,396...108,303,942
Ensembl chr14:108,039,431...108,303,929 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11894098) MGI
Ensembl		 PMID:11894098 GO_REF:0000107 NCBI chr 4:47,026,558...47,075,133
Ensembl chr 4:47,027,098...47,074,704 		JBrowse link
G TLR2 toll like receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TNIP2 TNFAIP3 interacting protein 2 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:1,530,534...1,554,677
Ensembl chr 8:1,533,429...1,554,683 		JBrowse link
toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868 		JBrowse link
G ECSIT ECSIT signaling integrator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:70,154,861...70,170,762
Ensembl chr 2:70,154,843...70,170,744 		JBrowse link
G HMGB1 high mobility group box 1 involved_in IDA (PMID:14660645) UniProt PMID:14660645 NCBI chr11:7,195,556...7,321,071 JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:10549626) GO_Central
MGI		 PMID:10549626 GO_REF:0000033 NCBI chr  X:124,717,604...124,724,855
Ensembl chr  X:124,717,612...124,724,860 		JBrowse link
G IRAK2 interleukin 1 receptor associated kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:66,350,606...66,416,834
Ensembl chr13:66,350,606...66,416,827 		JBrowse link
G IRF3 interferon regulatory factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,701,733...54,706,079
Ensembl chr 6:54,701,668...54,707,151 		JBrowse link
G LGALS9 galectin 9 NOT|involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr12:44,155,079...44,173,634 JBrowse link
G LY96 lymphocyte antigen 96 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:61,919,806...61,950,712
Ensembl chr 4:61,926,064...61,950,697 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,793,492...75,903,496 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:58,482,046...58,548,087
Ensembl chr 1:58,481,956...58,548,057 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G NAGLU N-acetyl-alpha-glucosaminidase involved_in IEA Ensembl GO_REF:0000107 Ensembl chr12:20,271,351...20,279,777 JBrowse link
G NFKBIA NFKB inhibitor alpha involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:18261938) TreeGrafter
GO_Central
MGI		 PMID:18261938 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277 		JBrowse link
G NMI N-myc and STAT interactor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:941,379...966,519
Ensembl chr15:941,475...967,321 		JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:38,851,083...38,867,427
Ensembl chr14:38,851,918...38,859,409 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:108,038,396...108,303,942
Ensembl chr14:108,039,431...108,303,929 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894098) Ensembl
MGI		 PMID:11894098 GO_REF:0000107 NCBI chr 4:47,026,558...47,075,133
Ensembl chr 4:47,027,098...47,074,704 		JBrowse link
G S100A14 S100 calcium binding protein A14 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:96,027,746...96,029,878
Ensembl chr 4:96,027,639...96,029,869 		JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:51,772,635...51,794,107
Ensembl chr12:51,773,448...51,794,104 		JBrowse link
G TBK1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:28,880,210...28,929,964
Ensembl chr 5:28,880,205...28,929,963 		JBrowse link
G TICAM1 TIR domain containing adaptor molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:74,004,566...74,021,100
Ensembl chr 2:74,004,308...74,021,873 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:28630139) UniProt PMID:28630139 NCBI chr 2:119,758,622...119,778,650 JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:53,374,559...53,394,172
Ensembl chr 9:53,375,644...53,394,165 		JBrowse link
G TLR4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:25549946) Ensembl
MGI
TreeGrafter
GO_Central		 PMID:25549946 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TMEM126A transmembrane protein 126A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25549946) Ensembl
MGI		 PMID:25549946 GO_REF:0000107 NCBI chr 9:19,576,241...19,585,869
Ensembl chr 9:19,576,295...19,585,277 		JBrowse link
G TNIP3 TNFAIP3 interacting protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:102,892,427...102,990,902
Ensembl chr 8:102,892,366...102,991,848 		JBrowse link
G TRAF3 TNF receptor associated factor 3 involved_in IEA Ensembl GO_REF:0000107
G TRAF6 TNF receptor associated factor 6 involved_in ISO (PMID:25371197) UniProt PMID:25371197 NCBI chr 2:24,602,749...24,628,263
Ensembl chr 2:24,602,804...24,626,072 		JBrowse link
G TRIL TLR4 interactor with leucine rich repeats involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr18:43,725,910...43,833,993 JBrowse link
toll-like receptor 5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TIRAP TIR domain containing adaptor protein NOT|involved_in ISO (MGI:3531416|PMID:12447442) BHF-UCL PMID:12447442 MGI:3531416 NCBI chr 9:53,374,559...53,394,172
Ensembl chr 9:53,375,644...53,394,165 		JBrowse link
G TLR5 toll like receptor 5 involved_in ISO (PMID:17128265) BHF-UCL PMID:17128265 NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024 		JBrowse link
TRAM-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCE protein kinase C epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:94,351,277...94,864,549
Ensembl chr 3:94,349,889...94,866,306 		JBrowse link
G RAB11FIP2 RAB11 family interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:128,068,085...128,110,949
Ensembl chr14:128,068,959...128,110,512 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:19412184)
(PMID:22685567)		 UniProt PMID:19412184 PMID:22685567 NCBI chr 2:119,758,622...119,778,650 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17805
    immune system process 2496
      activation of immune response 520
        immune response-activating signaling pathway 455
          innate immune response-activating signaling pathway 266
            innate immune response activating cell surface receptor signaling pathway 86
              cell surface pattern recognition receptor signaling pathway + 75
              stimulatory C-type lectin receptor signaling pathway 12
              stimulatory killer cell immunoglobulin-like receptor signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 17805
    response to stimulus 10056
      response to biotic stimulus 1716
        response to external biotic stimulus 1673
          response to other organism 1669
            defense response to other organism 1151
              defense response to symbiont 1034
                innate immune response 837
                  regulation of innate immune response 425
                    positive regulation of innate immune response 351
                      activation of innate immune response 287
                        innate immune response-activating signaling pathway 266
                          innate immune response activating cell surface receptor signaling pathway 86
                            cell surface pattern recognition receptor signaling pathway + 75
                            stimulatory C-type lectin receptor signaling pathway 12
                            stimulatory killer cell immunoglobulin-like receptor signaling pathway 1
paths to the root