MYD88 (MYD88 innate immune signal transduction adaptor) - Rat Genome Database

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Pathways
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Gene: MYD88 (MYD88 innate immune signal transduction adaptor) Sus scrofa
Analyze
Symbol: MYD88
Name: MYD88 innate immune signal transduction adaptor
RGD ID: 13994040
Description: ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); signaling receptor binding (ortholog); Toll binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); cellular response to lipopolysaccharide (ortholog); cytokine-mediated signaling pathway (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; ASSOCIATED WITH anemia (ortholog); anogenital venereal wart (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extrinsic component of cytoplasmic side of plasma membrane (ortholog); INTERACTS WITH 3-methyladenine; bisphenol A; cadmium nitrate
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,966,137 - 22,983,109 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11322,976,951 - 22,979,568 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,181,100 - 25,183,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
anemia  (ISO)
anogenital venereal wart  (ISO)
asthma  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Bacterial Keratitis  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Brugada syndrome  (ISO)
Cachexia  (ISO)
Carcinoma, Lewis Lung  (ISO)
central nervous system lymphoma  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic lymphocytic leukemia  (ISO)
Colitis-Associated Neoplasms  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Polyps  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
colorectal cancer  (ISO)
Colorectal Cancer 10  (ISO)
colorectal carcinoma  (ISO)
Coronavirus infectious disease  (ISO)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (ISO)
Eosinophilia  (ISO)
esophageal cancer  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
extrahepatic cholestasis  (ISO)
follicular lymphoma  (ISO)
gastroenteritis  (ISO)
genetic disease  (ISO)
Helicobacter Infections  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
hypertension  (ISO)
Immunodeficiency 68  (ISO)
Inflammation  (ISO)
Intestinal Polyps  (ISO)
Liver Injury  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoma  (ISO)
lymphoplasmacytic lymphoma  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
monoclonal gammopathy of uncertain significance  (ISO)
multiple myeloma  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
non-Hodgkin lymphoma  (ISO)
Paraproteinemias  (ISO)
plasma cell neoplasm  (ISO)
pneumonia  (ISO)
pulmonary eosinophilia  (ISO)
Reperfusion Injury  (ISO)
severe acute respiratory syndrome  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
testicular lymphoma  (ISO)
Visceral Heterotaxy 4, Autosomal  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA stabilization  (IEA)
apoptotic process  (IEA)
cell surface receptor signaling pathway  (IEA,ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (IEA)
cellular response to organic substance  (IEA)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
cytokine-mediated signaling pathway  (ISO)
defense response to bacterium  (IEA)
defense response to Gram-positive bacterium  (IBA,IEA,ISO,ISS)
defense response to protozoan  (ISO)
defense response to virus  (IEA,ISS)
establishment of endothelial intestinal barrier  (IEA,ISO)
gene expression  (IEA,ISO)
immune system process  (IEA)
immunoglobulin mediated immune response  (IEA,ISO)
induced systemic resistance  (IEA,ISO)
inflammatory response  (IEA,ISO)
innate immune response  (IBA,IEA)
interleukin-1-mediated signaling pathway  (IEA)
interleukin-33-mediated signaling pathway  (IEA)
JNK cascade  (IEA,ISO)
leukocyte activation involved in inflammatory response  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
microglia differentiation  (IEA,ISO)
MyD88-dependent toll-like receptor signaling pathway  (IEA,ISO)
neurogenesis  (IEA,ISO)
neutrophil activation involved in immune response  (IEA,ISO)
neutrophil-mediated killing of bacterium  (IEA,ISO)
phagocytosis  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of interleukin-1 beta production  (IEA,ISS)
positive regulation of interleukin-17 production  (IEA)
positive regulation of interleukin-23 production  (IEA)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of lymphocyte proliferation  (IEA,ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISS)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type I interferon production  (IEA)
regulation of cell population proliferation  (IEA,ISO)
regulation of chemokine (C-X-C motif) ligand 1 production  (IEA,ISO)
regulation of chemokine (C-X-C motif) ligand 2 production  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of inflammatory response  (IEA)
regulation of interleukin-6 production  (IEA,ISO)
regulation of neutrophil migration  (IEA,ISO)
regulation of tumor necrosis factor production  (IEA,ISO)
response to amine  (ISO)
response to amino acid  (ISO)
response to ethanol  (ISO)
response to interleukin-1  (IEA)
response to lipopolysaccharide  (IEA,ISO)
response to molecule of fungal origin  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to peptidoglycan  (IEA,ISO)
response to virus  (IEA,ISO)
skin development  (IEA)
Toll signaling pathway  (IBA,IEA,ISO)
toll-like receptor 4 signaling pathway  (IBA,IEA)
toll-like receptor 8 signaling pathway  (IEA,ISS)
type I interferon-mediated signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:15183000   PMID:17330086   PMID:17976317   PMID:22301074   PMID:25380861   PMID:26581603   PMID:30032202  


Genomics

Comparative Map Data
MYD88
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,966,137 - 22,983,109 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11322,976,951 - 22,979,568 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,181,100 - 25,183,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYD88
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,138,661 - 38,143,022 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,138,552 - 38,143,024 (+)EnsemblGRCh38hg38GRCh38
GRCh37338,180,152 - 38,184,513 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,155,009 - 38,159,517 (+)NCBINCBI36Build 36hg18NCBI36
Build 34338,155,156 - 38,159,514NCBI
Celera338,115,770 - 38,120,314 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,220,931 - 38,225,475 (+)NCBIHuRef
CHM1_1338,131,949 - 38,136,493 (+)NCBICHM1_1
T2T-CHM13v2.0338,144,330 - 38,148,691 (+)NCBIT2T-CHM13v2.0
Myd88
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,165,000 - 119,169,084 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,165,000 - 119,170,477 (-)EnsemblGRCm39 Ensembl
GRCm389119,335,934 - 119,340,018 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,335,934 - 119,341,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,245,106 - 119,249,158 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,184,686 - 119,188,738 (-)NCBIMGSCv36mm8
Celera9119,805,118 - 119,809,170 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
Myd88
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,952,161 - 127,956,230 (-)NCBIGRCr8
mRatBN7.28119,074,439 - 119,078,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,074,437 - 119,079,415 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,656,479 - 124,660,550 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,855,496 - 122,859,567 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,689,025 - 120,693,095 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,022,512 - 128,027,462 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,022,473 - 128,026,841 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,229,273 - 127,234,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,299,729 - 124,303,798 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,319,465 - 124,323,535 (-)NCBI
Celera8118,225,640 - 118,229,709 (-)NCBICelera
Cytogenetic Map8q32NCBI
Myd88
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,553,589 - 25,559,138 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542725,553,589 - 25,557,654 (+)NCBIChiLan1.0ChiLan1.0
MYD88
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,091,180 - 38,096,494 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,096,783 - 38,101,258 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,036,565 - 38,041,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,319,024 - 38,323,572 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,319,024 - 38,323,572 (+)Ensemblpanpan1.1panPan2
MYD88
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,901,578 - 7,905,274 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,901,250 - 7,904,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha237,943,535 - 7,947,227 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,191,155 - 8,194,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,191,134 - 8,194,847 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,005,061 - 8,008,753 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,146,176 - 8,149,868 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,138,449 - 8,142,140 (+)NCBIUU_Cfam_GSD_1.0
Myd88
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,532,893 - 194,537,794 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647327,671,797 - 27,676,372 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647327,672,237 - 27,676,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYD88
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,276,804 - 1,281,811 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl151,276,798 - 1,281,166 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606310,006,548 - 10,011,071 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myd88
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247312,677,290 - 2,681,489 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247312,677,259 - 2,681,408 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MYD88
21 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1 2
Low 8 4 3 4 2 22 2 3 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000012318   ⟹   ENSSSCP00000011996
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1322,966,137 - 22,981,205 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000069576   ⟹   ENSSSCP00000059999
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1322,976,958 - 22,983,109 (+)Ensembl
RefSeq Acc Id: NM_001099923   ⟹   NP_001093393
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11322,976,951 - 22,979,568 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001093393   ⟸   NM_001099923
- UniProtKB: C6ZCT2 (UniProtKB/Swiss-Prot),   B1B361 (UniProtKB/Swiss-Prot),   A8I488 (UniProtKB/Swiss-Prot),   A7UL70 (UniProtKB/Swiss-Prot),   A2TF48 (UniProtKB/Swiss-Prot),   A0A4P8ET58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000011996   ⟸   ENSSSCT00000012318
RefSeq Acc Id: ENSSSCP00000059999   ⟸   ENSSSCT00000069576
Protein Domains
Death   TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011251 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012318 ENTREZGENE
  ENSSSCT00000012318.6 UniProtKB/TrEMBL
  ENSSSCT00000069576.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MyD88_Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myelin_different_resp_MyD88 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396646 UniProtKB/Swiss-Prot
NCBI Gene MYD88 ENTREZGENE
PANTHER MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15079 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF MyD88 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAK4_PIG UniProtKB/TrEMBL
  A0A4P8ET58 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2Q7F0_PIG UniProtKB/TrEMBL
  A2TF48 ENTREZGENE
  A7UL70 ENTREZGENE
  A8I488 ENTREZGENE
  B1B361 ENTREZGENE
  C6ZCT2 ENTREZGENE
  MYD88_PIG UniProtKB/Swiss-Prot
  Q6T5D4_PIG UniProtKB/TrEMBL
UniProt Secondary A7UL70 UniProtKB/Swiss-Prot
  A8I488 UniProtKB/Swiss-Prot
  B1B361 UniProtKB/Swiss-Prot
  C6ZCT2 UniProtKB/Swiss-Prot
VGNC ID VGNC:109468 ENTREZGENE