WDFY1 (WD repeat and FYVE domain containing 1) - Rat Genome Database

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Gene: WDFY1 (WD repeat and FYVE domain containing 1) Sus scrofa
Analyze
Symbol: WDFY1
Name: WD repeat and FYVE domain containing 1
RGD ID: 14251402
Description: ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); metal ion binding (inferred); INVOLVED IN positive regulation of toll-like receptor 3 signaling pathway (inferred); positive regulation of toll-like receptor 4 signaling pathway (inferred); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN cell junction (inferred); cytosol (inferred); early endosome (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: WD repeat and FYVE domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15125,669,842 - 125,720,158 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115125,674,142 - 125,720,187 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,069,876 - 139,081,534 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
WDFY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15125,669,842 - 125,720,158 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115125,674,142 - 125,720,187 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,069,876 - 139,081,534 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDFY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,875,348 - 223,945,335 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,855,716 - 223,945,357 (-)EnsemblGRCh38hg38GRCh38
GRCh372224,740,065 - 224,810,052 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,448,309 - 224,518,296 (-)NCBINCBI36Build 36hg18NCBI36
Build 342224,565,569 - 224,635,557NCBI
Celera2218,505,977 - 218,575,969 (-)NCBICelera
Cytogenetic Map2q36.1NCBI
HuRef2216,592,701 - 216,661,805 (-)NCBIHuRef
CHM1_12224,746,548 - 224,816,548 (-)NCBICHM1_1
T2T-CHM13v2.02224,358,556 - 224,428,591 (-)NCBIT2T-CHM13v2.0
Wdfy1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39179,679,979 - 79,753,764 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl179,679,979 - 79,753,860 (-)EnsemblGRCm39 Ensembl
GRCm38179,702,262 - 79,776,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl179,702,262 - 79,776,143 (-)EnsemblGRCm38mm10GRCm38
MGSCv37179,698,837 - 79,758,344 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36179,605,440 - 79,640,756 (-)NCBIMGSCv36mm8
Celera179,790,257 - 79,790,462 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map140.94NCBI
Wdfy1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8988,459,613 - 88,541,215 (-)NCBIGRCr8
mRatBN7.2981,034,852 - 81,092,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,034,849 - 81,092,775 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx989,464,594 - 89,522,539 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0994,593,490 - 94,651,433 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0992,976,004 - 93,033,955 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0985,477,070 - 85,528,885 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,475,841 - 85,528,869 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0985,228,597 - 85,280,673 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4979,010,150 - 79,059,470 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1979,193,571 - 79,242,889 (-)NCBI
Celera978,532,988 - 78,582,544 (-)NCBICelera
Cytogenetic Map9q34NCBI
Wdfy1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545310,101,576 - 10,149,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545310,101,576 - 10,148,205 (+)NCBIChiLan1.0ChiLan1.0
WDFY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213126,466,931 - 126,564,889 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B126,509,926 - 126,579,858 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B111,121,073 - 111,190,968 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B229,697,353 - 229,767,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B229,697,353 - 229,767,308 (-)Ensemblpanpan1.1panPan2
WDFY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13729,544,956 - 29,658,544 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3729,444,082 - 29,677,312 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3730,395,512 - 30,511,040 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03729,584,614 - 29,700,361 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3729,570,379 - 29,700,372 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13729,565,490 - 29,610,275 (-)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.13729,494,822 - 29,546,540 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03729,429,613 - 29,546,246 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03729,439,312 - 29,557,601 (-)NCBIUU_Cfam_GSD_1.0
LOC101955400
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,147,492 - 179,262,826 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365695,575,961 - 5,604,970 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049365695,490,319 - 5,544,250 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365695,574,591 - 5,604,948 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDFY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110109,815,043 - 109,889,120 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10109,818,422 - 109,889,023 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604089,515,457 - 89,583,083 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdfy1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248231,353,621 - 1,401,160 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248231,353,601 - 1,405,762 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WDFY1
2207 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 1 17 2 3 3
Low 2 1 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000029006   ⟹   ENSSSCP00000021461
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15125,669,842 - 125,720,158 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000061593   ⟹   ENSSSCP00000048604
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15125,669,842 - 125,720,158 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000073242   ⟹   ENSSSCP00000062714
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15125,669,842 - 125,720,158 (-)Ensembl
RefSeq Acc Id: NM_001243647   ⟹   NP_001230576
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115125,674,142 - 125,720,187 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001230576   ⟸   NM_001243647
- UniProtKB: I3LBP0 (UniProtKB/TrEMBL),   A0A4X1UAW7 (UniProtKB/TrEMBL),   A0A287AXD6 (UniProtKB/TrEMBL),   A0A8D0XYP0 (UniProtKB/TrEMBL),   A0A8D1FW73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000021461   ⟸   ENSSSCT00000029006
RefSeq Acc Id: ENSSSCP00000048604   ⟸   ENSSSCT00000061593
RefSeq Acc Id: ENSSSCP00000062714   ⟸   ENSSSCT00000073242
Protein Domains
FYVE-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000025174 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015011726 UniProtKB/TrEMBL
  ENSSSCG00025033480 UniProtKB/TrEMBL
  ENSSSCG00030065799 UniProtKB/TrEMBL
  ENSSSCG00035072746 UniProtKB/TrEMBL
  ENSSSCG00040069811 UniProtKB/TrEMBL
  ENSSSCG00045004123 UniProtKB/TrEMBL
  ENSSSCG00050006445 UniProtKB/TrEMBL
  ENSSSCG00055022382 UniProtKB/TrEMBL
  ENSSSCG00060019449 UniProtKB/TrEMBL
  ENSSSCG00070015332 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000029006.4 UniProtKB/TrEMBL
  ENSSSCT00000061593 ENTREZGENE
  ENSSSCT00000061593.3 UniProtKB/TrEMBL
  ENSSSCT00000073242.2 UniProtKB/TrEMBL
  ENSSSCT00015015428.1 UniProtKB/TrEMBL
  ENSSSCT00015015451.1 UniProtKB/TrEMBL
  ENSSSCT00015015498.1 UniProtKB/TrEMBL
  ENSSSCT00025045573.1 UniProtKB/TrEMBL
  ENSSSCT00025045654.1 UniProtKB/TrEMBL
  ENSSSCT00030091939.1 UniProtKB/TrEMBL
  ENSSSCT00030091956.1 UniProtKB/TrEMBL
  ENSSSCT00035098479.1 UniProtKB/TrEMBL
  ENSSSCT00035098483.1 UniProtKB/TrEMBL
  ENSSSCT00035098493.1 UniProtKB/TrEMBL
  ENSSSCT00040095699.1 UniProtKB/TrEMBL
  ENSSSCT00040095828.1 UniProtKB/TrEMBL
  ENSSSCT00045006870.1 UniProtKB/TrEMBL
  ENSSSCT00045006873.1 UniProtKB/TrEMBL
  ENSSSCT00045006876.1 UniProtKB/TrEMBL
  ENSSSCT00050008821.1 UniProtKB/TrEMBL
  ENSSSCT00050008842.1 UniProtKB/TrEMBL
  ENSSSCT00055043968.1 UniProtKB/TrEMBL
  ENSSSCT00055044078.1 UniProtKB/TrEMBL
  ENSSSCT00060026219.1 UniProtKB/TrEMBL
  ENSSSCT00060026223.1 UniProtKB/TrEMBL
  ENSSSCT00060026232.1 UniProtKB/TrEMBL
  ENSSSCT00070030136.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  WDFY1/WDFY2 UniProtKB/TrEMBL
  WDFY1_FYVE UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report ssc:100157180 UniProtKB/TrEMBL
NCBI Gene WDFY1 ENTREZGENE
PANTHER PTHR46189 UniProtKB/TrEMBL
  WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam FYVE UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/TrEMBL
SMART FYVE UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt A0A287AXD6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UAW7 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QEU3_PIG UniProtKB/TrEMBL
  A0A8D0MPC3_PIG UniProtKB/TrEMBL
  A0A8D0XYP0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1FW73 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1GJU4_PIG UniProtKB/TrEMBL
  I3LBP0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:99733 ENTREZGENE