APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) - Rat Genome Database

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Gene: APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Sus scrofa
Analyze
Symbol: APPL2
Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
RGD ID: 14072001
Description: ENCODES a protein that exhibits identical protein binding (inferred); phosphatidylinositol binding (inferred); phosphatidylserine binding (inferred); INVOLVED IN adiponectin-activated signaling pathway (ortholog); cellular response to hepatocyte growth factor stimulus (ortholog); cold acclimation (ortholog); ASSOCIATED WITH genetic disease (ortholog); Prostatic Neoplasms (ortholog); substance-related disorder (ortholog); FOUND IN early phagosome (ortholog); early phagosome membrane (ortholog); macropinosome (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amyloid beta (A4) precursor-like protein 2; DCC-interacting protein 13-beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl579,356,067 - 79,412,235 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1579,356,046 - 79,412,235 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2582,650,763 - 82,706,934 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q2.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17901702   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
APPL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl579,356,067 - 79,412,235 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1579,356,046 - 79,412,235 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2582,650,763 - 82,706,934 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q2.3NCBI
APPL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812105,173,300 - 105,236,174 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12105,173,297 - 105,236,203 (-)EnsemblGRCh38hg38GRCh38
GRCh3712105,567,078 - 105,629,952 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612104,091,205 - 104,154,138 (-)NCBINCBI36Build 36hg18NCBI36
Celera12105,231,366 - 105,294,273 (-)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12102,626,453 - 102,689,404 (-)NCBIHuRef
CHM1_112105,532,775 - 105,595,738 (-)NCBICHM1_1
T2T-CHM13v2.012105,135,121 - 105,197,990 (-)NCBIT2T-CHM13v2.0
Appl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391083,435,897 - 83,484,741 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1083,435,897 - 83,484,602 (-)EnsemblGRCm39 Ensembl
GRCm381083,600,033 - 83,648,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1083,600,033 - 83,648,738 (-)EnsemblGRCm38mm10GRCm38
MGSCv371083,062,778 - 83,111,409 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361083,029,832 - 83,078,463 (-)NCBIMGSCv36mm8
Celera1085,587,519 - 85,636,067 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.29NCBI
Appl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,019,480 - 22,072,386 (+)NCBIGRCr8
mRatBN7.2720,135,248 - 20,184,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl720,135,375 - 20,184,754 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx722,105,205 - 22,156,954 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,267,960 - 24,319,709 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,044,969 - 24,096,718 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0726,256,179 - 26,306,128 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl726,256,459 - 26,306,126 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0726,387,115 - 26,436,564 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4722,279,273 - 22,328,427 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera717,339,053 - 17,386,872 (+)NCBICelera
Cytogenetic Map7q13NCBI
Appl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540539,503,020 - 39,540,335 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540539,503,020 - 39,540,069 (-)NCBIChiLan1.0ChiLan1.0
APPL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210113,243,186 - 113,306,443 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112113,239,582 - 113,302,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012102,755,388 - 102,818,686 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112106,150,955 - 106,214,038 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12106,151,969 - 106,206,879 (-)Ensemblpanpan1.1panPan2
APPL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11033,192,261 - 33,243,034 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1033,191,602 - 33,242,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1033,111,933 - 33,162,406 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01034,033,756 - 34,084,221 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1034,033,772 - 34,084,225 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11033,769,093 - 33,819,698 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01034,053,225 - 34,103,854 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01034,246,325 - 34,297,170 (+)NCBIUU_Cfam_GSD_1.0
Appl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494516,467,066 - 16,530,048 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364929,477,373 - 9,526,692 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364929,477,483 - 9,526,692 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APPL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111100,400,093 - 100,469,234 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11100,400,084 - 100,462,507 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037144,551,093 - 144,614,465 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Appl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247503,789,022 - 3,827,079 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247503,789,015 - 3,827,079 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in APPL2
1620 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 17 2 3 3
Low 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000000915   ⟹   ENSSSCP00000000895
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl579,356,067 - 79,412,235 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000042610   ⟹   ENSSSCP00000052577
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl579,356,189 - 79,412,233 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000069223   ⟹   ENSSSCP00000065718
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl579,363,628 - 79,412,235 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000084295   ⟹   ENSSSCP00000072804
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl579,356,187 - 79,412,233 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000091562   ⟹   ENSSSCP00000068011
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl579,356,164 - 79,386,070 (+)Ensembl
RefSeq Acc Id: NM_001135961   ⟹   NP_001129433
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1579,356,265 - 79,411,241 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013997990   ⟹   XP_013853444
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1579,356,046 - 79,412,235 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013853444   ⟸   XM_013997990
- Peptide Label: isoform X1
- UniProtKB: A0A480MKA2 (UniProtKB/TrEMBL),   A0A8D0PE43 (UniProtKB/TrEMBL),   A0A8D0SPD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001129433   ⟸   NM_001135961
- UniProtKB: B6DZ39 (UniProtKB/TrEMBL),   A0A4X1TB82 (UniProtKB/TrEMBL),   F6Q7B0 (UniProtKB/TrEMBL),   A0A8D0M6P6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000000895   ⟸   ENSSSCT00000000915
RefSeq Acc Id: ENSSSCP00000072804   ⟸   ENSSSCT00000084295
RefSeq Acc Id: ENSSSCP00000065718   ⟸   ENSSSCT00000069223
RefSeq Acc Id: ENSSSCP00000068011   ⟸   ENSSSCT00000091562
RefSeq Acc Id: ENSSSCP00000052577   ⟸   ENSSSCT00000042610
Protein Domains
BAR   PH   PID


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000841 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005044973 UniProtKB/TrEMBL
  ENSSSCG00015054548 UniProtKB/TrEMBL
  ENSSSCG00025056439 UniProtKB/TrEMBL
  ENSSSCG00040071615 UniProtKB/TrEMBL
  ENSSSCG00045011505 UniProtKB/TrEMBL
  ENSSSCG00050045960 UniProtKB/TrEMBL
  ENSSSCG00055020390 UniProtKB/TrEMBL
  ENSSSCG00060041860 UniProtKB/TrEMBL
  ENSSSCG00065036877 UniProtKB/TrEMBL
  ENSSSCG00070007714 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000000915 ENTREZGENE
  ENSSSCT00000000915.5 UniProtKB/TrEMBL
  ENSSSCT00000042610.1 UniProtKB/TrEMBL
  ENSSSCT00000069223.2 UniProtKB/TrEMBL
  ENSSSCT00000084295.1 UniProtKB/TrEMBL
  ENSSSCT00000091562.1 UniProtKB/TrEMBL
  ENSSSCT00005072601.1 UniProtKB/TrEMBL
  ENSSSCT00005072619.1 UniProtKB/TrEMBL
  ENSSSCT00005072645.1 UniProtKB/TrEMBL
  ENSSSCT00005072651.1 UniProtKB/TrEMBL
  ENSSSCT00005072655.1 UniProtKB/TrEMBL
  ENSSSCT00005072667.1 UniProtKB/TrEMBL
  ENSSSCT00015073086.1 UniProtKB/TrEMBL
  ENSSSCT00015073801.1 UniProtKB/TrEMBL
  ENSSSCT00015074010.1 UniProtKB/TrEMBL
  ENSSSCT00025077354.1 UniProtKB/TrEMBL
  ENSSSCT00025077724.1 UniProtKB/TrEMBL
  ENSSSCT00025078432.1 UniProtKB/TrEMBL
  ENSSSCT00040098661.1 UniProtKB/TrEMBL
  ENSSSCT00040098865.1 UniProtKB/TrEMBL
  ENSSSCT00040099326.1 UniProtKB/TrEMBL
  ENSSSCT00045019600.1 UniProtKB/TrEMBL
  ENSSSCT00045019709.1 UniProtKB/TrEMBL
  ENSSSCT00045019758.1 UniProtKB/TrEMBL
  ENSSSCT00050062534.1 UniProtKB/TrEMBL
  ENSSSCT00050062546.1 UniProtKB/TrEMBL
  ENSSSCT00050062560.1 UniProtKB/TrEMBL
  ENSSSCT00055040259.1 UniProtKB/TrEMBL
  ENSSSCT00055040440.1 UniProtKB/TrEMBL
  ENSSSCT00055040575.1 UniProtKB/TrEMBL
  ENSSSCT00060056763.1 UniProtKB/TrEMBL
  ENSSSCT00060056802.1 UniProtKB/TrEMBL
  ENSSSCT00060056814.1 UniProtKB/TrEMBL
  ENSSSCT00065050323.1 UniProtKB/TrEMBL
  ENSSSCT00065050346.1 UniProtKB/TrEMBL
  ENSSSCT00065050348.1 UniProtKB/TrEMBL
  ENSSSCT00070015032.1 UniProtKB/TrEMBL
  ENSSSCT00070015058.1 UniProtKB/TrEMBL
  ENSSSCT00070015079.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  BAR_APPL2 UniProtKB/TrEMBL
  BAR_dom UniProtKB/TrEMBL
  DP13A/B UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_DP13A/B UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
  PTB_APPL UniProtKB/TrEMBL
KEGG Report ssc:100190991 UniProtKB/TrEMBL
NCBI Gene APPL2 ENTREZGENE
PANTHER ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2 UniProtKB/TrEMBL
  DCC-INTERACTING PROTEIN 13-BETA UniProtKB/TrEMBL
Pfam BAR_3 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF103657 UniProtKB/TrEMBL
UniProt A0A480MKA2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TAL7_PIG UniProtKB/TrEMBL
  A0A4X1TB82 ENTREZGENE
  A0A4X1TCN1_PIG UniProtKB/TrEMBL
  A0A5G2R903_PIG UniProtKB/TrEMBL
  A0A8D0M5V1_PIG UniProtKB/TrEMBL
  A0A8D0M6P6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0PE43 ENTREZGENE
  A0A8D0SPD5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1B4U8_PIG UniProtKB/TrEMBL
  A0A8D1VFP5_PIG UniProtKB/TrEMBL
  A0A8D2BJP7_PIG UniProtKB/TrEMBL
  B6DZ39 ENTREZGENE, UniProtKB/TrEMBL
  F6Q7B0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287B924 UniProtKB/TrEMBL
  A0A4X1TB82 UniProtKB/TrEMBL
  A0A5G2QM86 UniProtKB/TrEMBL
  A0A5G2QSV3 UniProtKB/TrEMBL
  A0A8D0PE43 UniProtKB/TrEMBL
VGNC ID VGNC:85427 ENTREZGENE