TYROBP (transmembrane immune signaling adaptor TYROBP) - Rat Genome Database

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Gene: TYROBP (transmembrane immune signaling adaptor TYROBP) Sus scrofa
Analyze
Symbol: TYROBP
Name: transmembrane immune signaling adaptor TYROBP
RGD ID: 14184002
Description: ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); apoptotic cell clearance (ortholog); forebrain development (ortholog); ASSOCIATED WITH Brugada syndrome 5 (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); INTERACTS WITH dibromine; Estradiol 17beta-cyclopentylpropionate
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DAP12; DNAX-activation protein 12; immunoreceptor DAP12; TYRO protein tyrosine kinase-binding protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,309,201 - 45,312,539 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,309,199 - 45,312,562 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,711,873 - 40,716,395 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
apoptotic cell clearance  (ISS)
forebrain development  (ISO)
immune system process  (IEA)
integrin-mediated signaling pathway  (ISO)
macrophage activation involved in immune response  (ISO)
microglial cell activation involved in immune response  (IBA,IEA)
myeloid leukocyte activation  (IEA)
negative regulation of B cell proliferation  (IBA,IEA)
negative regulation of interleukin-10 production  (ISO)
negative regulation of long-term synaptic potentiation  (ISO)
negative regulation of transforming growth factor beta1 production  (IBA,IEA)
negative regulation of type I interferon production  (IEA)
neutrophil activation involved in immune response  (IBA,IEA)
osteoclast differentiation  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of macrophage fusion  (IBA,IEA)
positive regulation of microglial cell mediated cytotoxicity  (IBA,IEA)
positive regulation of natural killer cell activation  (IBA,IEA)
positive regulation of osteoclast development  (ISO)
positive regulation of protein localization to cell surface  (IEA)
positive regulation of receptor localization to synapse  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
protein stabilization  (IEA)
regulation of osteoclast development  (ISO)
response to axon injury  (ISO)
stimulatory C-type lectin receptor signaling pathway  (IEA,ISS)
stimulatory killer cell immunoglobulin-like receptor signaling pathway  (IEA,ISS)

Cellular Component
cell surface  (IBA,IEA,ISS)
membrane  (IEA)
plasma membrane  (IEA,ISS)

Molecular Function

References
Additional References at PubMed
PMID:10866110   PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
TYROBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,309,201 - 45,312,539 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,309,199 - 45,312,562 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,711,873 - 40,716,395 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TYROBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,904,403 - 35,908,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,904,401 - 35,908,295 (-)EnsemblGRCh38hg38GRCh38
GRCh371936,395,305 - 36,399,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,087,143 - 41,091,026 (-)NCBINCBI36Build 36hg18NCBI36
Build 341941,087,143 - 41,091,026NCBI
Celera1933,109,494 - 33,113,402 (-)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,900,548 - 32,904,456 (-)NCBIHuRef
CHM1_11936,396,596 - 36,400,504 (-)NCBICHM1_1
T2T-CHM13v2.01938,450,168 - 38,454,060 (-)NCBIT2T-CHM13v2.0
Tyrobp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,113,207 - 30,117,007 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,113,185 - 30,117,010 (+)EnsemblGRCm39 Ensembl
GRCm38730,413,782 - 30,417,582 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,413,760 - 30,417,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv37731,198,807 - 31,202,601 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,122,548 - 30,126,342 (+)NCBIMGSCv36mm8
Celera725,005,487 - 25,009,294 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map717.45NCBI
Tyrobp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,800,372 - 94,804,307 (+)NCBIGRCr8
mRatBN7.2185,672,931 - 85,676,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,672,994 - 85,676,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,088,757 - 91,092,672 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,556,044 - 99,559,908 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,847,020 - 92,850,937 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,875,370 - 88,879,305 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,875,375 - 88,879,303 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,031,123 - 90,034,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,365,371 - 85,369,224 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1185,443,481 - 85,447,330 (+)NCBI
Celera180,045,174 - 80,049,027 (+)NCBICelera
Cytogenetic Map1q21NCBI
Tyrobp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,673,980 - 2,677,321 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554682,673,657 - 2,677,633 (+)NCBIChiLan1.0ChiLan1.0
TYROBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,902,807 - 41,907,241 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,887,571 - 43,891,929 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,821,279 - 32,825,488 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,570,674 - 41,575,226 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,570,683 - 41,575,226 (-)Ensemblpanpan1.1panPan2
TYROBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,757,271 - 116,760,453 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,757,289 - 116,772,325 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,162,854 - 116,166,018 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,360,454 - 117,363,633 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,359,870 - 117,363,633 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,924,025 - 116,927,189 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,547,561 - 116,550,722 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,603,321 - 117,606,485 (+)NCBIUU_Cfam_GSD_1.0
Tyrobp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,185,145 - 11,187,925 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570458,054 - 460,579 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936570457,993 - 460,735 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TYROBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,816,675 - 30,820,816 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,816,678 - 30,820,597 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660738,609,470 - 8,613,375 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tyrobp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,183,515 - 10,187,244 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479410,183,934 - 10,187,180 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TYROBP
100 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High 1
Medium 10 2 1 5 17 3 2
Low 2 2 2 6 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003224   ⟹   ENSSSCP00000003143
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl645,309,201 - 45,312,539 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000070801   ⟹   ENSSSCP00000073909
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl645,309,201 - 45,312,464 (-)Ensembl
RefSeq Acc Id: NM_214202   ⟹   NP_999367
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1645,309,199 - 45,312,486 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005664506   ⟹   XP_005664563
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1645,309,199 - 45,312,562 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005664563   ⟸   XM_005664506
- Peptide Label: isoform X1
- UniProtKB: A0A8D0SP33 (UniProtKB/TrEMBL),   A0A5S6FVY3 (UniProtKB/TrEMBL),   A0A8D1G423 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999367   ⟸   NM_214202
- Peptide Label: precursor
- UniProtKB: Q9TU45 (UniProtKB/Swiss-Prot),   A0A8D1G423 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000073909   ⟸   ENSSSCT00000070801
RefSeq Acc Id: ENSSSCP00000003143   ⟸   ENSSSCT00000003224
Protein Domains
ITAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002919 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00015032766 UniProtKB/TrEMBL
  ENSSSCG00025058890 UniProtKB/TrEMBL
  ENSSSCG00030024634 UniProtKB/TrEMBL
  ENSSSCG00035031439 UniProtKB/TrEMBL
  ENSSSCG00040073862 UniProtKB/TrEMBL
  ENSSSCG00045025638 UniProtKB/TrEMBL
  ENSSSCG00050021849 UniProtKB/TrEMBL
  ENSSSCG00055024525 UniProtKB/TrEMBL
  ENSSSCG00060067425 UniProtKB/TrEMBL
  ENSSSCG00065067355 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00065067610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00065067723 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003224 ENTREZGENE
  ENSSSCT00000003224.4 UniProtKB/TrEMBL
  ENSSSCT00000003224.5 UniProtKB/Swiss-Prot
  ENSSSCT00000070801 ENTREZGENE
  ENSSSCT00000070801.2 UniProtKB/TrEMBL
  ENSSSCT00015043806.1 UniProtKB/TrEMBL
  ENSSSCT00015044036.1 UniProtKB/TrEMBL
  ENSSSCT00025080666.1 UniProtKB/TrEMBL
  ENSSSCT00025080772.1 UniProtKB/TrEMBL
  ENSSSCT00030034353.1 UniProtKB/TrEMBL
  ENSSSCT00030034363.1 UniProtKB/TrEMBL
  ENSSSCT00030034375.1 UniProtKB/TrEMBL
  ENSSSCT00035041616.1 UniProtKB/TrEMBL
  ENSSSCT00035041629.1 UniProtKB/TrEMBL
  ENSSSCT00035041634.1 UniProtKB/TrEMBL
  ENSSSCT00040102053.1 UniProtKB/TrEMBL
  ENSSSCT00040102085.1 UniProtKB/TrEMBL
  ENSSSCT00040102159.1 UniProtKB/TrEMBL
  ENSSSCT00045043797.1 UniProtKB/TrEMBL
  ENSSSCT00045043903.1 UniProtKB/TrEMBL
  ENSSSCT00050029455.1 UniProtKB/TrEMBL
  ENSSSCT00050029483.1 UniProtKB/TrEMBL
  ENSSSCT00055048500.1 UniProtKB/TrEMBL
  ENSSSCT00055048610.1 UniProtKB/TrEMBL
  ENSSSCT00060092010.1 UniProtKB/TrEMBL
  ENSSSCT00060092049.1 UniProtKB/TrEMBL
  ENSSSCT00065092466.1 UniProtKB/TrEMBL
  ENSSSCT00065092489.1 UniProtKB/TrEMBL
  ENSSSCT00065092514.1 UniProtKB/Swiss-Prot
  ENSSSCT00065092817.1 UniProtKB/TrEMBL
  ENSSSCT00065092831.1 UniProtKB/Swiss-Prot
  ENSSSCT00065092964.1 UniProtKB/TrEMBL
Gene3D-CATH YojJ-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Tyrobp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397405 UniProtKB/Swiss-Prot
NCBI Gene TYROBP ENTREZGENE
PANTHER DNAX-ACTIVATION PROTEIN 12 UniProtKB/TrEMBL
  PTHR17554 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRO PROTEIN TYROSINE KINASE-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5G2RMP7_PIG UniProtKB/TrEMBL
  A0A5S6FVY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0NFL9_PIG UniProtKB/TrEMBL
  A0A8D0SP33 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0T298_PIG UniProtKB/TrEMBL
  A0A8D0W3H1_PIG UniProtKB/TrEMBL
  A0A8D0ZKM4_PIG UniProtKB/TrEMBL
  A0A8D1G1N2_PIG UniProtKB/TrEMBL
  A0A8D1G423 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1G4T9_PIG UniProtKB/TrEMBL
  A0A8D1LRP4_PIG UniProtKB/TrEMBL
  A0A8D1UAB7_PIG UniProtKB/TrEMBL
  Q9TU45 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:94619 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-08 TYROBP  transmembrane immune signaling adaptor TYROBP  TYROBP  TYRO protein tyrosine kinase binding protein  Symbol and/or name change 5135510 APPROVED