CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: profenofos
Accession: CHEBI:38845
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Definition: An organophosphate insecticide that has formula C11H15BrClO3PS.
Synonyms: exact_synonym: O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
related_synonym: Curacron; Formula=C11H15BrClO3PS; InChI=1S/C11H15BrClO3PS/c1-3-7-18-17(14,15-4-2)16-11-6-5-9(12)8-10(11)13/h5-6,8H,3-4,7H2,1-2H3; InChIKey=QYMMJNLHFKGANY-UHFFFAOYSA-N; O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl thiophosphate; Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester; SMILES=CCCSP(=O)(OCC)Oc1ccc(Br)cc1Cl
xref: Beilstein:2150258; CAS:41198-08-7; KEGG:C18404
xref_mesh: MESH:C024273
xref: PPDB:538
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Ache
acetylcholinesterase
decreases activity
ISO EXP
profenofos results in decreased activity of ACHE protein profenofos metabolite results in decreased activity of ACHE protein; profenofos results in decreased activity of ACHE protein
CTD
PMID:16978018 PMID:21251949 PMID:30625376 PMID:33651127
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Alb
albumin
affects binding
ISO
profenofos binds to ALB protein
CTD
PMID:28407546
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Arid1a
AT-rich interaction domain 1A
decreases expression
EXP
profenofos results in decreased expression of ARID1A mRNA
CTD
PMID:17569032
NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564
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Bche
butyrylcholinesterase
decreases activity
ISO
profenofos results in decreased activity of BCHE protein
CTD
PMID:9890196
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Casp3
caspase 3
multiple interactions
ISO
[cypermethrin co-treated with Chlorpyrifos co-treated with profenofos] results in increased cleavage of CASP3 protein
CTD
PMID:21987380
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
increases expression
EXP
profenofos results in increased expression of CAT mRNA
CTD
PMID:23495063
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Chrdl1
chordin-like 1
decreases expression
EXP
profenofos results in decreased expression of CHRDL1 mRNA
CTD
PMID:17569032
NCBI chr X:106,889,125...106,992,937
Ensembl chr X:106,889,125...106,992,921
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
increases expression
EXP
profenofos results in increased expression of CYP11A1 mRNA
CTD
PMID:17569032
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
increases expression
EXP
profenofos results in increased expression of CYP17A1 mRNA
CTD
PMID:17569032
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases expression
EXP
profenofos results in decreased expression of CYP19A1 mRNA
CTD
PMID:18828448
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
profenofos results in decreased activity of CYP1A1 protein
CTD
PMID:20183062
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression decreases activity
ISO
profenofos results in increased expression of CYP1A2 mRNA profenofos results in decreased activity of CYP1A2 protein
CTD
PMID:20183062 PMID:22310298
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression decreases activity multiple interactions increases metabolic processing
ISO
profenofos results in increased expression of CYP2B6 mRNA profenofos results in decreased activity of CYP2B6 protein [CYP2B6 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol
CTD
PMID:22310298 PMID:23415833
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases expression
EXP
profenofos results in decreased expression of CYP2C11 mRNA; profenofos results in decreased expression of CYP2C11 protein
CTD
PMID:18828448
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases metabolic processing multiple interactions
ISO
CYP2C19 protein results in increased metabolism of profenofos [CYP2C19 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol
CTD
PMID:23415833
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions decreases activity
ISO
profenofos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone] profenofos results in decreased activity of CYP2E1 protein
CTD
PMID:22634058
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases expression increases expression increases metabolic processing increases activity multiple interactions
EXP ISO
profenofos results in decreased expression of CYP3A2 mRNA; profenofos results in decreased expression of CYP3A2 protein profenofos results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased metabolism of profenofos profenofos results in increased activity of CYP3A4 protein [CYP3A4 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol
CTD
PMID:18828448 PMID:22310298 PMID:23415833
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Faah
fatty acid amide hydrolase
decreases activity
ISO
profenofos results in decreased activity of FAAH protein
CTD
PMID:11350214
NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
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Gch1
GTP cyclohydrolase 1
decreases expression
EXP
profenofos results in decreased expression of GCH1 mRNA
CTD
PMID:17569032
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
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Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
decreases expression
EXP
profenofos results in decreased expression of GRIN2A mRNA
CTD
PMID:17569032
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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Hao2
hydroxyacid oxidase 2
increases expression
EXP
profenofos results in increased expression of HAO2 mRNA
CTD
PMID:17569032
NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
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Hp
haptoglobin
increases expression
EXP
profenofos results in increased expression of HP mRNA
CTD
PMID:17569032
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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Lamc1
laminin subunit gamma 1
decreases expression
EXP
profenofos results in decreased expression of LAMC1 mRNA
CTD
PMID:17569032
NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492
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Mcam
melanoma cell adhesion molecule
decreases expression
EXP
profenofos results in decreased expression of MCAM mRNA
CTD
PMID:17569032
NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571
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Ms4a6a
membrane spanning 4-domains A6A
increases expression
EXP
profenofos results in increased expression of MS4A6A mRNA
CTD
PMID:17569032
NCBI chr 1:208,401,465...208,414,831
Ensembl chr 1:208,401,466...208,414,758
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Myo1d
myosin ID
decreases expression
EXP
profenofos results in decreased expression of MYO1D mRNA
CTD
PMID:17569032
NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,489,154...65,766,349
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Nceh1
neutral cholesterol ester hydrolase 1
decreases activity
ISO
profenofos results in decreased activity of NCEH1 protein
CTD
PMID:16978018
NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
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Nell1
neural EGFL like 1
decreases expression
EXP
profenofos results in decreased expression of NELL1 mRNA
CTD
PMID:17569032
NCBI chr 1:99,709,305...100,573,872
Ensembl chr 1:99,709,793...100,573,860
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases expression
ISO
profenofos results in increased expression of NR1I3 mRNA
CTD
PMID:22310298
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nrbf2
nuclear receptor binding factor 2
decreases expression
EXP
profenofos results in decreased expression of NRBF2 mRNA
CTD
PMID:17569032
NCBI chr20:21,308,555...21,326,881
Ensembl chr20:21,308,576...21,326,818
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Pdzrn3
PDZ domain containing RING finger 3
increases expression
EXP
profenofos results in increased expression of PDZRN3 mRNA
CTD
PMID:17569032
NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959
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Rgs2
regulator of G-protein signaling 2
increases expression
EXP
profenofos results in increased expression of RGS2 mRNA
CTD
PMID:17569032
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Rwdd2b
RWD domain containing 2B
increases expression
EXP
profenofos results in increased expression of RWDD2B mRNA
CTD
PMID:17569032
NCBI chr11:26,665,877...26,677,986
Ensembl chr11:26,665,877...26,674,603
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Slc1a1
solute carrier family 1 member 1
decreases expression
EXP
profenofos results in decreased expression of SLC1A1 mRNA
CTD
PMID:17569032
NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
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Sod1
superoxide dismutase 1
increases expression
EXP
profenofos results in increased expression of SOD1 mRNA
CTD
PMID:23495063
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Star
steroidogenic acute regulatory protein
increases expression
EXP
profenofos results in increased expression of STAR mRNA
CTD
PMID:17569032
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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