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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-bromo-2-chlorophenol
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Accession:CHEBI:38852 term browser browse the term
Definition:A halophenol that is phenol in which the hydrogens at positions 2 and 4 have been replaced by chlorine and bromine, respectively.
Synonyms:related_synonym: 2-Chloro-4-bromophenol;   Formula=C6H4BrClO;   InChI=1S/C6H4BrClO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H;   InChIKey=VIBJPUXLAKVICD-UHFFFAOYSA-N;   SMILES=Oc1ccc(Br)cc1Cl
 xref: Beilstein:2042867;   CAS:3964-56-5
 xref_mesh: MESH:C075205


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4-bromo-2-chlorophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP2B6 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol CTD PMID:23415833 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [CYP2C19 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol CTD PMID:23415833 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol CTD PMID:23415833 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
profenofos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP		 profenofos results in decreased activity of ACHE protein
profenofos metabolite results in decreased activity of ACHE protein; profenofos results in decreased activity of ACHE protein		 CTD PMID:16978018 PMID:21251949 PMID:30625376 PMID:33651127 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Alb albumin affects binding ISO profenofos binds to ALB protein CTD PMID:28407546 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Arid1a AT-rich interaction domain 1A decreases expression EXP profenofos results in decreased expression of ARID1A mRNA CTD PMID:17569032 NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO profenofos results in decreased activity of BCHE protein CTD PMID:9890196 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [cypermethrin co-treated with Chlorpyrifos co-treated with profenofos] results in increased cleavage of CASP3 protein CTD PMID:21987380 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases expression EXP profenofos results in increased expression of CAT mRNA CTD PMID:23495063 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Chrdl1 chordin-like 1 decreases expression EXP profenofos results in decreased expression of CHRDL1 mRNA CTD PMID:17569032 NCBI chr  X:106,889,125...106,992,937
Ensembl chr  X:106,889,125...106,992,921 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP profenofos results in increased expression of CYP11A1 mRNA CTD PMID:17569032 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression EXP profenofos results in increased expression of CYP17A1 mRNA CTD PMID:17569032 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression EXP profenofos results in decreased expression of CYP19A1 mRNA CTD PMID:18828448 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO profenofos results in decreased activity of CYP1A1 protein CTD PMID:20183062 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity		 ISO profenofos results in increased expression of CYP1A2 mRNA
profenofos results in decreased activity of CYP1A2 protein		 CTD PMID:20183062 PMID:22310298 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
increases metabolic processing
multiple interactions
decreases activity		 ISO profenofos results in increased expression of CYP2B6 mRNA
CYP2B6 protein results in increased metabolism of profenofos
[CYP2B6 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol
profenofos results in decreased activity of CYP2B6 protein		 CTD PMID:22310298 PMID:23415833 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP profenofos results in decreased expression of CYP2C11 mRNA; profenofos results in decreased expression of CYP2C11 protein CTD PMID:18828448 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing
multiple interactions		 ISO CYP2C19 protein results in increased metabolism of profenofos
[CYP2C19 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol		 CTD PMID:23415833 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity		 ISO profenofos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
profenofos results in decreased activity of CYP2E1 protein		 CTD PMID:22634058 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
multiple interactions
increases activity
increases metabolic processing
increases expression		 EXP
ISO		 profenofos results in decreased expression of CYP3A2 mRNA; profenofos results in decreased expression of CYP3A2 protein
[CYP3A4 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol
profenofos results in increased activity of CYP3A4 protein
profenofos results in increased expression of CYP3A4 mRNA		 CTD PMID:18828448 PMID:22310298 PMID:23415833 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO profenofos results in decreased activity of FAAH protein CTD PMID:11350214 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677 		JBrowse link
G Gch1 GTP cyclohydrolase 1 decreases expression EXP profenofos results in decreased expression of GCH1 mRNA CTD PMID:17569032 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression EXP profenofos results in decreased expression of GRIN2A mRNA CTD PMID:17569032 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Hao2 hydroxyacid oxidase 2 increases expression EXP profenofos results in increased expression of HAO2 mRNA CTD PMID:17569032 NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425 		JBrowse link
G Hp haptoglobin increases expression EXP profenofos results in increased expression of HP mRNA CTD PMID:17569032 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Lamc1 laminin subunit gamma 1 decreases expression EXP profenofos results in decreased expression of LAMC1 mRNA CTD PMID:17569032 NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492 		JBrowse link
G Mcam melanoma cell adhesion molecule decreases expression EXP profenofos results in decreased expression of MCAM mRNA CTD PMID:17569032 NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571 		JBrowse link
G Ms4a6a membrane spanning 4-domains A6A increases expression EXP profenofos results in increased expression of MS4A6A mRNA CTD PMID:17569032 NCBI chr 1:208,401,465...208,414,831
Ensembl chr 1:208,401,466...208,414,758 		JBrowse link
G Myo1d myosin ID decreases expression EXP profenofos results in decreased expression of MYO1D mRNA CTD PMID:17569032 NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,489,154...65,766,349 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO profenofos results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588 		JBrowse link
G Nell1 neural EGFL like 1 decreases expression EXP profenofos results in decreased expression of NELL1 mRNA CTD PMID:17569032 NCBI chr 1:99,709,305...100,573,872
Ensembl chr 1:99,709,793...100,573,860 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO profenofos results in increased expression of NR1I3 mRNA CTD PMID:22310298 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nrbf2 nuclear receptor binding factor 2 decreases expression EXP profenofos results in decreased expression of NRBF2 mRNA CTD PMID:17569032 NCBI chr20:21,308,555...21,326,881
Ensembl chr20:21,308,576...21,326,818 		JBrowse link
G Pdzrn3 PDZ domain containing RING finger 3 increases expression EXP profenofos results in increased expression of PDZRN3 mRNA CTD PMID:17569032 NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression EXP profenofos results in increased expression of RGS2 mRNA CTD PMID:17569032 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rwdd2b RWD domain containing 2B increases expression EXP profenofos results in increased expression of RWDD2B mRNA CTD PMID:17569032 NCBI chr11:26,665,877...26,677,986
Ensembl chr11:26,665,877...26,674,603 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression EXP profenofos results in decreased expression of SLC1A1 mRNA CTD PMID:17569032 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP profenofos results in increased expression of SOD1 mRNA CTD PMID:23495063 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP profenofos results in increased expression of STAR mRNA CTD PMID:17569032 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      molecular entity 19839
        polyatomic entity 19797
          heteroatomic molecular entity 19754
            halide 18661
              organohalogen compound 18535
                organobromine compound 6580
                  4-bromo-2-chlorophenol 36
                    profenofos 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                carbocyclic compound 18588
                                  benzenoid aromatic compound 18000
                                    benzenes 17862
                                      chlorobenzenes 14839
                                        monochlorobenzenes 11638
                                          4-bromo-2-chlorophenol 36
                                            profenofos 36
paths to the root