CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: benzazepine alkaloid
Accession: CHEBI:38523
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Synonyms: related_synonym: benzazepine alkaloids
G
Ache
acetylcholinesterase
decreases activity multiple interactions
EXP ISO
Galantamine results in decreased activity of ACHE protein Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein] Galantamine binds to and results in decreased activity of ACHE protein; Galantamine inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Galantamine inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Galantamine promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
CTD
PMID:14535624 PMID:18571635 PMID:18573242 PMID:19345205 PMID:25522658 PMID:27238725 PMID:28837785 PMID:29886234 PMID:30905860 PMID:31125207 More...
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Ager
advanced glycosylation end product-specific receptor
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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App
amyloid beta precursor protein
multiple interactions
ISO
Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]
CTD
PMID:25881725
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Bche
butyrylcholinesterase
decreases activity
EXP ISO
Galantamine results in decreased activity of BCHE protein
CTD
PMID:19345205 PMID:29886234 PMID:31125207
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Ces2h
carboxylesterase 2H
decreases activity
ISO
Galantamine results in decreased activity of CES2 protein
CTD
PMID:23123248
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Chrm1
cholinergic receptor, muscarinic 1
decreases expression
EXP
Galantamine results in decreased expression of CHRM1 protein
CTD
PMID:28837785
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
affects binding multiple interactions
ISO
Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein] Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:15733544
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
multiple interactions
ISO
Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]
CTD
PMID:25881725
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
affects binding multiple interactions
ISO
Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein] Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:15733544
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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Hmgb1
high mobility group box 1
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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Icam1
intercellular adhesion molecule 1
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il10
interleukin 10
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Mpo
myeloperoxidase
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Socs3
suppressor of cytokine signaling 3
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Tnf
tumor necrosis factor
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Ahi1
Abelson helper integration site 1
increases expression
ISO
Homoharringtonine results in increased expression of AHI1 protein alternative form
CTD
PMID:19379585
NCBI chr 1:15,762,485...15,891,213
Ensembl chr 1:15,762,462...15,891,041
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of AKT1 protein
CTD
PMID:31726078
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Bad
BCL2-associated agonist of cell death
increases expression
ISO
Homoharringtonine results in increased expression of BAD protein
CTD
PMID:31726078
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Homoharringtonine results in increased expression of BAX protein
CTD
PMID:31726078
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Homoharringtonine results in decreased expression of BCL2 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP3 protein Homoharringtonine results in increased cleavage of CASP3 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
increases cleavage
ISO
Homoharringtonine results in increased cleavage of CASP7 protein
CTD
PMID:31726078
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP9 protein Homoharringtonine results in increased cleavage of CASP9 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Ccna2
cyclin A2
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNA2 protein
CTD
PMID:31726078
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNB1 protein
CTD
PMID:31726078
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccne1
cyclin E1
increases expression
ISO
Homoharringtonine results in increased expression of CCNE1 protein
CTD
PMID:31726078
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Cd34
CD34 molecule
multiple interactions decreases expression
ISO
Arsenic Trioxide promotes the reaction [Homoharringtonine results in decreased expression of CD34 mRNA]
CTD
PMID:31307525
NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832
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Cd38
CD38 molecule
increases expression multiple interactions
ISO
Homoharringtonine results in increased expression of CD38 mRNA [Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of CD38 mRNA
CTD
PMID:31307525
NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
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Cd96
CD96 molecule
multiple interactions
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of CD96 mRNA
CTD
PMID:31307525
NCBI chr11:54,702,290...54,776,618
Ensembl chr11:54,702,290...54,776,621
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Cdk1
cyclin-dependent kinase 1
increases expression
ISO
Homoharringtonine results in increased expression of CDK1 protein
CTD
PMID:31726078
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdk2
cyclin dependent kinase 2
increases expression
ISO
Homoharringtonine results in increased expression of CDK2 protein
CTD
PMID:31726078
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
multiple interactions increases phosphorylation
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein]; crenigacestat inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein]
CTD
PMID:31307525
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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Ephb4
EPH receptor B4
multiple interactions decreases expression
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein]
CTD
PMID:31726078
NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK1 protein
CTD
PMID:31726078
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK3 protein
CTD
PMID:31726078
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression
ISO
Homoharringtonine results in decreased expression of MCL1 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
Homoharringtonine results in decreased expression of MKI67 protein
CTD
PMID:31726078
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MTOR protein
CTD
PMID:31726078
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Nfkb2
nuclear factor kappa B subunit 2
multiple interactions increases expression
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NFKB2 protein]
CTD
PMID:31307525
NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
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Notch1
notch receptor 1
multiple interactions increases expression
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NOTCH1 protein]
CTD
PMID:31307525
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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Notch2
notch receptor 2
multiple interactions
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of NOTCH2 protein
CTD
PMID:31307525
NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
decreases expression
ISO
Homoharringtonine results in decreased expression of PIK3CA protein
CTD
PMID:31726078
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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Pten
phosphatase and tensin homolog
increases expression
ISO
Homoharringtonine results in increased expression of PTEN protein
CTD
PMID:31726078
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases expression
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of RELA protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of RELA protein]
CTD
PMID:31307525
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Relb
RELB proto-oncogene, NF-kB subunit
increases expression multiple interactions
ISO
Homoharringtonine results in increased expression of RELB protein Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of RELB protein]
CTD
PMID:31307525
NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507
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Tp53
tumor protein p53
multiple interactions increases expression
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of TP53 protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of TP53 protein]
CTD
PMID:31307525
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tyr
tyrosinase
increases expression
ISO
Homoharringtonine results in increased expression of TYR mRNA
CTD
PMID:21071833
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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