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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-aminobenzoic acid
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Accession:CHEBI:30753 term browser browse the term
Definition:An aminobenzoic acid in which the amino group is para to the carboxy group.
Synonyms:related_synonym: 1-Amino-4-carboxybenzene;   4-Amino-benzoic acid;   4-Aminobenzoesaeure;   4-Carboxyaniline;   4-Carboxyphenylamine;   ABEE;   Formula=C7H7NO2;   InChI=1S/C7H7NO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H,9,10);   InChIKey=ALYNCZNDIQEVRV-UHFFFAOYSA-N;   PABA;   SMILES=C1(C(O)=O)=CC=C(N)C=C1;   gamma-aminobenzoic acid;   p-Aminobenzoesaeure;   p-aminobenzoic acid;   p-carboxyaniline;   p-carboxyphenylamine;   para-aminobenzoic acid
 alt_id: CHEBI:113372;   CHEBI:1783;   CHEBI:20315;   CHEBI:44778
 xref: Beilstein:471605;   CAS:150-13-0;   DrugBank:DB02362;   Drug_Central:2049;   ECMDB:ECMDB01392;   Gmelin:50150;   HMDB:HMDB0001392;   KEGG:C00568;   KEGG:D02456;   KNApSAcK:C00001401
 xref_mesh: MESH:D010129
 xref: PDBeChem:PAB;   PMID:12039592;   PMID:14745019;   PMID:15115392;   PMID:1527790;   PMID:16290145;   PMID:17149871;   PMID:17743450;   PMID:17800214;   PMID:19469519;   PMID:22767283;   PMID:22994574;   PMID:23063996;   PMID:23084339;   PMID:23144588;   PMID:23471007;   PMID:3599019;   PMID:3820215;   PMID:3950915;   PMID:8411009;   PMID:9406595;   Reaxys:471605;   Wikipedia:4-Aminobenzoic_acid;   YMDB:YMDB00493
 cyclic_relationship: is_conjugate_acid_of CHEBI:17836;   is_conjugate_base_of CHEBI:194473;   is_tautomer_of CHEBI:194474


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4-aminobenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 affects expression ISO 4-Aminobenzoic Acid affects the expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Il2 interleukin 2 increases expression ISO 4-Aminobenzoic Acid results in increased expression of IL2 protein CTD PMID:22381623 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4i1 interleukin 4 induced 1 decreases activity ISO 4-Aminobenzoic Acid results in decreased activity of IL4I1 protein CTD PMID:15383589 NCBI chr 1:95,299,457...95,324,564
Ensembl chr 1:95,295,601...95,324,562 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
increases metabolic processing
affects acetylation
increases acetylation		 ISO Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Pentachlorophenol inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]
NAT1 protein results in increased metabolism of 4-Aminobenzoic Acid
NAT1 protein affects the acetylation of 4-Aminobenzoic Acid		 CTD PMID:11470991 PMID:15627487 PMID:15880531 PMID:16003948 PMID:23958860 More... NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
multiple interactions		 ISO
EXP		 NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid
4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid]		 CTD PMID:15627487 PMID:18842621 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects expression ISO 4-Aminobenzoic Acid affects the expression of NFKB1 mRNA CTD PMID:20385217 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO
EXP		 4-Aminobenzoic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid] CTD PMID:22981274 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Tnf tumor necrosis factor affects expression ISO 4-Aminobenzoic Acid affects the expression of TNF mRNA CTD PMID:20385217 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
butamben term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding EXP butamben binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO butamben promotes the reaction [NR1I2.L protein binds to MED1 protein]; butamben promotes the reaction [NR1I2.S protein binds to MED1 protein] CTD PMID:12198127 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO butamben promotes the reaction [NR1I2.L protein binds to NCOA1 protein]; butamben promotes the reaction [NR1I2.S protein binds to NCOA1 protein] CTD PMID:12198127 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO butamben promotes the reaction [NR1I2.L protein binds to NCOA2 protein] CTD PMID:12198127 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO butamben promotes the reaction [NR1I2.L protein binds to NCOA3 protein] CTD PMID:12198127 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
procaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO Procaine results in increased phosphorylation of AKT1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]		 CTD PMID:32061592 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Procaine results in increased expression of ALPL mRNA CTD PMID:22083529 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion ISO Procaine results in increased secretion of CALCA protein CTD PMID:18172555 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Capn1 calpain 1 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN1 protein] CTD PMID:26998625 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn2 calpain 2 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN2 protein] CTD PMID:26998625 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP12 protein]; Procaine inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 PMID:26998625 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein] CTD PMID:26998625 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdh5 cadherin 5 decreases expression
multiple interactions		 ISO Procaine results in decreased expression of CDH5 protein
HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]		 CTD PMID:32061592 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Procaine CTD PMID:9300133 PMID:15475733 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Procaine results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
affects binding		 ISO [HRH1 protein binds to Procaine] which results in increased import of Calcium; HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]; HRH1 protein affects the reaction [Procaine results in increased transport of fluorescein isothiocyanate bovine serum albumin] CTD PMID:32061592 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [Procaine co-treated with Paraoxon] results in increased expression of HSPA5 protein CTD PMID:26998625 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases phosphorylation
multiple interactions		 ISO Procaine results in increased phosphorylation of ITPR1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]		 CTD PMID:32061592 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Procaine results in increased phosphorylation of MAPK1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:32061592 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Procaine results in increased phosphorylation of MAPK3 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:32061592 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Procaine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation
multiple interactions		 ISO Procaine results in increased phosphorylation of PLCG1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]		 CTD PMID:32061592 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity EXP Procaine results in increased activity of TRPV1 protein CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        aetiopathogenetic role 19166
          allergen 17646
            4-aminobenzoic acid 31
              4-(oxaloamino)benzoic acid 0
              4-acetamidobenzoic acid 0
              ascr#8 0
              butamben + 5
              procaine 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        amino acid 15928
                                          aromatic amino acid 3806
                                            aminobenzoic acid 1641
                                              4-aminobenzoic acid 31
                                                4-(oxaloamino)benzoic acid 0
                                                4-acetamidobenzoic acid 0
                                                ascr#8 0
                                                butamben + 5
                                                procaine 18
paths to the root