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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glyoxylic acid
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Accession:CHEBI:16891 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom.
Synonyms:exact_synonym: oxoacetic acid
 related_synonym: Formula=C2H2O3;   Glyoxalate;   Glyoxalsaeure;   Glyoxylate;   Glyoxylsaeure;   InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5);   InChIKey=HHLFWLYXYJOTON-UHFFFAOYSA-N;   SMILES=[H]C(=O)C(O)=O;   alpha-ketoacetic acid;   formylformic acid;   oxalaldehydic acid;   oxoethanoic acid
 alt_id: CHEBI:24421;   CHEBI:42767;   CHEBI:5509
 xref: Beilstein:741891;   CAS:298-12-4;   DrugBank:DB04343;   Gmelin:25752;   HMDB:HMDB0000119;   KEGG:C00048;   KNApSAcK:C00001186
 xref_mesh: MESH:C031150
 xref: MetaCyc:GLYOX;   PDBeChem:GLV;   PMID:11479160;   PMID:16396466;   PMID:22580421;   PMID:23790896;   Reaxys:741891;   Wikipedia:Glyoxylic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:36655


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glyoxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a increases expression EXP glyoxylic acid results in increased expression of AGTR1 protein CTD PMID:37454925 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO glyoxylic acid results in increased expression of BAX protein
Resveratrol inhibits the reaction [glyoxylic acid results in increased expression of BAX protein]		 CTD PMID:34333021 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO glyoxylic acid results in decreased expression of BCL2 protein
Resveratrol inhibits the reaction [glyoxylic acid results in decreased expression of BCL2 protein]		 CTD PMID:34333021 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO Resveratrol inhibits the reaction [glyoxylic acid results in increased cleavage of CASP3 protein] CTD PMID:34333021 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 EXP glyoxylic acid results in increased expression of CCL2 protein
2-aminoethyl diphenylborinate inhibits the reaction [glyoxylic acid results in increased expression of CCL2 protein]; Losartan inhibits the reaction [glyoxylic acid results in increased expression of CCL2 protein]		 CTD PMID:37454925 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd44 CD44 molecule increases expression
multiple interactions		 EXP glyoxylic acid results in increased expression of CD44 protein
2-aminoethyl diphenylborinate inhibits the reaction [glyoxylic acid results in increased expression of CD44 protein]; Losartan inhibits the reaction [glyoxylic acid results in increased expression of CD44 protein]		 CTD PMID:37454925 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
increases expression		 EXP 2-aminoethyl diphenylborinate inhibits the reaction [glyoxylic acid results in increased expression of NOX2 protein] CTD PMID:37454925 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP glyoxylic acid results in decreased activity of G6PD protein CTD PMID:15144222 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO glyoxylic acid results in increased expression of HMOX1 protein CTD PMID:34333021 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in decreased abundance of glyoxylic acid analog CTD PMID:26820058 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP glyoxylic acid results in increased expression of ITPR1 protein CTD PMID:37454925 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 increases expression EXP glyoxylic acid results in increased expression of ITPR2 protein CTD PMID:37454925 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 increases expression EXP glyoxylic acid results in increased expression of ITPR3 protein CTD PMID:37454925 NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression
multiple interactions		 EXP glyoxylic acid results in increased expression of NOX4 protein
2-aminoethyl diphenylborinate inhibits the reaction [glyoxylic acid results in increased expression of NOX4 protein]		 CTD PMID:37454925 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Sirt1 sirtuin 1 decreases expression ISO glyoxylic acid results in decreased expression of SIRT1 protein CTD PMID:34333021 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression		 EXP 2-aminoethyl diphenylborinate inhibits the reaction [glyoxylic acid results in increased expression of SPP1 protein]; [glyoxylic acid co-treated with Calcitriol] results in increased expression of SPP1 mRNA; Losartan inhibits the reaction [glyoxylic acid results in increased expression of SPP1 protein] CTD PMID:7571189 PMID:8325891 PMID:37454925 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
phenylglyoxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        solvent 17012
          formic acid 9037
            formyl group 8999
              aldehyde 8999
                aldehydic acid 23
                  glyoxylic acid 18
                    2-aminophenylglyoxylic acid 0
                    3,5-dihydroxyphenylglyoxylic acid 0
                    4-hydroxyphenylglyoxylic acid 0
                    glyoxylate ester + 0
                    phenylglyoxylic acid + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          formyl group 8999
                                            aldehyde 8999
                                              aldehydic acid 23
                                                glyoxylic acid 18
                                                  2-aminophenylglyoxylic acid 0
                                                  3,5-dihydroxyphenylglyoxylic acid 0
                                                  4-hydroxyphenylglyoxylic acid 0
                                                  glyoxylate ester + 0
                                                  phenylglyoxylic acid + 2
paths to the root