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Pathways

RAR target genes

All-trans RA, directly or indirectly, regulates the expression of hundred of genes including some involved in retinoid metabolism and signaling. Some of the genes that are thought to be unquestionably direct targets are listed (species information is available, in some cases only human or human and mouse, in some others also rat, and these are the genes listed here, the total is 27). For a compilation of targets as reported in the literature and categorized, check PMID 12401878; for an overview of retinoid metabolism and function check PMID 16688755. The genes are listed with aliases in parentheses, full names and links to gene report pages:

Drd2 (D2R) – dopamine receptor D2
Egr1 (Zif268, Ngfi) – early growth response 1
Pck1 (Pepck) – phosphoenolpyruvate carboxykinase 1
Pou1f1 (Pit1, GHF1A) – POU class 1 homeobox 1
Rarb (Rrb2, Nr1b2) – retinoic acid receptor, beta
Rarg (Nr1b3, Rarc) – retinoic acid receptor, gamma
Tgm2 (Tgasell, transglutaminase 2, C polypeptide) – transglutaminase 2
Ucp1 (Ucpa, SLC25A7) – uncoupling protein 1


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.