Pou1f1 (POU class 1 homeobox 1) - Rat Genome Database

Name: Pou1f1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Pou1f1 (POU class 1 homeobox 1) Rattus norvegicus

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Symbol:

Pou1f1

Name:

POU class 1 homeobox 1

RGD ID:

3367

Description:

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and lncRNA binding activity. Involved in adenohypophysis development; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Part of chromatin. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GHF-1; GHF1; GHF1A; growth hormone factor 1; homeodomain protein for Growth Hormone (GH); pit-1; Pit1; PIT1Z; Pituary specific transcription factor 1 (growth hormone factor 1); pituitary-specific positive transcription factor 1; pituitary-specific positive transcription factor 1 variant w; POU domain, class 1, transcription factor 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	POU1F1 (POU class 1 homeobox 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pou1f1 (POU domain, class 1, transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pou1f1 (POU class 1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	POU1F1 (POU class 1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	POU1F1 (POU class 1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pou1f1 (POU class 1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	POU1F1 (POU class 1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	POU1F1 (POU class 1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pou1f1 (POU class 1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Pou1f1 (POU domain, class 1, transcription factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	POU1F1 (POU class 1 homeobox 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pou1f1 (POU class 1 homeobox 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YOX1	Alliance	DIOPT (Hieranoid\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	pou1f1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	16,763,312 - 16,781,295 (+)	NCBI		GRCr8
mRatBN7.2	11	3,316,818 - 3,334,804 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	3,317,058 - 3,334,801 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	11,912,997 - 11,930,774 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	4,706,108 - 4,723,885 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	3,811,141 - 3,828,918 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	2,645,659 - 2,662,581 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	2,645,865 - 2,662,579 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	2,630,048 - 2,647,084 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	2,959,383 - 2,980,545 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	2,959,382 - 2,980,543 (+)	NCBI
Celera	11	3,294,195 - 3,311,824 (+)	NCBI		Celera
Cytogenetic Map	11	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Combined Pituitary Hormone Deficiency 1 (ISO)

Combined Pituitary Hormone Deficiency 2 (ISO)

frontotemporal dementia (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (ISO)

genetic disease (ISO)

isolated growth hormone deficiency (ISO)

panhypopituitarism (ISO)

pituitary gland disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

ammonium chloride (EXP)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP)

CGP 52608 (ISO)

chromium(6+) (EXP)

colforsin daropate hydrochloride (EXP)

Cuprizon (EXP)

D-mannitol (ISO)

diethylstilbestrol (ISO)

fenvalerate (EXP)

hydrogen peroxide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

paracetamol (ISO)

paraquat (ISO)

potassium dichromate (EXP)

propanal (ISO)

resveratrol (EXP)

silicon dioxide (ISO)

streptozocin (ISO)

T-2 toxin (EXP)

thimerosal (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenohypophysis development (IMP)

B cell differentiation (ISO)

cell fate specification (ISO)

cell population proliferation (ISO)

determination of adult lifespan (ISO)

inositol trisphosphate biosynthetic process (ISO)

negative regulation of transcription by RNA polymerase II (IDA,IGI)

pituitary gland development (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of DNA-templated transcription (IDA,ISO)

positive regulation of inositol trisphosphate biosynthetic process (ISO)

positive regulation of multicellular organism growth (ISO)

positive regulation of transcription by RNA polymerase II (IDA,IMP,ISO)

regulation of DNA-templated transcription (ISO)

regulation of insulin-like growth factor receptor signaling pathway (ISO)

regulation of transcription by RNA polymerase II (IBA,IEA)

somatotropin secreting cell development (ISO)

somatotropin secreting cell differentiation (ISO)

Cellular Component

chromatin (IMP)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

Molecular Function

chromatin binding (ISO)

DNA binding (IEA,ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (IMP,ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA,ISO,ISS)

lncRNA binding (IDA)

protein binding (IPI,ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IMP)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities.	Amendt BA, etal., J Biol Chem. 1998 Aug 7;273(32):20066-72.
2.	The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein.	Bodner M, etal., Cell 1988 Nov 4;55(3):505-18.
3.	MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary.	Du Q, etal., Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012. Epub 2019 Apr 11.
4.	Differential utilization of transcription activation subdomains by distinct coactivators regulates Pit-1 basal and Ras responsiveness.	Duval DL, etal., Mol Endocrinol. 2007 Jan;21(1):172-85. Epub 2006 Oct 4.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype.	Ingraham HA, etal., Cell 1988 Nov 4;55(3):519-29.
8.	A Pit-1 threonine 220 phosphomimic reduces binding to monomeric DNA sites to inhibit Ras and estrogen stimulation of the prolactin gene promoter.	Jean A, etal., Mol Endocrinol. 2010 Jan;24(1):91-103. doi: 10.1210/me.2009-0279. Epub 2009 Nov 3.
9.	Functional isoforms of Pit-1 generated by alternative messenger RNA splicing.	Konzak KE and Moore DD, Mol Endocrinol 1992 Feb;6(2):241-7.
10.	Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression.	Lipkin SM, etal., Genes Dev 1993 Sep;7(9):1674-87.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	Pitx factors are involved in basal and hormone-regulated activity of the human prolactin promoter.	Quentien MH, etal., J Biol Chem 2002 Nov 15;277(46):44408-16.
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Dominant negative dimerization of a mutant homeodomain protein in Axenfeld-Rieger syndrome.	Saadi I, etal., Mol Cell Biol. 2003 Mar;23(6):1968-82.
18.	Repression of the prolactin promoter: a functional consequence of the heterodimerization between Pit-1 and Pit-1 beta.	Sporici RA, etal., J Mol Endocrinol. 2005 Oct;35(2):317-31.
19.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20.	Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene.	Tatsumi K, etal., Nat Genet. 1992 Apr;1(1):56-8.
21.	Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins.	Theill LE, etal., EMBO J 1992 Jun;11(6):2261-9.
22.	Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus.	Voss TC, etal., J Cell Sci. 2005 Aug 1;118(Pt 15):3277-88. Epub 2005 Jul 19.

Additional References at PubMed

PMID:1334535	PMID:1561093	PMID:1972784	PMID:2142999	PMID:6194978	PMID:7390396	PMID:7902581	PMID:8391647	PMID:9009203	PMID:9300691	PMID:9305891	PMID:9482665
PMID:9973256	PMID:10367888	PMID:10431247	PMID:11301317	PMID:11371619	PMID:11447259	PMID:11891224	PMID:12651892	PMID:12810539	PMID:15031321	PMID:15637144	PMID:16200459
PMID:16556738	PMID:16678101	PMID:16914737	PMID:17015435	PMID:17392792	PMID:17536003	PMID:17933456	PMID:17941086	PMID:19442651	PMID:19556346	PMID:19608642	PMID:20819513
PMID:21075822	PMID:21745476	PMID:21980073	PMID:25822178	PMID:26612202	PMID:26875730	PMID:27840385

Genomics

Comparative Map Data

Pou1f1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	16,763,312 - 16,781,295 (+)	NCBI		GRCr8
mRatBN7.2	11	3,316,818 - 3,334,804 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	3,317,058 - 3,334,801 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	11,912,997 - 11,930,774 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	4,706,108 - 4,723,885 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	3,811,141 - 3,828,918 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	2,645,659 - 2,662,581 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	2,645,865 - 2,662,579 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	2,630,048 - 2,647,084 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	2,959,383 - 2,980,545 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	2,959,382 - 2,980,543 (+)	NCBI
Celera	11	3,294,195 - 3,311,824 (+)	NCBI		Celera
Cytogenetic Map	11	p12	NCBI

POU1F1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	87,259,404 - 87,276,584 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	87,259,404 - 87,276,584 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	87,308,554 - 87,325,734 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	87,391,473 - 87,408,427 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	87,391,472 - 87,408,427	NCBI
Celera	3	88,061,261 - 88,078,194 (-)	NCBI		Celera
Cytogenetic Map	3	p11.2	NCBI
HuRef	3	87,322,012 - 87,338,945 (-)	NCBI		HuRef
CHM1_1	3	87,261,327 - 87,278,276 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	87,333,763 - 87,350,936 (-)	NCBI		T2T-CHM13v2.0

Pou1f1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	65,317,398 - 65,331,904 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	65,317,397 - 65,331,183 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	65,520,512 - 65,535,018 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	65,520,511 - 65,535,005 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	65,520,964 - 65,534,316 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	65,438,862 - 65,453,277 (+)	NCBI		MGSCv36	mm8
Celera	16	65,789,753 - 65,803,104 (+)	NCBI		Celera
Cytogenetic Map	16	C1.3	NCBI
cM Map	16	37.25	NCBI

Pou1f1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	5,996,016 - 6,011,483 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	5,996,016 - 6,011,483 (+)	NCBI	ChiLan1.0	ChiLan1.0

POU1F1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	87,402,260 - 87,421,371 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	87,407,048 - 87,426,159 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	87,390,157 - 87,407,611 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	89,504,290 - 89,521,168 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	89,501,298 - 89,521,168 (-)	Ensembl	panpan1.1		panPan2

POU1F1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	769,454 - 788,761 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	769,487 - 787,626 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	811,941 - 830,171 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	752,910 - 771,826 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	752,910 - 771,826 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	732,210 - 750,323 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	780,641 - 799,190 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	1,084,150 - 1,102,357 (+)	NCBI		UU_Cfam_GSD_1.0

Pou1f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	2,262,715 - 2,279,098 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936610	2,262,715 - 2,279,098 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936610	2,262,715 - 2,279,098 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POU1F1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	168,510,774 - 168,529,345 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	168,510,671 - 168,530,394 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	179,453,195 - 179,469,328 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POU1F1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	89,649,971 - 89,668,675 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	89,649,999 - 89,668,941 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	77,064,668 - 77,081,513 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pou1f1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624789	3,592,214 - 3,605,537 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624789	3,589,863 - 3,605,655 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pou1f1
119 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	629
Count of miRNA genes:	277
Interacting mature miRNAs:	341
Transcripts:	ENSRNOT00000000905
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
1598842	Glom10	Glomerulus QTL 10	3.4		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	1	35331169	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	1041931	66113562	Rat
634341	Bw121	Body weight QTL 121	3.56		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	11	1	21836709	Rat

Markers in Region

D11Wox18

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	3,327,687 - 3,327,839 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	2,655,474 - 2,655,625	NCBI	Rnor6.0
Rnor_5.0	11	2,639,739 - 2,639,890	UniSTS	Rnor5.0
RGSC_v3.4	11	2,969,799 - 2,969,950	UniSTS	RGSC3.4
Celera	11	3,304,869 - 3,305,020	UniSTS
Cytogenetic Map	11	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low					12					3	12	12
Below cutoff	12	36	112	40	51	40	36	36	93	28	57	45	24

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB622208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L01506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L01507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M23253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X12658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X53660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X56085	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X65364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X65365	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X65368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000905 ⟹ ENSRNOP00000000905

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	3,317,058 - 3,334,801 (+)	Ensembl
Rnor_6.0 Ensembl	11	2,645,865 - 2,662,579 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110019 ⟹ ENSRNOP00000087323

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	3,319,629 - 3,333,880 (+)	Ensembl

RefSeq Acc Id:

NM_013008 ⟹ NP_037140

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	16,763,518 - 16,781,295 (+)	NCBI
mRatBN7.2	11	3,317,024 - 3,334,804 (+)	NCBI
Rnor_6.0	11	2,645,865 - 2,662,581 (+)	NCBI
Rnor_5.0	11	2,630,048 - 2,647,084 (+)	NCBI
RGSC_v3.4	11	2,959,383 - 2,980,545 (+)	RGD
Celera	11	3,294,195 - 3,311,824 (+)	RGD

Sequence:

show sequence

AGAGCCGCCCTGATGTATATATGCAATAGGGAGCCGTGAATCGGCCCTTTGATACAGTAATATA
ATAAAAGCGGACTGGCAAGCGGTGCGTCTTAGTTCTCTACTCTCTTGTGGGAATGAGTTGCCAA
CCTTTCACCTCGGCTGATACCTTTATACCTCTGAATTCTGACGCTTCTGCTGCCCTGCCTCTGA
GAATGCACCACAATGCCGCTGAGGGTCTCCCAGCCTCCAACCACGCCACCAACGTGATGTCCAC
AGCGACAGGACTTCATTATTCTGTGCCTTCCTGTCATTATGGAAACCAGCCATCCACCTACGGA
GTGATGGCAGGCACTTTAACCCCTTGTCTTTACAAGTTTCCAGACCACACCCTGAGTCATGGGT
TTCCTCCCCTGCACCAACCTCTGCTGGCGGAGGACCCAACAGCCTCTGAATTTAAGCAGGAACT
CAGGCGGAAAAGTAAATTGGTGGAAGAGCCAATAGACATGGACTCCCCGGAAATCCGAGAACTG
GAGCAGTTTGCCAACGAATTTAAAGTGAGAAGAATTAAGTTAGGATACACCCAGACAAACGTGG
GCGAAGCTCTGGCCGCTGTCCACGGCTCCGAATTCAGTCAAACAACCATCTGCCGATTTGAAAA
CTTGCAGCTCAGTTTCAAAAATGCTTGCAAACTGAAAGCAATTTTATCCAAGTGGCTGGAGGAA
GCTGAGCAGGTCGGAGCTTTGTACAATGAAAAAGTGGGAGCAAACGAAAGGAAGAGGAAACGGA
GGACAACTATCAGTATCGCCGCTAAGGATGCTTTGGAGAGACACTTTGGAGAGCACAGCAAACC
TTCTTCGCAGGAGATCATGCGGATGGCTGAAGAATTGAATCTCGAGAAAGAAGTAGTAAGAGTG
TGGTTTTGCAACCGAAGGCAGAGAGAAAAACGGGTGAAAACGAGTCTCAATCAAAGTCTGTTCT
CTATTTCAAAGGAGCATCTTGAGTGCAGATAAGACTTGCCTGTGGTAGCCATGTGTGGTAGCCT
TTCCATTCCTTTCTGATTTCAAGAAAAATCAGAAGTTACTTAGCTTCATAAACTAGATTAAATC
AGCAACCCCTGCAGTTTTTGTTTCACTTTCTTTCTTTCCTTTTTAGATCCAATGATTTAAAACA
AGACGTTTTATTTAGTTGTTCTCAGAATTCATAGCATTGCCTTTACTCCTAAATCATCACCAAG
AATGCTCACAATACCTCTTCCAATTCTGCCTTTATACCTAATACACAGAGAGGTGGGGATAACT
GGGAGAGAGGCCATCATATATGCGAATATTTTGAGTTTAAAATTACCTTTTGTAAGTCAATTTA
TTGTTCTTTAAATTTTAATCAGTAAGGACAAATATTTACCGACTATTAACCAGGGATGGCTCAA
GTTGATAATCTATTGACTTGGCCAGAGAGATGTCTCAGTGGTTAAGAGCATCTGTTGCTCTTCC
AGAGGATGTGGGTTCCATCACCTATACAGCTCACAACTGTCTGTCACACTATTTCCAGAGGAAA
TCCAAGGAGTCTCCTGGGTTCCATTGACACTTGGCCTGAAAATGGAGCACAGACATACATGTAG
ACAAAATACTCATACATATACAGTAAAAATAATAAATCTATAAACAAAAAGAAAATATATTGGT
TTATACTCAGTATGCCCCTAGCACTATGTTTTGTTTTGTTTTGTTTTGTTTTGGAGTAAGGTTT
GACAATCCAGAGGTGACTAGAGACAACTAAGAATTTTATTAATTGCCTTCAGAAATAATCTTCA
GTCAGAATCTATTGATATCTTTGACATTAACACTTAGGACGCGTTTTTTGAACAATTTGTAGGA
GCATTTAGGCATGACATCTGGGCGTATTCTTTTATACACATTAGCTTTCTGAGGCTCTGCTACA
GAAAACATGTGAGCTGCAAGCTAAACTTGCTGACACAATAATCCTTCAGTTTTGGCTTTGTTTT
GTTTTGTTTGGTAGTGAGTTCAATCCTGAGCACAAGTGAAATTTAAAAATGAAAAATATGGTTT
AGGGATCCCTAACCTATATCATAAATCTGTGTGGAAGCTGCACTAGGGCGAGGCTACGTGGCTT
ACTTGCTGTTATGTTTCCAGTGACTGAAAAAGCACTCGCTCCTAGTAGGTATGTATAGACCATG
CTAAAGGAATGGGCCCAATGGTGAACAACCGCTACAAATATGAAGGGTACCAGGCAACCTGAAA
AATCTAACTTGTTTTTGAAGTCTCATTGTAGAAACTCACCTGAGGTTCCTTAACAAAGTGTCAA
TTTTGGTCTCACTGGTCACATTTTGATTTATTAATAAAAATTGGAAATATGGAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006247974 ⟹ XP_006248036

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	16,763,312 - 16,781,295 (+)	NCBI
mRatBN7.2	11	3,316,818 - 3,334,802 (+)	NCBI
Rnor_6.0	11	2,645,659 - 2,662,579 (+)	NCBI
Rnor_5.0	11	2,630,048 - 2,647,084 (+)	NCBI

Sequence:

show sequence

ACTTATTGACGTCAAATAAAGTTTCTGTTTTTTGCCTTCTCCTCACTTCGTACGTCACAACCAG
GTTTCTCCGTGGGCACAGATAGTATTTGGGTAAGAAAGACAGTTCGGGTTAACAAAGCAACACT
CCTGGGAAAAAAACTATTAACATGTATAAATGGATTTCCTCAGAGTATAAATACTAGCCTGCAC
CCTCCTGGTGCCTCAGAGCCGCCCTGATGTATATATGCAATAGGGAGCCGTGAATCGGCCCTTT
GATACAGTAATATAATAAAAGCGGACTGGCAAGCGGTGCGTCTTAGTTCTCTACTCTCTTGTGG
GAATGAGTTGCCAACCTTTCACCTCGGCTGATACCTTTATACCTCTGAATTCTGACGCTTCTGC
TGCCCTGCCTCTGAGAATGCACCACAGTGCCGCTGAGGGTCTCCCAGCCTCCAACCACGCCACC
AACGTGATGTCCACAGTCCCGTCTATTTTGTCTTTGATCCAAACTCCTAAATGTTTGCACACAT
ATTTCTCGATGACAACGATGGGAAATACAGCGACAGGACTTCATTATTCTGTGCCTTCCTGTCA
TTATGGAAACCAGCCATCCACCTACGGAGTGATGGCAGGCACTTTAACCCCTTGTCTTTACAAG
TTTCCAGACCACACCCTGAGTCATGGGTTTCCTCCCCTGCACCAACCTCTGCTGGCGGAGGACC
CAACAGCCTCTGAATTTAAGCAGGAACTCAGGCGGAAAAGTAAATTGGTGGAAGAGCCAATAGA
CATGGACTCCCCGGAAATCCGAGAACTGGAGCAGTTTGCCAACGAATTTAAAGTGAGAAGAATT
AAGTTAGGATACACCCAGACAAACGTGGGCGAAGCTCTGGCCGCTGTCCACGGCTCCGAATTCA
GTCAAACAACCATCTGCCGATTTGAAAACTTGCAGCTCAGTTTCAAAAATGCTTGCAAACTGAA
AGCAATTTTATCCAAGTGGCTGGAGGAAGCTGAGCAGGTCGGAGCTTTGTACAATGAAAAAGTG
GGAGCAAACGAAAGGAAGAGGAAACGGAGGACAACTATCAGTATCGCCGCTAAGGATGCTTTGG
AGAGACACTTTGGAGAGCACAGCAAACCTTCTTCGCAGGAGATCATGCGGATGGCTGAAGAATT
GAATCTCGAGAAAGAAGTAGTAAGAGTGTGGTTTTGCAACCGAAGGCAGAGAGAAAAACGGGTG
AAAACGAGTCTCAATCAAAGTCTGTTCTCTATTTCAAAGGAGCATCTTGAGTGCAGATAAGACT
TGCCTGTGGTAGCCATGTGTGGTAGCCTTTCCATTCCTTTCTGATTTCAAGAAAAATCAGAAGT
TACTTAGCTTCATAAACTAGATTAAATCAGCAACCCCTGCAGTTTTTGTTTCACTTTCTTTCTT
TCCTTTTTAGATCCAATGATTTAAAACAAGACGTTTTATTTAGTTGTTCTCAGAATTCATAGCA
TTGCCTTTACTCCTAAATCATCACCAAGAATGCTCACAATACCTCTTCCAATTCTGCCTTTATA
CCTAATACACAGAGAGGTGGGGATAACTGGGAGAGAGGCCATCATATATGCGAATATTTTGAGT
TTAAAATTACCTTTTGTAAGTCAATTTATTGTTCTTTAAATTTTAATCAGTAAGGACAAATATT
TACCGACTATTAACCAGGGATGGCTCAAGTTGATAATCTATTGACTTGGCCAGAGAGATGTCTC
AGTGGTTAAGAGCATCTGTTGCTCTTCCAGAGGATGTGGGTTCCATCACCTATACAGCTCACAA
CTGTCTGTCACACTATTTCCAGAGGAAATCCAAGGAGTCTCCTGGGTTCCATTGACACTTGGCC
TGAAAATGGAGCACAGACATACATGTAGACAAAATACTCATACATATACAGTAAAAATAATAAA
TCTATAAACAAAAAGAAAATATATTGGTTTATACTCAGTATGCCCCTAGCACTATGTTTTGTTT
TGTTTTGTTTTGTTTTGGAGTAAGGTTTGACAATCCAGAGGTGACTAGAGACAACTAAGAATTT
TATTAATTGCCTTCAGAAATAATCTTCAGTCAGAATCTATTGATATCTTTGACATTAACACTTA
GGACGCGTTTTTTGAACAATTTGTAGGAGCATTTAGGCATGACATCTGGGCGTATTCTTTTATA
CACATTAGCTTTCTGAGGCTCTGCTACAGAAAACATGTGAGCTGCAAGCTAAACTTGCTGACAC
AATAATCCTTCAGTTTTGGCTTTGTTTTGTTTTGTTTGGTAGTGAGTTCAATCCTGAGCACAAG
TGAAATTTAAAAATGAAAAATATGGTTTAGGGATCCCTAACCTATATCATAAATCTGTGTGGAA
GCTGCACTAGGGCGAGGCTACGTGGCTTACTTGCTGTTATGTTTCCAGTGACTGAAAAAGCACT
CGCTCCTAGTAGGTATGTATAGACCATGCTAAAGGAATGGGCCCAATGGTGAACAACCGCTACA
AATATGAAGGGTACCAGGCAACCTGAAAAATCTAACTTGTTTTTGAAGTCTCATTGTAGAAACT
CACCTGAGGTTCCTTAACAAAGTGTCAATTTTGGTCTCACTGGTCACATTTTGATTTATTAATA
AAAATTGGAAATATGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_037140	(Get FASTA)	NCBI Sequence Viewer
	XP_006248036	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41850	(Get FASTA)	NCBI Sequence Viewer
	AAA41851	(Get FASTA)	NCBI Sequence Viewer
	AAA41852	(Get FASTA)	NCBI Sequence Viewer
	AAA41853	(Get FASTA)	NCBI Sequence Viewer
	AAA41854	(Get FASTA)	NCBI Sequence Viewer
	AAH61563	(Get FASTA)	NCBI Sequence Viewer
	AAH61564	(Get FASTA)	NCBI Sequence Viewer
	BAK09362	(Get FASTA)	NCBI Sequence Viewer
	CAA31185	(Get FASTA)	NCBI Sequence Viewer
	CAA37705	(Get FASTA)	NCBI Sequence Viewer
	CAA39565	(Get FASTA)	NCBI Sequence Viewer
	CAA46440	(Get FASTA)	NCBI Sequence Viewer
	CAA46442	(Get FASTA)	NCBI Sequence Viewer
	EDL75906	(Get FASTA)	NCBI Sequence Viewer
	EDL75907	(Get FASTA)	NCBI Sequence Viewer
	EDL75908	(Get FASTA)	NCBI Sequence Viewer
	EDL75909	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000905.6
	ENSRNOP00000087323.1
GenBank Protein	P10037	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_037140 ⟸ NM_013008

- UniProtKB:

Q6P7Q8 (UniProtKB/TrEMBL), Q6P7Q7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSCQPFTSADTFIPLNSDASAALPLRMHHNAAEGLPASNHATNVMSTATGLHYSVPSCHYGNQP
STYGVMAGTLTPCLYKFPDHTLSHGFPPLHQPLLAEDPTASEFKQELRRKSKLVEEPIDMDSPE
IRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSK
WLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKE
VVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR

hide sequence

RefSeq Acc Id:	XP_006248036 ⟸ XM_006247974
- Peptide Label:	isoform X1
- UniProtKB:	A6K4W6 (UniProtKB/TrEMBL), Q6P7Q7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSCQPFTSADTFIPLNSDASAALPLRMHHSAAEGLPASNHATNVMSTVPSILSLIQTPKCLHTY FSMTTMGNTATGLHYSVPSCHYGNQPSTYGVMAGTLTPCLYKFPDHTLSHGFPPLHQPLLAEDP TASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFS QTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALE RHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR hide sequence

Ensembl Acc Id:

ENSRNOP00000000905 ⟸ ENSRNOT00000000905

Ensembl Acc Id:

ENSRNOP00000087323 ⟸ ENSRNOT00000110019

Protein Domains

Homeobox POU-specific

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P10037-F1-model_v2	AlphaFold	P10037	1-291	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3367	AgrOrtholog
BioCyc Gene	G2FUF-22310	BioCyc
Ensembl Genes	ENSRNOG00000000715	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000905.7	UniProtKB/Swiss-Prot
	ENSRNOT00000110019.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.260.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6918965	IMAGE-MGC_LOAD
	IMAGE:6919261	IMAGE-MGC_LOAD
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Lambda_DNA-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU_domain_TF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25517	UniProtKB/TrEMBL
MGC_CLONE	MGC:72907	IMAGE-MGC_LOAD
	MGC:72908	IMAGE-MGC_LOAD
NCBI Gene	25517	ENTREZGENE
PANTHER	POU DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11636:SF84	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pou	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pou1f1	PhenoGen
PRINTS	POUDOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000715	RatGTEx
SMART	HOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF47413	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6GFW1_RAT	UniProtKB/TrEMBL
	A6K4W6	ENTREZGENE, UniProtKB/TrEMBL
	A6K4W9_RAT	UniProtKB/TrEMBL
	P10037	ENTREZGENE, UniProtKB/Swiss-Prot
	Q6P7Q7	ENTREZGENE, UniProtKB/TrEMBL
	Q6P7Q8	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	Q63431	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-05-15	Pou1f1	POU class 1 homeobox 1	Pou1f1	POU domain, class 1, transcription factor 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	Pou1f1	POU domain, class 1, transcription factor 1		Pituary specific transcription factor 1 (growth hormone factor 1)	Symbol and Name updated	629477	APPROVED
2001-10-24	Pou1f1	Pituary specific transcription factor 1 (growth hormone factor 1)			Symbol updated	68913	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed exclusively in the anterior pituitary gland in both somatotroph and lactotroph cell types	729549

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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