Pou1f1 (POU class 1 homeobox 1) - Rat Genome Database

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Gene: Pou1f1 (POU class 1 homeobox 1) Rattus norvegicus
Analyze
Symbol: Pou1f1
Name: POU class 1 homeobox 1
RGD ID: 3367
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and lncRNA binding activity. Involved in adenohypophysis development; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Colocalizes with chromatin. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GHF-1; GHF1; GHF1A; growth hormone factor 1; homeodomain protein for Growth Hormone (GH); pit-1; Pit1; PIT1Z; Pituary specific transcription factor 1 (growth hormone factor 1); pituitary-specific positive transcription factor 1; pituitary-specific positive transcription factor 1 variant w; POU domain, class 1, transcription factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2113,316,818 - 3,334,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl113,317,058 - 3,334,801 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1111,912,997 - 11,930,774 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0114,706,108 - 4,723,885 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0113,811,141 - 3,828,918 (+)NCBIRnor_WKY
Rnor_6.0112,645,659 - 2,662,581 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,645,865 - 2,662,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0112,630,048 - 2,647,084 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,959,383 - 2,980,545 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1112,959,382 - 2,980,543 (+)NCBI
Celera113,294,195 - 3,311,824 (+)NCBICelera
Cytogenetic Map11p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IMP)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities. Amendt BA, etal., J Biol Chem. 1998 Aug 7;273(32):20066-72.
2. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Bodner M, etal., Cell 1988 Nov 4;55(3):505-18.
3. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Du Q, etal., Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012. Epub 2019 Apr 11.
4. Differential utilization of transcription activation subdomains by distinct coactivators regulates Pit-1 basal and Ras responsiveness. Duval DL, etal., Mol Endocrinol. 2007 Jan;21(1):172-85. Epub 2006 Oct 4.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Ingraham HA, etal., Cell 1988 Nov 4;55(3):519-29.
8. A Pit-1 threonine 220 phosphomimic reduces binding to monomeric DNA sites to inhibit Ras and estrogen stimulation of the prolactin gene promoter. Jean A, etal., Mol Endocrinol. 2010 Jan;24(1):91-103. doi: 10.1210/me.2009-0279. Epub 2009 Nov 3.
9. Functional isoforms of Pit-1 generated by alternative messenger RNA splicing. Konzak KE and Moore DD, Mol Endocrinol 1992 Feb;6(2):241-7.
10. Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression. Lipkin SM, etal., Genes Dev 1993 Sep;7(9):1674-87.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Pitx factors are involved in basal and hormone-regulated activity of the human prolactin promoter. Quentien MH, etal., J Biol Chem 2002 Nov 15;277(46):44408-16.
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Dominant negative dimerization of a mutant homeodomain protein in Axenfeld-Rieger syndrome. Saadi I, etal., Mol Cell Biol. 2003 Mar;23(6):1968-82.
18. Repression of the prolactin promoter: a functional consequence of the heterodimerization between Pit-1 and Pit-1 beta. Sporici RA, etal., J Mol Endocrinol. 2005 Oct;35(2):317-31.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene. Tatsumi K, etal., Nat Genet. 1992 Apr;1(1):56-8.
21. Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins. Theill LE, etal., EMBO J 1992 Jun;11(6):2261-9.
22. Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus. Voss TC, etal., J Cell Sci. 2005 Aug 1;118(Pt 15):3277-88. Epub 2005 Jul 19.
Additional References at PubMed
PMID:1334535   PMID:1561093   PMID:1972784   PMID:2142999   PMID:6194978   PMID:7390396   PMID:7902581   PMID:8391647   PMID:9009203   PMID:9300691   PMID:9305891   PMID:9482665  
PMID:9973256   PMID:10367888   PMID:10431247   PMID:11301317   PMID:11371619   PMID:11447259   PMID:11891224   PMID:12651892   PMID:12810539   PMID:15031321   PMID:15637144   PMID:16200459  
PMID:16556738   PMID:16678101   PMID:16914737   PMID:17015435   PMID:17392792   PMID:17536003   PMID:17933456   PMID:17941086   PMID:19442651   PMID:19556346   PMID:19608642   PMID:20819513  
PMID:21075822   PMID:21745476   PMID:21980073   PMID:25822178   PMID:26612202   PMID:26875730   PMID:27840385  


Genomics

Comparative Map Data
Pou1f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2113,316,818 - 3,334,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl113,317,058 - 3,334,801 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1111,912,997 - 11,930,774 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0114,706,108 - 4,723,885 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0113,811,141 - 3,828,918 (+)NCBIRnor_WKY
Rnor_6.0112,645,659 - 2,662,581 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,645,865 - 2,662,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0112,630,048 - 2,647,084 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,959,383 - 2,980,545 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1112,959,382 - 2,980,543 (+)NCBI
Celera113,294,195 - 3,311,824 (+)NCBICelera
Cytogenetic Map11p12NCBI
POU1F1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38387,259,404 - 87,276,584 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl387,259,404 - 87,276,584 (-)EnsemblGRCh38hg38GRCh38
GRCh37387,308,554 - 87,325,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36387,391,473 - 87,408,427 (-)NCBINCBI36Build 36hg18NCBI36
Build 34387,391,472 - 87,408,427NCBI
Celera388,061,261 - 88,078,194 (-)NCBICelera
Cytogenetic Map3p11.2NCBI
HuRef387,322,012 - 87,338,945 (-)NCBIHuRef
CHM1_1387,261,327 - 87,278,276 (-)NCBICHM1_1
T2T-CHM13v2.0387,333,763 - 87,350,936 (-)NCBIT2T-CHM13v2.0
Pou1f1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391665,317,398 - 65,331,904 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1665,317,397 - 65,331,891 (+)EnsemblGRCm39 Ensembl
GRCm381665,520,512 - 65,535,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1665,520,511 - 65,535,005 (+)EnsemblGRCm38mm10GRCm38
MGSCv371665,520,964 - 65,534,316 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361665,438,862 - 65,453,277 (+)NCBIMGSCv36mm8
Celera1665,789,753 - 65,803,104 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1637.25NCBI
Pou1f1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554075,996,016 - 6,011,483 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554075,996,016 - 6,011,483 (+)NCBIChiLan1.0ChiLan1.0
POU1F1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1389,504,290 - 89,521,168 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl389,501,298 - 89,521,168 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0387,390,157 - 87,407,611 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
POU1F1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.131769,454 - 788,761 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl31769,487 - 787,626 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha31811,941 - 830,171 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.031752,910 - 771,826 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl31752,910 - 771,826 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.131732,210 - 750,323 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.031780,641 - 799,190 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0311,084,150 - 1,102,357 (+)NCBIUU_Cfam_GSD_1.0
Pou1f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049712,262,715 - 2,279,098 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366102,262,715 - 2,279,098 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366102,262,715 - 2,279,098 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POU1F1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13168,510,774 - 168,529,345 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113168,510,671 - 168,530,394 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213179,453,195 - 179,469,328 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POU1F1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12289,649,971 - 89,668,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2289,649,999 - 89,668,941 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604177,064,668 - 77,081,513 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pou1f1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247893,592,214 - 3,605,537 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247893,589,863 - 3,605,655 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pou1f1
108 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:629
Count of miRNA genes:277
Interacting mature miRNAs:341
Transcripts:ENSRNOT00000000905
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)11121836709Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat

Markers in Region
D11Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2113,327,687 - 3,327,839 (+)MAPPERmRatBN7.2
Rnor_6.0112,655,474 - 2,655,625NCBIRnor6.0
Rnor_5.0112,639,739 - 2,639,890UniSTSRnor5.0
RGSC_v3.4112,969,799 - 2,969,950UniSTSRGSC3.4
Celera113,304,869 - 3,305,020UniSTS
Cytogenetic Map11p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 4 1 4 4
Below cutoff 2 8 25 9 13 9 8 8 25 8 12 7 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000905   ⟹   ENSRNOP00000000905
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl113,317,058 - 3,334,801 (+)Ensembl
Rnor_6.0 Ensembl112,645,865 - 2,662,579 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110019   ⟹   ENSRNOP00000087323
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl113,319,629 - 3,333,880 (+)Ensembl
RefSeq Acc Id: NM_013008   ⟹   NP_037140
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2113,317,024 - 3,334,804 (+)NCBI
Rnor_6.0112,645,865 - 2,662,581 (+)NCBI
Rnor_5.0112,630,048 - 2,647,084 (+)NCBI
RGSC_v3.4112,959,383 - 2,980,545 (+)RGD
Celera113,294,195 - 3,311,824 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247974   ⟹   XP_006248036
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2113,316,818 - 3,334,802 (+)NCBI
Rnor_6.0112,645,659 - 2,662,579 (+)NCBI
Rnor_5.0112,630,048 - 2,647,084 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037140   ⟸   NM_013008
- UniProtKB: Q6P7Q8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248036   ⟸   XM_006247974
- Peptide Label: isoform X1
- UniProtKB: P10037 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000905   ⟸   ENSRNOT00000000905
RefSeq Acc Id: ENSRNOP00000087323   ⟸   ENSRNOT00000110019
Protein Domains
Homeobox   POU-specific

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10037-F1-model_v2 AlphaFold P10037 1-291 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3367 AgrOrtholog
BioCyc Gene G2FUF-22310 BioCyc
Ensembl Genes ENSRNOG00000000715 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000905 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000087323.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000905 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000110019.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.260.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6918965 IMAGE-MGC_LOAD
  IMAGE:6919261 IMAGE-MGC_LOAD
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lambda_DNA-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pit_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POU_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25517 UniProtKB/TrEMBL
MGC_CLONE MGC:72907 IMAGE-MGC_LOAD
  MGC:72908 IMAGE-MGC_LOAD
NCBI Gene 25517 ENTREZGENE
PANTHER PTHR11636:SF84 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pou UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pou1f1 PhenoGen
PRINTS POUDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POU_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POU_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POU_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47413 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GFW1_RAT UniProtKB/TrEMBL
  P10037 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6P7Q7_RAT UniProtKB/TrEMBL
  Q6P7Q8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q63431 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-15 Pou1f1  POU class 1 homeobox 1  Pou1f1  POU domain, class 1, transcription factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Pou1f1  POU domain, class 1, transcription factor 1    Pituary specific transcription factor 1 (growth hormone factor 1)  Symbol and Name updated 629477 APPROVED
2001-10-24 Pou1f1  Pituary specific transcription factor 1 (growth hormone factor 1)      Symbol updated 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed exclusively in the anterior pituitary gland in both somatotroph and lactotroph cell types 729549