RGD Reference Report - Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat.

Authors: Bilusic, M  Bataillard, A  Tschannen, MR  Gao, L  Barreto, NE  Vincent, M  Wang, T  Jacob, HJ  Sassard, J  Kwitek, AE 
Citation: Bilusic M, etal., Hypertension 2004 Nov;44(5):695-701. Epub 2004 Sep 27.
RGD ID: 1302893
Pubmed: PMID:15452030   (View Abstract at PubMed)
DOI: DOI:10.1161/01.HYP.0000144542.57306.5e   (Journal Full-text)

The complex nature of hypertension makes identifying the pathophysiology and its genetic contributions a challenging task. One powerful approach for the genetic dissection of blood pressure regulation is studying inbred rat models of hypertension, as they provide natural allele variants but reduced heterogeneity (both genetic and etiologic). Furthermore, the detailed physiologic studies to which the rat is amenable allow for the determination of intermediate phenotypes. We have performed a total genome scan in offspring of an F2 intercross between the Lyon hypertensive (LH) and Lyon normotensive rat strains to identify linkage of anthropometric, blood pressure, renal, metabolic, and endocrine phenotypes. Quantitative trait locus (QTL) regions involved in blood pressure regulation, end-stage organ damage, body and organ weight, and lipid metabolism in the LH rat were identified on chromosomes 1, 2, 3, 5, 7, 10, 13, and 17, with 2 phenotypes associated with the metabolic syndrome identified on chromosomes 1 and 17. Regions on chromosomes 2, 13, and 17 were revealed to be important for blood pressure regulation. Regions on chromosome 17 were found to significantly contribute to both metabolic homeostasis and blood pressure regulation; 2 aggregates of a total of 23 QTLs were identified, including several "intermediate phenotypes." These intermediate phenotypes may be used as closer surrogates to the mechanisms leading to hypertension and metabolic dysfunction in the LH rat.



Disease Annotations    Click to see Annotation Detail View
RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Srn6Ratcardiovascular system disease  IAGP  RGD 
Scl30RatHypercholesterolemia  IAGP  RGD 
Scl31RatHypercholesterolemia  IAGP  RGD 
Scl32RatHypercholesterolemia  IAGP  RGD 
Stl13RatHypercholesterolemia  IAGP  RGD 
Bp240Rathypertension  IAGP  RGD 
Bp241Rathypertension  IAGP  RGD 
Bp242Rathypertension  IAGP  RGD 
Bp243Rathypertension  IAGP  RGD 
Bp244Rathypertension  IAGP  RGD 
Bp245Rathypertension  IAGP  RGD 
Bp246Rathypertension  IAGP  RGD 
Bp247Rathypertension  IAGP  RGD 
Kidm12Rathypertension  IAGP  RGD 
Kidm13Rathypertension  IAGP  RGD 
Kidm14Rathypertension  IAGP  RGD 
Kidm15Rathypertension  IAGP  RGD 
Kidm16Rathypertension  IAGP  RGD 
Kidm17Rathypertension  IAGP  RGD 
Kidm18Rathypertension  IAGP  RGD 
Kidm19Rathypertension  IAGP  RGD 
Kidm20Rathypertension  IAGP  RGD 
Kidm21Rathypertension  IAGP  RGD 
Rf46Rathypertension  IAGP  RGD 
Rf47Rathypertension  IAGP  RGD 
Rf48Rathypertension  IAGP  RGD 
Rf49Rathypertension  IAGP  RGD 
Rf50Rathypertension  IAGP  RGD 
Scl68Rathypertension  IAGP  RGD 
Scort1Rathypertension  IAGP  RGD 
Spl4Rathypertension  IAGP  RGD 
Spl5Rathypertension  IAGP  RGD 
Spl7Rathypertension  IAGP  RGD 
Spl8Rathypertension  IAGP  RGD 
Stl13RatHypertriglyceridemia  IAGP  RGD 
Srn6Ratkidney disease  IAGP  RGD 
Cm32RatLeft Ventricular Hypertrophy  IAGP  RGD 
Cm33RatLeft Ventricular Hypertrophy  IAGP  RGD 
Cm34RatLeft Ventricular Hypertrophy  IAGP  RGD 
Cm35RatLeft Ventricular Hypertrophy  IAGP  RGD 
Cm36RatLeft Ventricular Hypertrophy  IAGP  RGD 
Bp240RatMetabolic Syndrome  IAGP  RGD 
Bp241RatMetabolic Syndrome  IAGP  RGD 
Bp242RatMetabolic Syndrome  IAGP  RGD 
Bp243RatMetabolic Syndrome  IAGP  RGD 
Bp244RatMetabolic Syndrome  IAGP  RGD 
Bp245RatMetabolic Syndrome  IAGP  RGD 
Cm32RatMetabolic Syndrome  IAGP  RGD 
Cm33RatMetabolic Syndrome  IAGP  RGD 
Cm34RatMetabolic Syndrome  IAGP  RGD 
Cm35RatMetabolic Syndrome  IAGP  RGD 
Cm36RatMetabolic Syndrome  IAGP  RGD 
Insul1RatMetabolic Syndrome  IAGP  RGD 
Scl30RatMetabolic Syndrome  IAGP  RGD 
Scl31RatMetabolic Syndrome  IAGP  RGD 
Scl32RatMetabolic Syndrome  IAGP  RGD 
Srn6RatMetabolic Syndrome  IAGP  RGD 
Stl13RatMetabolic Syndrome  IAGP  RGD 
Bw31Ratobesity  IDA  RGD 
Bw32Ratobesity  IDA  RGD 
Bw33Ratobesity  IDA  RGD 
Bw34Ratobesity  IDA  RGD 
Bw35Ratobesity  IDA  RGD 
Bw36Ratobesity  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw31Ratabnormal body weight  QTM  RGD 
Bw32Ratabnormal body weight  QTM  RGD 
Bw33Ratabnormal body weight  QTM  RGD 
Bw34Ratabnormal body weight  QTM  RGD 
Bw35Ratabnormal body weight  QTM  RGD 
Bw36Ratabnormal body weight  QTM  RGD 
Scl30Ratabnormal circulating cholesterol level  QTM  RGD 
Scl31Ratabnormal circulating cholesterol level  QTM  RGD 
Scort1Ratabnormal circulating corticosterone level  QTM  RGD 
Rf46Ratabnormal circulating creatinine level  QTM  RGD 
Rf48Ratabnormal circulating creatinine level  QTM  RGD 
Rf49Ratabnormal circulating creatinine level  QTM  RGD 
Scl32Ratabnormal circulating HDL cholesterol level  QTM  RGD 
Insul1Ratabnormal circulating insulin level  QTM  RGD 
Spl5Ratabnormal circulating LDL cholesterol level  QTM  RGD 
Spl4Ratabnormal circulating phospholipid level  QTM  RGD 
Spl7Ratabnormal circulating phospholipid level  QTM  RGD 
Rf47Ratabnormal circulating renin level  QTM  RGD 
Srn6Ratabnormal circulating renin level  QTM  RGD 
Scl68Ratabnormal circulating VLDL cholesterol level  QTM  RGD 
Spl8Ratabnormal circulating VLDL cholesterol level  QTM  RGD 
Cm32Ratabnormal heart size  QTM  RGD 
Cm33Ratabnormal heart size  QTM  RGD 
Cm34Ratabnormal heart size  QTM  RGD 
Cm35Ratabnormal heart size  QTM  RGD 
Cm36Ratabnormal heart size  QTM  RGD 
Kidm12Ratabnormal kidney weight  QTM  RGD 
Kidm13Ratabnormal kidney weight  QTM  RGD 
Kidm14Ratabnormal kidney weight  QTM  RGD 
Kidm15Ratabnormal kidney weight  QTM  RGD 
Kidm16Ratabnormal kidney weight  QTM  RGD 
Kidm17Ratabnormal kidney weight  QTM  RGD 
Kidm18Ratabnormal kidney weight  QTM  RGD 
Kidm19Ratabnormal kidney weight  QTM  RGD 
Kidm20Ratabnormal kidney weight  QTM  RGD 
Kidm21Ratabnormal kidney weight  QTM  RGD 
Bp240Ratabnormal systemic arterial blood pressure  QTM  RGD 
Bp241Ratabnormal systemic arterial blood pressure  QTM  RGD 
Bp242Ratabnormal systemic arterial blood pressure  QTM  RGD 
Bp243Ratabnormal systemic arterial blood pressure  QTM  RGD 
Bp244Ratabnormal systemic arterial blood pressure  QTM  RGD 
Bp245Ratabnormal systemic arterial blood pressure  QTM  RGD 
Bp246Ratabnormal systemic arterial blood pressure  QTM  RGD 
Bp247Ratabnormal systemic arterial blood pressure  QTM  RGD 
Lmblg1Ratabnormal tibia morphology  QTM  RGD 
Lmblg2Ratabnormal tibia morphology  QTM  RGD 
Stl13Ratabnormal triglyceride level  QTM  RGD 
Srn6Ratdecreased circulating renin level  IAGP  RGD 
Cm32Ratheart left ventricle hypertrophy  IAGP  RGD 
Cm33Ratheart left ventricle hypertrophy  IAGP  RGD 
Cm34Ratheart left ventricle hypertrophy  IAGP  RGD 
Cm35Ratheart left ventricle hypertrophy  IAGP  RGD 
Cm36Ratheart left ventricle hypertrophy  IAGP  RGD 
Scl30Ratincreased circulating cholesterol level  IAGP  RGD 
Scl31Ratincreased circulating cholesterol level  IAGP  RGD 
Scl32Ratincreased circulating HDL cholesterol level  IAGP  RGD 
Stl13Ratincreased circulating triglyceride level  IAGP  RGD 
Stl13Ratincreased circulating VLDL cholesterol level  IAGP  RGD 
Bp246Ratincreased pulse pressure  IAGP  RGD 
Bp247Ratincreased pulse pressure  IAGP  RGD 
Bp240Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp245Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp243Ratincreased systemic arterial diastolic blood pressure  IAGP  RGD 
Bp244Ratincreased systemic arterial diastolic blood pressure  IAGP  RGD 
Bp241Ratincreased systemic arterial systolic blood pressure  IAGP  RGD 
Bp242Ratincreased systemic arterial systolic blood pressure  IAGP  RGD 
Rf50Ratpolyuria  QTM  RGD 
Objects Annotated

QTLs
Bp240  (Blood pressure QTL 240)
Bp241  (Blood pressure QTL 241)
Bp242  (Blood pressure QTL 242)
Bp243  (Blood pressure QTL 243)
Bp244  (Blood pressure QTL 244)
Bp245  (Blood pressure QTL 245)
Bp246  (Blood pressure QTL 246)
Bp247  (Blood pressure QTL 247)
Bw31  (Body weight QTL 31)
Bw32  (Body weight QTL 32)
Bw33  (Body weight QTL 33)
Bw34  (Body weight QTL 34)
Bw35  (Body weight QTL 35)
Bw36  (Body weight QTL 36)
Cm32  (Cardiac mass QTL 32)
Cm33  (Cardiac mass QTL 33)
Cm34  (Cardiac mass QTL 34)
Cm35  (Cardiac mass QTL35)
Cm36  (Cardiac mass QTL 36)
Insul1  (Insulin level QTL 1)
Kidm12  (Kidney mass QTL 12)
Kidm13  (Kidney mass QTL 13)
Kidm14  (Kidney mass QTL 14)
Kidm15  (Kidney mass QTL 15)
Kidm16  (Kidney mass QTL 16)
Kidm17  (Kidney mass QTL 17)
Kidm18  (Kidney mass QTL 18)
Kidm19  (Kidney mass QTL 19)
Kidm20  (Kidney mass QTL 20)
Kidm21  (Kidney mass QTL 21)
Lmblg1  (Limb length QTL 1)
Lmblg2  (Limb length QTL 2)
Rf46  (Renal function QTL 46)
Rf47  (Renal function QTL 47)
Rf48  (Renal function QTL 48)
Rf49  (Renal function QTL 49)
Rf50  (Renal function QTL 50)
Scl30  (Serum cholesterol level QTL 30)
Scl31  (Serum cholesterol level QTL 31)
Scl32  (Serum cholesterol level QTL 32)
Scl68  (Serum cholesterol level QTL 68)
Scort1  (Serum corticosterone level QTL 1)
Spl4  (Serum phospholipid level QTL 4)
Spl5  (Serum phospholipid level QTL 5)
Spl7  (Serum phospholipid level QTL 7)
Spl8  (Serum phospholipid level QTL 8)
Srn6  (Serum renin concentration QTL 6)
Stl13  (Serum triglyceride level QTL 13)

Strains
LH/Mav  (NA)
LN/Mav  (NA)

Objects referenced in this article
QTL Bp15 Blood pressure QTL 15 Rattus norvegicus
Strain LL/Mav null Rattus norvegicus

Additional Information