Ubash3b (ubiquitin associated and SH3 domain containing, B) - Rat Genome Database

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Gene: Ubash3b (ubiquitin associated and SH3 domain containing, B) Rattus norvegicus
Analyze
Symbol: Ubash3b
Name: ubiquitin associated and SH3 domain containing, B
RGD ID: 1310357
Description: Enables ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including collagen-activated tyrosine kinase receptor signaling pathway; negative regulation of bone resorption; and platelet aggregation. Predicted to act upstream of or within several processes, including negative regulation of osteoclast differentiation; negative regulation of platelet aggregation; and platelet activation. Predicted to be active in cytoplasm. Orthologous to human UBASH3B (ubiquitin associated and SH3 domain containing B); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cbl-interacting protein Sts-1; LOC315579; RGD1310357; similar to RIKEN cDNA 2810457I06; Sts-1; Sts1; ubiquitin-associated and SH3 domain-containing protein B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8850,282,510 - 50,430,034 (-)NCBIGRCr8
mRatBN7.2841,385,419 - 41,532,248 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl841,388,341 - 41,532,201 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx846,882,006 - 47,025,074 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0845,160,614 - 45,303,702 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0843,028,175 - 43,171,244 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0845,224,053 - 45,375,450 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl845,223,992 - 45,375,435 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0843,702,541 - 43,853,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,992,862 - 44,135,847 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1844,001,003 - 44,067,551 (-)NCBI
Celera840,986,547 - 41,129,756 (-)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway. Peruzzi G, etal., J Immunol. 2007 Aug 15;179(4):2089-96.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20585042   PMID:23149425   PMID:25416956   PMID:27609517  


Genomics

Comparative Map Data
Ubash3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8850,282,510 - 50,430,034 (-)NCBIGRCr8
mRatBN7.2841,385,419 - 41,532,248 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl841,388,341 - 41,532,201 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx846,882,006 - 47,025,074 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0845,160,614 - 45,303,702 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0843,028,175 - 43,171,244 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0845,224,053 - 45,375,450 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl845,223,992 - 45,375,435 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0843,702,541 - 43,853,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,992,862 - 44,135,847 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1844,001,003 - 44,067,551 (-)NCBI
Celera840,986,547 - 41,129,756 (-)NCBICelera
Cytogenetic Map8q22NCBI
UBASH3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811122,655,722 - 122,814,473 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11122,655,722 - 122,814,473 (+)EnsemblGRCh38hg38GRCh38
GRCh3711122,526,430 - 122,685,181 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611122,031,640 - 122,190,391 (+)NCBINCBI36Build 36hg18NCBI36
Celera11119,685,695 - 119,844,497 (+)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11118,468,875 - 118,627,622 (+)NCBIHuRef
CHM1_111122,412,295 - 122,571,102 (+)NCBICHM1_1
T2T-CHM13v2.011122,683,359 - 122,842,181 (+)NCBIT2T-CHM13v2.0
Ubash3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,922,056 - 41,069,358 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl940,922,394 - 41,072,993 (-)EnsemblGRCm39 Ensembl
GRCm38941,010,760 - 41,161,692 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl941,011,098 - 41,161,697 (-)EnsemblGRCm38mm10GRCm38
MGSCv37940,821,724 - 40,965,577 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36940,764,710 - 40,908,563 (-)NCBIMGSCv36mm8
MGSCv36941,219,202 - 41,364,403 (-)NCBIMGSCv36mm8
Celera938,241,137 - 38,383,815 (-)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.84NCBI
Ubash3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541223,518,240 - 23,667,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541223,518,851 - 23,667,617 (+)NCBIChiLan1.0ChiLan1.0
UBASH3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29123,357,571 - 123,515,784 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111124,462,174 - 124,620,547 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011117,489,411 - 117,647,719 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111121,410,178 - 121,567,716 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11121,410,545 - 121,563,133 (+)Ensemblpanpan1.1panPan2
UBASH3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1511,496,254 - 11,614,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl511,500,669 - 11,614,675 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha511,551,610 - 11,690,824 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0511,446,452 - 11,586,409 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl511,447,895 - 11,586,395 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1511,549,978 - 11,689,276 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0511,488,972 - 11,628,138 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0511,527,189 - 11,666,755 (-)NCBIUU_Cfam_GSD_1.0
Ubash3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947104,304,260 - 104,451,965 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365427,225,977 - 7,373,381 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365427,225,387 - 7,370,163 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBASH3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,630,793 - 49,770,897 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,630,678 - 49,772,348 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2954,975,101 - 55,118,054 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBASH3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,053,792 - 114,218,909 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,054,384 - 114,218,912 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604311,913,397 - 12,072,484 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ubash3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248802,270,679 - 2,427,298 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248802,269,247 - 2,427,531 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ubash3b
1272 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:132
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000010873
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815442692818Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat

Markers in Region
D8Rat188  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2841,435,262 - 41,435,385 (+)MAPPERmRatBN7.2
Rnor_6.0845,272,853 - 45,272,975NCBIRnor6.0
Rnor_5.0843,751,341 - 43,751,463UniSTSRnor5.0
RGSC_v3.4844,039,525 - 44,039,648RGDRGSC3.4
RGSC_v3.4844,039,526 - 44,039,648UniSTSRGSC3.4
RGSC_v3.1844,048,291 - 44,048,414RGD
Celera841,032,972 - 41,033,094UniSTS
SHRSP x BN Map832.42RGD
SHRSP x BN Map832.42UniSTS
Cytogenetic Map8q22UniSTS
D8Got200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2841,463,731 - 41,463,953 (+)MAPPERmRatBN7.2
Rnor_6.0845,302,911 - 45,303,132NCBIRnor6.0
Rnor_5.0843,781,140 - 43,781,361UniSTSRnor5.0
RGSC_v3.4844,067,791 - 44,068,048RGDRGSC3.4
RGSC_v3.4844,067,826 - 44,068,047UniSTSRGSC3.4
RGSC_v3.1844,076,592 - 44,076,813RGD
Celera841,061,532 - 41,061,753UniSTS
RH 3.4 Map8393.7RGD
RH 3.4 Map8393.7UniSTS
Cytogenetic Map8q22UniSTS
RH129595  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2841,387,996 - 41,388,179 (+)MAPPERmRatBN7.2
Rnor_6.0845,226,630 - 45,226,812NCBIRnor6.0
Rnor_5.0843,705,118 - 43,705,300UniSTSRnor5.0
RGSC_v3.4843,992,260 - 43,992,442UniSTSRGSC3.4
Celera840,985,945 - 40,986,127UniSTS
RH 3.4 Map8394.3UniSTS
Cytogenetic Map8q22UniSTS
AU049662  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2841,485,202 - 41,485,375 (+)MAPPERmRatBN7.2
Rnor_6.0845,324,379 - 45,324,551NCBIRnor6.0
Rnor_5.0843,802,608 - 43,802,780UniSTSRnor5.0
RGSC_v3.4844,089,294 - 44,089,466UniSTSRGSC3.4
Celera841,083,000 - 41,083,168UniSTS
Cytogenetic Map8q22UniSTS
UniSTS:236101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2841,389,092 - 41,389,296 (+)MAPPERmRatBN7.2
Rnor_6.0845,227,726 - 45,227,929NCBIRnor6.0
Rnor_5.0843,706,214 - 43,706,417UniSTSRnor5.0
RGSC_v3.4843,993,356 - 43,993,559UniSTSRGSC3.4
Celera840,987,041 - 40,987,244UniSTS
Cytogenetic Map8q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 6 6 11 6 60 14 16 11
Low 3 33 51 35 8 35 8 9 14 21 25 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010873   ⟹   ENSRNOP00000010873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl841,388,341 - 41,532,201 (-)Ensembl
Rnor_6.0 Ensembl845,223,992 - 45,375,435 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102848   ⟹   ENSRNOP00000076960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl841,388,341 - 41,456,261 (-)Ensembl
RefSeq Acc Id: NM_001191792   ⟹   NP_001178721
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8850,285,689 - 50,429,021 (-)NCBI
mRatBN7.2841,388,599 - 41,531,954 (-)NCBI
Rnor_6.0845,227,232 - 45,375,134 (-)NCBI
Rnor_5.0843,702,541 - 43,853,864 (-)NCBI
Celera840,986,547 - 41,129,756 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242848   ⟹   XP_006242910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8850,282,510 - 50,430,034 (-)NCBI
mRatBN7.2841,385,419 - 41,532,248 (-)NCBI
Rnor_6.0845,224,053 - 45,375,450 (-)NCBI
Rnor_5.0843,702,541 - 43,853,864 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081414   ⟹   XP_038937342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8850,282,510 - 50,430,034 (-)NCBI
mRatBN7.2841,385,419 - 41,532,248 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178721 (Get FASTA)   NCBI Sequence Viewer  
  XP_006242910 (Get FASTA)   NCBI Sequence Viewer  
  XP_038937342 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95238 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010873
  ENSRNOP00000010873.7
  ENSRNOP00000076960
  ENSRNOP00000076960.1
Reference Protein Sequences
RefSeq Acc Id: NP_001178721   ⟸   NM_001191792
- UniProtKB: A0A8I5YC04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242910   ⟸   XM_006242848
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YC04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010873   ⟸   ENSRNOT00000010873
RefSeq Acc Id: XP_038937342   ⟸   XM_039081414
- Peptide Label: isoform X2
- UniProtKB: F1LV21 (UniProtKB/TrEMBL),   A0A8I5YC04 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000076960   ⟸   ENSRNOT00000102848
Protein Domains
SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LV21-F1-model_v2 AlphaFold F1LV21 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695872
Promoter ID:EPDNEW_R6397
Type:single initiation site
Name:Ubash3b_1
Description:ubiquitin associated and SH3 domain containing, B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0845,375,377 - 45,375,437EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310357 AgrOrtholog
BioCyc Gene G2FUF-30824 BioCyc
Ensembl Genes ENSRNOG00000008187 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010873.8 UniProtKB/TrEMBL
  ENSRNOT00000102848 ENTREZGENE
  ENSRNOT00000102848.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1240 UniProtKB/TrEMBL
  Cyclic phosphodiesterase UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro His_Pase_superF_clade-1 UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  UBA-like UniProtKB/TrEMBL
  UBASH3B_SH3 UniProtKB/TrEMBL
NCBI Gene 315579 ENTREZGENE
PANTHER UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED UniProtKB/TrEMBL
  UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING PROTEIN B UniProtKB/TrEMBL
Pfam His_Phos_1 UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PhenoGen Ubash3b PhenoGen
PROSITE SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008187 RatGTEx
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP SH3 UniProtKB/TrEMBL
  SSF53254 UniProtKB/TrEMBL
  UBA_like UniProtKB/TrEMBL
UniProt A0A8I5YC04 ENTREZGENE, UniProtKB/TrEMBL
  F1LV21 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-15 Ubash3b  ubiquitin associated and SH3 domain containing, B  Sts-1  Cbl-interacting protein Sts-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Sts-1  Cbl-interacting protein Sts-1  Ubash3b  ubiquitin associated and SH3 domain containing, B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-27 Ubash3b  ubiquitin associated and SH3 domain containing, B  RGD1310357_predicted  similar to RIKEN cDNA 2810457I06 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1310357_predicted  similar to RIKEN cDNA 2810457I06 (predicted)  LOC315579_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC315579_predicted  similar to RIKEN cDNA 2810457I06 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL