Klf10 (KLF transcription factor 10) - Rat Genome Database

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Gene: Klf10 (KLF transcription factor 10) Rattus norvegicus
Analyze
Symbol: Klf10
Name: KLF transcription factor 10
RGD ID: 621652
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and core promoter sequence-specific DNA binding activity. Involved in cellular response to endothelin and regulation of circadian rhythm. Located in nucleus. Orthologous to human KLF10 (KLF transcription factor 10); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Krueppel-like factor 10; Kruppel-like factor 10; TGFB inducible early growth response; TGFB-inducible early growth response protein 1; Tieg; TIEG-1; transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor homolog CPG20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,352,612 - 71,358,680 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl771,350,573 - 71,358,948 (-)EnsemblGRCr8
mRatBN7.2769,467,658 - 69,473,726 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,465,619 - 69,473,994 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx771,347,410 - 71,353,478 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,549,944 - 73,556,012 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,417,968 - 73,424,036 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0777,156,010 - 77,162,096 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl777,156,006 - 77,162,148 (-)Ensemblrn6Rnor6.0
Rnor_5.0777,258,859 - 77,265,053 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4773,821,190 - 73,826,866 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera766,529,946 - 66,535,877 (-)NCBICelera
RGSC_v3.1773,842,010 - 73,847,864 (-)NCBI
RH 3.4 Map7631.6RGD
Cytogenetic Map7q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
atrazine  (ISO)
avobenzone  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
chromium atom  (ISO)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycine betaine  (EXP)
glyphosate  (EXP)
graphene oxide  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
inulin  (ISO)
iron dichloride  (ISO)
kainic acid  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP,ISO)
nicotine  (ISO)
okadaic acid  (ISO)
orotic acid  (EXP)
orphenadrine  (EXP)
paracetamol  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP,ISO)
raloxifene  (ISO)
ritodrine  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. Hevroni D, etal., J Mol Neurosci 1998 Apr;10(2):75-98.
4. Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork. Hirota T, etal., Genes Cells. 2010 Feb;15(2):111-21. doi: 10.1111/j.1365-2443.2009.01371.x. Epub 2010 Jan 13.
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. Tachibana I, etal., J Clin Invest 1997 May 15;99(10):2365-74.
Additional References at PubMed
PMID:12477932   PMID:15087465   PMID:15657444   PMID:19379700   PMID:20155803   PMID:21856285   PMID:25448845   PMID:26252173  


Genomics

Comparative Map Data
Klf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,352,612 - 71,358,680 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl771,350,573 - 71,358,948 (-)EnsemblGRCr8
mRatBN7.2769,467,658 - 69,473,726 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,465,619 - 69,473,994 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx771,347,410 - 71,353,478 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,549,944 - 73,556,012 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,417,968 - 73,424,036 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0777,156,010 - 77,162,096 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl777,156,006 - 77,162,148 (-)Ensemblrn6Rnor6.0
Rnor_5.0777,258,859 - 77,265,053 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4773,821,190 - 73,826,866 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera766,529,946 - 66,535,877 (-)NCBICelera
RGSC_v3.1773,842,010 - 73,847,864 (-)NCBI
RH 3.4 Map7631.6RGD
Cytogenetic Map7q22NCBI
KLF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388102,648,784 - 102,655,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8102,648,783 - 102,655,728 (-)Ensemblhg38GRCh38
GRCh378103,661,012 - 103,667,953 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,730,188 - 103,737,128 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348103,730,196 - 103,737,128NCBI
Celera899,848,329 - 99,855,302 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef898,862,246 - 98,869,150 (-)NCBIHuRef
CHM1_18103,701,211 - 103,708,326 (-)NCBICHM1_1
T2T-CHM13v2.08103,777,028 - 103,783,970 (-)NCBIT2T-CHM13v2.0
Klf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391538,291,702 - 38,300,950 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1538,291,707 - 38,300,950 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381538,291,464 - 38,300,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1538,291,463 - 38,300,706 (-)Ensemblmm10GRCm38
MGSCv371538,224,168 - 38,230,462 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361538,239,002 - 38,245,296 (-)NCBIMGSCv36mm8
Celera1538,920,503 - 38,926,796 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.15NCBI
Klf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541727,164,839 - 27,168,604 (-)Ensembl
ChiLan1.0NW_00495541727,165,146 - 27,168,604 (-)NCBIChiLan1.0ChiLan1.0
KLF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27120,013,188 - 120,020,500 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1895,549,150 - 95,556,311 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0899,302,943 - 99,310,099 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18101,462,915 - 101,469,965 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,462,915 - 101,469,982 (-)EnsemblpanPan2panpan1.1
KLF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1134,216,745 - 4,223,708 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl134,218,084 - 4,223,691 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha134,218,182 - 4,224,873 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0134,376,923 - 4,383,610 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl134,376,925 - 4,383,607 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1134,219,256 - 4,225,960 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0134,336,504 - 4,343,201 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0134,349,283 - 4,355,987 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,554,546 - 33,560,778 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647040,980,487 - 40,986,885 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647040,980,487 - 40,986,880 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,429,941 - 34,436,004 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1434,430,132 - 34,435,990 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,443,363 - 37,449,221 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLF10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,496,695 - 97,503,818 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl897,496,678 - 97,503,620 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603943,100,548 - 43,107,671 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476319,581,730 - 19,587,730 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476319,582,019 - 19,592,447 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Klf10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11211,765,547 - 211,771,889 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Klf10
57 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:566
Count of miRNA genes:275
Interacting mature miRNAs:339
Transcripts:ENSRNOT00000008350
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH127848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,467,809 - 69,467,989 (+)MAPPERmRatBN7.2
Rnor_6.0777,156,162 - 77,156,341NCBIRnor6.0
Rnor_5.0777,259,011 - 77,259,190UniSTSRnor5.0
RGSC_v3.4773,821,342 - 73,821,521UniSTSRGSC3.4
Celera766,530,098 - 66,530,277UniSTS
RH 3.4 Map7632.9UniSTS
Cytogenetic Map7q22UniSTS
Tieg  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,467,817 - 69,467,967 (+)MAPPERmRatBN7.2
Rnor_6.0777,156,170 - 77,156,319NCBIRnor6.0
Rnor_5.0777,259,019 - 77,259,168UniSTSRnor5.0
RGSC_v3.4773,821,350 - 73,821,499UniSTSRGSC3.4
Celera766,530,106 - 66,530,255UniSTS
RH 3.4 Map7631.6UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008350   ⟹   ENSRNOP00000008350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl771,352,703 - 71,358,948 (-)Ensembl
mRatBN7.2 Ensembl769,467,749 - 69,473,994 (-)Ensembl
Rnor_6.0 Ensembl777,156,006 - 77,162,148 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085626   ⟹   ENSRNOP00000070160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl771,350,573 - 71,358,948 (-)Ensembl
mRatBN7.2 Ensembl769,465,619 - 69,473,994 (-)Ensembl
Rnor_6.0 Ensembl777,157,458 - 77,159,457 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094319   ⟹   ENSRNOP00000079465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl771,352,613 - 71,356,548 (-)Ensembl
mRatBN7.2 Ensembl769,467,659 - 69,473,644 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128373   ⟹   ENSRNOP00000101003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl771,352,613 - 71,358,442 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135589   ⟹   ENSRNOP00000102477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl771,352,613 - 71,357,381 (-)Ensembl
RefSeq Acc Id: NM_031135   ⟹   NP_112397
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,352,612 - 71,358,680 (-)NCBI
mRatBN7.2769,467,658 - 69,473,726 (-)NCBI
Rnor_6.0777,156,010 - 77,162,096 (-)NCBI
Rnor_5.0777,258,859 - 77,265,053 (-)NCBI
RGSC_v3.4773,821,190 - 73,826,866 (-)RGD
Celera766,529,946 - 66,535,877 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264302   ⟹   XP_063120372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,352,612 - 71,358,243 (-)NCBI
RefSeq Acc Id: NP_112397   ⟸   NM_031135
- UniProtKB: Q4QRA4 (UniProtKB/Swiss-Prot),   O08876 (UniProtKB/Swiss-Prot),   A6HR55 (UniProtKB/TrEMBL),   P97848 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008350   ⟸   ENSRNOT00000008350
Ensembl Acc Id: ENSRNOP00000070160   ⟸   ENSRNOT00000085626
Ensembl Acc Id: ENSRNOP00000079465   ⟸   ENSRNOT00000094319
RefSeq Acc Id: XP_063120372   ⟸   XM_063264302
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000102477   ⟸   ENSRNOT00000135589
Ensembl Acc Id: ENSRNOP00000101003   ⟸   ENSRNOT00000128373
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08876-F1-model_v2 AlphaFold O08876 1-480 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695301
Promoter ID:EPDNEW_R5826
Type:initiation region
Name:Klf10_1
Description:Kruppel-like factor 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0777,162,157 - 77,162,217EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621652 AgrOrtholog
BioCyc Gene G2FUF-33591 BioCyc
Ensembl Genes ENSRNOG00000006118 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008350 ENTREZGENE
  ENSRNOT00000008350.4 UniProtKB/Swiss-Prot
  ENSRNOT00000128373 ENTREZGENE
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7387595 IMAGE-MGC_LOAD
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:81813 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114305 IMAGE-MGC_LOAD
NCBI Gene 81813 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 10 UniProtKB/Swiss-Prot
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Klf10 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006118 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt A0A0G2JX73_RAT UniProtKB/TrEMBL
  A0A8I6G3C1_RAT UniProtKB/TrEMBL
  A0ABK0LCN0_RAT UniProtKB/TrEMBL
  A0ABK0LLG1_RAT UniProtKB/TrEMBL
  A6HR55 ENTREZGENE, UniProtKB/TrEMBL
  KLF10_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P97848 ENTREZGENE, UniProtKB/TrEMBL
  Q4QRA4 ENTREZGENE
UniProt Secondary Q4QRA4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf10  KLF transcription factor 10  Klf10  Kruppel-like factor 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Klf10  Kruppel-like factor 10  Tieg  TGFB inducible early growth response  Symbol and Name updated 1299863 APPROVED
2005-01-20 Tieg  TGFB inducible early growth response      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tieg  TGFB inducible early growth response      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process induces apoptosis in TGFbeta-sensitive epithelial cell line PANC1 724783
gene_product member of Sp1-like zinc finger proteins 724783