KLF10 (Kruppel like factor 10) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: KLF10 (Kruppel like factor 10) Homo sapiens
Analyze
Symbol: KLF10
Name: Kruppel like factor 10
RGD ID: 1348365
HGNC Page HGNC
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to chromatin and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: early growth response-alpha; EGR-alpha; EGRA; Krueppel-like factor 10; Kruppel-like factor 10; TGFB inducible early growth response; TGFB-inducible early growth response protein 1; TIEG; TIEG-1; TIEG1; transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor TIEG
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8102,648,784 - 102,655,725 (-)EnsemblGRCh38hg38GRCh38
GRCh388102,648,784 - 102,655,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378103,661,012 - 103,667,953 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,730,188 - 103,737,128 (-)NCBINCBI36hg18NCBI36
Build 348103,730,196 - 103,737,128NCBI
Celera899,848,329 - 99,855,302 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef898,862,246 - 98,869,150 (-)NCBIHuRef
CHM1_18103,701,211 - 103,708,326 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
15-acetyldeoxynivalenol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
atrazine  (EXP)
avobenzone  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bromobenzene  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
chromium atom  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
diethyl maleate  (ISO)
dioxygen  (ISO)
disulfiram  (EXP)
doxazosin  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
fenofibrate  (EXP,ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
glucose  (EXP,ISO)
glycine betaine  (ISO)
graphene oxide  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (EXP)
kainic acid  (ISO)
leflunomide  (EXP)
menadione  (EXP)
methamphetamine  (ISO)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP,ISO)
nicotine  (ISO)
orphenadrine  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenol  (EXP)
PhIP  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
raloxifene  (EXP)
ritodrine  (ISO)
rotenone  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
tamibarotene  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (EXP)
valsartan  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8532536   PMID:8584037   PMID:9153278   PMID:9443078   PMID:9492071   PMID:9622090   PMID:9721211   PMID:9748269   PMID:10573529   PMID:10816551   PMID:10861837   PMID:10976766  
PMID:11438660   PMID:12065093   PMID:12072443   PMID:12173049   PMID:12477932   PMID:12788480   PMID:12804117   PMID:15087465   PMID:15218362   PMID:15231748   PMID:15489334   PMID:15570219  
PMID:16344560   PMID:16964243   PMID:17207965   PMID:17377371   PMID:17659279   PMID:17689119   PMID:17931948   PMID:18278048   PMID:18359287   PMID:18483178   PMID:18798273   PMID:18930345  
PMID:19240061   PMID:19274049   PMID:19453261   PMID:20087894   PMID:20201926   PMID:20301725   PMID:20385766   PMID:20628624   PMID:20691807   PMID:20863814   PMID:20934684   PMID:20953893  
PMID:21262377   PMID:21471442   PMID:21524276   PMID:21559363   PMID:21873635   PMID:21900206   PMID:22025675   PMID:22094256   PMID:22234868   PMID:22349513   PMID:22563190   PMID:22688058  
PMID:23057549   PMID:23134681   PMID:23232713   PMID:23414517   PMID:23569208   PMID:23770605   PMID:23994618   PMID:24162774   PMID:24885297   PMID:24944246   PMID:25472963   PMID:25613138  
PMID:25728284   PMID:26119394   PMID:26288249   PMID:26922828   PMID:27260002   PMID:28108300   PMID:28249899   PMID:28473536   PMID:29198712   PMID:29691553   PMID:30060954   PMID:30948420  
PMID:31393228  


Genomics

Comparative Map Data
KLF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8102,648,784 - 102,655,725 (-)EnsemblGRCh38hg38GRCh38
GRCh388102,648,784 - 102,655,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378103,661,012 - 103,667,953 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,730,188 - 103,737,128 (-)NCBINCBI36hg18NCBI36
Build 348103,730,196 - 103,737,128NCBI
Celera899,848,329 - 99,855,302 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef898,862,246 - 98,869,150 (-)NCBIHuRef
CHM1_18103,701,211 - 103,708,326 (-)NCBICHM1_1
Klf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391538,291,708 - 38,300,955 (-)NCBIGRCm39mm39
GRCm39 Ensembl1538,291,707 - 38,300,950 (-)Ensembl
GRCm381538,291,464 - 38,300,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1538,291,463 - 38,300,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv371538,224,168 - 38,230,462 (-)NCBIGRCm37mm9NCBIm37
MGSCv361538,239,002 - 38,245,296 (-)NCBImm8
Celera1538,920,503 - 38,926,796 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
Klf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2769,467,658 - 69,473,726 (-)NCBI
Rnor_6.0 Ensembl777,156,006 - 77,162,148 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0777,156,010 - 77,162,096 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0777,258,859 - 77,265,053 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4773,821,190 - 73,826,866 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1773,842,010 - 73,847,864 (-)NCBI
Celera766,529,946 - 66,535,877 (-)NCBICelera
RH 3.4 Map7631.6RGD
Cytogenetic Map7q22NCBI
Klf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541727,164,839 - 27,168,604 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541727,165,146 - 27,168,604 (-)NCBIChiLan1.0ChiLan1.0
KLF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18101,462,915 - 101,469,965 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,462,915 - 101,469,982 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0899,302,943 - 99,310,099 (-)NCBIMhudiblu_PPA_v0panPan3
KLF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1134,216,745 - 4,223,708 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl134,218,084 - 4,223,691 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha134,218,182 - 4,224,873 (-)NCBI
ROS_Cfam_1.0134,376,923 - 4,383,610 (-)NCBI
UMICH_Zoey_3.1134,219,256 - 4,225,960 (-)NCBI
UNSW_CanFamBas_1.0134,336,504 - 4,343,201 (-)NCBI
UU_Cfam_GSD_1.0134,349,283 - 4,355,987 (-)NCBI
Klf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,554,546 - 33,560,778 (+)NCBI
SpeTri2.0NW_00493647040,980,487 - 40,986,880 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,421,359 - 34,436,009 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1434,430,132 - 34,435,990 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,443,363 - 37,449,221 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLF10
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,496,695 - 97,503,818 (-)NCBI
ChlSab1.1 Ensembl897,496,678 - 97,503,620 (-)Ensembl
Klf10
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476319,582,019 - 19,592,447 (-)NCBI

Position Markers
SGC30492  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378103,661,015 - 103,661,153UniSTSGRCh37
Build 368103,730,191 - 103,730,329RGDNCBI36
Celera899,848,339 - 99,848,477RGD
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map8q22.2UniSTS
HuRef898,862,256 - 98,862,394UniSTS
GeneMap99-GB4 RH Map8440.12UniSTS
Whitehead-RH Map8573.8UniSTS
NCBI RH Map81090.6UniSTS
TIEG__5259  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378103,660,911 - 103,661,798UniSTSGRCh37
Build 368103,730,087 - 103,730,974RGDNCBI36
Celera899,848,235 - 99,849,116RGD
HuRef898,862,152 - 98,863,039UniSTS
A006S39  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378103,661,179 - 103,661,292UniSTSGRCh37
Build 368103,730,355 - 103,730,468RGDNCBI36
Celera899,848,503 - 99,848,616RGD
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map8q22.2UniSTS
HuRef898,862,420 - 98,862,533UniSTS
GeneMap99-GB4 RH Map8438.18UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:962
Count of miRNA genes:377
Interacting mature miRNAs:424
Transcripts:ENST00000285407, ENST00000395884
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 2
Medium 2400 2294 1621 536 1468 390 4333 1995 1194 387 1380 1604 159 1201 2769 4
Low 32 690 102 86 479 74 22 198 2509 30 66 5 12 3 19
Below cutoff 2 3 1 3 1 3 11 2 4 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_033271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001032282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_103759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_103760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF050110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI560615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ575313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA720479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA756360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF546210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF546211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U21847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000285407   ⟹   ENSP00000285407
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,648,784 - 102,655,725 (-)Ensembl
RefSeq Acc Id: ENST00000395884   ⟹   ENSP00000379222
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,648,786 - 102,654,375 (-)Ensembl
RefSeq Acc Id: NM_001032282   ⟹   NP_001027453
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,648,784 - 102,653,743 (-)NCBI
GRCh378103,661,005 - 103,668,130 (-)NCBI
Build 368103,730,188 - 103,735,195 (-)NCBI Archive
HuRef898,862,246 - 98,869,150 (-)NCBI
CHM1_18103,701,211 - 103,706,388 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005655   ⟹   NP_005646
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,648,784 - 102,655,725 (-)NCBI
GRCh378103,661,005 - 103,668,130 (-)NCBI
Build 368103,730,197 - 103,737,128 (-)NCBI Archive
HuRef898,862,246 - 98,869,150 (-)NCBI
CHM1_18103,701,211 - 103,708,326 (-)NCBI
Sequence:
RefSeq Acc Id: NR_103759
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,648,784 - 102,653,743 (-)NCBI
GRCh378103,661,005 - 103,668,130 (-)NCBI
HuRef898,862,246 - 98,869,150 (-)NCBI
CHM1_18103,701,211 - 103,706,388 (-)NCBI
Sequence:
RefSeq Acc Id: NR_103760
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,648,784 - 102,653,743 (-)NCBI
GRCh378103,661,005 - 103,668,130 (-)NCBI
HuRef898,862,246 - 98,869,150 (-)NCBI
CHM1_18103,701,211 - 103,706,388 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005646   ⟸   NM_005655
- Peptide Label: isoform a
- UniProtKB: Q13118 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001027453   ⟸   NM_001032282
- Peptide Label: isoform b
- UniProtKB: Q13118 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000285407   ⟸   ENST00000285407
RefSeq Acc Id: ENSP00000379222   ⟸   ENST00000395884

Promoters
RGD ID:7213931
Promoter ID:EPDNEW_H12711
Type:initiation region
Name:KLF10_1
Description:Kruppel like factor 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,655,723 - 102,655,783EPDNEW
RGD ID:6814799
Promoter ID:HG_XEF:8053
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_031135
Position:
Human AssemblyChrPosition (strand)Source
Build 368103,734,221 - 103,734,721 (-)MPROMDB
RGD ID:6806829
Promoter ID:HG_KWN:61844
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001032282,   UC003YKU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 368103,735,286 - 103,736,307 (-)MPROMDB
RGD ID:6806831
Promoter ID:HG_KWN:61845
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_005655,   UC003YKV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 368103,737,056 - 103,738,072 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q22.3(chr8:101962098-103357772)x3 copy number gain See cases [RCV000050760] Chr8:101962098..103357772 [GRCh38]
Chr8:102974326..104370000 [GRCh37]
Chr8:103043502..104439176 [NCBI36]
Chr8:8q22.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q22.3-23.1(chr8:101884819-107356143)x1 copy number loss See cases [RCV000134099] Chr8:101884819..107356143 [GRCh38]
Chr8:102897047..108368371 [GRCh37]
Chr8:102966223..108437547 [NCBI36]
Chr8:8q22.3-23.1
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q22.3-23.1(chr8:101199826-105802098)x1 copy number loss See cases [RCV000136812] Chr8:101199826..105802098 [GRCh38]
Chr8:102212054..106814326 [GRCh37]
Chr8:102281230..106883502 [NCBI36]
Chr8:8q22.3-23.1
pathogenic
GRCh38/hg38 8q22.3-23.1(chr8:101171263-109127664)x1 copy number loss See cases [RCV000138134] Chr8:101171263..109127664 [GRCh38]
Chr8:102183491..110139893 [GRCh37]
Chr8:102252667..110209069 [NCBI36]
Chr8:8q22.3-23.1
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8q22.2-23.1(chr8:100179408-106524667)x1 copy number loss See cases [RCV000141697] Chr8:100179408..106524667 [GRCh38]
Chr8:101191636..107536895 [GRCh37]
Chr8:101260812..107606071 [NCBI36]
Chr8:8q22.2-23.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.3(chr8:103131039-103661336)x3 copy number gain See cases [RCV000447650] Chr8:103131039..103661336 [GRCh37]
Chr8:8q22.3
uncertain significance
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.3(chr8:102590127-104034598)x1 copy number loss See cases [RCV000511503] Chr8:102590127..104034598 [GRCh37]
Chr8:8q22.3
likely pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q22.3(chr8:102584167-104236192)x1 copy number loss not provided [RCV000683013] Chr8:102584167..104236192 [GRCh37]
Chr8:8q22.3
likely pathogenic
GRCh37/hg19 8q22.2-22.3(chr8:100551211-103676738)x1 copy number loss not provided [RCV000683023] Chr8:100551211..103676738 [GRCh37]
Chr8:8q22.2-22.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8q22.3(chr8:103560355-103697253)x1 copy number loss not provided [RCV001006127] Chr8:103560355..103697253 [GRCh37]
Chr8:8q22.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11810 AgrOrtholog
COSMIC KLF10 COSMIC
Ensembl Genes ENSG00000155090 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000285407 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000379222 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000285407 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000395884 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000155090 GTEx
HGNC ID HGNC:11810 ENTREZGENE
Human Proteome Map KLF10 Human Proteome Map
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report hsa:7071 UniProtKB/Swiss-Prot
NCBI Gene 7071 ENTREZGENE
OMIM 601878 OMIM
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PharmGKB PA36517 PharmGKB
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt KLF10_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A8MVH0 UniProtKB/Swiss-Prot
  B2R794 UniProtKB/Swiss-Prot
  L0R4P6 UniProtKB/Swiss-Prot
  L0R679 UniProtKB/Swiss-Prot
  O75411 UniProtKB/Swiss-Prot
  Q503B2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-07 KLF10  Kruppel like factor 10    Kruppel-like factor 10  Symbol and/or name change 5135510 APPROVED