Pde7b (phosphodiesterase 7B) - Rat Genome Database

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Gene: Pde7b (phosphodiesterase 7B) Rattus norvegicus
Analyze
Symbol: Pde7b
Name: phosphodiesterase 7B
RGD ID: 621016
Description: Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in negative regulation of cAMP/PKA signal transduction. Orthologous to human PDE7B (phosphodiesterase 7B); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3',5'-cyclic-AMP phosphodiesterase 7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pde7b_v2 ; Pde7b_v3 ; Pde7b_v1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8116,994,072 - 17,312,828 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl117,002,286 - 17,312,456 (-)EnsemblGRCr8
mRatBN7.2115,174,001 - 15,493,267 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl115,182,704 - 15,492,900 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx114,936,547 - 15,247,768 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0120,938,474 - 21,249,645 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0115,162,548 - 15,472,725 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0115,889,845 - 16,203,909 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,893,533 - 16,203,909 (-)Ensemblrn6Rnor6.0
Rnor_5.0117,438,266 - 17,650,404 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4115,701,127 - 15,929,632 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera113,613,403 - 13,825,920 (-)NCBICelera
RGSC_v3.1115,701,194 - 15,929,679NCBI
Cytogenetic Map1p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dipyridamole  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
papaverine  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
Vinpocetine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Novel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-specific expression and phosphorylation. Sasaki T, etal., Biochem J 2002 Jan 15;361(Pt 2):211-20.
Additional References at PubMed
PMID:10872825   PMID:15056290   PMID:19913519  


Genomics

Comparative Map Data
Pde7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8116,994,072 - 17,312,828 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl117,002,286 - 17,312,456 (-)EnsemblGRCr8
mRatBN7.2115,174,001 - 15,493,267 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl115,182,704 - 15,492,900 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx114,936,547 - 15,247,768 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0120,938,474 - 21,249,645 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0115,162,548 - 15,472,725 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0115,889,845 - 16,203,909 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,893,533 - 16,203,909 (-)Ensemblrn6Rnor6.0
Rnor_5.0117,438,266 - 17,650,404 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4115,701,127 - 15,929,632 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera113,613,403 - 13,825,920 (-)NCBICelera
RGSC_v3.1115,701,194 - 15,929,679NCBI
Cytogenetic Map1p12NCBI
PDE7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386135,851,701 - 136,195,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6135,851,701 - 136,195,574 (+)Ensemblhg38GRCh38
GRCh376136,172,839 - 136,516,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366136,214,527 - 136,558,402 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346136,214,526 - 136,558,402NCBI
Celera6136,913,199 - 137,257,146 (+)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6133,737,120 - 134,081,400 (+)NCBIHuRef
CHM1_16136,435,326 - 136,779,229 (+)NCBICHM1_1
T2T-CHM13v2.06137,039,966 - 137,383,688 (+)NCBIT2T-CHM13v2.0
Pde7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391020,272,798 - 20,600,824 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1020,273,750 - 20,600,824 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381020,397,052 - 20,725,078 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1020,398,004 - 20,725,078 (-)Ensemblmm10GRCm38
MGSCv371020,117,810 - 20,444,874 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361020,087,420 - 20,414,494 (-)NCBIMGSCv36mm8
Celera1020,287,078 - 20,614,904 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map109.75NCBI
Pde7b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955439686,130 - 985,732 (-)Ensembl
ChiLan1.0NW_004955439686,197 - 985,591 (-)NCBIChiLan1.0ChiLan1.0
PDE7B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25155,820,649 - 156,166,366 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16153,720,560 - 154,065,701 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06133,615,008 - 133,960,120 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16137,707,611 - 138,049,929 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6137,707,863 - 138,047,756 (+)EnsemblpanPan2panpan1.1
PDE7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1128,479,641 - 28,795,644 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl128,479,968 - 28,792,008 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha129,359,759 - 29,673,797 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0128,635,495 - 28,950,152 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl128,635,503 - 28,950,201 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1128,521,375 - 28,837,232 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0128,406,547 - 28,720,220 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0128,712,981 - 29,020,890 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pde7b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946123,544,020 - 123,853,873 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365603,323,230 - 3,633,251 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365603,323,264 - 3,633,083 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE7B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl127,958,270 - 28,302,666 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1127,958,261 - 28,425,754 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2131,384,842 - 31,434,768 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE7B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11337,230,419 - 37,560,391 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1337,226,606 - 37,378,218 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660409,418,592 - 9,751,149 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde7b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248861,473,491 - 1,827,688 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248861,474,076 - 1,827,608 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pde7b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12215,870,960 - 216,183,235 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pde7b
1342 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:101
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000018556
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
D1Rat186  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2115,321,100 - 15,321,325 (+)MAPPERmRatBN7.2
Rnor_6.0116,033,078 - 16,033,302NCBIRnor6.0
Rnor_5.0117,574,243 - 17,574,467UniSTSRnor5.0
RGSC_v3.4115,833,442 - 15,833,667RGDRGSC3.4
RGSC_v3.4115,833,443 - 15,833,667UniSTSRGSC3.4
Celera113,748,791 - 13,749,015UniSTS
RGSC_v3.1115,833,505 - 15,833,729RGD
RH 3.4 Map1166.11RGD
RH 3.4 Map1166.11UniSTS
RH 2.0 Map183.1RGD
SHRSP x BN Map111.45RGD
Cytogenetic Map1p12UniSTS
D1Rat150  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8117,065,183 - 17,065,426 (+)Marker Load Pipeline
mRatBN7.2115,245,598 - 15,245,841 (+)MAPPERmRatBN7.2
Rnor_6.0115,955,566 - 15,955,808NCBIRnor6.0
Rnor_5.0117,499,606 - 17,499,848UniSTSRnor5.0
RGSC_v3.4115,786,924 - 15,787,282RGDRGSC3.4
RGSC_v3.4115,786,927 - 15,787,169UniSTSRGSC3.4
RGSC_v3.1115,786,989 - 15,787,231RGD
RH 3.4 Map1148.43UniSTS
RH 3.4 Map1148.43RGD
RH 2.0 Map177.2RGD
SHRSP x BN Map111.4099RGD
Cytogenetic Map1p12UniSTS
D1Got18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2115,218,672 - 15,218,826 (+)MAPPERmRatBN7.2
Rnor_6.0115,928,984 - 15,929,137NCBIRnor6.0
Rnor_5.0117,473,101 - 17,473,254UniSTSRnor5.0
RGSC_v3.4115,759,773 - 15,759,927RGDRGSC3.4
RGSC_v3.4115,759,774 - 15,759,927UniSTSRGSC3.4
Celera113,648,764 - 13,648,917UniSTS
RGSC_v3.1115,759,836 - 15,759,989RGD
RH 3.4 Map1147.61UniSTS
RH 3.4 Map1147.61RGD
RH 2.0 Map173.9RGD
Cytogenetic Map1p12UniSTS
D1Got21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2115,313,278 - 15,313,403 (+)MAPPERmRatBN7.2
Rnor_6.0116,025,256 - 16,025,380NCBIRnor6.0
Rnor_5.0117,566,421 - 17,566,545UniSTSRnor5.0
RGSC_v3.4115,825,620 - 15,825,745RGDRGSC3.4
RGSC_v3.4115,825,621 - 15,825,745UniSTSRGSC3.4
Celera113,740,969 - 13,741,093UniSTS
RGSC_v3.1115,825,683 - 15,825,807RGD
RH 3.4 Map1164.3UniSTS
RH 3.4 Map1164.3RGD
RH 2.0 Map184.2RGD
Cytogenetic Map1p12UniSTS
D1Got20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2115,341,811 - 15,342,030 (+)MAPPERmRatBN7.2
Rnor_6.0116,053,785 - 16,054,003NCBIRnor6.0
Rnor_5.0117,594,950 - 17,595,168UniSTSRnor5.0
RGSC_v3.4115,854,109 - 15,854,399RGDRGSC3.4
RGSC_v3.4115,854,110 - 15,854,328UniSTSRGSC3.4
Celera113,769,427 - 13,769,645UniSTS
RGSC_v3.1115,854,172 - 15,854,390RGD
RH 3.4 Map1166.11RGD
RH 3.4 Map1166.11UniSTS
Cytogenetic Map1p12UniSTS
D1Ztm10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2115,248,417 - 15,248,567 (+)MAPPERmRatBN7.2
mRatBN7.2X30,661,961 - 30,662,016 (+)MAPPERmRatBN7.2
Rnor_6.0115,960,444 - 15,960,595NCBIRnor6.0
Rnor_5.0117,501,719 - 17,501,870UniSTSRnor5.0
Celera113,676,385 - 13,676,536UniSTS
Cytogenetic Map1p12UniSTS
D1Ztm8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2115,202,832 - 15,203,054 (+)MAPPERmRatBN7.2
Rnor_6.0115,913,643 - 15,913,864NCBIRnor6.0
Rnor_5.0117,458,256 - 17,458,477UniSTSRnor5.0
RGSC_v3.4115,722,312 - 15,722,533UniSTSRGSC3.4
Celera113,633,354 - 13,633,575UniSTS
Cytogenetic Map1p12UniSTS
D1Ztm9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2115,188,935 - 15,189,169 (+)MAPPERmRatBN7.2
Rnor_6.0115,899,765 - 15,899,998NCBIRnor6.0
Rnor_5.0117,444,498 - 17,444,731UniSTSRnor5.0
RGSC_v3.4115,707,359 - 15,707,592UniSTSRGSC3.4
Celera113,619,635 - 13,619,868UniSTS
Cytogenetic Map1p12UniSTS
BF397880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2115,340,378 - 15,340,529 (+)MAPPERmRatBN7.2
Rnor_6.0116,052,352 - 16,052,502NCBIRnor6.0
Rnor_5.0117,593,517 - 17,593,667UniSTSRnor5.0
RGSC_v3.4115,852,677 - 15,852,827UniSTSRGSC3.4
Celera113,767,994 - 13,768,144UniSTS
RH 3.4 Map1166.22UniSTS
Cytogenetic Map1p12UniSTS
RH135386  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2115,329,499 - 15,329,683 (+)MAPPERmRatBN7.2
Rnor_6.0116,041,474 - 16,041,657NCBIRnor6.0
Rnor_5.0117,582,639 - 17,582,822UniSTSRnor5.0
RGSC_v3.4115,841,799 - 15,841,982UniSTSRGSC3.4
Celera113,757,116 - 13,757,299UniSTS
RH 3.4 Map1164.4UniSTS
Cytogenetic Map1p12UniSTS
AU049907  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2115,218,598 - 15,218,801 (+)MAPPERmRatBN7.2
Rnor_6.0115,928,910 - 15,929,112NCBIRnor6.0
Rnor_5.0117,473,027 - 17,473,229UniSTSRnor5.0
RGSC_v3.4115,759,700 - 15,759,902UniSTSRGSC3.4
Celera113,648,690 - 13,648,892UniSTS
Cytogenetic Map1p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 90 59 6 354 190 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018556   ⟹   ENSRNOP00000018556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl117,002,286 - 17,312,386 (-)Ensembl
mRatBN7.2 Ensembl115,182,704 - 15,492,830 (-)Ensembl
Rnor_6.0 Ensembl115,893,533 - 16,203,838 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078586   ⟹   ENSRNOP00000070401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl117,002,286 - 17,312,456 (-)Ensembl
mRatBN7.2 Ensembl115,182,704 - 15,492,900 (-)Ensembl
Rnor_6.0 Ensembl115,893,533 - 16,203,909 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101303   ⟹   ENSRNOP00000094058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl117,002,286 - 17,148,675 (-)Ensembl
mRatBN7.2 Ensembl115,182,704 - 15,397,916 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113170   ⟹   ENSRNOP00000083905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl115,182,704 - 15,336,818 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117741   ⟹   ENSRNOP00000088274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl117,002,286 - 17,081,621 (-)Ensembl
mRatBN7.2 Ensembl115,182,704 - 15,292,530 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000133196   ⟹   ENSRNOP00000112398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl117,002,584 - 17,312,456 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000151353   ⟹   ENSRNOP00000108964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl117,005,434 - 17,312,456 (-)Ensembl
RefSeq Acc Id: NM_080894   ⟹   NP_543170
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8117,002,286 - 17,312,456 (-)NCBI
mRatBN7.2115,182,704 - 15,492,900 (-)NCBI
Rnor_6.0115,893,533 - 16,203,909 (-)NCBI
Rnor_5.0117,438,266 - 17,650,404 (-)NCBI
RGSC_v3.4115,701,127 - 15,929,632 (-)RGD
Celera113,613,403 - 13,825,920 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758591   ⟹   XP_008756813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,999,296 - 17,156,353 (-)NCBI
mRatBN7.2115,179,711 - 15,332,491 (-)NCBI
Rnor_6.0115,889,845 - 16,041,143 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758592   ⟹   XP_008756814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,999,296 - 17,082,768 (-)NCBI
mRatBN7.2115,179,711 - 15,263,151 (-)NCBI
Rnor_6.0115,889,845 - 15,975,193 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082826   ⟹   XP_038938754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,994,072 - 17,156,368 (-)NCBI
mRatBN7.2115,174,001 - 15,332,499 (-)NCBI
RefSeq Acc Id: XM_039082864   ⟹   XP_038938792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,999,296 - 17,312,828 (-)NCBI
mRatBN7.2115,179,711 - 15,493,267 (-)NCBI
RefSeq Acc Id: XM_039082890   ⟹   XP_038938818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,999,296 - 17,083,365 (-)NCBI
mRatBN7.2115,179,711 - 15,263,752 (-)NCBI
RefSeq Acc Id: XR_005488707
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,994,072 - 17,156,368 (-)NCBI
mRatBN7.2115,174,263 - 15,332,499 (-)NCBI
RefSeq Acc Id: NP_543170   ⟸   NM_080894
- UniProtKB: Q8VIE4 (UniProtKB/TrEMBL),   A6JPD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008756813   ⟸   XM_008758591
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWQ4 (UniProtKB/TrEMBL),   A6JPD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008756814   ⟸   XM_008758592
- Peptide Label: isoform X4
- UniProtKB: Q8VIE3 (UniProtKB/TrEMBL),   A0A8I6A9G5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018556   ⟸   ENSRNOT00000018556
Ensembl Acc Id: ENSRNOP00000070401   ⟸   ENSRNOT00000078586
RefSeq Acc Id: XP_038938754   ⟸   XM_039082826
- Peptide Label: isoform X2
- UniProtKB: A6JPD3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938792   ⟸   XM_039082864
- Peptide Label: isoform X3
- UniProtKB: F1LN39 (UniProtKB/TrEMBL),   Q8VIE2 (UniProtKB/TrEMBL),   A0A8I6AIQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938818   ⟸   XM_039082890
- Peptide Label: isoform X4
- UniProtKB: Q8VIE3 (UniProtKB/TrEMBL),   A0A8I6A9G5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088274   ⟸   ENSRNOT00000117741
Ensembl Acc Id: ENSRNOP00000083905   ⟸   ENSRNOT00000113170
Ensembl Acc Id: ENSRNOP00000094058   ⟸   ENSRNOT00000101303
Ensembl Acc Id: ENSRNOP00000112398   ⟸   ENSRNOT00000133196
Ensembl Acc Id: ENSRNOP00000108964   ⟸   ENSRNOT00000151353
Protein Domains
PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VIE2-F1-model_v2 AlphaFold Q8VIE2 1-459 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621016 AgrOrtholog
BioCyc Gene G2FUF-62193 BioCyc
Ensembl Genes ENSRNOG00000013436 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018556 ENTREZGENE
  ENSRNOT00000018556.8 UniProtKB/TrEMBL
  ENSRNOT00000078586 ENTREZGENE
  ENSRNOT00000078586.3 UniProtKB/TrEMBL
  ENSRNOT00000101303 ENTREZGENE
  ENSRNOT00000101303.2 UniProtKB/TrEMBL
  ENSRNOT00000117741 ENTREZGENE
  ENSRNOT00000117741.2 UniProtKB/TrEMBL
  ENSRNOT00000133196.1 UniProtKB/TrEMBL
  ENSRNOT00000151353.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
InterPro Metal-dep_PHydrolase_HD_dom UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
KEGG Report rno:140929 UniProtKB/TrEMBL
NCBI Gene 140929 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/TrEMBL
Pfam PDEase_I UniProtKB/TrEMBL
PhenoGen Pde7b PhenoGen
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013436 RatGTEx
SMART HDc UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/TrEMBL
UniProt A0A8I5ZWQ4 ENTREZGENE
  A0A8I6A9G5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIQ8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LVF1_RAT UniProtKB/TrEMBL
  A0ABK0M2T3_RAT UniProtKB/TrEMBL
  A6JPD2 ENTREZGENE, UniProtKB/TrEMBL
  A6JPD3 ENTREZGENE, UniProtKB/TrEMBL
  F1LN39 ENTREZGENE
  Q8VIE2 ENTREZGENE, UniProtKB/TrEMBL
  Q8VIE3 ENTREZGENE, UniProtKB/TrEMBL
  Q8VIE4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LN39 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pde7b  phosphodiesterase 7B      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pde7b  phosphodiesterase 7B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in the striatum and testis 625534