Advanced Search (OLGA)

Gene: Adcy2 (adenylate cyclase 2) Rattus norvegicus

Analyze

Symbol:

Adcy2

Name:

adenylate cyclase 2

RGD ID:

619965

Description:

Enables several functions, including G-protein beta/gamma-subunit complex binding activity; adenylate cyclase binding activity; and metal ion binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and cellular response to forskolin. Located in membrane raft and plasma membrane. Part of protein-containing complex. Orthologous to human ADCY2 (adenylate cyclase 2); PARTICIPATES IN adenosine signaling pathway; dopamine signaling pathway via D1 family of receptors; endothelin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AC2; adenylate cyclase 2 (brain); adenylate cyclase type 2; adenylate cyclase type II; adenylyl cyclase 2; ATP pyrophosphate-lyase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADCY2 (adenylate cyclase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Adcy2 (adenylate cyclase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Adcy2 (adenylate cyclase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADCY2 (adenylate cyclase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADCY2 (adenylate cyclase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adcy2 (adenylate cyclase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADCY2 (adenylate cyclase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADCY2 (adenylate cyclase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adcy2 (adenylate cyclase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Adcy2 (adenylate cyclase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	OR2T29 (olfactory receptor family 2 subfamily T member 29)	HGNC	OMA
Homo sapiens (human):	OR2T5 (olfactory receptor family 2 subfamily T member 5)	HGNC	OMA
Homo sapiens (human):	OR2T4 (olfactory receptor family 2 subfamily T member 4)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ADCY2 (adenylate cyclase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Adcy2 (adenylate cyclase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	adcy2a (adenylate cyclase 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	adcy2b (adenylate cyclase 2b (brain))	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	acy-4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ACXA	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	ACXB	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	ACXD	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ac76E	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ac76E	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG32305	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	acy-2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	acy-2	Alliance	DIOPT (Ensembl Compara\|OMA\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	36,204,054 - 36,650,645 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	36,204,054 - 36,650,645 (+)	Ensembl				GRCr8
mRatBN7.2	1	34,375,639 - 34,822,252 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	34,375,895 - 34,822,236 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	34,237,007 - 34,683,571 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	40,227,844 - 40,674,423 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	34,402,593 - 34,849,151 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	37,043,071 - 37,698,390 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	37,507,276 - 37,698,390 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	39,075,253 - 39,080,014 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	1	38,434,800 - 39,001,909 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	4,543,466 - 5,040,433 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	32,960,049 - 33,391,637 (+)	NCBI		Celera
Cytogenetic Map	1	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asthma (ISO)

bipolar disorder (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

allethrin (EXP)

alpha-amanitin (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

amphotericin B (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

Butylbenzyl phthalate (EXP)

choline (ISO)

clofibrate (ISO)

clothianidin (ISO)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

cyhalothrin (EXP)

cypermethrin (EXP)

dextran sulfate (ISO)

diazinon (EXP)

dichlorine (EXP)

divanadium pentaoxide (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

entinostat (ISO)

ethanol (EXP,ISO)

fenvalerate (EXP)

flavonoids (EXP)

folic acid (ISO)

fonofos (ISO)

genistein (EXP,ISO)

L-methionine (ISO)

lead(0) (ISO)

maneb (ISO)

mercury dibromide (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

miconazole (EXP)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (EXP,ISO)

paraquat (ISO)

parathion (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenethyl caffeate (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (EXP)

pyrethrins (EXP)

raloxifene (EXP)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (EXP)

sodium arsenite (ISO)

sunitinib (ISO)

terbufos (ISO)

titanium dioxide (ISO)

topotecan (EXP)

tributylstannane (EXP)

trichloroethene (EXP)

triclosan (ISO)

triptonide (ISO)

valproic acid (ISO)

vitamin E (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IBA,IDA)

adenylate cyclase-modulating G protein-coupled receptor signaling pathway (IDA,IEA)

cAMP biosynthetic process (IBA,IDA,IEA)

cellular response to forskolin (IDA)

cyclic nucleotide biosynthetic process (IEA)

intracellular signal transduction (IEA)

Cellular Component

cytoplasm (IEA,ISO)

dendrite (ISO,ISS)

membrane (IDA,IEA,ISO,ISS)

membrane raft (IDA)

plasma membrane (IBA,IDA,IEA,ISO)

protein-containing complex (IDA)

Molecular Function

adenylate cyclase activity (IBA,IDA,IEA)

adenylate cyclase binding (IDA,IEA,ISO)

ATP binding (IEA)

G-protein beta/gamma-subunit complex binding (IEA,IPI)

lyase activity (IEA)

magnesium ion binding (IDA)

manganese ion binding (IDA)

metal ion binding (IEA)

nucleotide binding (IEA)

phosphorus-oxygen lyase activity (IEA)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

adenosine signaling pathway (ISO)

bile acid transport pathway (IEA)

calcium/calcium-mediated signaling pathway (IEA)

chemokine mediated signaling pathway (IEA)

dilated cardiomyopathy pathway (IEA)

dopamine signaling pathway via D1 family of receptors (ISO)

endothelin signaling pathway (ISO)

follicle-stimulating hormone signaling pathway (ISO)

G protein mediated signaling pathway via Galphas family (ISO)

glutamate signaling pathway (IEA)

gonadotropin-releasing hormone signaling pathway (IEA)

histamine signaling pathway, immunological (ISO)

luteinizing hormone signaling pathway (ISO)

melanocortin system pathway (ISO)

prostaglandin D2 signaling pathway (ISO)

prostaglandin I2 signaling pathway (ISO)

protein kinase A (PKA) signaling pathway (ISO)

purine metabolic pathway (IEA)

serotonin signaling pathway via receptors engaging G alphas protein family (ISO)

vasopressin signaling pathway via receptor type 2 (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.	Baragli A, etal., Cell Signal. 2008 Mar;20(3):480-92. doi: 10.1016/j.cellsig.2007.10.033. Epub 2007 Nov 22.
2.	A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits.	Chen J, etal., Science. 1995 May 26;268(5214):1166-9.
3.	Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain.	Feinstein PG, etal., Proc Natl Acad Sci U S A 1991 Nov 15;88(22):10173-7.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex.	Halls ML and Cooper DM, EMBO J. 2010 Aug 18;29(16):2772-87. doi: 10.1038/emboj.2010.168. Epub 2010 Jul 27.
7.	Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries.	Jourdan KB, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1359-69.
8.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts.	Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
12.	The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain.	Piggott LA, etal., Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13835-40. Epub 2008 Sep 4.
13.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
14.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
16.	GOA pipeline	RGD automated data pipeline
17.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
19.	Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.	Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
20.	Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes.	Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
21.	Two-metal-Ion catalysis in adenylyl cyclase.	Tesmer JJ, etal., Science. 1999 Jul 30;285(5428):756-60.
22.	Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein.	Wang HY and Burns LH, J Neurobiol. 2006 Oct;66(12):1302-10.

Additional References at PubMed

PMID:9069282	PMID:9417641	PMID:9870949	PMID:11549699	PMID:19008230	PMID:22871113	PMID:22906005

Genomics

Comparative Map Data

Adcy2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	36,204,054 - 36,650,645 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	36,204,054 - 36,650,645 (+)	Ensembl				GRCr8
mRatBN7.2	1	34,375,639 - 34,822,252 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	34,375,895 - 34,822,236 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	34,237,007 - 34,683,571 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	40,227,844 - 40,674,423 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	34,402,593 - 34,849,151 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	37,043,071 - 37,698,390 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	37,507,276 - 37,698,390 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	39,075,253 - 39,080,014 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	1	38,434,800 - 39,001,909 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	4,543,466 - 5,040,433 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	32,960,049 - 33,391,637 (+)	NCBI		Celera
Cytogenetic Map	1	p11	NCBI

ADCY2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	7,396,138 - 7,830,081 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	7,395,681 - 7,830,081 (+)	Ensembl			hg38	GRCh38
GRCh37	5	7,396,251 - 7,830,194 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	7,449,343 - 7,883,194 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	7,449,344 - 7,883,194	NCBI
Celera	5	7,439,102 - 7,871,262 (+)	NCBI		Celera
Cytogenetic Map	5	p15.31	NCBI
HuRef	5	7,725,521 - 7,811,956 (+)	NCBI		HuRef
HuRef	5	7,378,757 - 7,709,814 (+)	NCBI		HuRef
CHM1_1	5	7,396,258 - 7,830,278 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	7,334,987 - 7,769,222 (+)	NCBI		T2T-CHM13v2.0

Adcy2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	68,768,162 - 69,147,719 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	68,768,162 - 69,147,660 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	68,620,043 - 68,999,600 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	68,620,043 - 68,999,541 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	68,758,920 - 69,138,419 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	69,087,431 - 69,466,658 (-)	NCBI		MGSCv36	mm8
Celera	13	70,976,336 - 71,362,097 (-)	NCBI		Celera
Cytogenetic Map	13	B3	NCBI
cM Map	13	35.55	NCBI

Adcy2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955504	5,004,903 - 5,376,328 (+)	Ensembl
ChiLan1.0	NW_004955504	4,990,634 - 5,376,990 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADCY2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	7,647,272 - 8,082,790 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	5,800,880 - 6,236,399 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	7,718,581 - 8,154,006 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	7,540,762 - 7,975,853 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	7,540,790 - 7,975,853 (+)	Ensembl			panPan2	panpan1.1

ADCY2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	6,139,931 - 6,527,677 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	6,140,276 - 6,527,677 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	10,648,056 - 11,035,866 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	6,045,474 - 6,434,089 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	6,045,476 - 6,434,095 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	6,095,233 - 6,483,250 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	6,075,965 - 6,464,063 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	6,288,901 - 6,677,489 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Adcy2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	239,063,958 - 239,560,683 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936643	47,837 - 339,007 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936643	47,830 - 338,891 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADCY2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	74,306,418 - 74,729,974 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	74,305,729 - 74,729,999 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	80,359,861 - 80,498,999 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADCY2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	6,989,077 - 7,415,282 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	6,989,169 - 7,414,617 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666064	21,200,037 - 21,628,571 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adcy2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624751	5,004,263 - 5,413,994 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624751	5,004,186 - 5,409,891 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Adcy2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	199,950,682 - 200,361,187 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Adcy2
5776 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	500
Count of miRNA genes:	246
Interacting mature miRNAs:	313
Transcripts:	ENSRNOT00000047627
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	7746118	52746118	Rat
1357397	Bw41	Body weight QTL 41	4.19	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	29409279	74409279	Rat
4889451	Eae29	Experimental allergic encephalomyelitis QTL 29	5.51		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	1	7746121	52746121	Rat
70179	Xhs2	X-ray hypersensitivity QTL 2	3.2		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	1	1	43965634	Rat
1558642	Prcr2	Prostate cancer resistance QTL 2	4.3		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	1	10379492	55379492	Rat
7421626	Bp360	Blood pressure QTL 360		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	6941022	51941022	Rat
1357401	Bw43	Body weight QTL 43	3.75		body mass (VT:0001259)	body weight (CMO:0000012)	1	6909353	51909353	Rat
631494	Bp95	Blood pressure QTL 95	40	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	17315378	51816258	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
5684998	Bss101	Bone structure and strength QTL 101	3.6		tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	1	6909353	51909353	Rat
5684999	Bss102	Bone structure and strength QTL 102	5.5	7e-07	tibia strength trait (VT:1000284)	tibia stiffness (CMO:0001735)	1	6909353	51909353	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
2302038	Pia31	Pristane induced arthritis QTL 31	5.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	1	12820494	57820494	Rat
634353	Rends2	Renal damage susceptibility QTL 2		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	1	20656420	65656420	Rat
1578756	Iddm22	Insulin dependent diabetes mellitus QTL 22	2.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	20508326	65508326	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	30708375	87558729	Rat
631508	Sald1	Serum aldosterone level QTL 1	3.7		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	1	11684464	56684464	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	34565726	79565726	Rat

Markers in Region

RH132673

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	34,821,898 - 34,822,099 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	37,698,053 - 37,698,253	NCBI	Rnor6.0
Rnor_5.0	1	39,079,677 - 39,079,877	UniSTS	Rnor5.0
RGSC_v3.4	17	5,040,096 - 5,040,296	UniSTS	RGSC3.4
Celera	1	33,391,300 - 33,391,500	UniSTS
Cytogenetic Map	17	p14	UniSTS

RH129915

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	34,722,815 - 34,723,021 (+)	MAPPER	mRatBN7.2
mRatBN7.2	15	29,079,099 - 29,079,905 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	34,266,157 - 34,266,962	NCBI	Rnor6.0
Rnor_6.0	1	37,559,558 - 37,559,763	NCBI	Rnor6.0
Rnor_5.0	15	38,156,352 - 38,157,157	UniSTS	Rnor5.0
Rnor_5.0	1	38,939,804 - 38,940,009	UniSTS	Rnor5.0
RGSC_v3.4	15	33,722,975 - 33,723,780	UniSTS	RGSC3.4
RGSC_v3.4	17	4,920,805 - 4,921,010	UniSTS	RGSC3.4
Celera	15	28,655,020 - 28,655,825	UniSTS
Celera	1	33,295,388 - 33,295,593	UniSTS
Cytogenetic Map	17	p14	UniSTS
Cytogenetic Map	15	p13	UniSTS

RH71322

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	34,722,825 - 34,722,996 (+)	MAPPER	mRatBN7.2
mRatBN7.2	13	38,190,170 - 38,190,341 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	43,080,194 - 43,080,364	NCBI	Rnor6.0
Rnor_6.0	1	37,559,568 - 37,559,738	NCBI	Rnor6.0
Rnor_5.0	13	48,181,613 - 48,181,783	UniSTS	Rnor5.0
Rnor_5.0	1	38,939,814 - 38,939,984	UniSTS	Rnor5.0
RGSC_v3.4	13	39,308,325 - 39,308,495	UniSTS	RGSC3.4
RGSC_v3.4	17	4,920,815 - 4,920,985	UniSTS	RGSC3.4
Celera	13	38,513,040 - 38,513,210	UniSTS
Celera	1	33,295,398 - 33,295,568	UniSTS
Cytogenetic Map	13	q11	UniSTS
Cytogenetic Map	17	p14	UniSTS
Cytogenetic Map	15	p13	UniSTS

MARC_4677-4678:996679594:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	34,722,607 - 34,722,680 (+)	MAPPER	mRatBN7.2
mRatBN7.2	15	29,080,316 - 29,081,409 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	34,267,374 - 34,268,466	NCBI	Rnor6.0
Rnor_6.0	1	37,559,350 - 37,559,422	NCBI	Rnor6.0
Rnor_5.0	15	38,157,569 - 38,158,661	UniSTS	Rnor5.0
Rnor_5.0	1	38,939,596 - 38,939,668	UniSTS	Rnor5.0
RGSC_v3.4	15	33,724,192 - 33,725,284	UniSTS	RGSC3.4
RGSC_v3.4	17	4,920,597 - 4,920,669	UniSTS	RGSC3.4
Celera	15	28,656,237 - 28,657,329	UniSTS
Celera	1	33,295,180 - 33,295,252	UniSTS
Cytogenetic Map	17	p14	UniSTS
Cytogenetic Map	15	p13	UniSTS

D5S1607E

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	34,693,066 - 34,694,119 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	37,516,712 - 37,517,764	NCBI	Rnor6.0
Rnor_5.0	1	38,896,677 - 38,897,729	UniSTS	Rnor5.0
RGSC_v3.4	17	4,888,656 - 4,889,708	UniSTS	RGSC3.4
Celera	1	33,265,638 - 33,266,690	UniSTS
Cytogenetic Map	17	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	66	160	90	89	58	37	58	6	298	136	11	139	80	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M80550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000047627 ⟹ ENSRNOP00000038994

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	36,204,054 - 36,650,645 (+)	Ensembl
mRatBN7.2 Ensembl	1	34,375,895 - 34,822,236 (+)	Ensembl
Rnor_6.0 Ensembl	1	37,507,276 - 37,698,390 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099050 ⟹ ENSRNOP00000090092

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	36,204,338 - 36,650,629 (+)	Ensembl
mRatBN7.2 Ensembl	1	34,375,895 - 34,822,236 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000127647 ⟹ ENSRNOP00000109970

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	36,204,144 - 36,650,630 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000173264 ⟹ ENSRNOP00000101380

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	36,204,054 - 36,650,645 (+)	Ensembl

RefSeq Acc Id:

NM_031007 ⟹ NP_112269

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	36,204,054 - 36,650,645 (+)	NCBI
mRatBN7.2	1	34,375,641 - 34,822,252 (+)	NCBI
Rnor_6.0	1	37,043,071 - 37,698,390 (+)	NCBI
Rnor_5.0	1	38,434,800 - 39,001,909 (+)	NCBI
Rnor_5.0	1	39,075,253 - 39,080,014 (+)	NCBI
RGSC_v3.4	17	4,543,466 - 5,040,433 (+)	RGD
Celera	1	32,960,049 - 33,391,637 (+)	NCBI

Sequence:

show sequence

CCCGGGCAGCGCGCTCTGCGGTCGCCTACCGCCTGCCGCCCCCGCGCCGCCGCGACGTGGCAGG
AGGCGATGCGGCGGCGCCGCTACCTGCGGGACCGCGCCGAGGCGGCGGCGGCAGCGGCGGCGGG
AGGCGGAGAGGGGCTGCAGCGGTCCCGGGACTGGCTCTACGAGTCCTACTACTGCATGAGCCAG
CAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCGCCTGCCTCGCCCTGCTAGCCG
TCTTCTTCGCGCTCGGGCTGGAGGTGGAAGACCATGTGGCATTTTTAATAACGGTTCCCACTGC
CCTGGCCATTTTCTTTGCCATATTCATTCTTGTCTGCATAGAGTCTGTGTTCAAGAAGCTACTC
CGTGTGTTTTCGCTGGTGATTTGGATATGTCTGGTTGCCATGGGATACCTGTTCATGTGCTTCG
GAGGGACTGTGTCTGCCTGGGACCAGGTGTCATTCTTCCTCTTCATCATCTTTGTGGTATATAC
CATGCTTCCCTTCAACATGCGAGATGCCATCATTGCCAGCATCCTCACATCTTCATCTCATACG
ATAGTGCTGAGCGTCTACCTGTCTGCAACACCAGGGGCCAAGGAGCACCTGTTCTGGCAGATAC
TGGCCAATGTGATCATTTTCATTTGTGGGAACTTGGCGGGAGCCTACCACAAGCACCTCATGGA
GCTTGCCTTGCAGCAAACCTATCGGGACACGTGTAATTGCATCAAGTCCCGGATCAAGCTGGAA
TTTGAAAAACGGCAGCAGGAACGGCTCCTGCTCTCCTTGCTGCCAGCTCACATCGCCATGGAGA
TGAAAGCTGAAATCATTCAGAGGCTGCAGGGCCCCAAAGCAGGACAGATGGAAAACACAAACAA
CTTCCACAATCTGTATGTCAAACGACACACCAACGTGAGCATATTATACGCTGACATTGTTGGC
TTCACCCGCCTTGCAAGCGATTGCTCCCCTGGCGAACTGGTCCACATGCTGAATGAACTCTTTG
GGAAGTTTGATCAAATAGCAAAGGAGAATGAATGCATGAGAATTAAAATTTTAGGAGACTGCTA
TTACTGTGTTTCCGGGCTCCCTATATCACTCCCTAACCATGCCAAGAACTGTGTGAAAATGGGA
TTGGATATGTGCGAAGCCATAAAGAAAGTGAGGGATGCTACCGGAGTTGATATCAACATGCGTG
TAGGAGTGCATTCTGGGAACGTTCTCTGTGGTGTGATTGGTCTCCAGAAGTGGCAGTATGATGT
GTGGTCTCATGATGTTACTCTGGCAAACCACATGGAAGCTGGAGGAGTCCCTGGGCGTGTTCAC
ATTTCTTCAGTCACTCTGGAGCACTTGAATGGGGCTTATAAAGTGGAGGAAGGAGATGGTGAGA
TAAGAGACCCATATTTAAAGCAGCACTTGGTGAAAACCTACTTTGTAATCAATCCCAAGGGAGA
GCGACGGAGTCCTCAGCATCTCTTCAGACCTCGACACACTCTGGACGGAGCCAAGATGAGAGCA
TCTGTCCGCATGACCCGGTACTTGGAGTCCTGGGGAGCAGCCAAGCCATTCGCACATCTGCACC
ACAGAGATAGCATGACCACAGAGAATGGGAAGATTAGTACCACGGATGTGCCAATGGGTCAACA
TAATTTTCAAAATCGCACCTTAAGAACTAAGTCACAGAAGAAGAGATTTGAAGAAGAACTGAAT
GAAAGGATGATCCAAGCAATTGATGGGATCAATGCACAGAAGCAATGGCTCAAGTCAGAAGACA
TTCAAAGAATCTCCCTGCTTTTCTATAACAAGAATATAGAGAAAGAATACCGAGCTACTGCACT
GCCAGCATTCAAGTACTACGTGACCTGTGCCTGCCTCATCTTTCTCTGCATCTTCATTGTACAG
ATACTTGTATTGCCAAAAACGTCCATCCTTGGCTTCTCCTTTGGAGCTGCATTTCTCTCCCTCA
TCTTCATCCTCTTTGTCTGCTTCGCTGGACAGCTTTTGCAATGCAGCAAAAAGGCCTCCACCTC
TCTCATGTGGCTTTTGAAATCATCAGGCATCATCGCCAACCGCCCATGGCCACGGATCTCCCTC
ACAATCGTCACCACGGCTATCATACTAACCATGGCTGTGTTCAACATGTTTTTCCTGAGCAACT
CTGAGGAGACAACCCTTCCCACTGCCAATACATCAAATGCAAACGTTTCTGTCCCGGATAACCA
GGCGTCGATTCTTCATGCTCGAAACTTGTTTTTCCTCCCGTACTTCATATACAGCTGCATCCTG
GGCTTGATCTCCTGCTCCGTTTTCCTGAGGGTGAACTATGAGTTAAAAATGTTAATCATGATGG
TGGCACTCGTGGGCTACAACACCATTCTACTCCACACCCATGCCCATGTTCTGGATGCGTACAG
CCAGGTCCTGTTTCAGAGACCAGGCATTTGGAAAGACCTGAAGACCATGGGCTCCGTGTCACTC
TCCATATTCTTCATCACGCTGCTGGTTCTGGGCAGACAGAGTGAATATTACTGTAGGTTAGACT
TCTTGTGGAAGAACAAGTTCAAAAAAGAGCGGGAGGAGATAGAAACCATGGAGAACCTAAATCG
AGTGCTGCTGGAGAACGTGCTTCCTGCACACGTGGCTGAACACTTCCTGGCCAGGAGCCTGAAA
AATGAGGAGCTGTACCACCAGTCCTACGACTGTGTCTGTGTCATGTTTGCCTCCATTCCGGACT
TCAAGGAGTTCTACACAGAGTCAGATGTGAACAAGGAAGGCTTGGAATGCCTGCGGCTCCTGAA
TGAGATCATTGCTGACTTTGATGATCTGCTTTCTAAGCCAAAGTTCAGTGGTGTTGAAAAGATC
AAGACCATTGGGAGCACATACATGGCAGCCACGGGACTGAGTGCCATACCCAGCCAGGAGCACG
CCCAGGAACCTGAGCGTCAGTACATGCACATAGGCACCATGGTGGAGTTTGCATATGCCCTGGT
GGGAAAACTGGATGCCATCAATAAGCACTCCTTCAACGACTTCAAACTGCGAGTGGGTATCAAC
CATGGGCCTGTAATAGCTGGCGTCATAGGGGCTCAAAAGCCACAGTATGACATCTGGGGCAACA
CTGTCAACGTGGCCAGCAGAATGGACAGCACCGGGGTCCTGGACAAAATACAGGTGACTGAGGA
GACAAGCCTCATCTTGCAGACGCTTGGCTACACGTGTACATGTCGAGGTATCATCAATGTGAAG
GGGAAAGGGGACCTGAAGACATATTTTGTAAACACAGAGATGTCAAGGTCCCTTTCTCAGAGCA
ACTTGGCATCCTGAGAAGCTGTCTCTTCCTGACAAGAAGAATGTACTTGCAGGAAGGTACCACG
CACTTTCTGACTGCAACCCTTCCCCTTCGTCCTGATGTACGTGCTCTGCCCCATCCTCTGGAGC
CCCTGCAGACTAGTTCCTGTGACCCAGTGACATACTGTTTGGTGTCTGCGCGTGCCCAGGTTGT
CCTGCCACTTGCACTGTGCTTGCTCCTAAGCAGGAGGGGAAGGAACCATGTCCTGGAAGGAGAG
CATTGGAAGAAGTGATGAAGAGGTGAAGTGAACACACATTCTTAAGGCAATAAAACCGGGGGGT
GTATATTATCTTCTGGTGCATGTTCTTCTCTGGAAAATACGGTAGCTCGTAACTGCATCCCTAG
TCTGATATTCAAACACACAGTATTTGTGAATAAGCTGATCCCGTCACCCAACATGGAGTCTGTG
TTCACCTACCCATGTGTCTCATTGCCAGTGGTCGTCCTTGGGGGCTCAGCTGAGACTCTCAGCT
TCTGTCACCTTGCTGTCCTGTCTTGTGGCAGCAGCACGTTGCCATCCATCACCAGAATTAGTCC
TCACAGCCTAGGACCAGTTTTGTACCAAACTCATCTGATGTTTTGATGCCATTTGTCAAAAGTA
AGGTTAATTCATTAAAAGTTTTATGTACTTTGAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039092032 ⟹ XP_038947960

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	36,204,057 - 36,650,629 (+)	NCBI
mRatBN7.2	1	34,375,641 - 34,822,237 (+)	NCBI

RefSeq Acc Id:

XM_039092037 ⟹ XP_038947965

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	36,204,058 - 36,650,629 (+)	NCBI
mRatBN7.2	1	34,375,642 - 34,822,237 (+)	NCBI

RefSeq Acc Id:

XM_039092038 ⟹ XP_038947966

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	36,204,056 - 36,604,774 (+)	NCBI
mRatBN7.2	1	34,375,640 - 34,783,103 (+)	NCBI

RefSeq Acc Id:

XM_039092044 ⟹ XP_038947972

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	36,204,055 - 36,596,659 (+)	NCBI
mRatBN7.2	1	34,375,639 - 34,762,623 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_112269	(Get FASTA)	NCBI Sequence Viewer
	XP_038947960	(Get FASTA)	NCBI Sequence Viewer
	XP_038947965	(Get FASTA)	NCBI Sequence Viewer
	XP_038947966	(Get FASTA)	NCBI Sequence Viewer
	XP_038947972	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40682	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000038994
	ENSRNOP00000109970
GenBank Protein	P26769	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_112269 ⟸ NM_031007

- UniProtKB:

P26769 (UniProtKB/Swiss-Prot), F1LV12 (UniProtKB/TrEMBL), A6JV23 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPLIVFLLLIVMGACLALLAVF
FALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRVFSLVIWICLVAMGYLFMCFGG
TVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIASILTSSSHTIVLSVYLSATPGAKEHLFWQILA
NVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMK
AEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGK
FDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVG
VHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGEIR
DPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHR
DSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQ
RISLLFYNKNIEKEYRATALPAFKYYVTCACLIFLCIFIVQILVLPKTSILGFSFGAAFLSLIF
ILFVCFAGQLLQCSKKASTSLMWLLKSSGIIANRPWPRISLTIVTTAIILTMAVFNMFFLSNSE
ETTLPTANTSNANVSVPDNQASILHARNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVA
LVGYNTILLHTHAHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFL
WKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFK
EFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAIPSQEHAQ
EPERQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTV
NVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNL
AS

hide sequence

Ensembl Acc Id:

ENSRNOP00000038994 ⟸ ENSRNOT00000047627

RefSeq Acc Id:	XP_038947972 ⟸ XM_039092044
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038947966 ⟸ XM_039092038
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038947960 ⟸ XM_039092032
- Peptide Label:	isoform X1
- UniProtKB:	P26769 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038947965 ⟸ XM_039092037
- Peptide Label:	isoform X2
- UniProtKB:	P26769 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000090092 ⟸ ENSRNOT00000099050

Ensembl Acc Id:

ENSRNOP00000109970 ⟸ ENSRNOT00000127647

Ensembl Acc Id:

ENSRNOP00000101380 ⟸ ENSRNOT00000173264

Protein Domains

Guanylate cyclase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P26769-F1-model_v2	AlphaFold	P26769	1-1090	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619965	AgrOrtholog
BioCyc Gene	G2FUF-61858	BioCyc
Ensembl Genes	ENSRNOG00000032150	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000047627	ENTREZGENE
	ENSRNOT00000127647	ENTREZGENE
Gene3D-CATH	3.30.70.1230	UniProtKB/Swiss-Prot
InterPro	A/G_cyclase	UniProtKB/Swiss-Prot
	A/G_cyclase_CS	UniProtKB/Swiss-Prot
	AC_N	UniProtKB/Swiss-Prot
	Adcy	UniProtKB/Swiss-Prot
	Adcy_conserved_dom	UniProtKB/Swiss-Prot
	Nucleotide_cyclase	UniProtKB/Swiss-Prot
KEGG Report	rno:81636	UniProtKB/Swiss-Prot
NCBI Gene	81636	ENTREZGENE
PANTHER	ADENYLATE CYCLASE TYPE 1	UniProtKB/Swiss-Prot
	ADENYLATE CYCLASE TYPE 2	UniProtKB/Swiss-Prot
Pfam	AC_N	UniProtKB/Swiss-Prot
	DUF1053	UniProtKB/Swiss-Prot
	Guanylate_cyc	UniProtKB/Swiss-Prot
PhenoGen	Adcy2	PhenoGen
PIRSF	Ade_cyc	UniProtKB/Swiss-Prot
PROSITE	GUANYLATE_CYCLASE_1	UniProtKB/Swiss-Prot
	GUANYLATE_CYCLASE_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000032150	RatGTEx
SMART	CYCc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF55073	UniProtKB/Swiss-Prot
UniProt	A0A8I6AMB0_RAT	UniProtKB/TrEMBL
	A0ABK0L0K3_RAT	UniProtKB/TrEMBL
	A0ABK0LGM5_RAT	UniProtKB/TrEMBL
	A6JV23	ENTREZGENE, UniProtKB/TrEMBL
	ADCY2_RAT	UniProtKB/Swiss-Prot
	F1LV12	ENTREZGENE, UniProtKB/TrEMBL
	P26769	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-29	Adcy2	adenylate cyclase 2	Adcy2	adenylate cyclase 2 (brain)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-18	Adcy2	adenylate cyclase 2 (brain)	Adcy2	adenylate cyclase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-12-14	Adcy2	adenylate cyclase 2		adenylyl cyclase 2	Name updated	1299863	APPROVED
2002-08-07	Adcy2	adenylyl cyclase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the membrane	724707
gene_regulation	activity is insensitive to Ca2+/calmodulin	724792

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

Send us a Message

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)