Rab7a (RAB7A, member RAS oncogene family) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Rab7a (RAB7A, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab7a
Name: RAB7A, member RAS oncogene family
RGD ID: 61908
Description: Enables GDP binding activity; GTP binding activity; and small GTPase binding activity. Involved in bone resorption and synaptic vesicle recycling via endosome. Located in alveolar lamellar body and late endosome. Is active in presynaptic endosome and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Orthologous to human RAB7A (RAB7A, member RAS oncogene family); PARTICIPATES IN autophagy pathway; interleukin-12 signaling pathway; endocytosis pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Rab7; RAB7, member RAS oncogene family; ras-related protein BRL-RAS; ras-related protein p23; ras-related protein Rab-7a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84122,019,281 - 122,068,067 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4121,983,938 - 122,064,185 (-)EnsemblGRCr8
mRatBN7.24120,461,966 - 120,510,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4120,461,963 - 120,506,889 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4125,934,506 - 125,979,324 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04121,709,288 - 121,754,108 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04120,333,533 - 120,378,346 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04119,910,461 - 119,963,065 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4119,910,478 - 119,959,173 (-)Ensemblrn6Rnor6.0
Rnor_5.04185,158,344 - 185,209,333 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44122,202,685 - 122,220,649 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4109,421,363 - 109,466,326 (-)NCBICelera
RGSC_v3.14122,447,168 - 122,465,130 (-)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
alginic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
cholic acid  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dimethylarsinic acid  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (EXP,ISO)
ivermectin  (ISO)
lanthanum trichloride  (EXP)
lead(0)  (ISO)
Maduramicin  (EXP)
melatonin  (EXP)
Mesaconitine  (EXP)
methamphetamine  (EXP)
methidathion  (ISO)
methoxychlor  (EXP)
N-acetyl-L-cysteine  (EXP)
N-hydroxy-PhIP  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nitrates  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thiram  (ISO)
triphenyl phosphate  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Critical role for Piccolo in synaptic vesicle retrieval. Ackermann F, etal., Elife. 2019 May 10;8. pii: 46629. doi: 10.7554/eLife.46629.
2. A new member of the ras gene superfamily identified in a rat liver cell line. Bucci C, etal., Nucleic Acids Res 1988 Nov 11;16(21):9979-93.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. Guo Z, etal., EMBO J. 2008 Sep 17;27(18):2444-56. doi: 10.1038/emboj.2008.164. Epub 2008 Aug 28.
5. Overview of macroautophagy regulation in mammalian cells. Mehrpour M, etal., Cell Res. 2010 Jul;20(7):748-62. Epub 2010 Jun 15.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. In vitro reconstitution of fusion between immature autophagosomes and endosomes. Morvan J, etal., Autophagy. 2009 Jul;5(5):676-89. Epub 2009 Jul 6.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Pavlos NJ, etal., J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Rak A, etal., Cell. 2004 Jun 11;117(6):749-60.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Possible role of direct Rac1-Rab7 interaction in ruffled border formation of osteoclasts. Sun Y, etal., J Biol Chem. 2005 Sep 16;280(37):32356-61. Epub 2005 Jul 21.
19. Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. Truckenbrodt S, etal., EMBO J. 2018 Aug 1;37(15):e98044. doi: 10.15252/embj.201798044. Epub 2018 Jun 27.
20. Lamellar bodies of rat alveolar type 2 cells have late endosomal marker proteins on their limiting membranes. Wasano K and Hirakawa Y, Histochemistry. 1994 Nov;102(5):329-35.
21. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
22. Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption. Zhao H, etal., J Biol Chem 2001 Oct 19;276(42):39295-302.
Additional References at PubMed
PMID:8522602   PMID:8586647   PMID:11042173   PMID:11172003   PMID:14617358   PMID:15078902   PMID:15489334   PMID:15588329   PMID:15978772   PMID:16282324   PMID:16306406   PMID:17010938  
PMID:18272684   PMID:18419753   PMID:18504258   PMID:18656450   PMID:19056867   PMID:19509052   PMID:19531583   PMID:19956673   PMID:20458337   PMID:20849920   PMID:20943658   PMID:21151572  
PMID:21248257   PMID:21255211   PMID:21700703   PMID:22072966   PMID:22115783   PMID:22431521   PMID:22660413   PMID:23028046   PMID:23230081   PMID:23376485   PMID:23533145   PMID:23616551  
PMID:23708524   PMID:24035762   PMID:24334765   PMID:24344282   PMID:24625528   PMID:24760869   PMID:25592972   PMID:26582200   PMID:26599499   PMID:26911690   PMID:27383256   PMID:27385586  
PMID:27390154   PMID:28726776   PMID:29476059   PMID:29712939   PMID:29932881   PMID:30721447   PMID:35474277   PMID:36592695   PMID:37820423  


Genomics

Comparative Map Data
Rab7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84122,019,281 - 122,068,067 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4121,983,938 - 122,064,185 (-)EnsemblGRCr8
mRatBN7.24120,461,966 - 120,510,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4120,461,963 - 120,506,889 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4125,934,506 - 125,979,324 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04121,709,288 - 121,754,108 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04120,333,533 - 120,378,346 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04119,910,461 - 119,963,065 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4119,910,478 - 119,959,173 (-)Ensemblrn6Rnor6.0
Rnor_5.04185,158,344 - 185,209,333 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44122,202,685 - 122,220,649 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4109,421,363 - 109,466,326 (-)NCBICelera
RGSC_v3.14122,447,168 - 122,465,130 (-)NCBI
Cytogenetic Map4q34NCBI
RAB7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383128,726,183 - 128,814,798 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3128,693,669 - 128,825,942 (+)Ensemblhg38GRCh38
GRCh373128,445,026 - 128,533,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,927,669 - 130,016,331 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343129,927,676 - 130,016,339NCBI
Celera3126,877,121 - 126,965,892 (+)NCBICelera
Cytogenetic Map3q21.3NCBI
HuRef3125,832,324 - 125,921,106 (+)NCBIHuRef
CHM1_13128,408,152 - 128,496,845 (+)NCBICHM1_1
T2T-CHM13v2.03131,470,839 - 131,559,516 (+)NCBIT2T-CHM13v2.0
Rab7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,976,088 - 88,022,252 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl687,976,088 - 88,022,252 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38687,999,106 - 88,045,270 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,999,106 - 88,045,270 (-)Ensemblmm10GRCm38
MGSCv37687,950,429 - 87,963,684 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36687,964,764 - 88,010,861 (-)NCBIMGSCv36mm8
Celera689,937,361 - 89,950,664 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map639.13NCBI
Rab7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542915,104,962 - 15,116,023 (-)Ensembl
ChiLan1.0NW_00495542915,103,792 - 15,167,498 (-)NCBIChiLan1.0ChiLan1.0
RAB7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22126,658,777 - 126,750,537 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13126,663,500 - 126,755,260 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03125,784,604 - 125,873,051 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13133,214,246 - 133,233,403 (+)NCBIPanPan1.1PanPan1.1panPan2
RAB7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1202,704,716 - 2,776,518 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl202,704,752 - 2,826,636 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha202,792,411 - 2,812,258 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0202,724,992 - 2,797,106 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl202,725,012 - 2,798,427 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1202,496,060 - 2,515,882 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0202,822,274 - 2,842,051 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0202,783,313 - 2,803,191 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rab7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494220,255,730 - 20,263,118 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936798296,066 - 305,176 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936798297,600 - 304,929 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1371,777,424 - 71,852,694 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11371,777,422 - 71,886,758 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21379,450,127 - 79,456,601 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAB7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12252,231,481 - 52,309,276 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2252,230,835 - 52,309,306 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041114,053,255 - 114,130,507 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462504256,517 - 112,612 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462504256,509 - 112,519 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rab7a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1658,276,096 - 58,320,896 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rab7a
101 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:462
Count of miRNA genes:226
Interacting mature miRNAs:277
Transcripts:ENSRNOT00000016432
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat

Markers in Region
Rab7-ps1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24120,462,698 - 120,462,929 (+)MAPPERmRatBN7.2
mRatBN7.2496,474,285 - 96,474,514 (+)MAPPERmRatBN7.2
Rnor_6.0498,100,457 - 98,100,685NCBIRnor6.0
Rnor_6.04119,911,199 - 119,911,429NCBIRnor6.0
Rnor_5.04185,159,082 - 185,159,312UniSTSRnor5.0
Rnor_5.04162,886,071 - 162,886,299UniSTSRnor5.0
RGSC_v3.44122,203,418 - 122,203,648UniSTSRGSC3.4
RGSC_v3.4496,977,370 - 96,977,598UniSTSRGSC3.4
Celera491,166,331 - 91,166,559UniSTS
Celera4109,422,096 - 109,422,326UniSTS
Cytogenetic Map4q34UniSTS
Cytogenetic Map4q31UniSTS
RH131958  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24120,507,584 - 120,507,777 (+)MAPPERmRatBN7.2
Rnor_6.04119,959,884 - 119,960,076NCBIRnor6.0
Rnor_5.04185,206,546 - 185,206,738UniSTSRnor5.0
Celera4109,467,037 - 109,467,229UniSTS
RH 3.4 Map4717.11UniSTS
Cytogenetic Map4q34UniSTS
Rab7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24120,506,727 - 120,506,964 (+)MAPPERmRatBN7.2
Rnor_6.04119,959,027 - 119,959,263NCBIRnor6.0
Rnor_5.04185,205,689 - 185,205,925UniSTSRnor5.0
Celera4109,466,180 - 109,466,416UniSTS
Cytogenetic Map4q34UniSTS
PMC124275P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84122,020,171 - 122,020,642 (+)Marker Load Pipeline
mRatBN7.24120,462,854 - 120,463,324 (+)MAPPERmRatBN7.2
Rnor_6.04119,911,355 - 119,911,824NCBIRnor6.0
Rnor_5.04185,159,238 - 185,159,707UniSTSRnor5.0
RGSC_v3.44122,203,574 - 122,204,043UniSTSRGSC3.4
Celera4109,422,252 - 109,422,721UniSTS
Cytogenetic Map4q34UniSTS
RAB7A  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84122,024,658 - 122,025,404 (+)Marker Load Pipeline
mRatBN7.24120,467,340 - 120,468,086 (+)MAPPERmRatBN7.2
Rnor_6.04119,915,841 - 119,916,586NCBIRnor6.0
Rnor_5.04185,163,724 - 185,164,469UniSTSRnor5.0
RGSC_v3.44122,208,061 - 122,208,806UniSTSRGSC3.4
Celera4109,426,737 - 109,427,482UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 83 214 91 90 59 152 59 6 485 278 22 192 117 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000016432   ⟹   ENSRNOP00000016432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4122,019,284 - 122,064,185 (-)Ensembl
mRatBN7.2 Ensembl4120,461,963 - 120,506,850 (-)Ensembl
Rnor_6.0 Ensembl4119,910,478 - 119,959,173 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077624   ⟹   ENSRNOP00000074838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4122,024,031 - 122,033,607 (-)Ensembl
mRatBN7.2 Ensembl4120,466,713 - 120,476,292 (-)Ensembl
Rnor_6.0 Ensembl4119,913,640 - 119,927,705 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108669   ⟹   ENSRNOP00000080334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4122,019,284 - 122,033,607 (-)Ensembl
mRatBN7.2 Ensembl4120,461,963 - 120,476,292 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115697   ⟹   ENSRNOP00000094834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4122,020,524 - 122,064,185 (-)Ensembl
mRatBN7.2 Ensembl4120,463,206 - 120,506,889 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173548   ⟹   ENSRNOP00000111278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4121,983,938 - 122,064,185 (-)Ensembl
RefSeq Acc Id: NM_023950   ⟹   NP_076440
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84122,019,284 - 122,064,185 (-)NCBI
mRatBN7.24120,461,966 - 120,506,874 (-)NCBI
Rnor_6.04119,910,466 - 119,959,173 (-)NCBI
Rnor_5.04185,158,344 - 185,209,333 (-)NCBI
RGSC_v3.44122,202,685 - 122,220,649 (-)RGD
Celera4109,421,363 - 109,466,326 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236849   ⟹   XP_006236911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84122,019,281 - 122,068,067 (-)NCBI
mRatBN7.24120,462,336 - 120,510,756 (-)NCBI
Rnor_6.04119,910,461 - 119,963,065 (-)NCBI
Rnor_5.04185,158,344 - 185,209,333 (-)NCBI
Sequence:
RefSeq Acc Id: NP_076440   ⟸   NM_023950
- UniProtKB: Q4AEF6 (UniProtKB/Swiss-Prot),   P09527 (UniProtKB/Swiss-Prot),   A6IB33 (UniProtKB/TrEMBL),   A0A8I5ZQG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236911   ⟸   XM_006236849
- Peptide Label: isoform X1
- UniProtKB: Q4AEF6 (UniProtKB/Swiss-Prot),   P09527 (UniProtKB/Swiss-Prot),   A6IB33 (UniProtKB/TrEMBL),   A0A8I5ZQG8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074838   ⟸   ENSRNOT00000077624
Ensembl Acc Id: ENSRNOP00000016432   ⟸   ENSRNOT00000016432
Ensembl Acc Id: ENSRNOP00000094834   ⟸   ENSRNOT00000115697
Ensembl Acc Id: ENSRNOP00000080334   ⟸   ENSRNOT00000108669
Ensembl Acc Id: ENSRNOP00000111278   ⟸   ENSRNOT00000173548

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09527-F1-model_v2 AlphaFold P09527 1-207 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693226
Promoter ID:EPDNEW_R3751
Type:initiation region
Name:Rab7a_1
Description:RAB7A, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04119,959,176 - 119,959,236EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61908 AgrOrtholog
BioCyc Gene G2FUF-43835 BioCyc
Ensembl Genes ENSRNOG00000012247 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016432 ENTREZGENE
  ENSRNOT00000016432.7 UniProtKB/Swiss-Prot
  ENSRNOT00000108669 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7098657 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
KEGG Report rno:29448 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91396 IMAGE-MGC_LOAD
NCBI Gene 29448 ENTREZGENE
PANTHER RAB FAMILY UniProtKB/Swiss-Prot
  RAS-RELATED PROTEIN RAB-7A UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rab7a PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012247 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2K930_RAT UniProtKB/TrEMBL
  A0A8I5ZQG8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMD0_RAT UniProtKB/TrEMBL
  A0ABK0LZM6_RAT UniProtKB/TrEMBL
  A6IB33 ENTREZGENE, UniProtKB/TrEMBL
  P09527 ENTREZGENE
  Q4AEF6 ENTREZGENE
  RAB7A_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4AEF6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Rab7a  RAB7A, member RAS oncogene family  Rab7  RAB7, member RAS oncogene family  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Rab7  RAB7, member RAS oncogene family      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference