Cryab (crystallin, alpha B) - Rat Genome Database

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Gene: Cryab (crystallin, alpha B) Rattus norvegicus
Analyze
Symbol: Cryab
Name: crystallin, alpha B
RGD ID: 2414
Description: Enables microtubule binding activity. Involved in several processes, including response to estradiol; response to hydrogen peroxide; and stress-activated MAPK cascade. Located in several cellular components, including dendritic spine; myofibril; and perikaryon. Biomarker of cataract and macular degeneration. Human ortholog(s) of this gene implicated in adult-onset myofibrillar myopathy 2A; cataract 16 multiple types; dilated cardiomyopathy 1II; and infantile-onset myofibrillar myopathy-2B. Orthologous to human CRYAB (crystallin alpha B); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AACRYA; alpha B-crystallin; alpha(B)-crystallin; alpha-crystallin B chain; crystallin alpha polypeptide 2; crystallin, alpha polypeptide 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,989,885 - 59,995,532 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl859,989,814 - 59,995,528 (+)EnsemblGRCr8
mRatBN7.2851,093,441 - 51,099,161 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,093,441 - 51,099,157 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx856,601,359 - 56,605,151 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,880,286 - 54,884,078 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,744,541 - 52,748,333 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,178,543 - 55,182,546 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,178,289 - 55,182,545 (+)Ensemblrn6Rnor6.0
Rnor_5.0853,776,100 - 53,779,780 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4854,107,824 - 54,111,502 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera850,642,744 - 50,646,745 (+)NCBICelera
RGSC_v3.1854,126,302 - 54,130,559 (+)NCBI
Cytogenetic Map8q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-diaminotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-nitroquinoline N-oxide  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
arecoline  (ISO)
aristolochic acid A  (EXP)
arotinoid acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Aurin  (ISO)
azetidinecarboxylic acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (EXP,ISO)
bromoacetate  (ISO)
bucladesine  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
captan  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (EXP)
CHIR 99021  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dihydroxyacetone  (ISO)
Diisodecyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
furfural  (ISO)
gentamycin  (EXP)
glutathione  (EXP)
glycidol  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
iopamidol  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
lead nitrate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese(II) chloride  (EXP)
masoprocol  (EXP)
melittin  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methanol  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP)
morphine  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
orphenadrine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctanoic acid  (EXP)
PF-3758309  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
prostaglandin A1  (EXP)
prostaglandin A2  (EXP)
prostaglandin D2  (EXP)
prostaglandin E2  (EXP)
prostaglandin J2  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
scopolamine  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium nitrate  (ISO)
sodium tungstate  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thiabendazole  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
ursodeoxycholic acid  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zinc atom  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament bundle  (IDA)
axon  (IDA)
cardiac myofibril  (IDA)
cell surface  (IDA)
contractile muscle fiber  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
dendritic spine  (IDA)
extracellular region  (IEA)
I band  (IDA,IEA)
lysosome  (IEA)
M band  (IDA)
mitochondrion  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
perikaryon  (IDA)
plasma membrane  (IEA,ISO)
protein-containing complex  (IEA,ISO,ISS)
synaptic membrane  (IDA)
Z disc  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of the specifically targeted lysine residues in the glycation dependent loss of chaperone activity of alpha A- and alpha B-crystallins. Abraham EC, etal., Mol Cell Biochem. 2008 Mar;310(1-2):235-9. Epub 2007 Dec 25.
2. Oxidative stress and calpain inhibition induce alpha B-crystallin phosphorylation via p38-MAPK and calcium signalling pathways in H9c2 cells. Aggeli IK, etal., Cell Signal. 2008 Jul;20(7):1292-302. Epub 2008 Mar 4.
3. alpha B subunit of lens-specific protein alpha-crystallin is present in other ocular and non-ocular tissues. Bhat SP and Nagineni CN, Biochem Biophys Res Commun 1989 Jan 16;158(1):319-25.
4. Aging skeletal muscle shows a drastic increase in the small heat shock proteins alphaB-crystallin/HspB5 and cvHsp/HspB7. Doran P, etal., Eur J Cell Biol. 2007 Oct;86(10):629-40. Epub 2007 Aug 29.
5. alphaB-Crystallin-coated MAP microtubule resists nocodazole and calcium-induced disassembly. Fujita Y, etal., J Cell Sci. 2004 Apr 1;117(Pt 9):1719-26. Epub 2004 Mar 9.
6. Small heat shock protein alphaB-crystallin is part of cell cycle-dependent Golgi reorganization. Gangalum RK, etal., J Biol Chem. 2004 Oct 15;279(42):43374-7. Epub 2004 Aug 31.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin. Golenhofen N, etal., J Mol Cell Cardiol 2002 Mar;34(3):309-19.
10. Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage. Hsu JT, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2982-7. Epub 2007 Feb 9.
11. Multiple mRNAs of rat brain alpha-crystallin B chain result from alternative transcriptional initiation. Iwaki A, etal., J Biol Chem 1990 Dec 25;265(36):22197-203.
12. Disulfide cross-links in the interaction of a cataract-linked alphaA-crystallin mutant with betaB1-crystallin. Kumar MS, etal., FEBS Lett. 2009 Jan 5;583(1):175-9. doi: 10.1016/j.febslet.2008.11.047. Epub 2008 Dec 9.
13. Alpha B-crystallin suppresses pressure overload cardiac hypertrophy. Kumarapeli AR, etal., Circ Res. 2008 Dec 5;103(12):1473-82. Epub 2008 Oct 30.
14. AlphaB-crystallin inhibits glucose-induced apoptosis in vascular endothelial cells. Liu B, etal., Biochem Biophys Res Commun. 2004 Aug 13;321(1):254-8.
15. Abundance and location of the small heat shock proteins HSP25 and alphaB-crystallin in rat and human heart. Lutsch G, etal., Circulation. 1997 Nov 18;96(10):3466-76.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. The mitochondria-targeted antioxidant SkQ1 restores aB-crystallin expression and protects against AMD-like retinopathy in OXYS rats. Muraleva NA, etal., Cell Cycle. 2014;13(22):3499-505. doi: 10.4161/15384101.2014.958393.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Changes in physicochemical parameters and alpha-crystallin expression in the lens during cataract development in OXYS rats. 5. Rumyantseva YV, etal., Biochemistry (Mosc). 2008 Nov;73(11):1176-82.
26. Phosphorylation-dependent subcellular localization of the small heat shock proteins HspB1/Hsp25 and HspB5/alphaB-crystallin in cultured hippocampal neurons. Schmidt T, etal., Histochem Cell Biol. 2012 Sep;138(3):407-18. doi: 10.1007/s00418-012-0964-x. Epub 2012 May 23.
27. Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation. Sugiyama Y, etal., J Biol Chem. 2000 Jan 14;275(2):1095-104.
Additional References at PubMed
PMID:1764082   PMID:1765091   PMID:1783614   PMID:8282729   PMID:8639509   PMID:10751411   PMID:11687538   PMID:12235146   PMID:12546709   PMID:12601044   PMID:14575708   PMID:14627610  
PMID:14752512   PMID:15308659   PMID:15856211   PMID:16303126   PMID:16439475   PMID:16675842   PMID:16680485   PMID:17092938   PMID:17196975   PMID:17438522   PMID:17634366   PMID:17893660  
PMID:18191123   PMID:18330356   PMID:18566458   PMID:19056867   PMID:19340546   PMID:19379782   PMID:19464326   PMID:19558454   PMID:19646995   PMID:19651604   PMID:20587334   PMID:20723582  
PMID:20802487   PMID:21311744   PMID:21423662   PMID:21464278   PMID:21617129   PMID:21777656   PMID:21975426   PMID:22143763   PMID:22153508   PMID:23071119   PMID:23106396   PMID:23153557  
PMID:23188086   PMID:23212619   PMID:23264262   PMID:23376485   PMID:23386121   PMID:23508955   PMID:23533145   PMID:23542032   PMID:23543138   PMID:23546289   PMID:23559016   PMID:24103517  
PMID:24183572   PMID:24464634   PMID:24466295   PMID:25319025   PMID:25596465   PMID:26465331   PMID:26475352   PMID:26708692   PMID:27085702   PMID:27226619   PMID:27264546   PMID:27851782  
PMID:28425051   PMID:28502773   PMID:29542021   PMID:30246229   PMID:30463298   PMID:31970633   PMID:32016842   PMID:32554860   PMID:33220080   PMID:35352799   PMID:37584866  


Genomics

Comparative Map Data
Cryab
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,989,885 - 59,995,532 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl859,989,814 - 59,995,528 (+)EnsemblGRCr8
mRatBN7.2851,093,441 - 51,099,161 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,093,441 - 51,099,157 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx856,601,359 - 56,605,151 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,880,286 - 54,884,078 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,744,541 - 52,748,333 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,178,543 - 55,182,546 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,178,289 - 55,182,545 (+)Ensemblrn6Rnor6.0
Rnor_5.0853,776,100 - 53,779,780 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4854,107,824 - 54,111,502 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera850,642,744 - 50,646,745 (+)NCBICelera
RGSC_v3.1854,126,302 - 54,130,559 (+)NCBI
Cytogenetic Map8q23NCBI
CRYAB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811111,908,564 - 111,923,740 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11111,908,564 - 111,923,722 (-)Ensemblhg38GRCh38
GRCh3711111,779,288 - 111,794,464 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,284,560 - 111,287,683 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411111,284,559 - 111,287,683NCBI
Celera11108,932,558 - 108,935,681 (-)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,703,256 - 107,706,379 (-)NCBIHuRef
CHM1_111111,662,430 - 111,665,553 (-)NCBICHM1_1
T2T-CHM13v2.011111,918,808 - 111,933,984 (-)NCBIT2T-CHM13v2.0
Cryab
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,657,251 - 50,667,936 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,662,625 - 50,667,936 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38950,745,951 - 50,756,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,751,325 - 50,756,636 (+)Ensemblmm10GRCm38
MGSCv37950,560,863 - 50,564,738 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36950,504,988 - 50,508,863 (+)NCBIMGSCv36mm8
Celera948,039,922 - 48,043,797 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Cryab
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,625,363 - 13,640,426 (-)Ensembl
ChiLan1.0NW_00495541213,626,018 - 13,629,495 (-)NCBIChiLan1.0ChiLan1.0
CRYAB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,659,159 - 112,682,506 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,753,439 - 113,756,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011106,795,406 - 106,800,019 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,639,442 - 110,644,245 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,639,442 - 110,644,272 (-)EnsemblpanPan2panpan1.1
CRYAB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,181,836 - 21,185,164 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,179,936 - 21,360,132 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha521,104,096 - 21,107,406 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0521,204,772 - 21,208,082 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,204,907 - 21,208,076 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,266,069 - 21,269,377 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,166,521 - 21,169,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,215,316 - 21,218,626 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cryab
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,169,136 - 94,173,881 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,532,812 - 2,537,495 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,532,851 - 2,536,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRYAB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,638,506 - 39,643,530 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1939,638,505 - 39,643,530 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,428,979 - 44,433,758 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRYAB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,258,715 - 103,263,274 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,257,347 - 103,261,990 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604322,707,897 - 22,722,116 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cryab
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,074,590 - 7,093,054 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247847,074,590 - 7,093,471 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cryab
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1845,217,637 - 45,221,312 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cryab
20 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:85
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000059127
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
RH143847  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,093,454 - 51,093,594 (+)MAPPERmRatBN7.2
Rnor_6.0855,176,840 - 55,176,979NCBIRnor6.0
Rnor_5.0853,774,076 - 53,774,215UniSTSRnor5.0
RGSC_v3.4854,105,800 - 54,105,939UniSTSRGSC3.4
Celera850,641,041 - 50,641,180UniSTS
Cytogenetic Map8q23UniSTS
PMC123035P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,094,546 - 51,095,517 (+)MAPPERmRatBN7.2
Rnor_6.0855,177,932 - 55,178,902NCBIRnor6.0
Rnor_5.0853,775,168 - 53,776,138UniSTSRnor5.0
RGSC_v3.4854,106,892 - 54,107,862UniSTSRGSC3.4
Celera850,642,133 - 50,643,103UniSTS
Cytogenetic Map8q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 57 59 6 321 157 11 140 81 92 31 13 13

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK357656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000059127   ⟹   ENSRNOP00000055901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl859,989,814 - 59,995,528 (+)Ensembl
mRatBN7.2 Ensembl851,093,441 - 51,099,157 (+)Ensembl
Rnor_6.0 Ensembl855,178,289 - 55,182,545 (+)Ensembl
RefSeq Acc Id: NM_012935   ⟹   NP_037067
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,991,531 - 59,995,532 (+)NCBI
mRatBN7.2851,095,158 - 51,099,161 (+)NCBI
Rnor_6.0855,178,543 - 55,182,546 (+)NCBI
Rnor_5.0853,776,100 - 53,779,780 (+)NCBI
RGSC_v3.4854,107,824 - 54,111,502 (+)RGD
Celera850,642,744 - 50,646,745 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080878   ⟹   XP_038936806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,991,469 - 59,995,532 (+)NCBI
mRatBN7.2851,095,199 - 51,099,161 (+)NCBI
RefSeq Acc Id: XM_039080879   ⟹   XP_038936807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,989,885 - 59,995,532 (+)NCBI
mRatBN7.2851,093,441 - 51,099,161 (+)NCBI
RefSeq Acc Id: NP_037067   ⟸   NM_012935
- UniProtKB: Q6LDR2 (UniProtKB/Swiss-Prot),   P23928 (UniProtKB/Swiss-Prot),   A6J4F4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055901   ⟸   ENSRNOT00000059127
RefSeq Acc Id: XP_038936807   ⟸   XM_039080879
- Peptide Label: isoform X1
- UniProtKB: P23928 (UniProtKB/Swiss-Prot),   Q6LDR2 (UniProtKB/Swiss-Prot),   A6J4F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936806   ⟸   XM_039080878
- Peptide Label: isoform X1
- UniProtKB: P23928 (UniProtKB/Swiss-Prot),   Q6LDR2 (UniProtKB/Swiss-Prot),   A6J4F4 (UniProtKB/TrEMBL)
Protein Domains
sHSP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23928-F1-model_v2 AlphaFold P23928 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695953
Promoter ID:EPDNEW_R6477
Type:initiation region
Name:Cryab_1
Description:crystallin, alpha B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0855,178,828 - 55,178,888EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2414 AgrOrtholog
BioCyc Gene G2FUF-30550 BioCyc
Ensembl Genes ENSRNOG00000010524 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000059127 ENTREZGENE
  ENSRNOT00000059127.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot
InterPro A-crystallin/Hsp20_dom UniProtKB/Swiss-Prot
  ACD_alphaB-crystallin UniProtKB/Swiss-Prot
  Alpha-crystallin/HSP UniProtKB/Swiss-Prot
  Alpha-crystallin/HSP_16 UniProtKB/Swiss-Prot
  Alpha-crystallin_N UniProtKB/Swiss-Prot
  HSP20-like_chaperone UniProtKB/Swiss-Prot
KEGG Report rno:25420 UniProtKB/Swiss-Prot
NCBI Gene 25420 ENTREZGENE
PANTHER ALPHA-CRYSTALLIN B CHAIN UniProtKB/Swiss-Prot
  PTHR45640 UniProtKB/Swiss-Prot
Pfam Crystallin UniProtKB/Swiss-Prot
  HSP20 UniProtKB/Swiss-Prot
PhenoGen Cryab PhenoGen
PIRSF Sm_HSP_B1 UniProtKB/Swiss-Prot
PRINTS ACRYSTALLIN UniProtKB/Swiss-Prot
PROSITE SHSP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010524 RatGTEx
Superfamily-SCOP SSF49764 UniProtKB/Swiss-Prot
UniProt A6J4F4 ENTREZGENE, UniProtKB/TrEMBL
  A6J4F7_RAT UniProtKB/TrEMBL
  CRYAB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6LDR2 ENTREZGENE
UniProt Secondary Q6LDR2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Cryab  crystallin, alpha B    Crystallin, alpha polypeptide 2  Name updated 625702 APPROVED
2002-06-10 Cryab  Crystallin, alpha polypeptide 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization translocated to the N(2)-line area of myofibrillar I-bands of cardiomyocytes during ischemia 704398