Uae8 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Uae8 (Urinary albumin excretion QTL 8) Rattus norvegicus

Symbol: Uae8
Name: Urinary albumin excretion QTL 8
RGD ID: 724540
Trait: urine albumin amount   (VT:0002871)    
Measurement Type: urine albumin level   (CMO:0000130)    
LOD Score: 5.0
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0830,845,450 - 33,558,764RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0833,603,024 - 100,888,674RGDRnor5.0
RGSC_v3.4832,203,394 - 98,986,263RGDRGSC3.4
RGSC_v3.1832,212,161 - 99,005,718RGD
Cross Type: intercross
Strains Crossed: SS/JrMco SHR/NHsd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View
Albuminuria  (IDA)
proteinuria  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
SHR/NHsd  (IEA)
SS/JrMco  (IEA)

References

References - curated
1. Garrett MR, etal., J Am Soc Nephrol 2003 May;14(5):1175-87.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
61971Kcnj5potassium inwardly-rectifying channel, subfamily J, member 583343549333463410Rat
69288St14ST14 transmembrane serine protease matriptase83224011332280813Rat
2128Aplp2amyloid beta precursor like protein 283229852632328821Rat
620958Ntmneurotrimin83003933231041755Rat
2957Kcnj1potassium inwardly-rectifying channel, subfamily J, member 183349028033519127Rat
1305586Tmem45btransmembrane protein 45b83256387232609212Rat
1308511Adamts8ADAM metallopeptidase with thrombospondin type 1 motif, 883201768432037529Rat
1309770Adamts15ADAM metallopeptidase with thrombospondin type 1 motif, 1583197700132000378Rat
1308984Zbtb44zinc finger and BTB domain containing 4483216538832223341Rat
1310558Nfrkbnuclear factor related to kappa B binding protein83253041232561955Rat
1309857Snx19sorting nexin 1983149703431534077Rat
1309837Fli1Fli-1 proto-oncogene, ETS transcription factor83354193233661111Rat
1305267Arhgap32Rho GTPase activating protein 3283313187433392198Rat
1563958RGD1563958similar to 60S ribosomal protein L3283243152632432223Rat
1562690RGD1562690similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M)83307510933076725Rat
1560384Prdm10PR/SET domain 1083241992132526357Rat
1584797Cct6a-ps7chaperonin containing Tcp1, subunit 6A (zeta 1), pseudogene 783307421333077943Rat
1585923LOC679666similar to S-adenosylmethionine decarboxylase proenzyme 1 (AdoMetDC 1) (SamdC 1)83264161032686865Rat
1587115LOC679568hypothetical protein LOC67956883241708232417646Rat
1584840Barx2BARX homeobox 283295087833018245Rat
1597168LOC300481similar to 40S ribosomal protein S1983306882633069275Rat
1597169LOC300479similar to Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate synthetase I) (PRS-I)83268867232690150Rat
1593195LOC367050similar to 60S ribosomal protein L3583334495133345463Rat
1593196LOC367047similar to Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)83143260831433944Rat
2323692LOC100359502aldo-keto reductase family 1, member D1-like83276791532769500Rat
2324608LOC100362981LRRGT00010-like83310462833121002Rat
6497528LOC10091068640S ribosomal protein S8-like83313021833131459Rat
7509758LOC102551288uncharacterized LOC10255128883312213433126107Rat
7690886LOC102555286uncharacterized LOC10255528683124960231257053Rat
7706377LOC102552976serine/arginine repetitive matrix protein 2-like83313921033151166Rat
7749928LOC10255186860S ribosomal protein L27a-like83330536733306375Rat
9290613LOC103693036ATP synthase F(0) complex subunit C1, mitochondrial pseudogene83339393533397051Rat
9457469LOC103693034small ubiquitin-related modifier 2 pseudogene83215246132153792Rat
11468735LOC108351666uncharacterized LOC10835166683137324031392092Rat
11459501LOC108351668uncharacterized LOC10835166883273242232750009Rat
11451281LOC108351667endogenous retrovirus group K member 9 Pol protein-like83156438831566330Rat
11384229LOC108351669uncharacterized LOC10835166983295341732960212Rat
11405255LOC108351841nucleolar protein 16 pseudogene83241612832417719Rat
11508065LOC10835181960S ribosomal protein L30-like83144967531492790Rat
11482315LOC108351665uncharacterized LOC10835166583125705631287671Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33559D8Mit512283355866033558764Ratregion
35481D8Rat5016783201049932010665Ratregion
37742D8Rat16317683288835232888527Ratregion
35663D8Rat5115683091811230918267Ratregion
40746D8Rat16224983220198132202233Ratregion
42236D8Arb2419083315533333155515Ratregion
42242D8Arb520083227227332272467Ratregion
44372D8Got3920483244981132450014Ratregion
44373D8Got3220783334676333346971Ratregion
44375D8Got3529983257074332571041Ratregion
60627D8Got4022083337978133379997Ratregion
1628575D8Wox2617383351853233518704Ratregion
1640284D8M9Mit18843183250196032502390Ratregion
7205968St148283224346632244170Ratregion
5038834RH12735918283256145332561634Ratregion
5039016RH12746418883229870832298895Ratregion
5036809AU04927411083242736332427472Ratregion
5036811AU04928028083207542732075706Ratregion
5029339RH14442015183153434331534493Ratregion
5029851AW53053120883224823132248438Ratregion
5034984Fli114683354341733543562Ratregion
5027379X5942110083354333433543433Ratregion
5035184BE09694915883152993231530089Ratregion
5053787RH14285010683127100031271105Ratregion
5059398AW53058019683343618133436376Ratregion
5041654RH12898119183221714932217339Ratregion
5049066RH13326620683343559333435798Ratregion
5048162RH13274421783301830533018521Ratregion
5048354RH13285518483295933832960175Ratregion
5074994RH13833819983227063132270829Ratregion
5077422RH13974720583354200333542207Ratregion
5080370RH14154019483224019732240390Ratregion
5071556RH13515018483197717731977360Ratregion
5068276AU04724314583091809930918243Ratregion
5064162AW52964915183153332031533470Ratregion
5064212BI29638716383277932132779483Ratregion
5066292PMC139861P163683338826133388896Ratregion
5064830BF40518911683337696733377082Ratregion
5082021BF41565716883126521231265380Ratregion
5089349AU04910326283237105732371318Ratregion
5083547BE10052615483343414233434295Ratregion
5087185BM38790817783301595533016131Ratregion
5089247AU04904316083094886530949026Ratregion
5507099UniSTS:22452715583106606931066223Ratregion
5500194SHGC-15200358883300689633007483Ratregion
5501313ECD1447749283104623831046729Ratregion
5501966MARC_21333-21334:1023126386:116683232782932328768Ratregion
5507327GDB:192496083264231332642458Ratregion
Position Markers

Flank 1: (D8Mit5)
Rat AssemblyChrPosition (strand)Source
Rnor_6.0833,558,660 - 33,558,764NCBI
Rnor_5.0833,603,024 - 33,603,128UniSTS
RGSC_v3.4832,203,394 - 32,203,499RGD
RGSC_v3.4832,203,395 - 32,203,499UniSTS
RGSC_v3.1832,212,161 - 32,212,265RGD
Celera832,299,483 - 32,299,583UniSTS
RH 3.4 Map8248.5UniSTS
RH 3.4 Map8248.5RGD
RH 2.0 Map8167.4RGD
Cytogenetic Map8q21UniSTS
Peak: (D8Rat162)
Rat AssemblyChrPosition (strand)Source
Rnor_6.0832,201,981 - 32,202,233NCBI
Rnor_5.0832,227,585 - 32,227,837UniSTS
RGSC_v3.4830,878,636 - 30,878,889RGD
RGSC_v3.4830,878,637 - 30,878,889UniSTS
RGSC_v3.1830,887,403 - 30,887,655RGD
Celera830,964,403 - 30,964,657UniSTS
RH 3.4 Map8246.2RGD
RH 3.4 Map8246.2UniSTS
SHRSP x BN Map821.82UniSTS
SHRSP x BN Map821.82RGD
Cytogenetic Map8q13UniSTS
Flank 2: (D8Rat130)
Rat AssemblyChrPosition (strand)Source
Rnor_5.08100,888,495 - 100,888,674NCBI
RGSC_v3.4898,986,085 - 98,986,263RGD
RGSC_v3.1899,005,540 - 99,005,718RGD
SHRSP x BN Map857.2699RGD
SHRSP x BN Map857.2699UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8210812847108128Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8210812847108128Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8210812847108128Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8210812847108128Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8736807652368076Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8736807652368076Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8736807652368076Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8873867753738677Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)81038843955388439Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)81038843955388439Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81137326757541668Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81137350945712344Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81137350945712344Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81144825156448251Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81144825156448251Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81766655562666555Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)82071759265717592Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82784149672841496Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82816802350708951Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82986798359908353Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)829867983106526740Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)829867983106526740Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)829867983106526740Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83014480075144800Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)83014480075144800Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)83084545033558764Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)83091811258858224Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)83091811275918112Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)830918112107206309Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83220198154065241Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83220198175971421Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)832888352101374135Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83355866044219353Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866046588570Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866062857995Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83355866065717592Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83355866065717592Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83355866089058369Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83355866089058369Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83355866089058369Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83355866089058369Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)833558660109028082Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)833558660109028082Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)833558660109028082Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)833558764113580387Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Uae8

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_general SS allele associated with increased urinary albumin excretion, highest at 12 weeks of age; at older age stage also linked to elevated urinary protein excretion (UPE) (LOD = 6.0) 634617