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Gene: Fzd8 (frizzled class receptor 8) Rattus norvegicus

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Symbol:

Fzd8

Name:

frizzled class receptor 8

RGD ID:

1560525

Description:

Predicted to enable several functions, including PDZ domain binding activity; Wnt receptor activity; and Wnt-protein binding activity. Predicted to be involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Predicted to act upstream of or within T cell differentiation in thymus; Wnt signaling pathway; and angiogenesis. Predicted to be located in Golgi apparatus and membrane. Predicted to be part of Wnt-Frizzled-LRP5/6 complex. Predicted to be active in neuronal dense core vesicle and plasma membrane. Orthologous to human FZD8 (frizzled class receptor 8); PARTICIPATES IN Wnt signaling pathway; basal cell carcinoma pathway; Wnt signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

frizzled family receptor 8; frizzled homolog 8; frizzled homolog 8 (Drosophila); frizzled-8; frizzled-8-like; fz-8; LOC100909849; MGC112790; similar to transmembrane receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FZD8 (frizzled class receptor 8)	RGD	RGD
Mus musculus (house mouse):	Fzd8 (frizzled class receptor 8)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Fzd8 (frizzled class receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FZD8 (frizzled class receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FZD8 (frizzled class receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fzd8 (frizzled class receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FZD8 (frizzled class receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FZD8 (frizzled class receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fzd8 (frizzled class receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Fzd8 (frizzled class receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FZD8 (frizzled class receptor 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fzd8 (frizzled class receptor 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fzd8a (frizzled class receptor 8a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fzd8b (frizzled class receptor 8b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fzd8b (frizzled class receptor 8b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	cfz-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cfz-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	fz2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	fzd8	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	fzd8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	62,007,849 - 62,015,485 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	62,007,627 - 62,015,961 (+)	Ensembl				GRCr8
mRatBN7.2	17	57,312,924 - 57,320,551 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	57,314,450 - 57,320,650 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	60,478,717 - 60,481,700 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	64,481,735 - 64,484,718 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	58,635,892 - 58,638,875 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	62,259,910 - 62,267,239 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	62,262,129 - 62,265,113 (+)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	17	62,999,666 - 63,002,650 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	64,033,702 - 64,040,990 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	65,968,739 - 65,971,724 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	58,595,549 - 58,598,534 (+)	NCBI		Celera
Cytogenetic Map	17	q12.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acetaldehyde (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

atorvastatin calcium (EXP)

atrazine (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

camptothecin (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (ISO)

deguelin (ISO)

dexamethasone (EXP)

dextran sulfate (ISO)

dibutyl phthalate (EXP,ISO)

dichloroacetic acid (ISO)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

dorsomorphin (ISO)

entinostat (ISO)

epoxiconazole (ISO)

flusilazole (ISO)

flutamide (EXP)

folic acid (ISO)

furan (ISO)

glafenine (EXP)

isoflurane (ISO)

kenpaullone (EXP)

kojic acid (ISO)

L-methionine (ISO)

lead diacetate (ISO)

leflunomide (EXP)

levofloxacin (EXP)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

N-nitrosodimethylamine (EXP)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

okadaic acid (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

SB 431542 (ISO)

sevoflurane (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

tamoxifen (ISO)

Tetrachlorobisphenol A (ISO)

tetrachloromethane (EXP,ISO)

thalidomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

trichostatin A (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (ISO)

biological_process (ND)

canonical Wnt signaling pathway (IBA,ISO)

cell surface receptor signaling pathway (IEA)

G protein-coupled receptor signaling pathway (IEA)

non-canonical Wnt signaling pathway (IBA)

positive regulation of JUN kinase activity (ISO)

positive regulation of protein phosphorylation (ISO)

signal transduction (IEA)

T cell differentiation in thymus (ISO)

Wnt signaling pathway (IEA,ISO)

Cellular Component

Golgi apparatus (IEA)

membrane (IEA)

neuronal dense core vesicle (IEA,ISO)

plasma membrane (IBA,IEA,ISO)

Wnt-Frizzled-LRP5/6 complex (IEA,ISO)

Molecular Function

G protein-coupled receptor activity (IEA)

PDZ domain binding (IEA,ISO)

protein binding (ISO)

signaling receptor binding (IEA,ISO)

transmembrane signaling receptor activity (IEA)

ubiquitin protein ligase binding (ISO)

Wnt receptor activity (IBA,IEA,ISO)

Wnt-protein binding (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

basal cell carcinoma pathway (IEA)

Wnt signaling pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Comprehensive gene review and curation	RGD comprehensive gene curation
6.	The Wnt Homepage	Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11029007	PMID:11265645	PMID:11357136	PMID:11448771	PMID:11520064	PMID:15035989	PMID:15064719	PMID:15143170	PMID:15195140	PMID:15454084	PMID:15489334	PMID:16115200
PMID:16543246	PMID:17360443	PMID:18256285	PMID:19129494	PMID:20093360	PMID:22138402	PMID:22575959	PMID:22653731	PMID:25619565	PMID:28733458	PMID:36047789

Genomics

Comparative Map Data

Fzd8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	62,007,849 - 62,015,485 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	62,007,627 - 62,015,961 (+)	Ensembl				GRCr8
mRatBN7.2	17	57,312,924 - 57,320,551 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	57,314,450 - 57,320,650 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	60,478,717 - 60,481,700 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	64,481,735 - 64,484,718 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	58,635,892 - 58,638,875 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	62,259,910 - 62,267,239 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	62,262,129 - 62,265,113 (+)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	17	62,999,666 - 63,002,650 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	64,033,702 - 64,040,990 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	65,968,739 - 65,971,724 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	58,595,549 - 58,598,534 (+)	NCBI		Celera
Cytogenetic Map	17	q12.1	NCBI

FZD8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	35,638,247 - 35,642,296 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	35,638,247 - 35,642,296 (-)	Ensembl			hg38	GRCh38
GRCh37	10	35,927,175 - 35,931,224 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	35,967,183 - 35,970,368 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	35,967,182 - 35,970,368	NCBI
Celera	10	35,693,623 - 35,696,808 (-)	NCBI		Celera
Cytogenetic Map	10	p11.21	NCBI
HuRef	10	35,646,354 - 35,649,248 (-)	NCBI		HuRef
CHM1_1	10	35,927,106 - 35,930,322 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	35,668,401 - 35,672,451 (-)	NCBI		T2T-CHM13v2.0

Fzd8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	9,212,856 - 9,216,201 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	9,212,163 - 9,218,136 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	9,212,856 - 9,216,201 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	9,212,163 - 9,218,136 (+)	Ensembl			mm10	GRCm38
MGSCv37	18	9,212,854 - 9,216,199 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	9,212,918 - 9,214,975 (+)	NCBI		MGSCv36	mm8
Celera	18	9,253,263 - 9,256,609 (+)	NCBI		Celera
Cytogenetic Map	18	A1	NCBI
cM Map	18	4.91	NCBI

Fzd8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955462	5,870,410 - 5,873,714 (+)	NCBI	ChiLan1.0	ChiLan1.0

FZD8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	48,286,961 - 48,290,837 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	48,292,290 - 48,296,336 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	35,766,112 - 35,770,154 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

FZD8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	1,319,179 - 1,322,103 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	1,319,268 - 1,321,421 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	1,407,611 - 1,410,494 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	1,601,202 - 1,604,080 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	1,601,454 - 1,603,400 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	1,372,933 - 1,375,806 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	1,415,773 - 1,418,646 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	1,536,985 - 1,539,859 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Fzd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	14,401,037 - 14,407,993 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936574	3,904,532 - 3,906,625 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936574	3,900,534 - 3,907,513 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FZD8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	58,094,689 - 58,096,769 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	58,093,980 - 58,096,790 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

FZD8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	34,918,916 - 34,922,687 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666056	44,086,991 - 44,090,879 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fzd8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624805	9,978,880 - 9,980,899 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624805	9,978,845 - 9,981,475 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Fzd8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	27,820,233 - 27,826,429 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Fzd8
79 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	85
Count of miRNA genes:	67
Interacting mature miRNAs:	82
Transcripts:	ENSRNOT00000058837
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631497	Bp98	Blood pressure QTL 98	3.66		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	49496932	65155015	Rat
70210	Cm15	Cardiac mass QTL 15	6.5		heart right ventricle mass (VT:0007033)	heart right ventricle wet weight (CMO:0000072)	17	30066472	75066472	Rat
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	42388164	87388164	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	58194064	87388164	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	33104645	78104645	Rat
1354654	Spl7	Serum phospholipid level QTL 7	5.5		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	17	38031354	83031354	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	54829503	93515804	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40968017	89341781	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27233445	83975845	Rat
1354629	Scl31	Serum cholesterol level QTL 31	4.1		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	17	38031354	83031354	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23286322	64246472	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	26522051	71522051	Rat
1600398	Edcs5	Endometrial carcinoma susceptibility QTL 5	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	17	35446949	75762341	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	22019705	67019705	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24390595	84432719	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	38031354	83031354	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	38031354	83031354	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	33104645	78104645	Rat
12904736	Cm121	Cardiac mass QTL 121		0.043	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	42388164	87388164	Rat
7394837	Memor18	Memory QTL 18			exploratory behavior trait (VT:0010471)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	17	61091446	68550213	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	46050126	91050126	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23858926	68858926	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23858926	68858926	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27233445	65155015	Rat
4889891	Eae32	Experimental allergic encephalomyelitis QTL 32	4.8	0.0002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	27233445	72233445	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23858926	68858926	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	55604597	93006569	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23858926	68858926	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	42654895	87654895	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23858926	68858926	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	37687877	82687877	Rat
1300129	Rf25	Renal function QTL 25	3.03		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	17	41062352	86062352	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	32199534	86201342	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			24136127	84432719	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	36045537	81045537	Rat

Markers in Region

RH142039

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	57,318,045 - 57,318,211 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	63,002,646 - 63,002,811	NCBI	Rnor6.0
Rnor_6.0	17	62,265,109 - 62,265,274	NCBI	Rnor6.0
Rnor_5.0	17	64,774,638 - 64,774,803	UniSTS	Rnor5.0
Rnor_5.0	17	64,038,864 - 64,039,029	UniSTS	Rnor5.0
RGSC_v3.4	17	65,971,719 - 65,971,884	UniSTS	RGSC3.4
Celera	17	58,598,529 - 58,598,694	UniSTS
RH 3.4 Map	17	589.4	UniSTS
Cytogenetic Map	17	q12.1	UniSTS

Fzd8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	57,316,814 - 57,316,969 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	63,001,415 - 63,001,569	NCBI	Rnor6.0
Rnor_6.0	17	62,263,878 - 62,264,032	NCBI	Rnor6.0
Rnor_5.0	17	64,037,633 - 64,037,787	UniSTS	Rnor5.0
Rnor_5.0	17	64,773,407 - 64,773,561	UniSTS	Rnor5.0
RGSC_v3.4	17	65,970,488 - 65,970,642	UniSTS	RGSC3.4
Celera	17	58,597,298 - 58,597,452	UniSTS
Cytogenetic Map	17	q12.1	UniSTS

Fzd8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	57,317,700 - 57,317,782 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	62,264,764 - 62,264,845	NCBI	Rnor6.0
Rnor_6.0	17	63,002,301 - 63,002,382	NCBI	Rnor6.0
Rnor_5.0	17	64,774,293 - 64,774,374	UniSTS	Rnor5.0
Rnor_5.0	17	64,038,519 - 64,038,600	UniSTS	Rnor5.0
Celera	17	58,598,184 - 58,598,265	UniSTS
Cytogenetic Map	17	q12.1	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	hemolymphoid system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	sensory system	visual system
7	1	18	49	62	133	90	11	48	36	32	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001044251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC100088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000058837 ⟹ ENSRNOP00000055627

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	17	62,999,666 - 63,002,650 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000073575 ⟹ ENSRNOP00000067651

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	17	62,262,129 - 62,265,113 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116071 ⟹ ENSRNOP00000093389

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	62,007,627 - 62,015,961 (+)	Ensembl
mRatBN7.2 Ensembl	17	57,314,450 - 57,320,650 (+)	Ensembl

RefSeq Acc Id:

NM_001044251 ⟹ NP_001037716

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	62,009,994 - 62,012,979 (+)	NCBI
mRatBN7.2	17	57,315,066 - 57,318,051 (+)	NCBI
Rnor_6.0	17	62,262,129 - 62,265,114 (+)	NCBI
Rnor_5.0	17	64,033,702 - 64,040,990 (+)	NCBI
RGSC_v3.4	17	65,968,739 - 65,971,724 (+)	RGD
Celera	17	58,595,549 - 58,598,534 (+)	RGD

Sequence:

show sequence

GTCTGCGGTCACCCCAGGAGAGGCGTGGGGGAGGGCCGGACGAGTCCTGCCTAGGTTTCCGACC
CTGCTGCCACAGACGCTGCCTGAAAAGGAGATAAATTGTTGGCAGATTCTCCTCTCGGCAGAGA
AAAGCCGGACAAGACCTTCTGGTCGCCTGCACTCCCTTTACTCAGGTTCCTCACCGTAGAGCCC
TTCTGCGCGGCGCCCGGAGAAGGAGGACTTGGGGTCCCGGCGCTCAGCATGGAGTGGGGTTACC
TGTTGGAAGTGACCTCGCTACTAGCCGCCTTGGCGGTGCTACAGCGCTCGAGCGGCGCTGCCGC
GGCTTCGGCCAAGGAGCTGGCGTGCCAAGAGATCACAGTGCCGCTGTGCAAGGGCATCGGTTAC
AACTACACCTACATGCCCAACCAGTTCAACCACGACACGCAAGATGAGGCGGGCCTAGAGGTAC
ACCAGTTCTGGCCGCTGGTGGAGATCCAGTGCTCCCCGGACCTCAAGTTCTTTCTGTGTAGCAT
GTACACGCCCATCTGCCTGGAGGACTACAAGAAACCTCTGCCGCCTTGCCGCTCTGTGTGTGAA
CGCGCCAAGGCCGGCTGCGCGCCGCTCATGCGCCAGTACGGCTTTGCCTGGCCTGACCGAATGC
GCTGCGATCGGCTGCCGGAGCAGGGCAACCCCGACACTCTGTGCATGGACTACAACCGCACCGA
CCTCACCACGGCCGCGCCCAGCCCACCGCGCCGCCTGCCGCCGCCGCAGCCTGGCGAGCAGCCG
CCCTCCGGCAGCGGCCACAGCCGCCCGCCAGGGGCCAGGCCCCCACATCGTGGCGGCAGCAGTA
GGGGCAGCGGGGACACGGCGGCTGCGCCCCCCTCTCGCGGCGGGAAGGCGAGGCCCCCTGGTGG
CGGCGCCGCTCCCTGCGAGCCCGGGTGCCAGTGCCGCGCGCCCATGGTGAGTGTGTCCAGCGAA
CGCCACCCGCTCTACAACCGCGTCAAGACCGGCCAGATCGCCAACTGTGCGCTGCCCTGCCACA
ACCCCTTCTTTAGCCAGGATGAGCGCGCCTTCACTGTCTTCTGGATCGGCTTGTGGTCGGTGCT
CTGCTTCGTCTCCACCTTCGCCACTGTCTCTACCTTCCTCATCGATATGGAGCGCTTTAAGTAC
CCGGAACGGCCCATTATATTCCTCTCTGCCTGCTACCTCTTCGTGTCTGTCGGGTACCTGGTGC
GCCTGGTGGCTGGACACGAGAAAGTGGCCTGCAGCGGCGGCGCGCCGGGTGCAGGAGGAGCTGG
GGGTGCTGGCGGCGCGGCGACCGCTGGCGCGGGGGCGGCGGGAGCGGGGGCGAGCAGCCCGGGC
GCGCGCGGCGAGTACGAGGAGCTGGGTGCAGTGGAGCAGCACGTGCGCTATGAGACCACTGGCC
CCGCGCTGTGCACGGTAGTCTTCCTCCTTGTCTACTTTTTTGGCATGGCTAGCTCCATCTGGTG
GGTAATCCTGTCTCTCACGTGGTTCTTGGCGGCTGGTATGAAATGGGGCAACGAGGCCATAGCA
GGCTACTCGCAATACTTCCACCTTGCCGCGTGGCTCGTGCCCAGCGTCAAGTCCATAGCGGTGC
TGGCGCTCAGCTCCGTGGACGGCGACCCGGTGGCGGGCATCTGCTACGTGGGCAACCAGAGCCT
TGACAACCTACGCGGCTTTGTACTGGCGCCACTGGTCATCTACCTCTTCATTGGGACTATGTTT
CTGTTAGCTGGCTTCGTGTCGCTGTTCCGAATCCGCTCAGTCATCAAGCAACAAGGAGGCCCAA
CCAAGACTCACAAGCTAGAAAAGCTCATGATCCGCTTGGGCCTCTTCACCGTGCTCTACACGGT
GCCCGCCGCCGTCGTTGTCGCCTGCCTTTTCTATGAGCAGCACAACCGACCGCGCTGGGAGGCC
ACGCACAACTGCCCATGCCTTCGCGACCTGCAGCCAGACCAGGCTCGCAGGCCCGACTACGCGG
TCTTCATGCTCAAGTACTTCATGTGCCTAGTGGTGGGCATCACATCAGGCGTGTGGGTCTGGTC
CGGCAAGACTCTGGAGTCCTGGCGTGCGTTGTGTACTCGCTGCTGCTGGGCCAGCAAGGGCGCT
GCAGTTGGCGCGGGCGCCGGAGGCAGCGGCCCTGGGGGCGGTGGCCCCGGGCCCGGTGGGGGTG
GGGGGCACGGCGGAGGTGGGGGATCCCTCTACAGCGACGTCAGCACCGGCCTGACGTGGCGGTC
TGGCACGGCCAGCTCTGTATCTTACCCTAAGCAAATGCCATTGTCCCAAGTCTGAACCCTGAAC
GGAAGCCCAGAAGGGGCGGAGAGGGGTGGGGGATGGAGAACCCGAGGGCGGCGAAGGGACCCCA
GATCGGCCGGGGTTCCCACCCCTTCACCGTGTTGACTGCTATTAGCATGATAATGAACTCTTAA
TGGTATCCATTAGCCACAGGGACTTAAATGATTCCCTTAGAACAAAGTACCTGGCATTGAAGCC
TCCCAGACCTAGCCCCTCCCCTCCGATGCTCCGGAGCGCCTACCCTAGACAATGGTTTCAGTGG
GCTAGCATAGTTGGAACCCTCCTGGATACCCTGGATGAGTCTTGAGGTAATACCACTACAAACT
TCACCCAAGGGACTGCTTCACCCTCGACTTCTTCAGCATAAATTCAACCCTTCATACATCCTAG
AGGAGGGACAACTGCTACCTTGTGGGACTGCACGGTTTGGGTATTCTTAATGACCAGGCAGATG
CCTTAAATAAACAATAAATGTCTTAATTATACACCCCAAGTAAATACGGGTTTCTTACATTAAA
GGATGTATTTATATAATTATTTGTTAAGTTGTAAAAAAAAAAAAGGTGTAAATTATGTATATAT
CCAAAGATATACAATGTGTACATTATTTGTAAAAAGTTTAGAGGCTACCCTGTAAGAACAAATA
TAAGTATTCTATTTTGTCAATAAAATGACTTTTGATAAATGAAAAAAAAAAAAAAAAAAAAAAA
AAAA

hide sequence

RefSeq Acc Id:

XM_006254142 ⟹ XP_006254204

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	62,007,849 - 62,015,485 (+)	NCBI
mRatBN7.2	17	57,312,924 - 57,320,551 (+)	NCBI
Rnor_6.0	17	62,259,910 - 62,267,239 (+)	NCBI
Rnor_5.0	17	64,033,702 - 64,040,990 (+)	NCBI

Sequence:

show sequence

GCACTATTCCTAAGAGGCTGTTGCATTGAACTGCAGCGAAGAGGAGGAAGACAGAGTACTATAA
CTCACAATACACCATGGTTGCTAATTTTGTTTTGCCACAAGGCTGTTTTAATGACGTTAACTGC
TATCTCCCCCACCACCACCATCACCACTCCACTGCCAAAGAACCTGCACAGCCTAGAACGGACC
TGCAGTCGCCTCTTCTCTACTCCCTGCCCAACTTTTGTTCTCCAGTTCCACTTGTTCCTGGTAA
GGAACTGAAGTGCCACAGGTCATGCGGCAATGGACACTTATGTACCACGCTCCTAGCACTCGGA
AAGGGCTACCAAGCAGTCTTGGCCAAACCTGGTCATCTAGCCCCAATAGAAGTCTCACTACTAT
CTCACCAAGTCGCCAAGTCCGAAAAGCCCTCGTTATGAGACTACCAAGAGGAAATCTCTCCCTG
AAATGCCCTAGCTCTGGATCTGGACCAGCCTTGGAGCCCTAGCTGTGCTTCCAAGACCATCTAG
ACCCCGCAGATATTGTCTGTGGAGCAAGAGACTGACTCAGAGAGCCCTGGAAGGTGATTCCAGA
GATCTCTCCTGGGAGAGATCCCAGGAGCAGACTCGGAGAAATGCGACCAAGACCTCTGAAGCGC
TGAACTCTTTGGGGACAGTCTGAGTAAATGCTCAATCCGTGTGGTCAACCCCATGGTGACCAAA
AACAAACTCTCCATCCGCCCAAAGCTAGGAAAGCAGTCCCAAAACTACGGACTTCCTTAAGGAA
GGCAGAGCCTTGAGAACGCAGATACTCCGCCCCGTTGCGCAGGGATTGGTGAAGCAGAAGAGGG
AGGAGACCAAATGCAGGCTGTATAAATATTCATGAGCCGGCCTGGAGGCGCTAGCTGACTAAAG
CCGGGAAGTTAGGCGAAGGGCGCAGCTCCTGTGGAGGAGGAGGAGGCTGGGACTACGGTGCTCA
GGTGTCCCCTCTGTCTTTTGCTCTGGATTTGTTTGTCGGTCTAGCAAGAAAGCACGTCCTGCAC
CCTGCCCGACTGTGGCCAGAACGCGGCTCGGACTTTTGGTGGCTGCAGATGCAAGAGGACCGAC
GCAGGAGTGAGAAGGCGGCGGCCTGAGCAGCCGAGGGCCCGGAACTCTGGCAGTGGCGGCGCGG
CCTGGAACGGACATGAACCCTCGGGGCCCGAAGAGGGGCCGCTAGGTCTGACCCGAGAGTCTAG
AGGCCAGACACAGCCATCTTGACTGAAGCCAGAAAGGAAACTTGAGGCGCCCTCTGAGCCTTCG
CTGCTGGGAGCCACACGAAGTGTCTGAGCTTGCAGGAGGACCTACAGGAGCTCAGGAGAATGAT
CCCGGGGGCCACCGCTCCGCTCCGGGAGGGCTGAGTGCGACTCAGAGGGCGCAGGACAGACCCT
GTGGAATTGTGGCGCGTCTGCGGTCACCCCAGGAGAGGCGTGGGGGAGGGCCGGACGAGTCCTG
CCTAGGTTTCCGACCCTGCTGCCACAGACGCTGCCTGAAAAGGAGATAAATTGTTGGCAGATTC
TCCTCTCGGCAGAGAAAAGCCGGACAAGACCTTCTGGTCGCCTGCACTCCCTTTACTCAGGTTC
CTCACCGTAGAGCCCTTCTGCGCGGCGCCCGGAGAAGGAGGACTTGGGGTCCCGGCGCTCAGCA
TGGAGTGGGGTTACCTGTTGGAAGTGACCTCGCTACTAGCCGCCTTGGCGGTGCTACAGCGCTC
GAGCGGCGCTGCCGCGGCTTCGGCCAAGGAGCTGGCGTGCCAAGAGATCACAGTGCCGCTGTGC
AAGGGCATCGGTTACAACTACACCTACATGCCCAACCAGTTCAACCACGACACGCAAGATGAGG
CGGGCCTAGAGGTACACCAGTTCTGGCCGCTGGTGGAGATCCAGTGCTCCCCGGACCTCAAGTT
CTTTCTGTGTAGCATGTACACGCCCATCTGCCTGGAGGACTACAAGAAACCTCTGCCGCCTTGC
CGCTCTGTGTGTGAACGCGCCAAGGCCGGCTGCGCGCCGCTCATGCGCCAGTACGGCTTTGCCT
GGCCTGACCGAATGCGCTGCGATCGGCTGCCGGAGCAGGGCAACCCCGACACTCTGTGCATGGA
CTACAACCGCACCGACCTCACCACGGCCGCGCCCAGCCCACCGCGCCGCCTGCCGCCGCCGCAG
CCTGGCGAGCAGCCGCCCTCCGGCAGCGGCCACAGCCGCCCGCCAGGGGCCAGGCCCCCACATC
GTGGCGGCAGCAGTAGGGGCAGCGGGGACACGGCGGCTGCGCCCCCCTCTCGCGGCGGGAAGGC
GAGGCCCCCTGGTGGCGGCGCCGCTCCCTGCGAGCCCGGGTGCCAGTGCCGCGCGCCCATGGTG
AGTGTGTCCAGCGAACGCCACCCGCTCTACAACCGCGTCAAGACCGGCCAGATCGCCAACTGTG
CGCTGCCCTGCCACAACCCCTTCTTTAGCCAGGATGAGCGCGCCTTCACTGTCTTCTGGATCGG
CTTGTGGTCGGTGCTCTGCTTCGTCTCCACCTTCGCCACTGTCTCTACCTTCCTCATCGATATG
GAGCGCTTTAAGTACCCGGAACGGCCCATTATATTCCTCTCTGCCTGCTACCTCTTCGTGTCTG
TCGGGTACCTGGTGCGCCTGGTGGCTGGACACGAGAAAGTGGCCTGCAGCGGCGGCGCGCCGGG
TGCAGGAGGAGCTGGGGGTGCTGGCGGCGCGGCGACCGCTGGCGCGGGGGCGGCGGGAGCGGGG
GCGAGCAGCCCGGGCGCGCGCGGCGAGTACGAGGAGCTGGGTGCAGTGGAGCAGCACGTGCGCT
ATGAGACCACTGGCCCCGCGCTGTGCACGGTAGTCTTCCTCCTTGTCTACTTTTTTGGCATGGC
TAGCTCCATCTGGTGGGTAATCCTGTCTCTCACGTGGTTCTTGGCGGCTGGTATGAAATGGGGC
AACGAGGCCATAGCAGGCTACTCGCAATACTTCCACCTTGCCGCGTGGCTCGTGCCCAGCGTCA
AGTCCATAGCGGTGCTGGCGCTCAGCTCCGTGGACGGCGACCCGGTGGCGGGCATCTGCTACGT
GGGCAACCAGAGCCTTGACAACCTACGCGGCTTTGTACTGGCGCCACTGGTCATCTACCTCTTC
ATTGGGACTATGTTTCTGTTAGCTGGCTTCGTGTCGCTGTTCCGAATCCGCTCAGTCATCAAGC
AACAAGGAGGCCCAACCAAGACTCACAAGCTAGAAAAGCTCATGATCCGCTTGGGCCTCTTCAC
CGTGCTCTACACGGTGCCCGCCGCCGTCGTTGTCGCCTGCCTTTTCTATGAGCAGCACAACCGA
CCGCGCTGGGAGGCCACGCACAACTGCCCATGCCTTCGCGACCTGCAGCCAGACCAGGCTCGCA
GGCCCGACTACGCGGTCTTCATGCTCAAGTACTTCATGTGCCTAGTGGTGGGCATCACATCAGG
CGTGTGGGTCTGGTCCGGCAAGACTCTGGAGTCCTGGCGTGCGTTGTGTACTCGCTGCTGCTGG
GCCAGCAAGGGCGCTGCAGTTGGCGCGGGCGCCGGAGGCAGCGGCCCTGGGGGCGGTGGCCCCG
GGCCCGGTGGGGGTGGGGGGCACGGCGGAGGTGGGGGATCCCTCTACAGCGACGTCAGCACCGG
CCTGACGTGGCGGTCTGGCACGGCCAGCTCTGTATCTTACCCTAAGCAAATGCCATTGTCCCAA
GTCTGAACCCTGAACGGAAGCCCAGAAGGGGCGGAGAGGGGTGGGGGATGGAGAACCCGAGGGC
GGCGAAGGGACCCCAGATCGGCCGGGGTTCCCACCCCTTCACCGTGTTGACTGCTATTAGCATG
ATAATGAACTCTTAATGGTATCCATTAGCCACAGGGACTTAAATGATTCCCTTAGAACAAAGTA
CCTGGCATTGAAGCCTCCCAGACCTAGCCCCTCCCCTCCGATGCTCCGGAGCGCCTACCCTAGA
CAATGGTTTCAGTGGGCTAGCATAGTTGGAACCCTCCTGGATACCCTGGATGAGTCTTGAGGTA
ATACCACTACAAACTTCACCCAAGGGACTGCTTCACCCTCGACTTCTTCAGCATAAATTCAACC
CTTCATACATCCTAGAGGAGGGACAACTGCTACCTTGTGGGACTGCACGGTTTGGGTATTCTTA
ATGACCAGGCAGATGCCTTAAATAAACAATAAATGTCTTAATTATACACCCCAAGTAAATACGG
GTTTCTTACATTAAAGGATGTATTTATATAATTATTTGTTAAGTTGTAAAAAAAAAAAAGGTGT
AAATTATGTATATATCCAAAGATATACAATGTGTACATTATTTGTAAAAAGTTTAGAGGCTACC
CTGTAAGAACAAATATAAGTATTCTATTTTGTCAATAAAATGACTTTTGATAAATGATTTAAGT
ACTACCCTGTCCCCCACCTCTTTTGAACTGTTCCCCATATGCTTGCTAAGGACATGTTCCTCAC
ATTGGACATTTTCTGGCTTGCCATTTTGTACTGACTTTAGGCATGGAGACAATTACCTGTTAAC
CTCTAATTCTTGAACTGTTAGCAAAGTAAATATCATTGTTGAATTGAAATCAAAATCGCGTTTT
TGCACTTTCCCCCAAAAATGGTGGTTTTTATGGTCTCTCCTTGCTGGCCTGTGTAGCTCTTCAT
GATGTGTGTGGGTGGACAATTTGCAAAGGTAGCCATTCCACTTGGCCTGTTTATTTGCTGGTAT
AATGCCACTTACACTAACAGCAGCCCTATGTGAGTATCTTCAGTCTGTGACTTTGAAAGCCCTG
GCCTTTTACAGACCTGACCACACTCAGAAATGTGGAGGTTAGTATTTGAGGCCACAGGTCACCT
CTATACTGTAAGTCACTTGACAATATGGTGTAGTAAAGCAGGTGCTGCCTAACAGATTGAACGA
ATGGGTTAACTTCTTAATAGCATTCCCTGCTTGTGTATTCCAAGTGTGCTGCTTTTCCTGGAGA
AAAAAAAAAGCTATTGTTCCTCTGTCAAGACTAAGCTAATTTATTTGAACAGAAGGCTGTTGAA
TCAGCAGAAGAATGTGCTGGCAATTGTTGAACTTTTTACCTGTCTGCCCAGTGCCTCTGCACAT
CATTCCTTTAAGAGGAGCTAAATGAATAGGGTTAATCTGTAGGGAACTTAGTCTTTTGAGTTTG
GAAAACTTTGATCTTTTCTCCTCTGTGAATGAGCTGTATAGTCTGAAGTTTCTTTCCCTGCTGC
CTGGCTCCTCTTGGTGCGGACCAATTGGCCACCGTGGAGCCTTAACGCTCTTCCATTAAAGGGA
TGTGGGACTTTTACTTTAAAAAGGAGAGGCAGAGAGGGAGAGGAAGACTTGTAACAGTTAGTGA
AGACCTGAGGCGCAAGTACGCTCAGCCTTTTCAACAGCTTTCCAGGGCTTTGTTAGCCAGCCTG
CAGGCAGCTAGGCCTGGGCTGTACATTATAGAAAAGGCTCTGAATGCCCCACAGGTGGTCTCTG
CACATAATCCCCCAATTTAAAGCAGTTTCCTTTGCTGGACAATTGCATTACAAAACTCCCTTCT
TTTACACTCCTAATTGAAGCAATGAACTATTATAAACTACAAGTTTTTCTTTAAAAAGAAAAAT
CCTCAGTGCCTAAATTCTATTGACTAAATGCTGGCAAATTTTCTAAACTGGACCTTTTAAATCA
CTTGTGGAGAACGCTTCTTCTGCAGATATTTTTCAGATATTTTTATTTCCTAGGCTTTTTAATT
TCTGGAAGATTAGCAATAATTTAAAAGTAATTGGTAAGATTGTATGTTCACACTGAAAAGATAG
CCCCAGGTCCCTTATTAACCTGTCAATCAAAATAAGAAACTGGCAGCTACCCTGCTAATAACTG
GAGTCCAGCATTGTGGATGGGGAGGGACCCTGGGTACCCTTCTTAGATGTTTGTTTCTCTTTGG
TTTTCCTTTAGTGACTAAATTCTGAATTAATAAGATGAAAGCTACTTATTTTACAGAAATTCAT
GAAGAGGCATTTTTAAAAAAAATTTTTTCTATTCCCTTTCAGAGTCACAGTTCGTGCTAACTGA
AATTTTAAAATTAGATATATAATGTGAATACATACTATAGTTGTCATGCCAATTTTACCTTCAA
AAATCAGGCACCTTGCCAGCAGTTTTATTCGTTAAATAATTACTGGTTTGTGACCTAGGTACAT
GCGAGCACTCCCACCTAACCCACACTTACAAGTGGGATGCTGAGTGTGTATAAACTGGCCATGA
ACTCTGTGTATTCAGTAATAAGGTCAAAGTTAGGGGCAAGGCTTTATCACATGTGTGGAAAAGA
GCTAAAAGTTGCCGGTTTATGACATTCTCGGTAGCAATTTTTAACCATGATAACTTTGGGGAGT
TGTTATTTTGAGTCTTTTACCTCATTAGTATTCCATGCATCCTTGTAAAATGTCATATTTGATA
ACTTTTACAAGATGGCTGTAATGGTGTACAGCTAAGCAAACTTATAAATAAAAAAAAGAAAAGC
ACTGTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001037716	(Get FASTA)	NCBI Sequence Viewer
	XP_006254204	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI00089	(Get FASTA)	NCBI Sequence Viewer
	EDL83775	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000093389
	ENSRNOP00000093389.1
GenBank Protein	Q498S8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001037716 ⟸ NM_001044251
- Peptide Label:	precursor
- UniProtKB:	Q498S8 (UniProtKB/Swiss-Prot), A6KPN0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDE AGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFA WPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPQPGEQPPSGSGHSRPPGARPPH RGGSSRGSGDTAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANC ALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVS VGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAATAGAGAAGAGASSPGARGEYEELGAVEQHVR YETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSV KSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIK QQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQAR RPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGGGP GPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV hide sequence

RefSeq Acc Id:	XP_006254204 ⟸ XM_006254142
- Peptide Label:	isoform X1
- UniProtKB:	Q498S8 (UniProtKB/Swiss-Prot), A6KPN0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDE AGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFA WPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPQPGEQPPSGSGHSRPPGARPPH RGGSSRGSGDTAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANC ALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVS VGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAATAGAGAAGAGASSPGARGEYEELGAVEQHVR YETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSV KSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIK QQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQAR RPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGGGP GPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV hide sequence

Ensembl Acc Id:

ENSRNOP00000067651 ⟸ ENSRNOT00000073575

Ensembl Acc Id:

ENSRNOP00000055627 ⟸ ENSRNOT00000058837

Ensembl Acc Id:

ENSRNOP00000093389 ⟸ ENSRNOT00000116071

Protein Domains

FZ G-protein coupled receptors family 2 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q498S8-F1-model_v2	AlphaFold	Q498S8	1-684	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560525	AgrOrtholog
BioCyc Gene	G2FUF-8950	BioCyc
Ensembl Genes	ENSRNOG00000059244	Ensembl
	ENSRNOG00000061031	Ensembl
	ENSRNOG00000069521	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000116071	ENTREZGENE
	ENSRNOT00000116071.1	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.2000.10	UniProtKB/Swiss-Prot
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7371338	IMAGE-MGC_LOAD
InterPro	Frizzled/SFRP	UniProtKB/Swiss-Prot
	Frizzled/Smoothened_TM	UniProtKB/Swiss-Prot
	Frizzled_dom	UniProtKB/Swiss-Prot
	Frizzled_dom_sf	UniProtKB/Swiss-Prot
	FZ8_CRD	UniProtKB/Swiss-Prot
	GPCR_2-like	UniProtKB/Swiss-Prot
KEGG Report	rno:364754	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112790	IMAGE-MGC_LOAD
NCBI Gene	364754	ENTREZGENE
PANTHER	FRIZZLED-8	UniProtKB/Swiss-Prot
	PTHR11309	UniProtKB/Swiss-Prot
Pfam	Frizzled	UniProtKB/Swiss-Prot
	PF01392	UniProtKB/Swiss-Prot
PhenoGen	Fzd8	PhenoGen
PRINTS	FRIZZLED	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F2_4	UniProtKB/Swiss-Prot
	PS50038	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000059244	RatGTEx
	ENSRNOG00000061031	RatGTEx
	ENSRNOG00000069521	RatGTEx
SMART	FRI	UniProtKB/Swiss-Prot
	Frizzled	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF63501	UniProtKB/Swiss-Prot
UniProt	A6KPN0	ENTREZGENE, UniProtKB/TrEMBL
	FZD8_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Fzd8	frizzled class receptor 8	LOC100909849	frizzled-8-like	Data merged from RGD:6501129	737654	PROVISIONAL
2014-02-06	Fzd8	frizzled class receptor 8	Fzd8	frizzled family receptor 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-05	LOC100909849	frizzled-8-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2011-08-02	Fzd8	frizzled family receptor 8	Fzd8	frizzled homolog 8 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Fzd8	frizzled homolog 8 (Drosophila)	MGC112790	similar to transmembrane receptor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	MGC112790	similar to transmembrane receptor			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)