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Gene: Trim34 (tripartite motif-containing 34) Rattus norvegicus

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Symbol:

Trim34

Name:

tripartite motif-containing 34

RGD ID:

7240857

Description:

Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of DNA-binding transcription factor activity; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be active in cytosol and nucleoplasm. Orthologous to human TRIM34 (tripartite motif containing 34); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase TRIM34; tripartite motif-containing protein 34

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TRIM34 (tripartite motif containing 34)	HGNC	Ensembl, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Trim34a (tripartite motif-containing 34A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TRIM34 (tripartite motif containing 34)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TRIM34 (tripartite motif containing 34)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TRIM34 (tripartite motif containing 34)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Trim34 (tripartite motif containing 34)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TRIM6-TRIM34 (TRIM6-TRIM34 readthrough)	HGNC	HomoloGene, OrthoDB
Homo sapiens (human):	TRIM22 (tripartite motif containing 22)	HGNC	OrthoDB
Homo sapiens (human):	TRIM6 (tripartite motif containing 6)	HGNC	EggNOG
Alliance orthologs ³
Homo sapiens (human):	TRIM34 (tripartite motif containing 34)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Trim34a (tripartite motif-containing 34A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Trim34b (tripartite motif-containing 34B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:194990	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:dkey-219e21.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:dkey-18p12.4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch211-114c12.5	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch73-364h19.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch211-120g10.1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	B0281.8	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	ZK1240.5	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	ZK1240.9	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	nhl-3	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK1240.8	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	ZK1240.3	Alliance	DIOPT (Ensembl Compara\|InParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	168,119,043 - 168,130,544 (+)	NCBI		GRCr8
mRatBN7.2	1	158,707,172 - 158,720,214 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	158,707,172 - 158,718,674 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	166,694,737 - 166,706,424 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	173,874,752 - 173,886,439 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	166,767,605 - 166,779,007 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	169,433,539 - 169,445,041 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	169,433,539 - 169,445,041 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	175,573,580 - 175,585,081 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	1	156,697,815 - 156,709,208 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

azoxystrobin (EXP)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chlorpyrifos (EXP,ISO)

cisplatin (ISO)

dexamethasone (ISO)

dioxygen (EXP,ISO)

doxorubicin (ISO)

endosulfan (EXP)

gentamycin (EXP)

glyphosate (EXP)

hydrogen peroxide (ISO)

imidacloprid (EXP)

indometacin (ISO)

methimazole (EXP)

methylmercury chloride (ISO)

ozone (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylephrine (EXP)

pirinixic acid (ISO)

propiconazole (EXP)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sulfadimethoxine (EXP)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

thiabendazole (EXP)

thioacetamide (EXP)

trichloroethene (EXP)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

innate immune response (IBA)

positive regulation of autophagy (IBA)

positive regulation of canonical NF-kappaB signal transduction (IBA)

positive regulation of DNA-binding transcription factor activity (ISO)

regulation of gene expression (IBA)

regulation of protein localization (IBA)

regulation of viral entry into host cell (IBA)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (IBA)

nucleoplasm (IBA)

Molecular Function

identical protein binding (ISO)

protein homodimerization activity (IBA)

protein kinase binding (IBA)

ubiquitin protein ligase activity (IBA)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17156811	PMID:23077300

Genomics

Comparative Map Data

Trim34
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	168,119,043 - 168,130,544 (+)	NCBI		GRCr8
mRatBN7.2	1	158,707,172 - 158,720,214 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	158,707,172 - 158,718,674 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	166,694,737 - 166,706,424 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	173,874,752 - 173,886,439 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	166,767,605 - 166,779,007 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	169,433,539 - 169,445,041 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	169,433,539 - 169,445,041 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	175,573,580 - 175,585,081 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	1	156,697,815 - 156,709,208 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

TRIM34
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	5,619,944 - 5,644,398 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	5,619,764 - 5,644,398 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	5,641,174 - 5,665,628 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	5,597,750 - 5,622,204 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	5,610,086 - 5,619,100	NCBI
Celera	11	5,759,992 - 5,784,582 (+)	NCBI		Celera
Cytogenetic Map	11	p15.4	NCBI
HuRef	11	5,300,832 - 5,325,294 (+)	NCBI		HuRef
CHM1_1	11	5,640,099 - 5,664,580 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	5,677,835 - 5,702,296 (+)	NCBI		T2T-CHM13v2.0

Trim34a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	103,893,657 - 103,911,446 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	103,893,664 - 103,911,441 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	104,244,448 - 104,262,244 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	104,244,457 - 104,262,234 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	111,392,971 - 111,410,753 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	104,203,167 - 104,210,608 (+)	NCBI		MGSCv36	mm8
Celera	7	104,628,965 - 104,632,673 (+)	NCBI		Celera
Cytogenetic Map	7	E3	NCBI
cM Map	7	55.69	NCBI

TRIM34
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	8,058,863 - 8,083,487 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	8,016,544 - 8,041,168 (+)	NCBI		NHGRI_mPanPan1

TRIM34
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	4,174,294 - 4,183,440 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	4,175,660 - 4,188,528 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	4,705,985 - 4,718,802 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRIM34
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	61,104,681 - 61,123,901 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666043	64,883,405 - 64,902,640 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trim34
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624817	7,086,719 - 7,103,630 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624817	7,086,639 - 7,103,561 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Trim34
102 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	278
Count of miRNA genes:	201
Interacting mature miRNAs:	219
Transcripts:	ENSRNOT00000023043, ENSRNOT00000055210
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	121767634	166767634	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	123350408	182418476	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	115585465	172949803	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat
152025232	Bw192	Body weight QTL 192	3.93		body mass (VT:0001259)		1	117917486	196963478	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	158633083	203633083	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	131763437	159756369	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	136745990	163747690	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
9685799	Bp375	Blood pressure QTL 375			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121833674	166833674	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
9685802	Bp376	Blood pressure QTL 376			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	126540680	171540680	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	123350408	182418476	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
634315	Niddm45	Non-insulin dependent diabetes mellitus QTL 45	7.16		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	144267916	172949660	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
61379	Bp44	Blood pressure QTL 44	19.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144267916	174133260	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
2313060	Bss71	Bone structure and strength QTL 71	2.6	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	1	118944747	163944747	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
724550	Thym3	Thymus enlargement QTL 3	7.82	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
71118	Thym1	Thymus enlargement QTL 1	10.17	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	136830018	181830018	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1582204	Livw1	Liver weight QTL 1	3.6	0.0003	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	1	155422851	172949803	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	168883176	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
8693608	Alc24	Alcohol consumption QTL 24	2.3	0.74	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	150452391	168228760	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	156677124	201278233	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350408	181759564	Rat
152025212	Bw190	Body weight QTL 190	5.7		body mass (VT:0001259)		1	123556856	196963478	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
631548	Bp88	Blood pressure QTL 88	5	0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	156677124	176484451	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	123350408	182418476	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat

Markers in Region

BI280655

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	158,718,469 - 158,718,595 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	169,444,837 - 169,444,962	NCBI	Rnor6.0
Rnor_5.0	1	175,584,877 - 175,585,002	UniSTS	Rnor5.0
RGSC_v3.4	1	162,094,486 - 162,094,611	UniSTS	RGSC3.4
Celera	1	156,709,004 - 156,709,129	UniSTS
RH 3.4 Map	1	1300.2	UniSTS
Cytogenetic Map	1	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001276491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC112864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO563709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000055210 ⟹ ENSRNOP00000052084

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	158,707,172 - 158,718,674 (+)	Ensembl
Rnor_6.0 Ensembl	1	169,433,539 - 169,445,041 (+)	Ensembl

RefSeq Acc Id:

NM_001276491 ⟹ NP_001263420

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	168,119,043 - 168,130,544 (+)	NCBI
mRatBN7.2	1	158,707,172 - 158,718,674 (+)	NCBI
Rnor_6.0	1	169,433,539 - 169,445,041 (+)	NCBI
Rnor_5.0	1	175,573,580 - 175,585,081 (+)	NCBI
Celera	1	156,697,815 - 156,709,208 (+)	NCBI

Sequence:

show sequence

TGGTCTGGAGTTTCAGTTTCTTTTTCTCGGCATCCAGAAAGGGGGGCGCTGCTGGTTGGCTGAT
TAAAGCCTGCCCCTGGCTTTTCCTCACCGCCCGCTTCTGCAGGGAAGAAAGATTTCACCTTCTG
GGCCTGAGATTCTGTCTGATCACGGCTGAAAACTGAGTGCTTTCAACCATAGTATTGTCCACTT
TGAAGGAGTCTTAGTGGCCGTGTTGCCTTGAGTTGTCTTTGAGGACTGATTCACCATTTGTTTT
ATAATCCTCCTAGCCATCCAGTAGCCCTTAAGAAAGAAGAGCCTCAGAGGTCAGGACAGGAAAG
GACAGGGGGCAGCATAATGGCCTCAACAGATCAGACAGATGTACAGAAGGAGGCCACTTGCCCT
GTCTGCCACGTGCTTTTGATAAAACCCTTGAATCTAGGCTCTGGCCACCATGTATCCCAAGCCT
GCCTCACCGTGAAGAAGACTGCAGTGACCAACCCCAGAGGGAAAAGCCTCTGTCCTATGTGTGG
CAATAGATTCTCATTTGAAAATCTACAGGCTAATAAGCATCTGGCAGATGTAGTAGAGAGACTC
AGGGAAGTCAAGTTGAGCCCTGACATTGGGAAAAAGGGAGATCTCTGCGTACACCATGGAGAGA
AACTCCTTCTCTTCTGTCAAGAGGACAAGAAGGTCATTTGCTGGGTTTGTGAGCGTTCTCAGGA
GCATCGTGGTCACCACACCTTCCTCCGGGACGAAGCAGTCAGGGAATGTCAGGAGAATCTCCAG
GAAGCTCTCAAGAGGCTGAGGAAGGAGCAGGAGAAGGTGGAGACATTTGAAGCTGACATCAAAG
AAGACAGAATTTCCTGGAAGCACCAGATCCAGACCGAGAGACAAAGGATCCAAACAGGCTATAA
TCAACTTAGAAGAATCCTGGACAAGGAGGAACAGAACGAGCTGAAAAGACTCAGGGAAGAGGAG
CAGATGATACTAGACAGCCTGGCAGGGGCAGAGGCTGAGCTGGCTCAGCAGAGCCAGTTGGTGG
AGGAACTCATCTCGGATCTAGAGCGTCGGTGTGAGTGGTCAGACACAGAGCTGCTGCAGGATGT
AAGCGGTATCTTGAAATGGAGTCAGATCTGGACACTAAAGAAGCCAAAAGCAGTTTCTAAGAAA
CTGAAGATGGTATTCCAAGCTCCTGATCTAAGTGGCATGCTACAAAAGTTTAGAGAGCTAACAG
CTGTCCGGGCCTACTGGGCGGACTTCACGTTTAATCCAGAAAACCTAAATTTGAATCTCATTCT
TTCAGAAGATCATAGACAAGTGACATCTGTGCCCATTTGGCCCTTTAAGTGTTGTAATAATGGT
ATCTTGGGCTCCAAATGTTTCTTGTCAGGAAAACATTACTGGGAAGTGGATGTGTCTGAAAAGA
ATGCCTGGACCCTGGGAGTTTACTCTAGAAAACGTACTTTGAAGTTTGATGTTAGACGATGCAG
CAAAAGTCAGCCAAATGGTTACCACAGATACAAACCTCAGAATGGCTACTGGGTTATAGGGTTA
CAGGATGGATCAAAGTATAGTATCTTTGAGGATTCTTCCAACTGTGGCCCTACAGTTCTGAACC
CCTTTGTGGCCACCCCTCTCCATCGGATTGGGGTTTTCCTTGACTGTGAAGAGGGCATAGTGTC
CTTCTTCAATGTCACAAACCACGGGTCACTCATTTACAAGTTTACCCAATGCCGCTTTTCCCAA
CCTGCCTATCCATACTTCAATCCTTGGGACTGCCCAGCCCCCATGACCCTCTGTCCTCGGAACG
CCTGAGTTTTCTCATTCTCATCAGTTTCTGATCTTCCTGCCTTGACCCTCACCTTCTGGATGTA
CCTGTGGGGTTTGGGCACCTCTTCCCATGGTCTCCCTTCTGTCATGCTTGGATGTGGTATATCC
GACATCATTTAGAAAAGATGCTTACCACTTACTCTAACTCATATTCTCAAAGACAGTGAGTCAA
GTCTAAAGCTGGGTCAGTATAACATCTGTGCCCTCTGACTTCCATATTTCCCTTTGTCTTGAAG
AAAGTTGACAAAGTCTGTTCGGCACTAGCTCATCCCTGCTGTTTAAGACATTCCGTAAGAACTG
GCCCCTGGCCACAACTAATGAATTTTTAACAATGTGTTGCTCAGGATATGTCATGTTCAACAGG
AAGTCAAGGAATAGGTAACGTGAACAGCAATATGTAGCCTAGAGTTGAGGATATGTCTAGTATC
AAATTCAAATGCTGCATCTTGTAAACTAATAAATTCTGAGGTTCTTAAACTAAAAATTAAAGTG
CATCTGACTTAAGATCATTGTATGAAACTAGAGATTTGTAAATATAAAATACCCACTTGAGTGC
CTGGTCCATAAGAAACATGGTCCTATAGTCCTTTGTACTCAATGAAATATCTTGTTGGAGTATT
TTAAATACCTGTTGTCTTCAAATGCTAGTTTTTCTTCCTTGCCAGTTTGATTTCATATGTATAA
CCTCATGTGGAGTGTGTCTGGTTTTAAAAATAAAAGGTTGGTCTTCAATGACATTCTAATTCAT
TTGCAG

hide sequence

RefSeq Acc Id:

XM_039103735 ⟹ XP_038959663

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	168,124,751 - 168,130,522 (+)	NCBI
mRatBN7.2	1	158,713,910 - 158,720,214 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001263420	(Get FASTA)	NCBI Sequence Viewer
	XP_038959663	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000052084.4

RefSeq Acc Id:

NP_001263420 ⟸ NM_001276491

- UniProtKB:

D3ZA88 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASTDQTDVQKEATCPVCHVLLIKPLNLGSGHHVSQACLTVKKTAVTNPRGKSLCPMCGNRFSF
ENLQANKHLADVVERLREVKLSPDIGKKGDLCVHHGEKLLLFCQEDKKVICWVCERSQEHRGHH
TFLRDEAVRECQENLQEALKRLRKEQEKVETFEADIKEDRISWKHQIQTERQRIQTGYNQLRRI
LDKEEQNELKRLREEEQMILDSLAGAEAELAQQSQLVEELISDLERRCEWSDTELLQDVSGILK
WSQIWTLKKPKAVSKKLKMVFQAPDLSGMLQKFRELTAVRAYWADFTFNPENLNLNLILSEDHR
QVTSVPIWPFKCCNNGILGSKCFLSGKHYWEVDVSEKNAWTLGVYSRKRTLKFDVRRCSKSQPN
GYHRYKPQNGYWVIGLQDGSKYSIFEDSSNCGPTVLNPFVATPLHRIGVFLDCEEGIVSFFNVT
NHGSLIYKFTQCRFSQPAYPYFNPWDCPAPMTLCPRNA

hide sequence

Ensembl Acc Id:

ENSRNOP00000052084 ⟸ ENSRNOT00000055210

RefSeq Acc Id:	XP_038959663 ⟸ XM_039103735
- Peptide Label:	isoform X1

Protein Domains

B box-type B30.2/SPRY

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZA88-F1-model_v2	AlphaFold	D3ZA88	1-486	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690279

Promoter ID:

EPDNEW_R804

Type:

multiple initiation site

Name:

Trim34_1

Description:

tripartite motif-containing 34

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	169,433,553 - 169,433,613	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:7240857	AgrOrtholog
BioCyc Gene	G2FUF-58095	BioCyc
Ensembl Genes	ENSRNOG00000042686	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000055210.5	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.920	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	B30.2/SPRY	UniProtKB/TrEMBL
	B30.2/SPRY_sf	UniProtKB/TrEMBL
	Butyrophylin	UniProtKB/TrEMBL
	ConA-like_dom	UniProtKB/TrEMBL
	SPRY_dom	UniProtKB/TrEMBL
	TRIM/RBCC	UniProtKB/TrEMBL
	TRIM34_PRY/SPRY	UniProtKB/TrEMBL
	Znf_B-box	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:101241893	UniProtKB/TrEMBL
NCBI Gene	Trim34	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE TRIM	UniProtKB/TrEMBL
	TRIPARTITE MOTIF-CONTAINING PROTEIN 34	UniProtKB/TrEMBL
Pfam	SPRY	UniProtKB/TrEMBL
	zf-B_box	UniProtKB/TrEMBL
PhenoGen	Trim34	PhenoGen
PRINTS	BUTYPHLNCDUF	UniProtKB/TrEMBL
PROSITE	B302_SPRY	UniProtKB/TrEMBL
	ZF_BBOX	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000042686	RatGTEx
SMART	BBOX	UniProtKB/TrEMBL
	SPRY	UniProtKB/TrEMBL
Superfamily-SCOP	B-box zinc-binding domain	UniProtKB/TrEMBL
	RING/U-box	UniProtKB/TrEMBL
	SSF49899	UniProtKB/TrEMBL
UniProt	D3ZA88	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-02-19	Trim34	tripartite motif-containing 34			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar