Nmu (neuromedin U) - Rat Genome Database

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Gene: Nmu (neuromedin U) Rattus norvegicus
Analyze
Symbol: Nmu
Name: neuromedin U
RGD ID: 68388
Description: Enables type 1 neuromedin U receptor binding activity and type 2 neuromedin U receptor binding activity. Involved in several processes, including negative regulation of digestive system process; positive regulation of cell communication; and positive regulation of sensory perception of pain. Acts upstream of or within neuropeptide signaling pathway. Located in terminal bouton. Used to study obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NMU (neuromedin U); INTERACTS WITH 6-propyl-2-thiouracil; 8-Br-cAMP; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neuromedin; neuromedin U precursor-related peptide/neuromedin U preproprotein; neuromedin-U
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81432,198,789 - 32,226,397 (+)NCBIGRCr8
mRatBN7.21431,844,564 - 31,872,196 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1431,844,728 - 31,872,192 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1432,211,304 - 32,238,600 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01433,519,191 - 33,546,489 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01432,004,310 - 32,031,606 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01434,353,683 - 34,381,968 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1434,354,503 - 34,381,828 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01434,140,106 - 34,167,815 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41434,115,472 - 34,143,662 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11434,115,471 - 34,143,789 (+)NCBI
Celera1431,146,133 - 31,173,459 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP)
glucose  (ISO)
irinotecan  (EXP)
mechlorethamine  (ISO)
MeIQx  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methylarsonic acid  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
perfluorononanoic acid  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
progesterone  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
thiram  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The motor effect of neuromedin U on rat stomach in vitro. Benito-Orfila MA, etal., Eur J Pharmacol. 1991 Feb 14;193(3):329-33.
2. Cardiovascular actions of central neuromedin U in conscious rats. Chu C, etal., Regul Pept. 2002 Apr 15;105(1):29-34.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Association between neuromedin U gene variants and overweight and obesity. Hainerova I, etal., J Clin Endocrinol Metab. 2006 Dec;91(12):5057-63. Epub 2006 Sep 19.
6. A role for neuromedin U in stress response. Hanada R, etal., Biochem Biophys Res Commun. 2001 Nov 23;289(1):225-8.
7. Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Hanada R, etal., Nat Med. 2004 Oct;10(10):1067-73. Epub 2004 Sep 26.
8. Identification of receptors for neuromedin U and its role in feeding. Howard AD, etal., Nature 2000 Jul 6;406(6791):70-4.
9. Evaluation of neuromedin U actions in energy homeostasis and pituitary function. Ivanov TR, etal., Endocrinology 2002 Oct;143(10):3813-21.
10. Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin. Jethwa PH, etal., Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E301-5. Epub 2005 Mar 22.
11. Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets. Kaczmarek P, etal., Int J Mol Med. 2006 Nov;18(5):951-5.
12. Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3). Kojima M, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):435-8.
13. Characterization of complementary DNA encoding the rat neuromedin U precursor. Lo G, etal., Mol Endocrinol 1992 Oct;6(10):1538-44.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Isolation and structural determination of rat neuromedin U. Minamino N, etal., Biochem Biophys Res Commun. 1988 Oct 14;156(1):355-60.
16. Neuromedin U acts in the central nervous system to inhibit gastric acid secretion via CRH system. Mondal MS, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Jun;284(6):G963-9. Epub 2003 Feb 12.
17. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. Mori K, etal., EMBO J 2005 Jan 26;24(2):325-35. Epub 2005 Jan 6.
18. Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release. Mori K, etal., Sci Rep. 2017 Sep 5;7(1):10468. doi: 10.1038/s41598-017-10319-9.
19. Presynaptic modulation by neuromedin U of sensory synaptic transmission in rat spinal dorsal horn neurones. Moriyama M, etal., J Physiol. 2004 Sep 15;559(Pt 3):707-13. Epub 2004 Aug 5.
20. Central effects of neuromedin U in the regulation of energy homeostasis. Nakazato M, etal., Biochem Biophys Res Commun. 2000 Oct 14;277(1):191-4.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Sensitivity of the hypothalamic paraventricular nucleus to the locomotor-activating effects of neuromedin U in obesity. Novak CM, etal., Brain Res. 2007 Jul 13;.
23. Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice. Prendergast CE, etal., Br J Pharmacol. 2006 Apr;147(8):886-96.
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Augurin stimulates the hypothalamo-pituitary-adrenal axis via the release of corticotrophin-releasing factor in rats. Tadross JA, etal., Br J Pharmacol. 2010 Apr;159(8):1663-71. doi: 10.1111/j.1476-5381.2010.00655.x. Epub 2010 Mar 8.
27. Novel Role of the Anorexigenic Peptide Neuromedin U in the Control of LH Secretion and its Regulation by Gonadal Hormones and Photoperiod. Vigo E, etal., Am J Physiol Endocrinol Metab. 2007 Aug 28;.
28. Hypothalamic actions of neuromedin U. Wren AM, etal., Endocrinology 2002 Nov;143(11):4227-34.
29. Pro-nociceptive effects of neuromedin U in rat. Yu XH, etal., Neuroscience. 2003;120(2):467-74.
Additional References at PubMed
PMID:3411332   PMID:7916966   PMID:12711715   PMID:15110767   PMID:15351702   PMID:15512854   PMID:16867180   PMID:17611645   PMID:18180374   PMID:19082512   PMID:22262923   PMID:23423171  
PMID:23538213   PMID:23843987   PMID:24164054   PMID:25108055   PMID:26826380   PMID:28400225   PMID:31069918   PMID:31344393   PMID:34916591  


Genomics

Comparative Map Data
Nmu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81432,198,789 - 32,226,397 (+)NCBIGRCr8
mRatBN7.21431,844,564 - 31,872,196 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1431,844,728 - 31,872,192 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1432,211,304 - 32,238,600 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01433,519,191 - 33,546,489 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01432,004,310 - 32,031,606 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01434,353,683 - 34,381,968 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1434,354,503 - 34,381,828 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01434,140,106 - 34,167,815 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41434,115,472 - 34,143,662 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11434,115,471 - 34,143,789 (+)NCBI
Celera1431,146,133 - 31,173,459 (+)NCBICelera
Cytogenetic Map14p11NCBI
NMU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38455,595,231 - 55,636,793 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl455,595,229 - 55,636,698 (-)EnsemblGRCh38hg38GRCh38
GRCh37456,461,398 - 56,502,960 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36456,156,155 - 56,197,222 (-)NCBINCBI36Build 36hg18NCBI36
Build 34456,302,325 - 56,343,393NCBI
Celera453,963,435 - 54,004,491 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef452,410,707 - 52,451,808 (-)NCBIHuRef
CHM1_1456,496,442 - 56,537,601 (-)NCBICHM1_1
T2T-CHM13v2.0459,083,363 - 59,124,965 (-)NCBIT2T-CHM13v2.0
Nmu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39576,481,342 - 76,511,624 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl576,481,342 - 76,511,635 (-)EnsemblGRCm39 Ensembl
GRCm38576,333,495 - 76,363,777 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl576,333,495 - 76,363,788 (-)EnsemblGRCm38mm10GRCm38
MGSCv37576,762,520 - 76,792,802 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36577,408,270 - 77,438,552 (-)NCBIMGSCv36mm8
Celera573,598,831 - 73,629,109 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map540.93NCBI
Nmu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544715,328,973 - 15,357,830 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544715,324,702 - 15,361,726 (+)NCBIChiLan1.0ChiLan1.0
NMU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2374,159,402 - 74,197,197 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1474,361,439 - 74,399,202 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0468,299,538 - 68,340,680 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1474,866,939 - 74,904,965 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl474,867,364 - 74,904,965 (+)Ensemblpanpan1.1panPan2
LOC611347
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11347,865,037 - 48,047,697 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1347,865,002 - 47,893,921 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1347,921,143 - 47,933,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01348,643,518 - 48,662,228 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11348,318,020 - 48,336,672 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01347,846,906 - 47,863,786 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01348,791,482 - 48,810,183 (-)NCBIUU_Cfam_GSD_1.0
Nmu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528528,335,709 - 28,363,577 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648217,936,467 - 17,961,711 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
NMU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl854,952,339 - 54,978,551 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1854,952,333 - 54,978,577 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2858,574,370 - 58,601,523 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NMU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1712,931,176 - 12,967,294 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl712,932,226 - 12,962,741 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606613,688,566 - 13,723,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nmu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476113,824,144 - 13,848,219 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476113,823,752 - 13,850,756 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nmu
142 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:15
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000002941
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142216796767167967Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 40 92 78 76 46 25 46 5 182 82 73 39 56 30

Sequence


Ensembl Acc Id: ENSRNOT00000002941   ⟹   ENSRNOP00000002941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1431,844,728 - 31,872,056 (+)Ensembl
Rnor_6.0 Ensembl1434,354,503 - 34,381,828 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113115   ⟹   ENSRNOP00000097729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1431,844,728 - 31,872,192 (+)Ensembl
RefSeq Acc Id: NM_022239   ⟹   NP_071575
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81432,198,943 - 32,226,269 (+)NCBI
mRatBN7.21431,844,728 - 31,872,056 (+)NCBI
Rnor_6.01434,354,503 - 34,381,828 (+)NCBI
Rnor_5.01434,140,106 - 34,167,815 (+)NCBI
RGSC_v3.41434,115,472 - 34,143,662 (+)RGD
Celera1431,146,133 - 31,173,459 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250872   ⟹   XP_006250934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81432,198,789 - 32,226,397 (+)NCBI
mRatBN7.21431,844,564 - 31,872,180 (+)NCBI
Rnor_6.01434,353,683 - 34,381,956 (+)NCBI
Rnor_5.01434,140,106 - 34,167,815 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001841028
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81432,198,791 - 32,226,397 (+)NCBI
mRatBN7.21431,844,564 - 31,872,196 (+)NCBI
Rnor_6.01434,353,683 - 34,381,968 (+)NCBI
Sequence:
RefSeq Acc Id: NP_071575   ⟸   NM_022239
- Peptide Label: precursor
- UniProtKB: P12760 (UniProtKB/Swiss-Prot),   A0A250SHE5 (UniProtKB/TrEMBL),   A6JCY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250934   ⟸   XM_006250872
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UHE1 (UniProtKB/TrEMBL),   A6JCY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002941   ⟸   ENSRNOT00000002941
Ensembl Acc Id: ENSRNOP00000097729   ⟸   ENSRNOT00000113115
Protein Domains
Neuromedin U C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12760-F1-model_v2 AlphaFold P12760 1-174 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699275
Promoter ID:EPDNEW_R9800
Type:single initiation site
Name:Nmu_1
Description:neuromedin U
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01434,354,502 - 34,354,562EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68388 AgrOrtholog
BioCyc Gene G2FUF-15944 BioCyc
Ensembl Genes ENSRNOG00000002164 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055005213 UniProtKB/Swiss-Prot
  ENSRNOG00060018393 UniProtKB/Swiss-Prot
  ENSRNOG00065020631 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002941.5 UniProtKB/TrEMBL
  ENSRNOT00000113115.1 UniProtKB/TrEMBL
  ENSRNOT00055008363 UniProtKB/Swiss-Prot
  ENSRNOT00060031582 UniProtKB/Swiss-Prot
  ENSRNOT00065034949 UniProtKB/Swiss-Prot
InterPro Neuromedin-U_amidation-site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NMU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NMU_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:63887 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 63887 ENTREZGENE
PANTHER NEUROMEDIN-U UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NMU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nmu PhenoGen
PROSITE NMU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002164 RatGTEx
  ENSRNOG00055005213 RatGTEx
  ENSRNOG00060018393 RatGTEx
  ENSRNOG00065020631 RatGTEx
SMART NMU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A250SHE5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B657_RAT UniProtKB/TrEMBL
  A0A8L2UHE1 ENTREZGENE, UniProtKB/TrEMBL
  A6JCY2 ENTREZGENE, UniProtKB/TrEMBL
  A6JCY3_RAT UniProtKB/TrEMBL
  NMU_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q80Z23_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Nmu  neuromedin U    neuromedin  Name updated 1299863 APPROVED
2002-06-10 Nmu  neuromedin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression high level of expression in anterior lobe corticotrophs of pituitary, brain stem, gastrointestinal tract, thyroid gland and ovary; expressed in mediobasal aspect of hypothalamus, pars tuberalis, caudal bain stem regions like area postrma, dorsal motor nuc 625713
gene_expression expressed in ileum, thyroid, and anterior pituitary 68280
gene_function ligand for two G protein-coupled receptors NMU1R and NMU2R 625713
gene_process involved in smooth muscle contraction, control of feeding and body temperature 625713
gene_process a physiological regulator of food intake; affects release of stress modulators like Acth and cortocosterone from pituitary and adranal glands (hypothalamo-pituitary-adrenal axis); plays a role in thyroid axis, arterial blood pressure regulation and ion tr 625713
gene_process activates c-fos expression in catecholaminergic neurons of arcuate nucleus and brain stem regions involved in feeding 625713