RGD Reference Report - Central effects of neuromedin U in the regulation of energy homeostasis. - Rat Genome Database

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Central effects of neuromedin U in the regulation of energy homeostasis.

Authors: Nakazato, M  Hanada, R  Murakami, N  Date, Y  Mondal, M S  Kojima, M  Yoshimatsu, H  Kangawa, K  Matsukura, S 
Citation: Nakazato M, etal., Biochem Biophys Res Commun. 2000 Oct 14;277(1):191-4.
RGD ID: 13461755
Pubmed: PMID:11027662   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2000.3669   (Journal Full-text)

Neuromedin U (NMU) is a brain-gut peptide whose peripheral activities are well-understood but whose central actions have yet to be clarified. The recent identification of two NMU receptors in rat brain has provided a springboard for further investigation into its role in the central nervous system. Intracerebroventricular administration of NMU to free-feeding rats decreased food intake and body weight. Conversely, NMU increased gross locomotor activity, body temperature, and heat production. NMU, a potent endogenous anorectic peptide, serves as a catabolic signaling molecule in the brain. Further investigation of the biochemical and physiological functions of NMU will help our better understanding of the mechanisms of energy homeostasis.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NmuRatenergy homeostasis involved_inIDA PMID:11027662UniProt 
NmuRatnegative regulation of eating behavior involved_inIDA PMID:11027662UniProt 
NmuRatpositive regulation of heat generation involved_inIDA PMID:11027662UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Nmu  (neuromedin U)


Additional Information