Stfa2l3 (stefin A2-like 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Stfa2l3 (stefin A2-like 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Stfa2l3
Name: stefin A2-like 3
RGD ID: 6491049
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be located in cytoplasm; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; lidocaine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100911790; LOC689331; similar to stefin A2 like 1; stefin-2-like; stefin-3-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,093,735 - 78,098,750 (+)NCBIGRCr8
mRatBN7.21164,588,401 - 64,593,418 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,588,465 - 64,593,327 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01167,523,815 - 67,528,953 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01170,611,292 - 70,616,430 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,370,544 - 66,376,818 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1164,012,955 - 64,017,992 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Stfa2l3
44 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
AW535292  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,545,182 - 64,545,401 (+)MAPPERmRatBN7.2
Rnor_6.01167,524,844 - 67,525,062NCBIRnor6.0
Rnor_6.01167,466,902 - 67,467,120NCBIRnor6.0
Rnor_5.01170,612,321 - 70,612,539UniSTSRnor5.0
Rnor_5.01170,554,866 - 70,555,084UniSTSRnor5.0
RGSC_v3.41166,371,246 - 66,371,464UniSTSRGSC3.4
RGSC_v3.41166,419,434 - 66,419,652UniSTSRGSC3.4
Celera1164,013,733 - 64,013,951UniSTS
Celera1164,057,694 - 64,057,912UniSTS
RH 3.4 Map11468.1UniSTS
Cytogenetic Map11q22UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000095388   ⟹   ENSRNOP00000095337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1164,588,465 - 64,593,327 (+)Ensembl
RefSeq Acc Id: NM_001408865   ⟹   NP_001395794
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,093,735 - 78,098,750 (+)NCBI
mRatBN7.21164,588,401 - 64,593,418 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395794 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095337.1
Ensembl Acc Id: ENSRNOP00000095337   ⟸   ENSRNOT00000095388
RefSeq Acc Id: NP_001395794   ⟸   NM_001408865
- UniProtKB: A0A8I6GLK6 (UniProtKB/TrEMBL)
Protein Domains
Cystatin

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-21218 BioCyc
Ensembl Genes ENSRNOG00000070861 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095388.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/TrEMBL
InterPro Cystatin_dom UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/TrEMBL
  Prot_inh_cystat_CS UniProtKB/TrEMBL
  Prot_inh_stefin UniProtKB/TrEMBL
NCBI Gene LOC100911790 ENTREZGENE
PANTHER CYSTATIN-A UniProtKB/TrEMBL
  PTHR11414 UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/TrEMBL
PhenoGen Stfa2l3 PhenoGen
PRINTS STEFINA UniProtKB/TrEMBL
PROSITE CYSTATIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000070861 RatGTEx
SMART SM00043 UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/TrEMBL
UniProt A0A8I6GLK6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-11-22 Stfa2l3  stefin A2-like 3  LOC100911790  stefin-3-like  Name and Symbol changed 629549 APPROVED
2015-07-29 LOC100911790  stefin-3-like  LOC689331  similar to stefin A2 like 1  Data merged from RGD:1593533 737654 PROVISIONAL
2012-07-05 LOC100911790  stefin-3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC689331  similar to stefin A2 like 1      Symbol and Name status set to provisional 70820 PROVISIONAL