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Gene: Otop1 (otopetrin 1) Rattus norvegicus

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Symbol:

Otop1

Name:

otopetrin 1

RGD ID:

631389

Description:

Predicted to enable identical protein binding activity and proton channel activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; negative regulation of type II interferon-mediated signaling pathway; and otolith development. Predicted to act upstream of or within detection of gravity and inner ear morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human OTOP1 (otopetrin 1); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; bisphenol A; C60 fullerene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

otopetrin-1; proton channel OTOP1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	OTOP1 (otopetrin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Otop1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Otop1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	OTOP1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	OTOP1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Otop1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	OTOP1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	OTOP1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Otop1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Otop1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	OTOP1 (otopetrin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Otop1 (otopetrin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	otop1 (otopetrin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-1	Alliance	DIOPT (InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	OtopLb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	OtopLb	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	otpl-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	OtopLc	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	OtopLc	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	otpl-4	Alliance	DIOPT (OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-7	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	OtopLa	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	OtopLa	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otpl-8	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	otop1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	otop1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	76,717,330 - 76,744,785 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	76,716,329 - 76,744,785 (-)	Ensembl				GRCr8
mRatBN7.2	14	72,505,036 - 72,532,497 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	72,503,592 - 72,532,497 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	76,946,691 - 76,974,144 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	78,187,579 - 78,215,028 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	74,627,630 - 74,655,089 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	77,236,278 - 77,263,729 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	77,236,278 - 77,263,729 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	77,217,741 - 77,245,192 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	77,784,515 - 77,811,966 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	71,456,163 - 71,483,694 (-)	NCBI		Celera
RGSC_v3.1	14	77,786,905 - 77,814,357 (-)	NCBI
Cytogenetic Map	14	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

aldehydo-D-glucose (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

C60 fullerene (EXP)

carbon nanotube (ISO)

choline (ISO)

D-glucose (ISO)

dibenz[a,h]anthracene (ISO)

folic acid (ISO)

fructose (ISO)

glucose (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

L-methionine (ISO)

N-ethyl-N-nitrosourea (ISO)

ozone (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

serpentine asbestos (ISO)

titanium dioxide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biomineral tissue development (IEA)

cellular response to insulin stimulus (IEA,ISO,ISS)

detection of gravity (ISO)

inner ear morphogenesis (ISO)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

negative regulation of type II interferon-mediated signaling pathway (IEA,ISO,ISS)

otolith formation (IBA)

otolith mineralization (IBA)

proton transmembrane transport (IBA,IEA,ISO,ISS)

Cellular Component

membrane (IEA,ISO)

microvillus (IEA)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

identical protein binding (IBA,ISS)

proton channel activity (IBA,IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1.	Hurle B, etal., Hum Mol Genet 2003 Apr 1;12(7):777-89.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:24379350	PMID:29371428

Genomics

Comparative Map Data

Otop1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	76,717,330 - 76,744,785 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	76,716,329 - 76,744,785 (-)	Ensembl				GRCr8
mRatBN7.2	14	72,505,036 - 72,532,497 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	72,503,592 - 72,532,497 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	76,946,691 - 76,974,144 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	78,187,579 - 78,215,028 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	74,627,630 - 74,655,089 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	77,236,278 - 77,263,729 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	77,236,278 - 77,263,729 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	77,217,741 - 77,245,192 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	77,784,515 - 77,811,966 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	71,456,163 - 71,483,694 (-)	NCBI		Celera
RGSC_v3.1	14	77,786,905 - 77,814,357 (-)	NCBI
Cytogenetic Map	14	q21	NCBI

OTOP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	4,188,726 - 4,226,929 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	4,188,726 - 4,226,929 (-)	Ensembl			hg38	GRCh38
GRCh37	4	4,190,453 - 4,228,656 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	4,241,431 - 4,279,522 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	4,308,601 - 4,346,693	NCBI
Celera	4	4,088,176 - 4,126,241 (-)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	4,126,235 - 4,164,307 (-)	NCBI		HuRef
CHM1_1	4	4,188,226 - 4,226,300 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	4,158,166 - 4,196,359 (-)	NCBI		T2T-CHM13v2.0

Otop1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	38,434,748 - 38,461,560 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	38,433,316 - 38,461,552 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	38,277,404 - 38,304,217 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	38,275,972 - 38,304,217 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	38,668,643 - 38,695,456 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	38,564,186 - 38,592,458 (+)	NCBI		MGSCv36	mm8
Celera	5	35,727,139 - 35,757,853 (+)	NCBI		Celera
Cytogenetic Map	5	B3	NCBI
cM Map	5	20.35	NCBI

Otop1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	5,407,946 - 5,435,605 (+)	Ensembl
ChiLan1.0	NW_004955514	5,407,931 - 5,436,547 (+)	NCBI	ChiLan1.0	ChiLan1.0

OTOP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	4,455,586 - 4,494,139 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	4,388,488 - 4,427,064 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	4	4,269,521 - 4,307,585 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	4,269,521 - 4,307,585 (-)	Ensembl			panPan2	panpan1.1

OTOP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	69,639,550 - 69,665,051 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	69,640,492 - 69,649,201 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	72,191,647 - 72,228,061 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	70,396,580 - 70,433,018 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	70,397,481 - 70,433,018 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	69,670,707 - 69,707,135 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	69,836,036 - 69,872,268 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	70,217,419 - 70,253,619 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Otop1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	63,173,931 - 63,197,685 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	16,876,725 - 16,899,007 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	16,876,725 - 16,899,007 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OTOP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	6,127,965 - 6,163,061 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	6,127,837 - 6,164,421 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	5,712,466 - 5,750,972 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OTOP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	40,295,314 - 40,332,625 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	40,295,676 - 40,332,533 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	87,092,033 - 87,129,372 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Otop1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	21,377,721 - 21,403,621 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624755	21,377,288 - 21,403,621 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Otop1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	66,886,611 - 66,914,061 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Otop1
96 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	56
Count of miRNA genes:	52
Interacting mature miRNAs:	56
Transcripts:	ENSRNOT00000050367
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	38023710	83023710	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	59848686	104848686	Rat
70214	Niddm28	Non-insulin dependent diabetes mellitus QTL 28	4.06		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	39009444	84009444	Rat
70153	Bp59	Blood pressure QTL 59	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	14	72970210	87582095	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30674469	85041098	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	33424686	102238540	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	74255551	109089856	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	38023710	83023710	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	62398852	107398852	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	60854936	105854936	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	74255551	109089856	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	59848686	104848686	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42616258	99224555	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	38023710	83023710	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	65920283	99224555	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39411170	87582095	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	38023710	83023710	Rat

Markers in Region

D14Rat29

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	72,528,812 - 72,528,942 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	77,260,049 - 77,260,178	NCBI	Rnor6.0
Rnor_5.0	14	77,241,512 - 77,241,641	UniSTS	Rnor5.0
RGSC_v3.4	14	77,808,285 - 77,808,415	RGD	RGSC3.4
RGSC_v3.4	14	77,808,286 - 77,808,415	UniSTS	RGSC3.4
Celera	14	71,479,691 - 71,479,822	UniSTS
RGSC_v3.1	14	77,810,676 - 77,810,806	RGD
FHH x ACI Map	14	54.0299	RGD
FHH x ACI Map	14	54.0299	UniSTS
Cytogenetic Map	14	q21	UniSTS

D14Rat39

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	76,720,835 - 76,721,081 (+)	Marker Load Pipeline
mRatBN7.2	14	72,508,541 - 72,508,789 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	77,239,784 - 77,240,029	NCBI	Rnor6.0
Rnor_5.0	14	77,221,247 - 77,221,492	UniSTS	Rnor5.0
RGSC_v3.4	14	77,787,938 - 77,788,272	RGD	RGSC3.4
RGSC_v3.4	14	77,788,021 - 77,788,266	UniSTS	RGSC3.4
Celera	14	71,459,669 - 71,459,914	UniSTS
RGSC_v3.1	14	77,790,329 - 77,790,663	RGD
SHRSP x BN Map	14	38.11	RGD
SHRSP x BN Map	14	38.11	UniSTS
FHH x ACI Map	14	55.78	RGD
Cytogenetic Map	14	q21	UniSTS

D14Got136

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	76,738,807 - 76,739,065 (+)	Marker Load Pipeline
mRatBN7.2	14	72,526,517 - 72,526,775 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	77,257,754 - 77,258,011	NCBI	Rnor6.0
Rnor_5.0	14	77,239,217 - 77,239,474	UniSTS	Rnor5.0
RGSC_v3.4	14	77,805,991 - 77,806,248	UniSTS	RGSC3.4
Celera	14	71,477,392 - 71,477,653	UniSTS
Cytogenetic Map	14	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	6	37	109	42	38	10	36	10	6	147	95	2	89	23	55	28	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_181433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BK000651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000050367 ⟹ ENSRNOP00000047534

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	76,716,329 - 76,744,785 (-)	Ensembl
mRatBN7.2 Ensembl	14	72,503,592 - 72,532,497 (-)	Ensembl
Rnor_6.0 Ensembl	14	77,236,278 - 77,263,729 (-)	Ensembl

RefSeq Acc Id:

NM_181433 ⟹ NP_852098

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	76,717,330 - 76,744,785 (-)	NCBI
mRatBN7.2	14	72,505,036 - 72,532,497 (-)	NCBI
Rnor_6.0	14	77,236,278 - 77,263,729 (-)	NCBI
Rnor_5.0	14	77,217,741 - 77,245,192 (-)	NCBI
RGSC_v3.4	14	77,784,515 - 77,811,966 (-)	RGD
Celera	14	71,456,163 - 71,483,694 (-)	RGD

Sequence:

show sequence

GCCGCCTGGGGACCAGACTGGAAGATGCCTGGGGACCGGGGCGCACTATCTTCTCCCGCAGCAT
CATCAGGCTCCCCGAGTGCCGCGCCGTCGGGGATCGCCGCATGCCCTCCGCCCCCGTCTCCCCT
AGCCCGGGCGTCTCCACAAGCTTCCGGTCCCCGACGCGGTGCCAGCGTCCCGCAGAAGCTGGCG
GAGACTCTGAGCAGCCAGTATGGACTGAACGTGTTCGTGGCGGGGCTTCTTTTCCTGCTGGCCT
GGGCGGTGCACGCGACGGGTGTGGGCAAGAGCGACCTGTTGTGCGTATTAACCGCACTCATGCT
GCTGCAGCTGCTCTGGATGCTGTGGTACGTGGGTCGCAGCTACATGCAGCGCCGCCTCATCCGC
CCCAAGGACACGCACGCGGGTGCGCGCTGGCTCCGCGGAAGCATCACATTGTTCGCATTCATCA
CCATCGTCCTGGGGTGCCTGAAAGTCGCATACTTCATTGGATTCTCAGAGTGCTTGTCAGCTAC
AGAGGGAGTTTTCCCAGTCACCCATGCAGTGCATACATTGTTGCAGGTCTATTTTCTCTGGGGC
CACGCTAAAGATATTATCATGTCTTTCAAAACACTGGAAAGGTTTGGGGTGATCCATTCAGTGT
TCACAAACCTGCTGCTGTGGGCCAACAGCGTCCTGAATGAGTCAAAACACCAGCTGAATGAACA
CAAGGAACGGCTGATCACTCTGGGCTTCGGCAACATCACCATAGTTTTGGATGACCACACACCA
CAGTGTAACTGCACACCGCCTGCCCTCTGCTCTGCCCTCTCCCACGGGATTTACTATCTGTACC
CCTTCAACATTGAGTACCAGATCCTGGCCTCGACCATGCTCTATGTGCTGTGGAAGAACATTGG
GCGCAGGGTGGACAGCTCCCGGCACCAGAAGATGCAGTGCAGATTCGACGGGGTCCTGGTGGGC
TCAGTGCTGGGCCTGACAGTGCTGGCTGCCACCATCGCGGTGGTTGTGGTGTACATGATCCATA
TCGGGCGCTCCAAGTCCAAGAGTGAGTCGGCTCTTATCATGTTCTATTTGTATGCGATCACGGT
GCTGCTGCTCATGGGGGCTGCGGGGCTGGTAGGAAGCTGGATTTACAGGGTGGATGAGAAGTCT
CTGGATGAGTCAAAGAACCCAGCCCGCAAGCTGGATGCTGACCTCTTGGTGGCCACTGCCTCGG
GTTCCTGGCTCCTCTCCTGGGGTTCCATTTTGGCCATCGCCTGCGCTGAGACCCGCCCACCGTA
CACCTGGTACAACCTCCCCTACTCTGTCCTGGTGATCGTGGAGAAGTACGTCCAGAACATTTTC
ATCATTGAGTCGGTGCACCTCGAGCCTGAGGGGGTCCCCGAGGATGTGCGCACTCTGCGTGTGG
TCACCGTCTGCAGTGGGGAGGCTGCTGCACTGGCTGCATCGAGTCTCGGGAGCCAGGGGACGGC
CCAGGATGGGTCACCTGCTGTCAATGGGAATCTGCATCTGCAGCAGAGGTGTGAGAAAGAGGAC
CAGGAGGCTGACTGGGAAGGAGCTACGGGGACAACCCGATGTCTGGACTTCCTTCAGGGAGGCA
TGAAGAGGAGGCTGCTCAGAAACATCACAGCCTTTCTGTTCCTTTGCAACATCTCGCTTTGGAT
TCCCCCTGCCTTTGGCTGCCGTCCCGAGTATGACAACGGACTGGAGGAAATTGTCTTTGGCTTT
GAACCCTGGATAATTGTGGTCAACCTGGCCATGCCCTTCTCCATTTTCTACAGGATGCACGCAG
CTGCCGCCCTCTTTGAGGTCTATTGTAAAATCTAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_852098	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	DAA00899	(Get FASTA)	NCBI Sequence Viewer
	EDM00001	(Get FASTA)	NCBI Sequence Viewer
	EDM00002	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000047534
	ENSRNOP00000047534.2
GenBank Protein	Q7M734	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_852098 ⟸ NM_181433

- UniProtKB:

Q7M734 (UniProtKB/Swiss-Prot), A6IJT7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPGDRGALSSPAASSGSPSAAPSGIAACPPPPSPLARASPQASGPRRGASVPQKLAETLSSQYG
LNVFVAGLLFLLAWAVHATGVGKSDLLCVLTALMLLQLLWMLWYVGRSYMQRRLIRPKDTHAGA
RWLRGSITLFAFITIVLGCLKVAYFIGFSECLSATEGVFPVTHAVHTLLQVYFLWGHAKDIIMS
FKTLERFGVIHSVFTNLLLWANSVLNESKHQLNEHKERLITLGFGNITIVLDDHTPQCNCTPPA
LCSALSHGIYYLYPFNIEYQILASTMLYVLWKNIGRRVDSSRHQKMQCRFDGVLVGSVLGLTVL
AATIAVVVVYMIHIGRSKSKSESALIMFYLYAITVLLLMGAAGLVGSWIYRVDEKSLDESKNPA
RKLDADLLVATASGSWLLSWGSILAIACAETRPPYTWYNLPYSVLVIVEKYVQNIFIIESVHLE
PEGVPEDVRTLRVVTVCSGEAAALAASSLGSQGTAQDGSPAVNGNLHLQQRCEKEDQEADWEGA
TGTTRCLDFLQGGMKRRLLRNITAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPWIIVVN
LAMPFSIFYRMHAAAALFEVYCKI

hide sequence

Ensembl Acc Id:

ENSRNOP00000047534 ⟸ ENSRNOT00000050367

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7M734-F1-model_v2	AlphaFold	Q7M734	1-600	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:631389	AgrOrtholog
BioCyc Gene	G2FUF-15386	BioCyc
Ensembl Genes	ENSRNOG00000028423	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000050367	ENTREZGENE
	ENSRNOT00000050367.3	UniProtKB/Swiss-Prot
InterPro	Otopetrin	UniProtKB/Swiss-Prot
KEGG Report	rno:305427	UniProtKB/Swiss-Prot
NCBI Gene	305427	ENTREZGENE
PANTHER	PROTON CHANNEL OTOP1	UniProtKB/Swiss-Prot
	PTHR21522	UniProtKB/Swiss-Prot
Pfam	Otopetrin	UniProtKB/Swiss-Prot
PhenoGen	Otop1	PhenoGen
RatGTEx	ENSRNOG00000028423	RatGTEx
UniProt	A6IJT7	ENTREZGENE, UniProtKB/TrEMBL
	A6IJT8_RAT	UniProtKB/TrEMBL
	OTOP1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-11	Otop1	otopetrin 1			Symbol and Name status set to approved	625702	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	mutation of the mouse homolog is detected in two mouse mutants, tilted (tlt) and mergulhador (mlh) which have impaired balance	633435
gene_domains	contains multiple transmembrane domains	633435

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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