Otop1 (otopetrin 1) - Rat Genome Database

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Gene: Otop1 (otopetrin 1) Mus musculus
Analyze
Symbol: Otop1
Name: otopetrin 1
RGD ID: 735812
MGI Page MGI
Description: Enables proton channel activity. Involved in cellular response to insulin stimulus; negative regulation of type II interferon-mediated signaling pathway; and proton transmembrane transport. Acts upstream of or within detection of gravity and inner ear morphogenesis. Located in plasma membrane. Is expressed in several structures, including adrenal gland; inner ear; integumental system; stomach; and thymus. Orthologous to human OTOP1 (otopetrin 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A530025J20Rik; otopetrin-1; Otp1; proton channel OTOP1; tilted; tl; tlt
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39538,434,748 - 38,461,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl538,433,316 - 38,461,552 (+)EnsemblGRCm39 Ensembl
GRCm38538,277,404 - 38,304,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl538,275,972 - 38,304,217 (+)EnsemblGRCm38mm10GRCm38
MGSCv37538,668,643 - 38,695,456 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36538,564,186 - 38,592,458 (+)NCBIMGSCv36mm8
Celera535,727,139 - 35,757,853 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map520.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IBA,IDA)
microvillus  (IEA)
plasma membrane  (IDA,ISO,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Hurle B, etal., Hum Mol Genet 2003 Apr 1;12(7):777-89.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9714575   PMID:10341082   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11597144   PMID:12524184   PMID:15109702   PMID:15561463   PMID:15730345   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:16972005   PMID:18355969   PMID:18459000   PMID:18719582   PMID:19176815   PMID:20554841   PMID:20856818   PMID:21236346   PMID:21873635   PMID:22808156  
PMID:23536097   PMID:23987512   PMID:24379350   PMID:27792272   PMID:28235587   PMID:29371428   PMID:29779876   PMID:29913187   PMID:30686738   PMID:31543264   PMID:31543453   PMID:33417862  
PMID:37798269   PMID:37812612   PMID:38355793  


Genomics

Comparative Map Data
Otop1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39538,434,748 - 38,461,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl538,433,316 - 38,461,552 (+)EnsemblGRCm39 Ensembl
GRCm38538,277,404 - 38,304,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl538,275,972 - 38,304,217 (+)EnsemblGRCm38mm10GRCm38
MGSCv37538,668,643 - 38,695,456 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36538,564,186 - 38,592,458 (+)NCBIMGSCv36mm8
Celera535,727,139 - 35,757,853 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map520.35NCBI
OTOP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3844,188,726 - 4,226,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl44,188,726 - 4,226,929 (-)EnsemblGRCh38hg38GRCh38
GRCh3744,190,453 - 4,228,656 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3644,241,431 - 4,279,522 (-)NCBINCBI36Build 36hg18NCBI36
Build 3444,308,601 - 4,346,693NCBI
Celera44,088,176 - 4,126,241 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef44,126,235 - 4,164,307 (-)NCBIHuRef
CHM1_144,188,226 - 4,226,300 (-)NCBICHM1_1
T2T-CHM13v2.044,158,166 - 4,196,359 (-)NCBIT2T-CHM13v2.0
Otop1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81476,717,330 - 76,744,785 (-)NCBIGRCr8
mRatBN7.21472,505,036 - 72,532,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1472,503,592 - 72,532,497 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1476,946,691 - 76,974,144 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01478,187,579 - 78,215,028 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01474,627,630 - 74,655,089 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01477,236,278 - 77,263,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1477,236,278 - 77,263,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01477,217,741 - 77,245,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41477,784,515 - 77,811,966 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11477,786,905 - 77,814,357 (-)NCBI
Celera1471,456,163 - 71,483,694 (-)NCBICelera
Cytogenetic Map14q21NCBI
Otop1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555145,407,946 - 5,435,605 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555145,407,931 - 5,436,547 (+)NCBIChiLan1.0ChiLan1.0
OTOP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v234,455,586 - 4,494,139 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan144,388,488 - 4,427,064 (-)NCBINHGRI_mPanPan1
PanPan1.144,269,521 - 4,307,585 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl44,269,521 - 4,307,585 (-)Ensemblpanpan1.1panPan2
OTOP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1369,639,550 - 69,665,051 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl369,640,492 - 69,649,201 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,191,647 - 72,228,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0370,396,580 - 70,433,018 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl370,397,481 - 70,433,018 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1369,670,707 - 69,707,135 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0369,836,036 - 69,872,268 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0370,217,419 - 70,253,619 (-)NCBIUU_Cfam_GSD_1.0
Otop1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528563,173,931 - 63,197,685 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647716,876,725 - 16,899,007 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647716,876,725 - 16,899,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTOP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl86,127,965 - 6,163,061 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.186,127,837 - 6,164,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.285,712,466 - 5,750,972 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OTOP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12740,295,314 - 40,332,625 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2740,295,676 - 40,332,533 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604787,092,033 - 87,129,372 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Otop1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475521,377,721 - 21,403,621 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475521,377,288 - 21,403,621 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Otop1
1675 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:732
Count of miRNA genes:283
Interacting mature miRNAs:315
Transcripts:ENSMUST00000063136, ENSMUST00000114099
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
36049766Ars22_mantibody response to SARS-CoV 22, day 29, IgG3 (mouse)53695734445457342Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
36049767Ars23_mantibody response to SARS-CoV 23, day 29, Total IgG (mouse)53695734445457342Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
1300951Gbvq1_mgallstone bladder volume QTL 1 (mouse)Not determined53811168172111798Mouse
1301845Lxw4_mlupus BXSB x NZW 4 (mouse)Not determined53569446269694594Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse
36049774Ars16_mantibody response to SARS-CoV 16, day 7, Total IgG (mouse)53695734445457342Mouse
36049775Ars17_mantibody response to SARS-CoV 17, day 15, IgG2a+IgG2c (mouse)53695734445457342Mouse
36049772Ars20_mantibody response to SARS-CoV 20, day 15, Total IgG (mouse)53695734445457342Mouse
36049773Ars21_mantibody response to SARS-CoV 21, day 29, IgG2a+IgG2c (mouse)53695734445457342Mouse
36049770Ars14_mantibody response to SARS-CoV 14, day 7, IgG3 (mouse)53695734445457342Mouse
36049771Ars15_mantibody response to SARS-CoV 15, day 7, IgM (mouse)53695734445457342Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53157045865570458Mouse
36049768Ars24_mantibody response to SARS-CoV 24, 4 days post-rechallenge, IgG3 (mouse)53695734445457342Mouse
36049769Ars13_mantibody response to SARS-CoV 13, day 7, IgG2a+IgG2c (mouse)53695734445457342Mouse
36049776Ars18_mantibody response to SARS-CoV 18, day 15, IgG3 (mouse)53695734445457342Mouse
36049777Ars19_mantibody response to SARS-CoV 19, day 15, IgM (mouse)53695734445457342Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
1301170Lith13_mlithogenic gene 13 (mouse)Not determined53649448670494598Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
1300926Hpi2_mhepatic PMN infiltration 2 (mouse)Not determined53758148864806579Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
4141647Hrvhf1_mheart rate variability, high frequency 1 (mouse)Not determined3643342370433423Mouse
11049561Lmr24e_mleishmaniasis resistance 24e (mouse)53569446269694594Mouse
13464252Ahl10_mage related hearing loss, early onset 10 (mouse)53585456869854714Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
1301223Hdlq7_mHDL QTL 7 (mouse)Not determined53585456869854714Mouse
13464245Ahl12_mage related hearing loss, early onset 12 (mouse)53811168172111798Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
13464246Ahl11_mage related hearing loss, early onset 11 (mouse)53764377771643896Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse
11049558Lmr24b_mleishmaniasis resistance 24b (mouse)53569446269694594Mouse
35673310Ari4_mantibody response to influenza 4, day 15-45, IgG2b (mouse)53695734445457342Mouse
11049559Lmr24c_mleishmaniasis resistance 24c (mouse)53569446269694594Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000063136   ⟹   ENSMUSP00000061805
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl538,433,316 - 38,461,552 (+)Ensembl
GRCm38.p6 Ensembl538,275,972 - 38,304,209 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114099   ⟹   ENSMUSP00000109734
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl538,434,748 - 38,461,551 (+)Ensembl
GRCm38.p6 Ensembl538,277,404 - 38,304,208 (+)Ensembl
Ensembl Acc Id: ENSMUST00000185357
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl538,277,404 - 38,304,217 (+)Ensembl
Ensembl Acc Id: ENSMUST00000187863
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl538,443,367 - 38,460,720 (+)Ensembl
GRCm38.p6 Ensembl538,286,023 - 38,303,377 (+)Ensembl
RefSeq Acc Id: NM_172709   ⟹   NP_766297
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39538,434,748 - 38,461,560 (+)NCBI
GRCm38538,277,404 - 38,304,217 (+)ENTREZGENE
MGSCv37538,668,643 - 38,695,456 (+)RGD
Celera535,727,139 - 35,757,853 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_766297   ⟸   NM_172709
- UniProtKB: Q8BS22 (UniProtKB/Swiss-Prot),   Q8BRZ4 (UniProtKB/Swiss-Prot),   Q80VM9 (UniProtKB/Swiss-Prot),   Q7M735 (UniProtKB/Swiss-Prot),   E9QMU2 (UniProtKB/Swiss-Prot),   A0A0R4J1J4 (UniProtKB/Swiss-Prot),   A0A5H1ZRK5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000109734   ⟸   ENSMUST00000114099
Ensembl Acc Id: ENSMUSP00000061805   ⟸   ENSMUST00000063136

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80VM9-F1-model_v2 AlphaFold Q80VM9 1-600 view protein structure

Promoters
RGD ID:6886586
Promoter ID:EPDNEW_M6744
Type:initiation region
Name:Otop1_1
Description:Mus musculus otopetrin 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38538,277,451 - 38,277,511EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2388363 AgrOrtholog
Ensembl Genes ENSMUSG00000051596 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000063136.15 UniProtKB/TrEMBL
  ENSMUST00000114099 ENTREZGENE
  ENSMUST00000114099.6 UniProtKB/Swiss-Prot
InterPro Otopetrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21906 UniProtKB/Swiss-Prot
MGD MGI:2388363 ENTREZGENE
NCBI Gene Otop1 ENTREZGENE
PANTHER PROTON CHANNEL OTOP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR21522 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Otopetrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Otop1 PhenoGen
UniProt A0A0R4J1J4 ENTREZGENE
  A0A5H1ZRK5 ENTREZGENE, UniProtKB/TrEMBL
  E9QMU2 ENTREZGENE
  OTOP1_MOUSE UniProtKB/Swiss-Prot
  Q7M735 ENTREZGENE
  Q80VM9 ENTREZGENE
  Q8BRZ4 ENTREZGENE
  Q8BS22 ENTREZGENE
UniProt Secondary A0A0R4J1J4 UniProtKB/Swiss-Prot
  E9QMU2 UniProtKB/Swiss-Prot
  Q7M735 UniProtKB/Swiss-Prot
  Q8BRZ4 UniProtKB/Swiss-Prot
  Q8BS22 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Otop1  otopetrin 1  A530025J20Rik  otopetrin 1  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 A530025J20Rik  otopetrin 1  Otop1  otopetrin 1  Symbol and/or name change 5135510 APPROVED