Oat (ornithine aminotransferase) - Rat Genome Database

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Gene: Oat (ornithine aminotransferase) Rattus norvegicus
Analyze
Symbol: Oat
Name: ornithine aminotransferase
RGD ID: 621724
Description: Predicted to enable identical protein binding activity; ornithine aminotransferase activity; and pyridoxal phosphate binding activity. Predicted to be involved in arginine catabolic process to glutamate and arginine catabolic process to proline via ornithine. Predicted to be located in mitochondrial matrix and nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in gyrate atrophy. Orthologous to human OAT (ornithine aminotransferase); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ornithine aminotransferase (gyrate atrophy); ornithine aminotransferase, mitochondrial; ornithine--oxo-acid aminotransferase; rOAT
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Slc22a7-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,777,973 - 196,797,754 (-)NCBIGRCr8
mRatBN7.21187,347,862 - 187,367,644 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1187,347,865 - 187,367,682 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1195,698,027 - 195,717,805 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01202,876,939 - 202,896,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01195,550,072 - 195,569,851 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01204,562,289 - 204,582,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1204,562,289 - 204,582,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,555,927 - 211,575,708 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41192,026,623 - 192,046,404 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11192,176,503 - 192,196,285 (-)NCBI
Celera1185,092,131 - 185,111,563 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-deoxy-D-glucose  (EXP)
2-nitrofluorene  (EXP)
3',5'-cyclic AMP  (EXP)
3,4-dihydrocoumarin  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP)
aldehydo-D-ribose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
bacitracin  (EXP)
benzatropine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
coumarin  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
D-glucitol  (EXP)
D-glucose  (EXP)
D-mannitol  (EXP)
D-mannopyranose  (EXP)
D-ribofuranose  (EXP)
dibenzofurans  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dihydroxyacetone  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
etoposide  (ISO)
fenbuconazole  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
galactose  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP)
glycerol  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inositol  (EXP)
irinotecan  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
Licochalcone B  (ISO)
lovastatin  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
menadione  (ISO)
metacetamol  (ISO)
metformin  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (EXP,ISO)
orphenadrine  (EXP)
p-toluidine  (EXP)
paclitaxel  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rhamnose  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sorbose  (EXP)
streptozocin  (EXP)
sulfasalazine  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
teriflunomide  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
uranium atom  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vorinostat  (ISO)
warfarin  (ISO)
xylitol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
mitochondrial matrix  (ISO,ISS)
mitochondrion  (ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II. Levillain O, etal., Am J Physiol Renal Physiol 2004 Apr;286(4):F727-38. Epub 2004 Feb 10.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. An initiator codon mutation in ornithine-delta-aminotransferase causing gyrate atrophy of the choroid and retina. Mitchell GA, etal., J Clin Invest. 1988 Feb;81(2):630-3.
7. Sequence of the precursor to rat ornithine aminotransferase deduced from a cDNA clone. Mueckler MM and Pitot HC, J Biol Chem 1985 Oct 25;260(24):12993-7.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Isolation and characterization of the rat gene encoding ornithine aminotransferase. Shull JD, etal., Biochim Biophys Acta 1992 Sep 24;1132(2):214-8.
16. Cell-type specific interactions between retinoic acid and thyroid hormone in the regulation of expression of the gene encoding ornithine aminotransferase. Shull JD, etal., Endocrinology 1995 May;136(5):2120-6.
17. The ornithine aminotransferase-encoding gene family of rat: cloning, characterization, and evolutionary relationships between a single expressed gene and three pseudogenes. Shull JD, etal., Gene 1991 Aug 15;104(2):203-9.
18. Promoter region of the rat gene encoding ornithine aminotransferase: transcriptional activity, sequence, and DNase-I-hypersensitive sites. Shull JD, etal., Gene 1993 Mar 30;125(2):169-75.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2229004   PMID:3170546   PMID:6819292   PMID:9514741   PMID:14651853   PMID:15489334   PMID:18614015   PMID:23076989   PMID:23106098   PMID:23656379   PMID:36755387  


Genomics

Comparative Map Data
Oat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,777,973 - 196,797,754 (-)NCBIGRCr8
mRatBN7.21187,347,862 - 187,367,644 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1187,347,865 - 187,367,682 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1195,698,027 - 195,717,805 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01202,876,939 - 202,896,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01195,550,072 - 195,569,851 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01204,562,289 - 204,582,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1204,562,289 - 204,582,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,555,927 - 211,575,708 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41192,026,623 - 192,046,404 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11192,176,503 - 192,196,285 (-)NCBI
Celera1185,092,131 - 185,111,563 (-)NCBICelera
Cytogenetic Map1q41NCBI
OAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810124,397,303 - 124,418,923 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10124,397,303 - 124,418,976 (-)EnsemblGRCh38hg38GRCh38
GRCh3710126,085,872 - 126,107,492 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610126,075,862 - 126,097,441 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410126,075,861 - 126,097,450NCBI
Celera10119,858,073 - 119,879,754 (-)NCBICelera
Cytogenetic Map10q26.13NCBI
HuRef10119,770,641 - 119,792,323 (-)NCBIHuRef
CHM1_110126,367,759 - 126,389,447 (-)NCBICHM1_1
T2T-CHM13v2.010125,275,480 - 125,297,100 (-)NCBIT2T-CHM13v2.0
Oat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397132,159,204 - 132,178,127 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7132,159,207 - 132,178,127 (-)EnsemblGRCm39 Ensembl
GRCm387132,557,475 - 132,576,398 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7132,557,478 - 132,576,398 (-)EnsemblGRCm38mm10GRCm38
MGSCv377139,749,158 - 139,768,081 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367132,395,822 - 132,408,481 (-)NCBIMGSCv36mm8
Celera7132,362,445 - 132,381,370 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map776.3NCBI
Oat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554772,429,776 - 2,450,624 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554772,430,146 - 2,450,135 (-)NCBIChiLan1.0ChiLan1.0
OAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28136,243,004 - 136,265,666 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110136,248,355 - 136,271,017 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010120,955,805 - 120,977,484 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110125,224,032 - 125,245,530 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10125,224,032 - 125,245,504 (-)Ensemblpanpan1.1panPan2
OAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12833,763,661 - 33,788,817 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2833,758,473 - 33,788,759 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2833,826,851 - 33,851,641 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02834,320,605 - 34,345,627 (-)NCBIROS_Cfam_1.0
UU_Cfam_GSD_1.02834,120,928 - 34,145,786 (-)NCBIUU_Cfam_GSD_1.0
Oat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721312,817,898 - 12,836,941 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648612,723,305 - 12,743,422 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648612,723,363 - 12,743,367 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14133,808,193 - 133,830,761 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114133,808,193 - 133,830,517 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214145,318,779 - 145,341,064 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19117,060,819 - 117,083,160 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9117,060,393 - 117,083,126 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604878,377,280 - 78,399,645 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473722,664,129 - 22,678,535 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473722,657,158 - 22,679,213 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Oat
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:83
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000022628
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat

Markers in Region
RH139534  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21187,352,792 - 187,352,983 (+)MAPPERmRatBN7.2
Rnor_6.01204,567,220 - 204,567,410NCBIRnor6.0
Rnor_5.01211,560,858 - 211,561,048UniSTSRnor5.0
RGSC_v3.41192,031,554 - 192,031,744UniSTSRGSC3.4
Celera1185,097,062 - 185,097,252UniSTS
Cytogenetic Map1q41UniSTS
RH127469  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21187,348,354 - 187,348,551 (+)MAPPERmRatBN7.2
Rnor_6.01204,562,782 - 204,562,978NCBIRnor6.0
Rnor_5.01211,556,420 - 211,556,616UniSTSRnor5.0
RGSC_v3.41192,027,116 - 192,027,312UniSTSRGSC3.4
Celera1185,092,624 - 185,092,820UniSTS
Cytogenetic Map1q41UniSTS
D1Bda37  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21187,348,178 - 187,348,548 (+)MAPPERmRatBN7.2
Rnor_6.01204,562,606 - 204,562,975NCBIRnor6.0
Rnor_5.01211,556,244 - 211,556,613UniSTSRnor5.0
RGSC_v3.41192,026,940 - 192,027,309UniSTSRGSC3.4
Celera1185,092,448 - 185,092,817UniSTS
Cytogenetic Map1q41UniSTS
RH140369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21187,352,827 - 187,352,984 (+)MAPPERmRatBN7.2
Rnor_6.01204,567,255 - 204,567,411NCBIRnor6.0
Rnor_5.01211,560,893 - 211,561,049UniSTSRnor5.0
RGSC_v3.41192,031,589 - 192,031,745UniSTSRGSC3.4
Celera1185,097,097 - 185,097,253UniSTS
RH 3.4 Map11432.7UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000022628   ⟹   ENSRNOP00000022628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1187,347,865 - 187,367,682 (-)Ensembl
Rnor_6.0 Ensembl1204,562,289 - 204,582,070 (-)Ensembl
RefSeq Acc Id: NM_022521   ⟹   NP_071966
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,777,973 - 196,797,754 (-)NCBI
mRatBN7.21187,347,862 - 187,367,644 (-)NCBI
Rnor_6.01204,562,289 - 204,582,070 (-)NCBI
Rnor_5.01211,555,927 - 211,575,708 (-)NCBI
RGSC_v3.41192,026,623 - 192,046,404 (-)RGD
Celera1185,092,131 - 185,111,563 (-)RGD
Sequence:
RefSeq Acc Id: NP_071966   ⟸   NM_022521
- Peptide Label: precursor
- UniProtKB: Q6LDF6 (UniProtKB/Swiss-Prot),   Q6LDF7 (UniProtKB/Swiss-Prot),   P04182 (UniProtKB/Swiss-Prot),   A6HWY7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022628   ⟸   ENSRNOT00000022628

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04182-F1-model_v2 AlphaFold P04182 1-439 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6849756
Promoter ID:EP37015
Type:single initiation site
Name:RN_OAT
Description:Ornithine aminotransferase, OAT gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 215; Mammalalian ornithine aminotransferase
Experiment Methods:RNA sequencing by primer extension
Regulation:most tissues; (modulated by) hormones
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41192,046,386 - 192,046,446EPD
RGD ID:13690483
Promoter ID:EPDNEW_R1008
Type:initiation region
Name:Oat_1
Description:ornithine aminotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01204,582,053 - 204,582,113EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621724 AgrOrtholog
BioCyc Gene G2FUF-57212 BioCyc
BioCyc Pathway ARG-PRO-PWY [L-arginine degradation VI (arginase 2 pathway)] BioCyc
  ARGASEDEG-PWY [L-arginine degradation I (arginase pathway)] BioCyc
  CITRULBIO-PWY [L-citrulline biosynthesis] BioCyc
BioCyc Pathway Image ARG-PRO-PWY BioCyc
  ARGASEDEG-PWY BioCyc
  CITRULBIO-PWY BioCyc
Ensembl Genes ENSRNOG00000016807 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055025556 UniProtKB/Swiss-Prot
  ENSRNOG00060022024 UniProtKB/Swiss-Prot
  ENSRNOG00065019383 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022628.6 UniProtKB/Swiss-Prot
  ENSRNOT00055044108 UniProtKB/Swiss-Prot
  ENSRNOT00060038168 UniProtKB/Swiss-Prot
  ENSRNOT00065032632 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type I PLP-dependent aspartate aminotransferase-like (Major domain) UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6890520 IMAGE-MGC_LOAD
InterPro Aminotrans_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminotrans_3_PPA_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Class-III_PLP-dep_AT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orn_aminotrans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
KEGG Report rno:64313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72829 IMAGE-MGC_LOAD
NCBI Gene 64313 ENTREZGENE
PANTHER AMINOTRANSFERASE CLASS III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aminotran_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oat PhenoGen
PIRSF Transaminase_4ab_Lys_Orn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AA_TRANSFER_CLASS_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016807 RatGTEx
  ENSRNOG00055025556 RatGTEx
  ENSRNOG00060022024 RatGTEx
  ENSRNOG00065019383 RatGTEx
Superfamily-SCOP PLP-dependent transferases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HWY6_RAT UniProtKB/TrEMBL
  A6HWY7 ENTREZGENE, UniProtKB/TrEMBL
  A6HWY9_RAT UniProtKB/TrEMBL
  OAT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6LDF6 ENTREZGENE
  Q6LDF7 ENTREZGENE
UniProt Secondary Q6LDF6 UniProtKB/Swiss-Prot
  Q6LDF7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Oat  ornithine aminotransferase  Oat  ornithine aminotransferase (gyrate atrophy)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Oat  ornithine aminotransferase (gyrate atrophy)  Oat  ornithine aminotransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Oat  ornithine aminotransferase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Oat        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver and kidney 1358948
gene_protein 439 amino acid residues with a molecular weight of 48,332 633396
gene_regulation mRNA expression is differentially regulated by retinoic acid and T3 1358948