Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Atp2c2 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Atp2c2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ATP2C2 mRNA | CTD | PMID:22206623 | Atp2c2 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of ATP2C2 mRNA | CTD | PMID:22206623 | Atp2c2 | Rat | 17beta-estradiol | multiple interactions | ISO | ATP2C2 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of ATP2C2 mRNA | CTD | PMID:30165855 | Atp2c2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ATP2C2 mRNA | CTD | PMID:33387578 | Atp2c2 | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of ATP2C2 mRNA | CTD | PMID:30851411 | Atp2c2 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | bisphenol S results in increased expression of ATP2C2 mRNA | CTD | PMID:30951980 | Atp2c2 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Atp2c2 (Mus musculus) | 6480464 | bisphenol S affects the methylation of ATP2C2 gene | CTD | PMID:31683443 | Atp2c2 | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Atp2c2 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of ATP2C2 exon | CTD | PMID:33297965 | Atp2c2 | Rat | aflatoxin B1 | decreases methylation | ISO | ATP2C2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of ATP2C2 intron | CTD | PMID:30157460 | Atp2c2 | Rat | Aflatoxin B2 alpha | decreases methylation | ISO | ATP2C2 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of ATP2C2 intron | CTD | PMID:30157460 | Atp2c2 | Rat | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of ATP2C2 mRNA | CTD | PMID:20488242 | Atp2c2 | Rat | amosite asbestos | increases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | Asbestos and Amosite results in increased expression of ATP2C2 mRNA | CTD | PMID:23917077 | Atp2c2 | Rat | aristolochic acid A | increases expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of ATP2C2 mRNA | CTD | PMID:33212167 | Atp2c2 | Rat | atrazine | decreases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | Atrazine results in decreased expression of ATP2C2 mRNA | CTD | PMID:26476475 and PMID:33960999 | Atp2c2 | Rat | atrazine | affects expression | ISO | Atp2c2 (Mus musculus) | 6480464 | Atrazine affects the expression of ATP2C2 mRNA | CTD | PMID:27112537 | Atp2c2 | Rat | atrazine | multiple interactions | ISO | Atp2c2 (Mus musculus) | 6480464 | Lycopene inhibits the reaction [Atrazine affects the expression of ATP2C2 mRNA] and Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2C2 mRNA] | CTD | PMID:26476475 more ... | Atp2c2 | Rat | Azoxymethane | multiple interactions | ISO | Atp2c2 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] affects the expression of ATP2C2 mRNA | CTD | PMID:29950665 | Atp2c2 | Rat | benzo[a]pyrene | affects methylation | ISO | ATP2C2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ATP2C2 intron | CTD | PMID:30157460 | Atp2c2 | Rat | benzo[a]pyrene | decreases methylation | ISO | ATP2C2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of ATP2C2 promoter | CTD | PMID:27901495 | Atp2c2 | Rat | bisphenol A | decreases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of ATP2C2 mRNA | CTD | PMID:26063408 | Atp2c2 | Rat | bisphenol A | multiple interactions | ISO | ATP2C2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of ATP2C2 gene | CTD | PMID:31601247 | Atp2c2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ATP2C2 mRNA | CTD | PMID:25181051 more ... | Atp2c2 | Rat | bisphenol F | increases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | bisphenol F results in increased expression of ATP2C2 mRNA | CTD | PMID:30951980 | Atp2c2 | Rat | bisphenol F | decreases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | bisphenol F results in decreased expression of ATP2C2 mRNA | CTD | PMID:38685157 | Atp2c2 | Rat | cadmium atom | decreases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | Cadmium results in decreased expression of ATP2C2 mRNA | CTD | PMID:21167921 | Atp2c2 | Rat | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of ATP2C2 mRNA | CTD | PMID:24386269 | Atp2c2 | Rat | dextran sulfate | multiple interactions | ISO | Atp2c2 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] affects the expression of ATP2C2 mRNA | CTD | PMID:29950665 | Atp2c2 | Rat | dorsomorphin | multiple interactions | ISO | ATP2C2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Atp2c2 | Rat | entinostat | multiple interactions | ISO | ATP2C2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP2C2 mRNA | CTD | PMID:27188386 | Atp2c2 | Rat | entinostat | increases expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | entinostat results in increased expression of ATP2C2 mRNA | CTD | PMID:26272509 | Atp2c2 | Rat | flavonoids | increases expression | EXP | | 6480464 | Flavonoids results in increased expression of ATP2C2 mRNA | CTD | PMID:18035473 | Atp2c2 | Rat | folic acid | multiple interactions | ISO | Atp2c2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ATP2C2 mRNA | CTD | PMID:22206623 | Atp2c2 | Rat | formaldehyde | decreases expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of ATP2C2 mRNA | CTD | PMID:27905399 | Atp2c2 | Rat | fulvestrant | multiple interactions | ISO | ATP2C2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of ATP2C2 gene | CTD | PMID:31601247 | Atp2c2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of ATP2C2 mRNA | CTD | PMID:33387578 | Atp2c2 | Rat | hydroquinone | increases expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | hydroquinone results in increased expression of ATP2C2 mRNA | CTD | PMID:31256213 | Atp2c2 | Rat | lycopene | multiple interactions | ISO | Atp2c2 (Mus musculus) | 6480464 | Lycopene inhibits the reaction [Atrazine affects the expression of ATP2C2 mRNA] and Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2C2 mRNA] | CTD | PMID:26476475 more ... | Atp2c2 | Rat | methotrexate | decreases expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of ATP2C2 mRNA | CTD | PMID:24449571 | Atp2c2 | Rat | panobinostat | multiple interactions | ISO | ATP2C2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP2C2 mRNA | CTD | PMID:27188386 | Atp2c2 | Rat | panobinostat | increases expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | panobinostat results in increased expression of ATP2C2 mRNA | CTD | PMID:26272509 | Atp2c2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of ATP2C2 mRNA | CTD | PMID:33387578 | Atp2c2 | Rat | progesterone | multiple interactions | ISO | Atp2c2 (Mus musculus) | 6480464 | NCOA2 protein affects the reaction [Progesterone results in increased expression of ATP2C2 mRNA] | CTD | PMID:17556502 | Atp2c2 | Rat | progesterone | increases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | Progesterone results in increased expression of ATP2C2 mRNA | CTD | PMID:17556502 | Atp2c2 | Rat | rac-lactic acid | decreases expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of ATP2C2 mRNA | CTD | PMID:30851411 | Atp2c2 | Rat | SB 431542 | multiple interactions | ISO | ATP2C2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Atp2c2 | Rat | silicon dioxide | decreases expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of ATP2C2 mRNA | CTD | PMID:25895662 | Atp2c2 | Rat | titanium dioxide | decreases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of ATP2C2 mRNA | CTD | PMID:23557971 | Atp2c2 | Rat | titanium dioxide | increases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of ATP2C2 mRNA | CTD | PMID:35295148 | Atp2c2 | Rat | titanium dioxide | multiple interactions | ISO | Atp2c2 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] affects the expression of ATP2C2 mRNA | CTD | PMID:29950665 | Atp2c2 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of ATP2C2 mRNA | CTD | PMID:33387578 | Atp2c2 | Rat | trichostatin A | increases expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of ATP2C2 mRNA | CTD | PMID:24935251 | Atp2c2 | Rat | triphenyl phosphate | affects expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of ATP2C2 mRNA | CTD | PMID:37042841 | Atp2c2 | Rat | triptonide | increases expression | ISO | Atp2c2 (Mus musculus) | 6480464 | triptonide results in increased expression of ATP2C2 mRNA | CTD | PMID:33045310 | Atp2c2 | Rat | valproic acid | increases expression | ISO | ATP2C2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ATP2C2 mRNA | CTD | PMID:23179753 more ... | Atp2c2 | Rat | valproic acid | multiple interactions | ISO | ATP2C2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP2C2 mRNA | CTD | PMID:27188386 | Atp2c2 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of ATP2C2 gene | CTD | PMID:31079544 | |