Efna1 (ephrin A1) - Rat Genome Database

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Gene: Efna1 (ephrin A1) Rattus norvegicus
Analyze
Symbol: Efna1
Name: ephrin A1
RGD ID: 620388
Description: Predicted to enable ephrin receptor binding activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; heart valve morphogenesis; and regulation of primary metabolic process. Predicted to act upstream of or within several processes, including negative regulation of thymocyte apoptotic process; nervous system development; and regulation of MAPK cascade. Predicted to be located in extracellular region and side of membrane. Predicted to be active in plasma membrane. Orthologous to human EFNA1 (ephrin A1); PARTICIPATES IN altered ephrin - ephrin receptor bidirectional signaling pathway; E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B61; EPH-related receptor tyrosine kinase ligand 1; ephrin-A1; immediate early response protein B61; LERK-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,979,434 - 176,988,675 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2176,979,434 - 176,988,726 (-)EnsemblGRCr8
mRatBN7.22174,681,676 - 174,689,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,681,682 - 174,690,866 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2181,827,299 - 181,834,468 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,849,677 - 179,856,846 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,449,638 - 174,457,020 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,588,808 - 188,596,156 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,588,796 - 188,596,222 (-)Ensemblrn6Rnor6.0
Rnor_5.02208,002,153 - 208,010,763 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42181,444,599 - 181,451,944 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2168,623,896 - 168,631,240 (-)NCBICelera
RGSC_v3.12181,394,706 - 181,402,050 (-)NCBI
RH 3.4 Map21155.2RGD
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
adefovir pivoxil  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (EXP)
cholanic acid  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clomiphene  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
estrone  (ISO)
Evodiamine  (ISO)
flavonoids  (EXP)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
GW 1929  (EXP)
hemin  (ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ifosfamide  (ISO)
indole-3-methanol  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
mancozeb  (ISO)
mercaptopurine  (EXP)
mercury dibromide  (ISO)
mestranol  (ISO)
metformin  (EXP)
methylmercury chloride  (EXP)
methylparaben  (ISO)
mifepristone  (EXP)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. Deroanne C, etal., J Cell Sci 2003 Apr 1;116(Pt 7):1367-76.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Expression and function of the Eph A receptors and their ligands ephrins A in the rat thymus. Munoz JJ, etal., J Immunol 2002 Jul 1;169(1):177-84.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. The role of ephrins and Eph receptors in cancer. Surawska H, etal., Cytokine Growth Factor Rev 2004 Dec;15(6):419-33.
11. Molecular cloning and expression of rat and mouse B61 gene: implications on organogenesis. Takahashi H and Ikeda T, Oncogene 1995 Sep 7;11(5):879-83.
Additional References at PubMed
PMID:10655584   PMID:11287184   PMID:12477932   PMID:14988728   PMID:15145949   PMID:15489334   PMID:15777695   PMID:16547242   PMID:16782872   PMID:17143272   PMID:18794797   PMID:20960543  
PMID:21603973   PMID:23376485   PMID:24217950   PMID:25677907   PMID:29350423  


Genomics

Comparative Map Data
Efna1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,979,434 - 176,988,675 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2176,979,434 - 176,988,726 (-)EnsemblGRCr8
mRatBN7.22174,681,676 - 174,689,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,681,682 - 174,690,866 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2181,827,299 - 181,834,468 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,849,677 - 179,856,846 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,449,638 - 174,457,020 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,588,808 - 188,596,156 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,588,796 - 188,596,222 (-)Ensemblrn6Rnor6.0
Rnor_5.02208,002,153 - 208,010,763 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42181,444,599 - 181,451,944 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2168,623,896 - 168,631,240 (-)NCBICelera
RGSC_v3.12181,394,706 - 181,402,050 (-)NCBI
RH 3.4 Map21155.2RGD
Cytogenetic Map2q34NCBI
EFNA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,127,876 - 155,134,899 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,127,876 - 155,134,899 (+)Ensemblhg38GRCh38
GRCh371155,100,352 - 155,107,375 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,366,973 - 153,374,010 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1128,171,631 - 128,178,823 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1126,462,656 - 126,469,862 (+)NCBIHuRef
CHM1_11156,496,085 - 156,503,124 (+)NCBICHM1_1
T2T-CHM13v2.01154,267,224 - 154,274,255 (+)NCBIT2T-CHM13v2.0
Efna1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,179,037 - 89,188,258 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,179,040 - 89,188,449 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38389,271,730 - 89,280,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,271,733 - 89,281,142 (-)Ensemblmm10GRCm38
MGSCv37389,075,652 - 89,084,873 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36389,357,663 - 89,365,568 (-)NCBIMGSCv36mm8
Celera389,306,600 - 89,315,813 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.04NCBI
Efna1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,610,929 - 1,617,460 (+)Ensembl
ChiLan1.0NW_0049555451,610,929 - 1,617,217 (+)NCBIChiLan1.0ChiLan1.0
EFNA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,706,485 - 94,713,499 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,437,935 - 94,444,930 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,475,128 - 130,482,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,083,855 - 134,091,228 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,083,855 - 134,091,228 (+)EnsemblpanPan2panpan1.1
EFNA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,373,197 - 42,381,161 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,373,639 - 42,378,946 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha741,864,150 - 41,871,485 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0742,242,784 - 42,248,044 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,242,185 - 42,248,036 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1742,022,598 - 42,027,856 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,076,452 - 42,081,711 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,360,084 - 42,365,344 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Efna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,624,127 - 25,630,504 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,654,503 - 4,660,966 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,654,503 - 4,660,950 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EFNA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,666,460 - 94,674,071 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1494,666,457 - 94,673,442 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,449,921 - 103,455,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EFNA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,695,446 - 8,702,556 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,696,241 - 8,702,379 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660388,027,359 - 8,034,821 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Efna1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,383,045 - 2,389,107 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248852,382,712 - 2,388,805 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Efna1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1364,395,861 - 64,403,121 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Efna1
311 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:473
Count of miRNA genes:248
Interacting mature miRNAs:295
Transcripts:ENSRNOT00000027920
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2176840779178247591Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2175279960178247591Rat

Markers in Region
Efna1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82176,980,204 - 176,980,509 (+)Marker Load Pipeline
mRatBN7.22174,682,446 - 174,682,751 (+)MAPPERmRatBN7.2
Rnor_6.02188,589,579 - 188,589,883NCBIRnor6.0
Rnor_5.02208,002,924 - 208,003,228UniSTSRnor5.0
RGSC_v3.42181,445,366 - 181,445,670UniSTSRGSC3.4
Celera2168,624,663 - 168,624,967UniSTS
RH 3.4 Map21155.2UniSTS
Cytogenetic Map2q34UniSTS
RH128971  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,681,741 - 174,681,946 (+)MAPPERmRatBN7.2
Rnor_6.02188,588,874 - 188,589,078NCBIRnor6.0
Rnor_5.02208,002,219 - 208,002,423UniSTSRnor5.0
RGSC_v3.42181,444,661 - 181,444,865UniSTSRGSC3.4
Celera2168,623,958 - 168,624,162UniSTS
RH 3.4 Map21156.4UniSTS
Cytogenetic Map2q34UniSTS
Efna1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82176,980,108 - 176,980,258 (+)Marker Load Pipeline
mRatBN7.22174,682,349 - 174,682,500 (+)MAPPERmRatBN7.2
Rnor_6.02188,589,482 - 188,589,632NCBIRnor6.0
Rnor_5.02208,002,827 - 208,002,977UniSTSRnor5.0
RGSC_v3.42181,445,269 - 181,445,419UniSTSRGSC3.4
Celera2168,624,566 - 168,624,716UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 71 59 6 335 171 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027920   ⟹   ENSRNOP00000027920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2176,979,434 - 176,986,821 (-)Ensembl
mRatBN7.2 Ensembl2174,681,685 - 174,689,061 (-)Ensembl
Rnor_6.0 Ensembl2188,588,796 - 188,596,222 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117150   ⟹   ENSRNOP00000082577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2176,979,434 - 176,988,726 (-)Ensembl
mRatBN7.2 Ensembl2174,681,682 - 174,690,866 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128592   ⟹   ENSRNOP00000099118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2176,979,434 - 176,986,791 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143126   ⟹   ENSRNOP00000107201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2176,979,434 - 176,986,630 (-)Ensembl
RefSeq Acc Id: NM_053599   ⟹   NP_446051
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,979,434 - 176,986,821 (-)NCBI
mRatBN7.22174,681,676 - 174,689,061 (-)NCBI
Rnor_6.02188,588,812 - 188,596,156 (-)NCBI
Rnor_5.02208,002,153 - 208,010,763 (-)NCBI
RGSC_v3.42181,444,599 - 181,451,944 (-)RGD
Celera2168,623,896 - 168,631,240 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761228   ⟹   XP_008759450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,979,438 - 176,986,612 (-)NCBI
mRatBN7.22174,681,676 - 174,688,852 (-)NCBI
Rnor_6.02188,588,808 - 188,595,996 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282651   ⟹   XP_063138721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,979,438 - 176,988,675 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446051 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759450 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138721 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH70514 (Get FASTA)   NCBI Sequence Viewer  
  BAA07242 (Get FASTA)   NCBI Sequence Viewer  
  EDM00644 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027920
  ENSRNOP00000082577
GenBank Protein P97553 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446051   ⟸   NM_053599
- Peptide Label: precursor
- UniProtKB: Q6NS29 (UniProtKB/Swiss-Prot),   P97553 (UniProtKB/Swiss-Prot),   A6J6E5 (UniProtKB/TrEMBL),   A0A8L2QHH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759450   ⟸   XM_008761228
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000027920   ⟸   ENSRNOT00000027920
Ensembl Acc Id: ENSRNOP00000082577   ⟸   ENSRNOT00000117150
RefSeq Acc Id: XP_063138721   ⟸   XM_063282651
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUD2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107201   ⟸   ENSRNOT00000143126
Ensembl Acc Id: ENSRNOP00000099118   ⟸   ENSRNOT00000128592
Protein Domains
Ephrin RBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97553-F1-model_v2 AlphaFold P97553 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691468
Promoter ID:EPDNEW_R1993
Type:initiation region
Name:Efna1_1
Description:ephrin A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02188,596,193 - 188,596,253EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620388 AgrOrtholog
BioCyc Gene G2FUF-52427 BioCyc
Ensembl Genes ENSRNOG00000020573 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027920 ENTREZGENE
  ENSRNOT00000117150 ENTREZGENE
Gene3D-CATH 2.60.40.420 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100462 IMAGE-MGC_LOAD
InterPro Cupredoxin UniProtKB/Swiss-Prot
  Ephrin UniProtKB/Swiss-Prot
  Ephrin-A_Ecto UniProtKB/Swiss-Prot
  Ephrin_CS UniProtKB/Swiss-Prot
  Ephrin_RBD UniProtKB/Swiss-Prot
KEGG Report rno:94268 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91567 IMAGE-MGC_LOAD
NCBI Gene 94268 ENTREZGENE
PANTHER EPHRIN-A1 UniProtKB/Swiss-Prot
  PTHR11304 UniProtKB/Swiss-Prot
Pfam Ephrin UniProtKB/Swiss-Prot
PhenoGen Efna1 PhenoGen
PRINTS EPHRIN UniProtKB/Swiss-Prot
PROSITE EPHRIN_RBD_1 UniProtKB/Swiss-Prot
  EPHRIN_RBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020573 RatGTEx
Superfamily-SCOP SSF49503 UniProtKB/Swiss-Prot
UniProt A0A8I5ZUD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QHH8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L4C1_RAT UniProtKB/TrEMBL
  A0ABK0LYZ2_RAT UniProtKB/TrEMBL
  A6J6E5 ENTREZGENE, UniProtKB/TrEMBL
  EFNA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6NS29 ENTREZGENE
UniProt Secondary Q6NS29 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Efna1  ephrin A1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Efna1  ephrin A1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in thymic epithelial cells and thymocytes 625721
gene_expression expressed in the early stage of thymic development 625721
gene_expression broadly expressed in both the thymic epithelial cells and thymocytes 625721
gene_expression expressed in epithelial cells of various organs, developing skeletal system and dorsal root ganglia 632612
gene_process involved in blood vessel destabilization via the Rac/PAK pathway 1299268