Gcsh (glycine cleavage system protein H) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gcsh (glycine cleavage system protein H) Rattus norvegicus
Analyze
Symbol: Gcsh
Name: glycine cleavage system protein H
RGD ID: 619946
Description: Enables aminomethyltransferase activity and enzyme binding activity. Involved in glycine decarboxylation via glycine cleavage system. Predicted to be part of glycine cleavage complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome. Orthologous to human GCSH (glycine cleavage system protein H); PARTICIPATES IN folate cycle metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycine cleavage system H protein, mitochondrial; glycine cleavage system protein H (aminomethyl carrier); MGC108603
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81961,944,850 - 61,955,607 (-)NCBIGRCr8
mRatBN7.21945,036,013 - 45,046,770 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,036,011 - 45,046,792 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1951,845,779 - 51,856,555 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01952,498,793 - 52,509,569 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01954,743,032 - 54,753,808 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01949,522,054 - 49,532,811 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1949,522,054 - 49,532,811 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01960,313,300 - 60,324,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41947,091,226 - 47,101,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11947,096,114 - 47,106,831 (-)NCBI
Celera1944,309,198 - 44,319,954 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Regulation of the glycine cleavage system in isolated rat liver mitochondria. Hampson RK, etal., J Biol Chem. 1983 Mar 10;258(5):2993-9.
3. Purification and properties of glycine decarboxylase, a component of the glycine cleavage system, from rat liver mitochondria and immunochemical comparison of this enzyme from various sources. Hayasaka K, etal., J Biochem (Tokyo). 1980 Oct;88(4):1193-9.
4. Glycine cleavage system in ketotic hyperglycinemia: a reduction of H-protein activity. Hayasaka K, etal., Pediatr Res. 1982 Jan;16(1):5-7.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Structure and expression of the glycine cleavage system in rat central nervous system. Sakata Y, etal., Brain Res Mol Brain Res 2001 Oct 19;94(1-2):119-30.
12. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Tibbetts AS and Appling DR, Annu Rev Nutr. 2010 Aug 21;30:57-81. doi: 10.1146/annurev.nutr.012809.104810.
13. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
Additional References at PubMed
PMID:1671321   PMID:12477932   PMID:15489334   PMID:18614015   PMID:34800366  


Genomics

Comparative Map Data
Gcsh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81961,944,850 - 61,955,607 (-)NCBIGRCr8
mRatBN7.21945,036,013 - 45,046,770 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,036,011 - 45,046,792 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1951,845,779 - 51,856,555 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01952,498,793 - 52,509,569 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01954,743,032 - 54,753,808 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01949,522,054 - 49,532,811 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1949,522,054 - 49,532,811 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01960,313,300 - 60,324,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41947,091,226 - 47,101,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11947,096,114 - 47,106,831 (-)NCBI
Celera1944,309,198 - 44,319,954 (-)NCBICelera
Cytogenetic Map19q12NCBI
GCSH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381681,081,945 - 81,096,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1681,081,945 - 81,096,395 (-)EnsemblGRCh38hg38GRCh38
GRCh371681,115,550 - 81,130,000 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361679,673,430 - 79,687,481 (-)NCBINCBI36Build 36hg18NCBI36
Build 341679,673,429 - 79,687,481NCBI
Celera1665,413,951 - 65,428,027 (-)NCBICelera
Cytogenetic Map16q23.2NCBI
HuRef1666,872,363 - 66,886,447 (-)NCBIHuRef
CHM1_11682,526,910 - 82,541,365 (-)NCBICHM1_1
T2T-CHM13v2.01687,143,482 - 87,157,585 (-)NCBIT2T-CHM13v2.0
Gcsh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398117,708,706 - 117,720,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8117,708,549 - 117,720,276 (-)EnsemblGRCm39 Ensembl
GRCm388116,981,967 - 116,993,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8116,981,810 - 116,993,537 (-)EnsemblGRCm38mm10GRCm38
MGSCv378119,505,728 - 119,517,349 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368119,867,805 - 119,879,426 (-)NCBIMGSCv36mm8
Celera8121,201,218 - 121,212,838 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map863.43NCBI
Gcsh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555223,857,628 - 3,870,228 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555223,858,156 - 3,869,730 (-)NCBIChiLan1.0ChiLan1.0
GCSH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21890,834,688 - 90,848,126 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11696,725,228 - 96,767,586 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01661,688,959 - 61,702,364 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11681,116,064 - 81,124,145 (-)NCBIpanpan1.1PanPan1.1panPan2
GCSH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1570,745,591 - 70,757,292 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl570,745,258 - 70,756,830 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha570,694,364 - 70,706,021 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0571,050,605 - 71,062,318 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl571,050,245 - 71,062,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1570,992,920 - 71,004,627 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0570,828,128 - 70,839,843 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0571,305,698 - 71,317,366 (+)NCBIUU_Cfam_GSD_1.0
Gcsh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934930,828,885 - 30,839,553 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647528,749,580 - 28,760,230 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647528,749,545 - 28,760,242 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCSH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl67,171,192 - 7,184,729 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.167,171,186 - 7,184,732 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GCSH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1566,538,377 - 66,551,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl566,538,871 - 66,550,817 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660479,286,311 - 9,298,577 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gcsh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247466,264,458 - 6,278,085 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247466,264,447 - 6,278,085 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gcsh
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:72
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000015967
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat

Markers in Region
RH129471  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01960,313,440 - 60,313,632NCBIRnor5.0
Rnor_5.01626,411,703 - 26,411,894NCBIRnor5.0
Rnor_5.01626,207,568 - 26,207,759NCBIRnor5.0
RGSC_v3.41626,388,485 - 26,388,675UniSTSRGSC3.4
RGSC_v3.41947,091,367 - 47,091,558UniSTSRGSC3.4
Celera1624,733,039 - 24,733,229UniSTS
Celera1944,309,339 - 44,309,530UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map19q12UniSTS
RH129771  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21945,036,029 - 45,036,179 (+)MAPPERmRatBN7.2
Rnor_6.01949,522,071 - 49,522,220NCBIRnor6.0
Rnor_5.01960,313,317 - 60,313,466UniSTSRnor5.0
RGSC_v3.41947,091,243 - 47,091,392UniSTSRGSC3.4
Celera1944,309,215 - 44,309,364UniSTS
RH 3.4 Map19613.8UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015967   ⟹   ENSRNOP00000015967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1945,036,011 - 45,046,792 (-)Ensembl
Rnor_6.0 Ensembl1949,522,054 - 49,532,811 (-)Ensembl
RefSeq Acc Id: NM_133598   ⟹   NP_598282
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81961,944,850 - 61,955,607 (-)NCBI
mRatBN7.21945,036,013 - 45,046,770 (-)NCBI
Rnor_6.01949,522,054 - 49,532,811 (-)NCBI
Rnor_5.01960,313,300 - 60,324,057 (-)NCBI
RGSC_v3.41947,091,226 - 47,101,983 (-)RGD
Celera1944,309,198 - 44,319,954 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_598282 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88114 (Get FASTA)   NCBI Sequence Viewer  
  CAB56621 (Get FASTA)   NCBI Sequence Viewer  
  EDL92643 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015967.5
  ENSRNOP00000070859.1
  ENSRNOP00055030218
  ENSRNOP00060030053
  ENSRNOP00065007294
GenBank Protein Q5I0P2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598282   ⟸   NM_133598
- Peptide Label: precursor
- UniProtKB: Q5I0P2 (UniProtKB/Swiss-Prot),   A6IZG4 (UniProtKB/TrEMBL),   A0A0G2JZ02 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015967   ⟸   ENSRNOT00000015967
Protein Domains
Lipoyl-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5I0P2-F1-model_v2 AlphaFold Q5I0P2 1-170 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701169
Promoter ID:EPDNEW_R11692
Type:initiation region
Name:Gcsh_1
Description:glycine cleavage system protein H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01949,532,792 - 49,532,852EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619946 AgrOrtholog
BioCyc Gene G2FUF-5558 BioCyc
BioCyc Pathway 1CMET2-PWY [folate transformations III (E. coli)] BioCyc
  GLYCINE-SYN2-PWY [glycine biosynthesis II] BioCyc
  GLYCLEAV-PWY [glycine cleavage] BioCyc
BioCyc Pathway Image 1CMET2-PWY BioCyc
  GLYCINE-SYN2-PWY BioCyc
  GLYCLEAV-PWY BioCyc
Ensembl Genes ENSRNOG00000011535 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000051496 UniProtKB/TrEMBL
  ENSRNOG00055021688 UniProtKB/Swiss-Prot
  ENSRNOG00060021071 UniProtKB/Swiss-Prot
  ENSRNOG00065006492 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015967.6 UniProtKB/Swiss-Prot
  ENSRNOT00000088966.2 UniProtKB/TrEMBL
  ENSRNOT00055037131 UniProtKB/Swiss-Prot
  ENSRNOT00060036518 UniProtKB/Swiss-Prot
  ENSRNOT00065010019 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7321648 IMAGE-MGC_LOAD
InterPro 2-oxoA_DH_lipoyl-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_H/Fam206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_H_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171133 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108603 IMAGE-MGC_LOAD
NCBI Gene 171133 ENTREZGENE
PANTHER GLYCINE CLEAVAGE SYSTEM H PROTEIN UniProtKB/TrEMBL
  GLYCINE CLEAVAGE SYSTEM H PROTEIN, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11715 UniProtKB/Swiss-Prot
Pfam GCV_H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gcsh PhenoGen
PROSITE BIOTINYL_LIPOYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011535 RatGTEx
  ENSRNOG00000051496 RatGTEx
  ENSRNOG00055021688 RatGTEx
  ENSRNOG00060021071 RatGTEx
  ENSRNOG00065006492 RatGTEx
Superfamily-SCOP Single hybrid motif UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A0G2JZ02 ENTREZGENE, UniProtKB/TrEMBL
  A6IZG4 ENTREZGENE, UniProtKB/TrEMBL
  GCSH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Gcsh  glycine cleavage system protein H  Gcsh  glycine cleavage system protein H (aminomethyl carrier)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gcsh  glycine cleavage system protein H (aminomethyl carrier)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Gcsh  glycine cleavage system protein H (aminomethyl carrier)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in the forebrain and cerebellum neuropathogenesis of nonketotic hyperglycinemia (NKH) 708332
gene_expression may be induced after certain types of damages to liver 70249
gene_function aminomethyl carrier 70249
gene_protein 170 amino acids 708332