Gcsh (glycine cleavage system protein H)

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Gene: Gcsh (glycine cleavage system protein H) Chinchilla lanigera

Analyze

Symbol:

Gcsh

Name:

glycine cleavage system protein H

RGD ID:

8731356

Description:

ENCODES a protein that exhibits aminomethyltransferase activity (ortholog); enzyme binding (ortholog); INVOLVED IN glycine decarboxylation via glycine cleavage system (ortholog); protein lipoylation (ortholog); PARTICIPATES IN folate cycle metabolic pathway; ASSOCIATED WITH amino acid metabolic disorder (ortholog); giant axonal neuropathy 1 (ortholog); glycine encephalopathy (ortholog); FOUND IN mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

glycine cleavage system H protein, mitochondrial; glycine cleavage system protein H (aminomethyl carrier)

RGD Orthologs

Human

Mouse

Rat

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955522	3,858,156 - 3,869,730 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amino acid metabolic disorder (ISO)

giant axonal neuropathy 1 (ISO)

glycine encephalopathy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glycine decarboxylation via glycine cleavage system (ISO)

protein lipoylation (ISO)

Cellular Component

mitochondrion (ISO)

Molecular Function

aminomethyltransferase activity (ISO)

enzyme binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

folate cycle metabolic pathway (ISO)

References

References - curated


1.	Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2.	OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data

Gcsh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955522	3,858,156 - 3,869,730 (-)	NCBI	ChiLan1.0	ChiLan1.0

GCSH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	16	81,081,938 - 81,096,425 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	16	81,081,945 - 81,096,395 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	16	81,081,945 - 81,096,395 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	16	81,115,552 - 81,129,980 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	16	81,115,550 - 81,130,000 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	79,673,430 - 79,687,481 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	16	79,673,429 - 79,687,481	NCBI
Celera	16	65,413,951 - 65,428,027 (-)	NCBI
Cytogenetic Map	16	q23.2	NCBI
HuRef	16	66,872,363 - 66,886,447 (-)	NCBI		HuRef
CHM1_1	16	82,526,910 - 82,541,365 (-)	NCBI		CHM1_1

Gcsh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	117,708,706 - 117,720,237 (-)	NCBI	GRCm39		mm39
GRCm38	8	116,981,967 - 116,993,498 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	116,981,810 - 116,993,537 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	119,505,728 - 119,517,349 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	119,867,805 - 119,879,426 (-)	NCBI			mm8
Celera	8	121,201,218 - 121,212,838 (-)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI

Gcsh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	45,036,013 - 45,046,770 (-)	NCBI
Rnor_6.0 Ensembl	19	49,522,054 - 49,532,811 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	19	49,522,054 - 49,532,811 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	19	60,313,300 - 60,324,057 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	47,091,226 - 47,101,983 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	19	47,096,114 - 47,106,831 (-)	NCBI
Celera	19	44,309,198 - 44,319,954 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

GCSH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	16	81,116,064 - 81,124,145 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	16	61,688,959 - 61,702,364 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

GCSH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	5	70,745,258 - 70,756,830 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	5	70,745,591 - 70,757,292 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Gcsh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936475	28,749,545 - 28,760,242 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GCSH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	7,171,186 - 7,184,732 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

GCSH
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	66,538,377 - 66,551,068 (-)	NCBI
ChlSab1.1 Ensembl	5	66,538,871 - 66,550,817 (-)	Ensembl

Gcsh
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624746	6,264,447 - 6,278,085 (+)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013507109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01068401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01068402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01077313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01228720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

XM_013507109 ⟹ XP_013362563

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955522	3,858,156 - 3,869,730 (-)	NCBI

Sequence:

show sequence

CTCCGCCCTCCCGGTTGCCCCGCCTCCCCGCTTCCCCGCCCCAGCCGGCCCGGTGGCCCCGGCC
CCCTCGCGGAGACCCTCGGAAGCCCCGCGAACATGGCGCTGCGAGTGGCCGGGAGCGTGCGCGC
CGCGGCCCGCAGCCTGCGCGCAGCCTCGGTGCCCTCCCCCCCCTGCCCGATTCGGCCCTGGAGG
CTGCGGGCGGGCGCAGTGCGGCCGCTGCACACCGGACCGAGTCTGCTCGCGGTGCGTAAATTCA
CAGAGAAACACGAATGGATAACAGCAGAAAATGGTATTGGAACAGTGGGAATCAGCAACTTTGC
ACAGGAAGCTTTGGGAGATGTGGTTTACTGTAGTCTACCGGAAGTCGGGACAAAACTGAAAAAG
CATGATGAGTTTGGTGCTTTGGAAAGCGTGAAAGCTGCCAGCGAACTCTACTCTCCTCTGTCGG
GGGAAGTAACGGAAGTTAACGAAGCACTTGCAGAAAACCCGGGACTCGTCAACAAGTCTTGTTA
TGAAGATGGCTGGCTGATCAAGATGACCGTGAGTGACCCTTCAGAGCTAGATGAGCTCATGAGC
GAAGAAGCATATGAGAAATACGTGAAATCGATTGAGGAGTGAAGTTGCACCCGGAAGAAACTAG
TGTGAAGTGACTTCTTCAGCGGAGTTGTCTGCAGTGAGTAGCAGACAAAGACCTGAGATAACAA
CTTTTAGCAGTACTATAATGATGGAAAAGAAACCACTCTCATCGCTGCTCCTGGACGAAAATAC
CCACTAACTCCCTAGTGATTGCAGAACACAATGTGCATCTTTTTATATATGCCTTATGATTTTT
AGACTAGGTTGTAGGTTCTGATATTCAGAATTCATTAAATTATCCATGGTAAAAACTAGTTATA
AGAATTATGCAATTCAAGGATAACACTGTTACCATAATATTATAACTTGCTTGTTATAATGTAA
TATTATAACTTGCTTACATTTCTTCCTGGACTTGGTCGAAATACTTAAAGAACATGTGTCACTT
GTATAATGTCAGATGAAGAACGACACTTTCTTAATTTTATAATAGACTGCATCGCCTGGAGCTG
TTTTTATACAGTGAAGCAACAGCTTTGCAGCACAATAAGAAACAAATAAAATATTCAACCTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013362563	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_013362563 ⟸ XM_013507109
- Sequence:	show sequence MALRVAGSVRAAARSLRAASVPSPPCPIRPWRLRAGAVRPLHTGPSLLAVRKFTEKHEWITAEN GIGTVGISNFAQEALGDVVYCSLPEVGTKLKKHDEFGALESVKAASELYSPLSGEVTEVNEALA ENPGLVNKSCYEDGWLIKMTVSDPSELDELMSEEAYEKYVKSIEE hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000000355	ENTREZGENE
Ensembl Protein	ENSCLAP00000000425	ENTREZGENE
Ensembl Transcript	ENSCLAT00000000454	ENTREZGENE
NCBI Gene	Gcsh	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Gcsh	glycine cleavage system protein H		glycine cleavage system protein H (aminomethyl carrier)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations