Mir182 (microRNA 182) - Rat Genome Database

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Gene: Mir182 (microRNA 182) Rattus norvegicus
Analyze
Symbol: Mir182
Name: microRNA 182
RGD ID: 4888616
Description: Predicted to enable mRNA base-pairing post-transcriptional repressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of cell migration; and negative regulation of cell population proliferation. Used to study retinoblastoma. Biomarker of retinoblastoma and sciatic neuropathy; INTERACTS WITH 2-acetamidofluorene; atrazine; benzophenone.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-182
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8459,752,246 - 59,752,307 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2458,784,818 - 58,784,879 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,784,818 - 58,784,879 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx463,761,933 - 63,761,994 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0459,678,100 - 59,678,161 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0458,080,005 - 58,080,066 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd461,495,392 - 61,495,453 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive458,894,358 - 58,894,419 (-)NCBILyon_Normotensive
Lyon_Hypertensive459,488,356 - 59,488,417 (-)NCBILyon_Hypertensive
F344_StmMcwi459,253,974 - 59,254,035 (-)NCBIF344_StmMcwi
Rnor_6.0457,459,773 - 57,459,834 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0457,221,574 - 57,221,635 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera453,884,389 - 53,884,450 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway. Huang Y, etal., J Cell Physiol. 2018 Oct;233(10):6693-6704. doi: 10.1002/jcp.26469. Epub 2018 Apr 25.
2. Downregulation of microRNA‑182 inhibits cell viability, invasion and angiogenesis in retinoblastoma through inhibition of the PI3K/AKT pathway and CADM2 upregulation. Huang YX, etal., Int J Oncol. 2018 Dec;53(6):2615-2626. doi: 10.3892/ijo.2018.4587. Epub 2018 Oct 9.
3. Circulating MicroRNAs in Extracellular Vesicles as Potential Biomarkers of Alcohol-Induced Neuroinflammation in Adolescence: Gender Differences. Ibáñez F, etal., Int J Mol Sci. 2020 Sep 14;21(18):6730. doi: 10.3390/ijms21186730.
4. miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage following sciatic nerve injury. Yu B, etal., Nucleic Acids Res. 2012 Nov 1;40(20):10356-65. doi: 10.1093/nar/gks750. Epub 2012 Aug 23.
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:20403161   PMID:23345246   PMID:25530976   PMID:25684245   PMID:26368940   PMID:26975828   PMID:27199451   PMID:27208084   PMID:27870928   PMID:28259995  
PMID:29196163   PMID:29236317   PMID:29671338   PMID:29733821   PMID:30292407   PMID:31210325   PMID:31373075   PMID:32105765   PMID:33336785   PMID:33491285   PMID:33626373   PMID:33691396  
PMID:33965964   PMID:34518490   PMID:35282795   PMID:35503215   PMID:38063104  


Genomics

Comparative Map Data
Mir182
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8459,752,246 - 59,752,307 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2458,784,818 - 58,784,879 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,784,818 - 58,784,879 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx463,761,933 - 63,761,994 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0459,678,100 - 59,678,161 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0458,080,005 - 58,080,066 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd461,495,392 - 61,495,453 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive458,894,358 - 58,894,419 (-)NCBILyon_Normotensive
Lyon_Hypertensive459,488,356 - 59,488,417 (-)NCBILyon_Hypertensive
F344_StmMcwi459,253,974 - 59,254,035 (-)NCBIF344_StmMcwi
Rnor_6.0457,459,773 - 57,459,834 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0457,221,574 - 57,221,635 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera453,884,389 - 53,884,450 (-)NCBICelera
Cytogenetic Map4q22NCBI
MIR182
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387129,770,383 - 129,770,492 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7129,770,383 - 129,770,492 (-)Ensemblhg38GRCh38
GRCh377129,410,223 - 129,410,332 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367129,197,458 - 129,197,567 (-)NCBIBuild 36Build 36hg18NCBI36
Celera7124,205,968 - 124,206,077 (-)NCBICelera
Cytogenetic Map7q32.2NCBI
HuRef7123,771,508 - 123,771,617 (-)NCBIHuRef
CHM1_17129,343,614 - 129,343,723 (-)NCBICHM1_1
T2T-CHM13v2.07131,083,517 - 131,083,626 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27128,794,499 - 128,794,608 (-)NCBI
Mir182
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39630,165,917 - 30,165,991 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl630,165,917 - 30,165,991 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38630,165,918 - 30,165,992 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl630,165,918 - 30,165,992 (-)Ensemblmm10GRCm38
MGSCv37630,115,918 - 30,115,992 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera630,172,634 - 30,172,708 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.52NCBI

miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mitfrno-miR-182Mirtarbaseexternal_infoWestern blotFunctional MTI19167416

Predicted Targets
Summary Value
Count of predictions:5812
Count of gene targets:4171
Count of transcripts:4466
Interacting mature miRNAs:rno-miR-182
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_037314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000107570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl458,784,818 - 58,784,879 (-)Ensembl
RefSeq Acc Id: NR_037314
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,752,246 - 59,752,307 (-)NCBI
mRatBN7.2458,784,818 - 58,784,879 (-)NCBI
Dahl_SR_JrHsd461,495,392 - 61,495,453 (-)NCBI
Lyon_Normotensive458,894,358 - 58,894,419 (-)NCBI
Lyon_Hypertensive459,488,356 - 59,488,417 (-)NCBI
F344_StmMcwi459,253,974 - 59,254,035 (-)NCBI
Rnor_6.0457,459,773 - 57,459,834 (-)NCBI
Rnor_5.0457,221,574 - 57,221,635 (-)NCBI
Celera453,884,389 - 53,884,450 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-45369 BioCyc
Ensembl Genes ENSRNOG00000068116 Ensembl
miRBase MI0006133 ENTREZGENE
NCBI Gene 100314172 ENTREZGENE
PhenoGen Mir182 PhenoGen
RatGTEx ENSRNOG00000068116 RatGTEx
RNAcentral URS00003D5044 RNACentral
  URS000075BE10 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Mir182  microRNA 182  Mir182  microRNA 182  Data merged from RGD:149736526 737654 PROVISIONAL
2021-08-09 Mir182  microRNA 182      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-04-09 Mir182  microRNA 182  Mir182  microRNA mir-182  Name updated 61478 APPROVED
2010-11-23 Mir182  microRNA mir-182      Symbol and Name status set to provisional 70820 PROVISIONAL