Tf (transferrin) - Rat Genome Database

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Gene: Tf (transferrin) Rattus norvegicus
Analyze
Symbol: Tf
Name: transferrin
RGD ID: 3845
Description: Enables ferric iron binding activity. Involved in several processes, including cellular response to cAMP; cellular response to follicle-stimulating hormone stimulus; and regulation of nervous system development. Located in several cellular components, including basement membrane; cell tip; and dendrite. Used to study hepatitis. Biomarker of anemia and obesity. Human ortholog(s) of this gene implicated in anemia (multiple); atransferrinemia; gastrointestinal system disease; glucose metabolism disease (multiple); and restless legs syndrome. Orthologous to human TF (transferrin); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; hypoxia inducible factor pathway; iron uptake pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-1 metal-binding globulin; liver regeneration-related protein LRRG03; MGC93500; serotransferrin; siderophilin; Tfn; Trf
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Hcar3
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88112,668,667 - 112,695,376 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8112,647,642 - 112,695,400 (-)EnsemblGRCr8
mRatBN7.28103,789,780 - 103,816,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8103,767,995 - 103,816,511 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8109,449,188 - 109,475,891 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08107,648,350 - 107,675,056 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08105,491,027 - 105,517,729 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08111,694,570 - 111,721,275 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,673,547 - 111,721,333 (-)Ensemblrn6Rnor6.0
Rnor_5.08111,085,984 - 111,112,688 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48108,217,774 - 108,244,487 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8103,167,171 - 103,194,045 (-)NCBICelera
RGSC_v3.18108,237,229 - 108,263,942 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-pantothenic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-methoxyethanol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nonylphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
acrylic acid  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alcohol  (ISO)
all-trans-retinoic acid  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (EXP,ISO)
amphetamine  (EXP)
Ampullosporin  (EXP)
aniline  (EXP)
Aroclor 1254  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
astemizole  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
bromobenzene  (EXP)
busulfan  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chromium atom  (EXP,ISO)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
citric acid  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(I) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
DDE  (EXP)
deferiprone  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diacetylmonoxime  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
dichlorvos  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
diiodine  (ISO)
diisopropyl fluorophosphate  (EXP,ISO)
dimethyl sulfoxide  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
divanadium pentaoxide  (EXP)
doxorubicin  (EXP,ISO)
drometrizole  (ISO)
endosulfan  (EXP)
erastin  (EXP)
ethanol  (ISO)
ethylene glycol  (EXP)
ferric ammonium citrate  (ISO)
ferric oxide  (EXP)
ferric pyrophosphate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gallium atom  (EXP,ISO)
gallium nitrate  (ISO)
genistein  (ISO)
glafenine  (EXP)
glycerol  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
haloperidol  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
indometacin  (ISO)
iodide salt  (EXP)
iron atom  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
iron(III) citrate  (ISO)
isoniazide  (EXP,ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
melatonin  (EXP)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methapyrilene  (EXP,ISO)
methyl beta-cyclodextrin  (ISO)
monocrotaline  (ISO)
N-ethylmaleimide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
Nivalenol  (ISO)
nocodazole  (ISO)
Nonylphenol  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
orlistat  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorobutyric acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP)
phenylarsine oxide  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
prednisolone  (ISO)
propanal  (ISO)
propane-1,2-diol  (ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
quinoxyfen  (ISO)
resveratrol  (EXP,ISO)
rhapontigenin  (ISO)
rosmarinic acid  (ISO)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
S-nitrosoglutathione  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
splitomicin  (ISO)
succimer  (ISO)
T-2 toxin  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (EXP)
thyroxine  (ISO)
titanium atom  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
tungsten  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
XAV939  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transferrin is not involved in the entry of 67Ga into hepatocytes from regenerating liver of partially hepatectomized rats. Abe S, etal., Biol Pharm Bull 2001 Dec;24(12):1343-6.
2. Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin. Adamo AM, etal., Exp Neurol. 2006 Apr;198(2):519-29. Epub 2006 Feb 14.
3. Nerve degeneration is prevented by a single intraneural apotransferrin injection into colchicine-injured sciatic nerves in the rat. Aquino JB, etal., Brain Res. 2006 Oct 30;1117(1):80-91. Epub 2006 Sep 28.
4. Target identification of the novel antiobesity agent tungstate in adipose tissue from obese rats. Barcelo-Batllori S, etal., Proteomics. 2005 Dec;5(18):4927-35.
5. IRON-HF study: A randomized trial to assess the effects of iron in heart failure patients with anemia. Beck-da-Silva L, etal., Int J Cardiol. 2013 May 13. pii: S0167-5273(13)00848-6. doi: 10.1016/j.ijcard.2013.04.181.
6. Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis. Brunner HI, etal., Arthritis Rheum. 2012 Aug;64(8):2687-97. doi: 10.1002/art.34426.
7. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego Cymerys M, etal., Pol Merkur Lekarski. 2003 Oct;15(88):352-4; discussion 354-5.
8. Iron metabolism and its relationship to anemia and immune system in Trypanosoma evansi infected rats. da Silva CB, etal., Exp Parasitol. 2013 Mar;133(3):357-64. doi: 10.1016/j.exppara.2012.12.010. Epub 2012 Dec 25.
9. Rat mammary-gland transferrin: nucleotide sequence, phylogenetic analysis and glycan structure. Escriva H, etal., Biochem J 1995 Apr 1;307 ( Pt 1):47-55.
10. Ferritin and transferrin are both predictive of the onset of hyperglycemia in men and women over 3 years: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. Fumeron F, etal., Diabetes Care. 2006 Sep;29(9):2090-4.
11. Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade. Gainey MA, etal., Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3590-9. doi: 10.1073/pnas.1510754112. Epub 2015 Jun 24.
12. Differential effects of apotransferrin on two populations of oligodendroglial cells. Garcia CI, etal., Glia 2003 Jun;42(4):406-16.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Immunolocalization of some plasmatic proteins in basement membranes during earliest rat morphogenesis with special reference to the gonadal differentiation. Gelly JL, etal., Histochemistry. 1991;96(4):323-6.
15. Intranasal administration of aTf protects and repairs the neonatal white matter after a cerebral hypoxic-ischemic event. Guardia Clausi M, etal., Glia. 2012 Oct;60(10):1540-54. doi: 10.1002/glia.22374. Epub 2012 Jun 26.
16. Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats. Han J, etal., Nutr Neurosci 2003 Feb;6(1):1-10.
17. Decisive indicator for gastrointestinal workup in anemic patients with nondialysis chronic kidney disease. Hwang HS, etal., Int J Med Sci. 2012;9(8):634-41. doi: 10.7150/ijms.4969. Epub 2012 Sep 19.
18. Time-dependent plasma protein changes in streptozotocin-induced diabetic rats before and after fungal polysaccharide treatments. Kim SW, etal., J Proteome Res. 2006 Nov;5(11):2966-76.
19. Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human. Kolachala VL, etal., World J Gastroenterol. 2007 Feb 21;13(7):1042-52.
20. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
21. Study of iron metabolism disturbances in an animal model of insulin resistance. Le Guenno G, etal., Diabetes Res Clin Pract. 2007 Mar 8;.
22. Human transferrin G277S mutation: a risk factor for iron deficiency anaemia. Lee PL, etal., Br J Haematol. 2001 Nov;115(2):329-33.
23. Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. Li Y, etal., BMC Nephrol. 2012 May 20;13:29. doi: 10.1186/1471-2369-13-29.
24. Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan. Lin CH, etal., Eur J Neurol. 2013 Feb 1. doi: 10.1111/ene.12095.
25. [Effects of p,p'-dDE on the expression of androgen-binding protein, transferrin and inhibin B mRNA in rat sertoli cells] Liu GH, etal., Zhonghua Nan Ke Xue. 2006 Feb;12(2):104-7, 111.
26. The immunobiology of apotransferrin in type 1 diabetes. Mangano K, etal., Clin Exp Immunol. 2012 Sep;169(3):244-52. doi: 10.1111/j.1365-2249.2012.04619.x.
27. [Influence of ischemia/hypoxia on the HIF-1 activity and expression of hypoxia-dependent genes in the cochlea of the newborn rat] Mazurek B, etal., HNO. 2006 Sep;54(9):689-97.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. Changes in serum parameters associated with iron metabolism in male rat exposed to lead. Moshtaghie M, etal., J Physiol Biochem. 2013 Jun;69(2):297-304. doi: 10.1007/s13105-012-0212-9. Epub 2012 Sep 25.
30. Role of the basic helix-loop-helix transcription factor, scleraxis, in the regulation of Sertoli cell function and differentiation. Muir T, etal., Mol Endocrinol. 2005 Aug;19(8):2164-74. Epub 2005 Apr 14.
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. Apotransferrin decreases migration and enhances differentiation of oligodendroglial progenitor cells in an in vitro system. Paez PM, etal., Dev Neurosci 2002;24(1):47-58.
33. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Alterations in intracerebral hemorrhage-induced brain injury in the iron deficient rat. Shao J, etal., Acta Neurochir Suppl. 2006;96:183-7.
37. Changes of gene expression of iron regulatory proteins during turpentine oil-induced acute-phase response in the rat. Sheikh N, etal., Lab Invest. 2007 Apr 9;.
38. Neural and oligodendrocyte progenitor cells: transferrin effects on cell proliferation. Silvestroff L, etal., ASN Neuro. 2013 Mar 8;5(1):e00107. doi: 10.1042/AN20120075.
39. [Dynamic change of lipid peroxidation-related protein expression and the intervention effects of Yiguanjian decoction in a rat model of CCl4-induced liver fibrosis]. Tao Q, etal., Zhonghua Gan Zang Bing Za Zhi. 2012 Feb;20(2):116-21. doi: 10.3760/cma.j.issn.1007-3418.2012.02.010.
40. Ferrritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population. The D.E.S.I.R. Study. Vari IS, etal., Diabetes Care. 2007 Apr 6;.
41. Reactive oxygen species modify oligosaccharides of glycoproteins in vivo: a study of a spontaneous acute hepatitis model rat (LEC rat). Yasuda J, etal., Biochem Biophys Res Commun. 2006 Mar 31;342(1):127-34. Epub 2006 Feb 2.
42. Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury. Zhang L, etal., Neurol Sci. 2013 May;34(5):639-45. doi: 10.1007/s10072-012-1090-1. Epub 2012 Apr 27.
43. Iron chelator alleviates tubulointerstitial fibrosis in diabetic nephropathy rats by inhibiting the expression of tenascinC and other correlation factors. Zou C, etal., Endocrine. 2013 Mar 7.
Additional References at PubMed
PMID:500689   PMID:1791188   PMID:3023031   PMID:3046665   PMID:6236811   PMID:8829802   PMID:9420335   PMID:9546397   PMID:9990067   PMID:11208127   PMID:11230685   PMID:11739192  
PMID:12121420   PMID:12477932   PMID:12704209   PMID:12857860   PMID:14701678   PMID:15047867   PMID:15229288   PMID:15247266   PMID:15292400   PMID:15469901   PMID:15489334   PMID:15637325  
PMID:15880641   PMID:16195351   PMID:16227996   PMID:16497717   PMID:16502470   PMID:17628542   PMID:18353247   PMID:18353773   PMID:18459135   PMID:18477453   PMID:18511206   PMID:18708193  
PMID:19056867   PMID:19061864   PMID:19250966   PMID:19252502   PMID:19464997   PMID:20080761   PMID:20202662   PMID:20427320   PMID:21195069   PMID:22206666   PMID:22479482   PMID:22516433  
PMID:22664934   PMID:23012479   PMID:23303939   PMID:23376485   PMID:23416069   PMID:23533145   PMID:23580065   PMID:24035762   PMID:25595122   PMID:25649872   PMID:26316108   PMID:29248829  
PMID:29388418   PMID:29476059   PMID:30758712   PMID:36361544  


Genomics

Comparative Map Data
Tf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88112,668,667 - 112,695,376 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8112,647,642 - 112,695,400 (-)EnsemblGRCr8
mRatBN7.28103,789,780 - 103,816,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8103,767,995 - 103,816,511 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8109,449,188 - 109,475,891 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08107,648,350 - 107,675,056 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08105,491,027 - 105,517,729 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08111,694,570 - 111,721,275 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,673,547 - 111,721,333 (-)Ensemblrn6Rnor6.0
Rnor_5.08111,085,984 - 111,112,688 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48108,217,774 - 108,244,487 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8103,167,171 - 103,194,045 (-)NCBICelera
RGSC_v3.18108,237,229 - 108,263,942 (-)NCBI
Cytogenetic Map8q32NCBI
TF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383133,661,998 - 133,796,641 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3133,746,040 - 133,796,641 (+)Ensemblhg38GRCh38
GRCh373133,380,842 - 133,515,485 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363134,947,925 - 134,980,325 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343134,947,932 - 134,980,333NCBI
Celera3131,892,092 - 131,924,970 (+)NCBICelera
Cytogenetic Map3q22.1NCBI
HuRef3130,844,635 - 130,877,514 (+)NCBIHuRef
CHM1_13133,428,386 - 133,461,264 (+)NCBICHM1_1
T2T-CHM13v2.03136,407,161 - 136,541,840 (+)NCBIT2T-CHM13v2.0
Trf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399103,086,075 - 103,107,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9103,081,200 - 103,107,643 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389103,208,876 - 103,230,286 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9103,204,001 - 103,230,444 (-)Ensemblmm10GRCm38
MGSCv379103,111,206 - 103,132,616 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369103,067,026 - 103,088,436 (-)NCBIMGSCv36mm8
Celera9102,759,422 - 102,780,824 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map955.03NCBI
LOC102027549
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555014,801,885 - 4,831,910 (-)Ensembl
ChiLan1.0NW_0049555014,801,710 - 4,832,025 (-)NCBIChiLan1.0ChiLan1.0
TF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22131,677,472 - 131,709,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13131,682,201 - 131,713,860 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03130,799,063 - 130,830,227 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13138,274,159 - 138,305,481 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3138,274,159 - 138,305,476 (+)EnsemblpanPan2panpan1.1
LOC477072
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12330,658,250 - 30,683,816 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2330,595,704 - 30,683,845 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2330,637,375 - 30,662,940 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02331,178,649 - 31,204,226 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12330,872,448 - 30,898,034 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02330,930,277 - 30,955,845 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02331,177,861 - 31,203,421 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101970551
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560270,095,470 - 70,135,492 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365296,856,042 - 6,895,989 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1374,930,655 - 74,972,763 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11374,930,655 - 74,970,599 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21382,429,021 - 82,469,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q31NCBI
LOC103241654
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11556,586,311 - 56,618,304 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1556,544,391 - 56,560,045 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 Ensembl1556,586,104 - 56,618,149 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604129,568,907 - 29,601,746 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101719398
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473010,078,165 - 10,109,349 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Tf
194 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:210
Count of miRNA genes:95
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000012725, ENSRNOT00000012946, ENSRNOT00000045628
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
Trf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28103,816,628 - 103,816,847 (+)MAPPERmRatBN7.2
Rnor_6.08111,721,417 - 111,721,635NCBIRnor6.0
Rnor_5.08111,112,830 - 111,113,048UniSTSRnor5.0
RGSC_v3.48108,244,629 - 108,244,847UniSTSRGSC3.4
Celera8103,194,187 - 103,194,402UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 13 76 206 91 90 59 144 59 6 442 263 22 183 96 120 31 26 26

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC119318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF468455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF476964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY327504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X77158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012725   ⟹   ENSRNOP00000012725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,647,642 - 112,695,400 (-)Ensembl
mRatBN7.2 Ensembl8103,767,995 - 103,816,511 (-)Ensembl
Rnor_6.0 Ensembl8111,673,547 - 111,721,333 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000045628   ⟹   ENSRNOP00000045637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,668,671 - 112,695,400 (-)Ensembl
mRatBN7.2 Ensembl8103,789,784 - 103,816,511 (-)Ensembl
Rnor_6.0 Ensembl8111,694,566 - 111,721,303 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155685   ⟹   ENSRNOP00000103795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,670,220 - 112,693,188 (-)Ensembl
RefSeq Acc Id: NM_001013110   ⟹   NP_001013128
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,668,667 - 112,695,376 (-)NCBI
mRatBN7.28103,789,780 - 103,816,487 (-)NCBI
Rnor_6.08111,694,570 - 111,721,275 (-)NCBI
Rnor_5.08111,085,984 - 111,112,688 (-)NCBI
RGSC_v3.48108,217,774 - 108,244,487 (-)RGD
Celera8103,167,171 - 103,194,045 (-)RGD
Sequence:
RefSeq Acc Id: NP_001013128   ⟸   NM_001013110
- Peptide Label: precursor
- UniProtKB: Q64630 (UniProtKB/Swiss-Prot),   Q64628 (UniProtKB/Swiss-Prot),   Q63602 (UniProtKB/Swiss-Prot),   Q7TNX0 (UniProtKB/Swiss-Prot),   P12346 (UniProtKB/Swiss-Prot),   A6I2I8 (UniProtKB/TrEMBL),   A6I2I9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045637   ⟸   ENSRNOT00000045628
Ensembl Acc Id: ENSRNOP00000012725   ⟸   ENSRNOT00000012725
Ensembl Acc Id: ENSRNOP00000103795   ⟸   ENSRNOT00000155685
Protein Domains
Transferrin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12346-F1-model_v2 AlphaFold P12346 1-698 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696228
Promoter ID:EPDNEW_R6753
Type:multiple initiation site
Name:Tf_1
Description:transferrin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08111,721,296 - 111,721,356EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3845 AgrOrtholog
BioCyc Gene G2FUF-29332 BioCyc
Ensembl Genes ENSRNOG00000030625 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045628 ENTREZGENE
  ENSRNOT00000045628.6 UniProtKB/Swiss-Prot
Gene3D-CATH Periplasmic binding protein-like II UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132382 IMAGE-MGC_LOAD
InterPro Serotransferrin_mammal UniProtKB/Swiss-Prot
  Transferrin UniProtKB/Swiss-Prot
  Transferrin-like_dom UniProtKB/Swiss-Prot
  Transferrin_Fe_BS UniProtKB/Swiss-Prot
KEGG Report rno:24825 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93500 IMAGE-MGC_LOAD
NCBI Gene 24825 ENTREZGENE
PANTHER SEROTRANSFERRIN UniProtKB/Swiss-Prot
  TRANSFERRIN UniProtKB/Swiss-Prot
Pfam Transferrin UniProtKB/Swiss-Prot
PhenoGen Tf PhenoGen
PIRSF Serotransferrin UniProtKB/Swiss-Prot
  Transferrin UniProtKB/Swiss-Prot
PRINTS TRANSFERRIN UniProtKB/Swiss-Prot
PROSITE TRANSFERRIN_LIKE_1 UniProtKB/Swiss-Prot
  TRANSFERRIN_LIKE_2 UniProtKB/Swiss-Prot
  TRANSFERRIN_LIKE_3 UniProtKB/Swiss-Prot
  TRANSFERRIN_LIKE_4 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030625 RatGTEx
SMART TR_FER UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
UniProt A0ABK0LPU0_RAT UniProtKB/TrEMBL
  A6I2I8 ENTREZGENE, UniProtKB/TrEMBL
  A6I2I9 ENTREZGENE, UniProtKB/TrEMBL
  P12346 ENTREZGENE
  Q63602 ENTREZGENE
  Q64628 ENTREZGENE
  Q64630 ENTREZGENE
  Q7TMC7_RAT UniProtKB/TrEMBL
  Q7TNX0 ENTREZGENE
  TRFE_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63602 UniProtKB/Swiss-Prot
  Q64628 UniProtKB/Swiss-Prot
  Q64630 UniProtKB/Swiss-Prot
  Q7TNX0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tf  transferrin  Trf  transferrin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Trf  transferrin  Tf  transferrin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tf  Transferrin      Symbol and Name status set to approved 70586 APPROVED